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Cancer: Kidney Cancer
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Total 216 results found since Jan 2013.
GSE175404 The RNA binding protein MEX3A controls G1/S transition via regulating RB/E2F pathway in clear cell renal cell carcinoma RNA-Seq
Contributor : Meng MengSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRNA-Seq was performed after siRNA transfection in ACHN cells.
Source: GEO: Gene Expression Omnibus - May 25, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Nodal is involved in chemoresistance of renal cell carcinoma cells via regulation of ABCB1
Renal cell carcinoma (RCC) is the third most frequent malignancy within urological oncology. Understanding mechanisms of chemoresistance in RCC cell is important for therapy and drug development. We established cisplatin (CDDP) resistant RCC cells by treating cells with increasing concentrations of CDDP. Nodal, an important embryonic morphogen, was increased in RCC/CDDP cells. Targeted inhibition of Nodal via its siRNA or neutralization antibody restored sensitivity of RCC resistant cells to CDDP treatment. It was due to that si-Nodal can decrease expression of P-glycoprotein (P-gp, encoded by ABCB1), one important ATP-bin...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Xingwang Zhu, Dongwei Xue, Jia Liu, Fengming Dong, Yongzhi Li, Yili Liu Tags: Research Paper Source Type: research
Pinin acts as a poor prognostic indicator for renal cell carcinoma by reducing apoptosis and promoting cell migration and invasion
J Cell Mol Med. 2021 Apr 3. doi: 10.1111/jcmm.16495. Online ahead of print.ABSTRACTPinin (PNN) was originally characterized as a desmosome-associated molecule. Its function and the mechanism of its regulation in renal cell carcinoma (RCC) are still undefined. Data on PNN expression, clinicopathological features, and prognosis of patients with RCC were obtained from The Cancer Genome Atlas (TCGA) database. Immunohistochemistry revealed high PNN expression in tumour cells. PNN expression showed negative correlation with survival in patients with RCC, acting as an independent prognostic factor in RCC. PNN up-regulation might ...
Source: J Cell Mol Med - April 3, 2021 Category: Molecular Biology Authors: Ming Jin Dan Li Weihong Liu Ping Wang Zhenfei Xiang Kaitai Liu Source Type: research
MBD2 mediates renal cell apoptosis via activation of Tox4 during rhabdomyolysis-induced acute kidney injury
J Cell Mol Med. 2021 Mar 25. doi: 10.1111/jcmm.16207. Online ahead of print.ABSTRACTOur study investigated the role of Methyl-CpG-binding domain protein 2 (MBD2) in RM-induced acute kidney injury (AKI) both in vitro and in vivo. MBD2 was induced by myoglobin in BUMPT cells and by glycerol in mice. MBD2 inhibition via MBD2 small interfering RNA and MBD2-knockout (KO) attenuated RM-induced AKI and renal cell apoptosis. The expression of TOX high mobility group box family member 4 (Tox4) induced by myoglobin was markedly reduced in MBD2-KO mice. Chromatin immunoprecipitation analysis indicated that MBD2 directly bound to CpG ...
Source: J Cell Mol Med - March 25, 2021 Category: Molecular Biology Authors: Tianshi Sun Qing Liu Yifan Wang Youwen Deng Dongshan Zhang Source Type: research
Glycyrrhetinic Acid Protects Renal Tubular Cells against Oxidative Injury via Reciprocal Regulation of JNK-Connexin 43-Thioredoxin 1 Signaling
Conclusion: ROS-JNK-Cx43-thioredoxin 1 signaling plays a crucial role in renal tubular cell injury. JNK is involved in the regulation of thioredoxin 1 and Cx43, and Cx43 reciprocally regulates thioredoxin 1. Inhibition of gap junctions by Ga alleviated renal tubular oxidative injury via improvement of thioredoxin 1-mediated redox signaling.
Source: Frontiers in Pharmacology - February 2, 2021 Category: Drugs & Pharmacology Source Type: research
Overexpression of chemokine receptor lymphotactin receptor 1 has prognostic value in clear cell renal cell carcinoma
ConclusionWe found higher XCR1 expression in ccRCC compared with that in normal tissues is related to longer overall survival in patients with ccRCC. XCR1 knockdown significantly increased RCC cells proliferation and migration, and decreased apoptosis. XCR1 might be used as a prognostic biomarker in ccRCC in the future.
