Statin use as a moderator on the association between metformin and breast cancer risk in women with type 2 diabetes mellitus
ConclusionsExtending metformin or statin usage by one year conferred breast cancer protection in women with T2DM. Enhanced protective effect of metformin was observed among those who also use statins. These results suggest the potential of combined metformin and statin therapy as promising breast cancer prevention strategies. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - April 12, 2024 Category: Cancer & Oncology Source Type: research
Purine salvage promotes treatment resistance in H3K27M-mutant diffuse midline glioma
ConclusionsOur results indicate that DMG-H3K27M cells rely on highly active purine synthesis, both from thede novo and salvage synthesis pathways. However, highly active salvage of free purine bases into mature guanylates can bypass inhibition of thede novo synthetic pathway. We conclude that inhibiting purine salvage may be a promising strategy to overcome treatment resistance in DMG-H3K27M tumors. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - April 9, 2024 Category: Cancer & Oncology Source Type: research
BCAA metabolism in pancreatic cancer affects lipid balance by regulating fatty acid import into mitochondria
ConclusionsOur data suggest that BCAA catabolism is required for the import of long chain carnitines (LC-CARs) into mitochondria, whereas the disruption of this link results in the redirection of activated FAs into TG synthesis and its deposition into LDs. We propose that this mechanism protects cells against mitochondrial overload with LC-CARs and it might be part of the universal reaction to amino acid perturbations during cancer growth, regulating FA handling and storage. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - March 26, 2024 Category: Cancer & Oncology Source Type: research
Serine synthesis and catabolism in starved lung cancer and primary bronchial epithelial cells
AbstractSerine and glycine give rise to important building blocks in proliferating cells. Both amino acids are either synthesized de novo or taken up from the extracellular space. In lung cancer, serine synthesis gene expression is variable, yet, expression of the initial enzyme, phosphoglycerate dehydrogenase (PHGDH), was found to be associated with poor prognosis. While the contribution of de novo synthesis to serine pools has been shown to be enhanced by serine starvation, the impact of glucose deprivation, a commonly found condition in solid cancers is poorly understood. Here, we utilized a stable isotopic tracing appr...
Source: Cancer and Metabolism - March 21, 2024 Category: Cancer & Oncology Source Type: research
Dietary patterns in relation to glioma: a case –control study
AbstractAlthough the association of individual foods and nutrients with glioma have been investigated, studies on the association of major dietary patterns and glioma are scarce. The aim of this study was to examine the association between major dietary patterns and risk of glioma in a group of Iranian adults. In this hospital-based case –control design, we recruited 128 newly diagnosed glioma cases and 256 controls in Tehran from 2009 to 2011. A Willett-format-validated 126-item semi-quantitative Food Frequency Questionnaire (FFQ) was used to assess participants' dietary intake. Factor analysis was used to identify majo...
Source: Cancer and Metabolism - March 18, 2024 Category: Cancer & Oncology Source Type: research
Elevated expression of HIGD1A drives hepatocellular carcinoma progression by regulating polyamine metabolism through c-Myc –ODC1 nexus
ConclusionsOur results demonstrated that HIGD1A activated c-Myc –ODC1 nexus to regulate polyamine synthesis and to promote HCC survival and malignant phenotype, implying that HIGD1A might represent a novel therapeutic target for HCC. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - February 23, 2024 Category: Cancer & Oncology Source Type: research
High-fat diet promotes prostate cancer metastasis via RPS27
ConclusionOur findings indicate that HFD increases the risk of PCa metastasis by elevating RPS27 expression and, subsequently, the expression of genes involved in PRAD progression. Therefore, RPS27 may serve as a novel target for the diagnosis and treatment of metastatic PCa. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - February 16, 2024 Category: Cancer & Oncology Source Type: research
Cone photoreceptor phosphodiesterase PDE6H inhibition regulates cancer cell growth and metabolism, replicating the dark retina response
ConclusionsOur results indicate that the changes in cGMP and purine pools, as well as mitochondrial function which is observed upon PDE6 γ′ depletion, are independent of the PKG pathway. We show that in HCT116,PDE6H deletion replicates many effects of the dark retina response and identifyPDE6H as a new target in preventing cancer cell proliferation and tumour growth. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - February 13, 2024 Category: Cancer & Oncology Source Type: research
Circulating metabolome landscape in Lynch syndrome
This study aims to characterize the circulating metabolome of Lynch syndrome carriers, shedding light on the energy metabolism status in this cancer predisposition syndrome.This study consists of a three-group cross-sectional analysis to compare the circulating metabolome of cancer-free Lynch syndrome carriers, sporadic colorectal cancer (CRC) patients, and healthy non-carrier controls. We detected elevated levels of circulating cholesterol, lipids, and lipoproteins in LS carriers. Furthermore, we unveiled that Lynch syndrome carriers and CRC patients displayed similar alterations compared to healthy non-carriers in circul...
