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Cancer: Kidney Cancer

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Total 216 results found since Jan 2013.

Tumor suppressive microRNA-200a inhibits renal cell carcinoma development by directly targeting TGFB2
Abstract A large body of evidence indicates that microRNAs play a critical role in tumor initiation and progression by negatively regulating oncogenes or tumor suppressor genes. Here, we report that the expression of miR-200a was notably downregulated in 45 renal cell carcinoma (RCC) samples. Restoration of miR-200a suppressed cell proliferation, migration, and invasion in two RCC cell lines. Furthermore, we used an epithelial-to-mesenchymal transition PCR array to explore the putative target genes of miR-200a. By performing quantitative real-time PCR, ELISA, and luciferase reporter assays, transforming growth fac...
Source: Tumor Biology - March 27, 2015 Category: Cancer & Oncology Source Type: research

PPARα inhibition modulates multiple reprogrammed metabolic pathways in kidney cancer and attenuates tumor growth.
Abstract Kidney cancer (RCC) is the 6(th) most common cancer in the US and its incidence is increasing. The current progression-free survival for patients with advanced RCC rarely extends beyond 1-2 years due to the development of therapeutic resistance. We previously identified PPARα as a potential therapeutic target for this disease and showed that a specific PPARα antagonist, GW6471, induced both apoptosis and cell cycle arrest at G0/G1 in RCC cell lines associated with attenuation of cell cycle regulatory proteins. We now extend that work and show that PPARα inhibition attenuates components of RCC metabolic...
Source: Am J Physiol Cell Ph... - March 25, 2015 Category: Cytology Authors: Abu Aboud O, Donohoe D, Bultman S, Fitch M, Riiff T, Hellerstein M, Weiss RH Tags: Am J Physiol Cell Physiol Source Type: research

Protease-activated receptor 2 enhances renal cell carcinoma cell invasion and migration via PI3K/AKT signaling pathway.
In this study, we found that PAR-2 was overexpressed in RCC cells. Activation of PAR-2 with PAR-2AP (PAR-2 agonist) enhanced the invasion and migration of RCC cells, and increased the expressions of MMP-13 and urokinase plasminogen activator (uPA). However, knockdown of PAR-2 by siRNA could intervene in all regulating effects of PAR-2AP. Furthermore, activation of PAR-2 induced the activation of PI3K and AKT, and PI3K/AKT inhibitor LY294002 attenuated the invasion and migration of RCC cells stimulated by PAR-2 activation. Altogether, our study demonstrates that PAR-2 stimulates the activation of PI3K/AKT pathway, subsequen...
Source: Experimental and Molecular Pathology - March 13, 2015 Category: Pathology Authors: Sun Z, Cao B, Wu J Tags: Exp Mol Pathol Source Type: research

Identification of novel long non-coding RNAs in clear cell renal cell carcinoma.
CONCLUSIONS: We identified many novel lncRNA transcripts dysregulated in ccRCC which may be useful for novel diagnostic biomarkers. PMID: 25685243 [PubMed]
Source: Clinical Prostate Cancer - February 18, 2015 Category: Cancer & Oncology Authors: Blondeau JJ, Deng M, Syring I, Schrödter S, Schmidt D, Perner S, Müller SC, Ellinger J Tags: Clin Epigenetics Source Type: research

Hypoxia-induced overexpression of stanniocalcin-1 is associated with the metastasis of early stage clear cell renal cell carcinoma
Conclusions: Our findings demonstrate a role for STC1 in metastasis of early stage ccRCC and suggest that STC1 may be a biomarker of potential value both for the prognosis of this disease and for guiding clinical decisions regarding surgical strategies and adjuvant treatment.
Source: Journal of Translational Medicine - February 12, 2015 Category: Research Authors: Xin MaLiangyou GuHongzhao LiYu GaoXintao LiDonglai ShenHuijie GongShichao LiShaoxi NiuYu ZhangYang FanQingbo HuangXiangjun LyuXu Zhang Source Type: research

Downregulation of tNASP inhibits proliferation through regulating cell cycle-related proteins and inactive ERK/MAPK signal pathway in renal cell carcinoma cells
Abstract Nuclear auto-antigenic sperm protein (NASP), initially described as a highly auto-immunogenic testis and sperm-specific protein, is a histone chaperone that is proved to present in all dividing cells. NASP has two splice variants: testicular NASP (tNASP) and somatic form of NASP (sNASP). Only cancer, germ, transformed, and embryonic cells have a high level of expression of the tNASP. Up to now, little has been known about tNASP in renal cell carcinoma (RCC). In the present study, the molecular mechanism of tNASP in RCC was explored. The expression level of tNASP in 16 paired human RCC specimens was determ...
Source: Tumor Biology - February 12, 2015 Category: Cancer & Oncology Source Type: research

Identification of novel long non-coding RNAs in clear cell renal cell carcinoma
Conclusions: We identified many novel lncRNA transcripts dysregulated in ccRCC which may be useful for novel diagnostic biomarkers.
Source: Clinical Epigenetics - February 8, 2015 Category: Research Authors: Jasmine BlondeauMario DengIsabella SyringSarah SchrödterDoris SchmidtSven PernerStefan MüllerJörg Ellinger Source Type: research