Source: Molecular Genetics & Genomic Medicine - December 30, 2020 Category: Genetics & Stem Cells Authors: Xian Chang,
Ya Cao,
Wan ‐Lei Fu,
Xue‐Feng Tang,
Ya‐Li Wang,
Yang‐Fan Lv,
Qiao‐Nan Guo Tags: ORIGINAL ARTICLE Source Type: research
Effect of small interfering RNA-mediated BIRC6 silencing on apoptosis and autophagy of renal cancer 786-O cells.
CONCLUSIONS: Interference of BIRC6 mediated by siRNA can inhibit autophagy and promote 5-FU-induced apoptosis to enhance the sensitivity of 786-O cells to 5-FU.
PMID: 33243730 [PubMed - in process]
Source: Journal of Southern Medical University - November 29, 2020 Category: Universities & Medical Training Authors: Zhong K, Chen D, Wu Z, Wang X, Pan B, Chen N, Zhong W Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research
Cancers, Vol. 12, Pages 2901: Dexamethasone Inhibits TRAIL-Induced Apoptosis through c-FLIP(L) Upregulation and DR5 Downregulation by GSK3 β Activation in Cancer Cells
This study was undertaken to investigate the effects of DEX on the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in cancer cells. We found that upregulation of c-FLIP(L) and downregulation of death receptor 5 (DR5; receptor for TRAIL ligand) contribute to the anti-apoptotic effect of DEX on TRAIL-induced apoptosis. DEX increased c-FLIP(L) expression at the transcriptional levels through the GSK-3β signaling pathway. The pharmacological inhibitor and catalytic mutant of GSK-3β suppressed DEX-induced upregulation of c-FLIP(L) expression. Furthermore, GSK-3&...
Source: Cancers - October 9, 2020 Category: Cancer & Oncology Authors: Mi-Yeon Jeon Seon Min Woo Seung Un Seo Sang Hyun Kim Ju-Ock Nam Shin Kim Jong-Wook Park Peter Kubatka Kyoung-jin Min Taeg Kyu Kwon Tags: Article Source Type: research
LncRNA FGD5-AS1/miR-5590-3p axis facilitates the proliferation and metastasis of renal cell carcinoma through ERK/AKT signalling.
CONCLUSIONS: Mechanistically, lncRNA FGD5-AS1 can competitively interact with miR-5590-3p and regulate the downstream signalling of ErkAKT to enhance the malignancy of tumours. This lncRNA could become a potential target molecule for treating and diagnosing RCC.
PMID: 32964964 [PubMed - as supplied by publisher]
Source: European Review for Medical and Pharmacological Sciences - September 24, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Overexpression of Spondin-2 Is Associated with Recurrence-Free Survival in Patients with Localized Clear Cell Renal Cell Carcinoma.
Conclusion: SPON2 expression might function as a prognostic biomarker in patients with localized ccRCC.
PMID: 32952742 [PubMed - in process]
Source: Disease Markers - September 22, 2020 Category: Laboratory Medicine Tags: Dis Markers Source Type: research
Role of Tropomyosin-related kinase B receptor and brain-derived neurotrophic factor in cancer.
Abstract
The tropomyosin-related kinase B (TrkB) receptor is a member of the neurotrophic tyrosine kinase receptors family and, together with the brain-derived neurotrophic factor (BDNF), plays an important role in the development of breast cancer, lung cancer, neuroblastoma, colorectal cancer, leukemia, cervical cancer, gallbladder cancer, gastric cancer, kidney cancer, Ewing's sarcoma, esophageal cancer, and head and neck cancer. Overexpression of these two factors has been associated with increased processes involved in carcinogenesis, such as invasion, migration, epithelial-mesenchymal transition (EMT), angiog...
Source: Cytokine - September 6, 2020 Category: Molecular Biology Authors: Serafim Junior V, Fernandes GMM, Oliveira-Cucolo JG, Pavarino EC, Goloni-Bertollo EM Tags: Cytokine Source Type: research