Source: Cancer and Metabolism - February 5, 2024 Category: Cancer & Oncology Source Type: research
Systemic inflammation and insulin resistance-related indicator predicts poor outcome in patients with cancer cachexia
ConclusionThe CTI can predict the short- and long-term survival of patients with cancer cachexia and provide a useful prognostic tool for clinical practice. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - January 25, 2024 Category: Cancer & Oncology Source Type: research
Deficiency of TOP1MT enhances glycolysis through the stimulation of PDK4 expression in gastric cancer
ConclusionsIn brief, our work demonstrated the critical function of TOP1MT in the regulation of glycolysis by PDK4 in gastric cancer. Inhibiting glycolysis and limiting tumor metastasis in GC may be accomplished by suppressing PDK4. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - January 10, 2024 Category: Cancer & Oncology Source Type: research
Assessment of lipolysis biomarkers in adipose tissue of patients with gastrointestinal cancer
ConclusionIn our cohort of GI cancer patients, we found a modulation in the expression of genes and proteins involved in lipolysis, and differences were interestingly detected according to cancer type. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - January 2, 2024 Category: Cancer & Oncology Source Type: research
A feedback loop of PPP and PI3K/AKT signal pathway drives regorafenib-resistance in HCC
ConclusionTaken together, a feedback loop of PPP and PI3K/AKT signal pathway drives regorafenib-resistance in HCC and targeting the feedback loop could be a promising approach to overcome drug resistance. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - December 18, 2023 Category: Cancer & Oncology Source Type: research
STEAP4 inhibits cisplatin-induced chemotherapy resistance through suppressing PI3K/AKT in hepatocellular carcinoma
AbstractChemotherapy resistance is the leading cause for hepatocellular carcinoma (HCC)-induced death. Exploring resistance generation mechanism is an urgent need for HCC therapy. Here, we found STEAP4 was significantly downregulated in HCC patients with recurrence. Patients with low STEAP4 had poor outcome, suggesting STEAP4 might inhibit chemotherapy resistance. Cell viability assay, colony formation assay, apoptosis assay, soft agar growth assay, and tumor animal model showed STEAP4 inhibited cisplatin resistance. Mechanism analysis showed STEAP4 inhibited PI3K/AKT pathway through directly interacting with AKT. Double k...
Source: Cancer and Metabolism - December 18, 2023 Category: Cancer & Oncology Source Type: research
A HIF-1 α inhibitor combined with palmitic acid and L-carnitine treatment can prevent the fat metabolic reprogramming under hypoxia and induce apoptosis in hepatocellular carcinoma cells
ConclusionsA combination therapy of YC-1 with PA + LC may be a unique anti-tumor therapy for targeting hypoxic HCC cells, specifically by ROS overproduction leading to forced FAO activation. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - December 8, 2023 Category: Cancer & Oncology Source Type: research