DCLK1 is a broadly dysregulated target against epithelial-mesenchymal transition, focal adhesion, and stemness in clear cell renal carcinoma.
Authors: Weygant N, Qu D, May R, Tierney RM, Berry WL, Zhao L, Agarwal S, Chandrakesan P, Chinthalapally HR, Murphy NT, Li JD, Sureban SM, Schlosser MJ, Tomasek JJ, Houchen CW Abstract Renal clear cell carcinoma (RCC) is the most common type of kidney cancer and the 8th most common cancer overall in the US. RCC survival rates drop precipitously with regional and distant spread and recent studies have demonstrated that RCC presents an epithelial-mesenchymal transition (EMT) phenotype linked to increased recurrence and decreased survival. EMT is a key characteristic of tumor stem cells (TSCs) along with chemo-resista...
Source: Oncotarget - January 27, 2015 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Cyclophilin D-mediated apoptosis attributes to sorafenib-induced cytotoxicity in clear cell -renal cell carcinoma.
In conclusion, our results suggested that CypD may represent a new therapeutic target for the treatment of ccRCC. Sorafenib induced apoptosis in ccRCC through CypD upregulation and this effect was related to the inhibition of p-ERK. PMID: 25614335 [PubMed - as supplied by publisher]
Source: European Journal of Pharmacology - January 19, 2015 Category: Drugs & Pharmacology Authors: Hu W, Yuan Q, Liu XH, Zhu HC, Lv SQ, Wang XH Tags: Eur J Pharmacol Source Type: research

pVHL Down-regulates NEK8 via HIFs Signal Transduction
In conclusion, our findings show that nek8 may be a new HIF target gene and pVHL can down-regulate NEK8 via HIFs to maintain the primary cilia structure in human renal cancer cells.
Source: Journal of Biological Chemistry - January 16, 2015 Category: Chemistry Authors: Ding, X.-F., Zhou, J., Hu, Q.-Y., Liu, S.-C., Chen, G. Tags: Cell Biology Source Type: research

Activation of aryl hydrocarbon receptor promotes invasion of clear cell renal cell carcinoma and is associated with poor prognosis and cigarette smoke
This article is protected by copyright. All rights reserved.
Source: International Journal of Cancer - December 19, 2014 Category: Cancer & Oncology Authors: Masaru Ishida, Shuji Mikami, Toshiaki Shinojima, Takeo Kosaka, Ryuichi Mizuno, Eiji Kikuchi, Akira Miyajima, Yasunori Okada, Mototsugu Oya Tags: Cancer Cell Biology Source Type: research

LOXL2 Regulates Integrin {alpha}5/{beta}1 in ccRCC Cells
In conclusion, LOXL2 is a potent regulator of integrin α5 and integrin β1 protein levels and functions in a tumor-promoting capacity in ccRCC. Implications: This is the first report demonstrating that LOXL2 is highly expressed and involved in ccRCC progression by regulating the levels of integrins α5 and β1. Mol Cancer Res; 12(12); 1807–17. ©2014 AACR.
Source: Molecular Cancer Research - December 17, 2014 Category: Cancer & Oncology Authors: Hase, H., Jingushi, K., Ueda, Y., Kitae, K., Egawa, H., Ohshio, I., Kawakami, R., Kashiwagi, Y., Tsukada, Y., Kobayashi, T., Nakata, W., Fujita, K., Uemura, M., Nonomura, N., Tsujikawa, K. Tags: Oncogenes and Tumor Suppressors Source Type: research

Cycloamylose‐nanogel drug delivery system‐mediated intratumor silencing of the vascular endothelial growth factor regulates neovascularization in tumor microenvironment
RNAi enables potent and specific gene silencing, potentially offering useful means for treatment of cancers. However, safe and efficient drug delivery systems (DDS) that are appropriate for intra‐tumor delivery of siRNA or shRNA have rarely been established, hindering clinical application of RNAi technology to cancer therapy. We have devised hydrogel polymer nanoparticles, or nanogel, and shown its validity as a novel DDS for various molecules. Here we examined the potential of self‐assembled nanogel of cholesterol‐bearing cycloamylose with spermine group (CH‐CA‐Spe) to deliver vascular endothelial growth factor ...
Source: Cancer Science - December 15, 2014 Category: Cancer & Oncology Authors: Hidetaka Fujii, Masaharu Shin‐Ya, Shigeo Takeda, Yoshihide Hashimoto, Sada‐atsu Mukai, Shin‐ichi Sawada, Tetsuya Adachi, Kazunari Akiyoshi, Tsuneharu Miki, Osam Mazda Tags: Original Article Source Type: research

Hypoxia promotes 786-O cells invasiveness and resistance to sorafenib via HIF-2α/COX-2
In conclusion, our results demonstrated that hypoxia promoted the invasiveness and resistance of 786-O cells to sorafenib via HIF2 and COX-2 and induced the activation of Snail/E-cadherin, suggesting that a signalling mechanism involving HIF2/COX2 modulates invasiveness and resistance to sorafenib in 786-O cells under hypoxia.
Source: Medical Oncology - December 7, 2014 Category: Cancer & Oncology Source Type: research

Upregulation of long non-coding RNA MALAT1 correlates with tumor progression and poor prognosis in clear cell renal cell carcinoma
Abstract Long noncoding RNAs (lncRNAs) have been investigated as a new class of regulators of cellular processes, such as cell growth, apoptosis, and carcinogenesis. LncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has recently been identified to be involved in tumorigenesis of several cancers such as lung cancer, pancreatic cancer, and cervical cancer. However, the role of lncRNA MALAT1 in clear cell renal cell carcinoma (ccRCC) remains unclear. Expression levels of lncRNA MALAT1 in ccRCC tissues and renal cancer cell lines were evaluated by quantitative real-time PCR (qRT-PCR), and its asso...
Source: Tumor Biology - December 6, 2014 Category: Cancer & Oncology Source Type: research