Filtered By:
Cancer: Kidney Cancer

This page shows you your search results in order of date. This is page number 13.

Order by Relevance | Date

Total 216 results found since Jan 2013.

Evaluation of NIN/RPN12 binding protein inhibits proliferation and growth in human renal cancer cells
Abstract The targeted delivery of small interfering RNA (siRNA) to specific tumor tissues and tumor cells remains as one of the key challenges in the development of RNA interference as a therapeutic application. The ribosome assembly factor NIN/RPN12 binding protein (NOB1) has been suggested to be essential for processing of the 20S pre-rRNA to the mature 18S rRNA, and is also reported to participate in proteasome biogenesis. However, it is unclear whether NOB1 is involved in tumor cells growth. The aim of this study was to determine whether the suppression of lentivirus mediated NOB1 siRNA inhibits the growth of ...
Source: Tumor Biology - November 26, 2014 Category: Cancer & Oncology Source Type: research

Oxidative stress by monosodium urate crystals promotes renal cell apoptosis through mitochondrial caspase-dependent pathway in human embryonic kidney 293 cells: mechanism for urate-induced nephropathy
Abstract The aim of this study is to clarify the effect of oxidative stress on monosodium urate (MSU)-mediated apoptosis of renal cells. Quantitative real-time polymerase chain reaction and immunoblotting for Bcl-2, caspase-9, caspase-3, iNOS, cyclooxygenase-2 (COX-2), interleukin-1β (IL-1β), IL-18, TNF receptor-associated factor-6 (TRAF-6), and mitogen-activated protein kinases were performed on human embryonic kidney 293 (HEK293) cells, which were stimulated by MSU crystals. Fluorescence-activated cell sorting was performed using annexin V for assessment of apoptosis. Reactive oxygen species (ROS) were measure...
Source: Apoptosis - November 15, 2014 Category: Molecular Biology Source Type: research

Abstract A36: Knockdown of integrin-linked kinase reduces invasive and metastatic potential of renal cell carcinoma
Conclusions: ILK is highly expressed in advanced RCC and its high expression is related to EMT-related protein in RCC. Knockdown of ILK inhibited molecular EMT markers and suppressed cell migration and invasion in vitro and metastasis in orthotopic tumor model. These results suggest the therapeutic potential of ILK inhibition on invasion and metastasis in advanced RCC.Citation Format: Han Kyung Seok, Raven Peter, Awrey Shannon, Li Estelle, Fazli Ladan, Gleave Martin, So Alan. Knockdown of integrin-linked kinase reduces invasive and metastatic potential of renal cell carcinoma. [abstract]. In: Proceedings of the AACR Specia...
Source: Molecular Cancer Research - November 13, 2014 Category: Cancer & Oncology Authors: Seok, H. K., Peter, R., Shannon, A., Estelle, L., Ladan, F., Martin, G., Alan, S. Tags: Target Discovery and Validation: Poster Presentations - Proffered Abstracts Source Type: research

The Expression and Role of MEKK3 in Renal Clear Cell Carcinoma.
Abstract To explore the relationship between Mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase 3(MEKK3) and cell apoptosis, clinicopathology and prognosis, we characterize the expression of MEKK3, survivin and stat3 in renal clear cell carcinoma (RCCC). The expressions were measured by RT-PCR and Western blot from 15 cases of RCCC and 15 cases of control group (CG). Protein expression was detected by tissue microarray and immunochemistry in 98 cases of RCCC, 28 cases of CG. Expression patterns were analyzed for their association with pathological factors, correlation and prognosi...
Source: Anatomical Record - November 12, 2014 Category: Anatomy Authors: Lu H, Cao X, Chen Q, Chen L, Chen L, Gan M Tags: Anat Rec (Hoboken) Source Type: research

The Expression and Role of MEKK3 in Renal Clear Cell Carcinoma
ABSTRACT To explore the relationship between Mitogen‐activated protein kinase/extracellular signal‐regulated kinase kinase kinase 3(MEKK3) and cell apoptosis, clinicopathology and prognosis, we characterize the expression of MEKK3, survivin and stat3 in renal clear cell carcinoma (RCCC). The expressions were measured by RT‐PCR and Western blot from 15 cases of RCCC and 15 cases of control group (CG). Protein expression was detected by tissue microarray and immunochemistry in 98 cases of RCCC, 28 cases of CG. Expression patterns were analyzed for their association with pathological factors, correlation and prognosis i...
Source: The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology - November 1, 2014 Category: Molecular Biology Authors: Hongsheng Lu, Xuequan Cao, Qi Chen, Lanxi Chen, Lili Chen, Meifu Gan Tags: Full Length Article Source Type: research

The role of dipeptidyl peptidase 4 (DPP4) in the preservation of renal function: DPP4 involvement in hemoglobin expression
In this study, to verify the role of DPP4 in the preservation of renal function, we performed a microarray analysis of the kidneys of WT and DPP4-deficient rats after STZ treatment, and gene expression analysis using rat kidneys, human embryonic kidney 293 (HEK293) cells, and human renal cancer cells (CakI-1). The microarray analysis indicated that the expression levels of the transporter activity, heme-binding, and pheromone binding-related genes changed significantly. The results of gene expression analysis indicated that there were no significant differences in the expression levels of hemoglobin mRNA between the DPP4-d...
Source: Journal of Endocrinology - October 8, 2014 Category: Endocrinology Authors: Sato, Y., Kamada, T., Yamauchi, A. Tags: Research Source Type: research

Integrative Bioinformatics Analysis Reveals New Prognostic Biomarkers of Clear Cell Renal Cell Carcinoma Molecular Diagnostics and Genetics
CONCLUSIONS: Using an integrative system biology approach, we identified 3 novel factors as potential biomarkers (AHR, GRHL2 and KIAA0101) involved in ccRCC pathogenesis and not linked to kidney cancer before.
Source: Clinical Chemistry - September 29, 2014 Category: Chemistry Authors: Butz, H., Szabo, P. M., Nofech-Mozes, R., Rotondo, F., Kovacs, K., Mirham, L., Girgis, H., Boles, D., Patocs, A., Yousef, G. M. Tags: Molecular Diagnostics and Genetics Source Type: research

Cycloamylose‐Nanogel DDS‐mediated intratumor silencing of the vascular endothelial growth factor regulates neovascularization in tumor microenvironment
This article is protected by copyright. All rights reserved.
Source: Cancer Science - September 1, 2014 Category: Cancer & Oncology Authors: Hidetaka Fujii, Masaharu Shin‐Ya, Shigeo Takeda, Yoshihide Hashimoto, Sadaatsu Mukai, Shin‐ichi Sawada, Tetsuya Adachi, Kazunari Akiyoshi, Tsuneharu Miki, Osam Mazda Tags: Original Article Source Type: research

Decreased expression of a novel lncRNA CADM1-AS1 is associated with poor prognosis in patients with clear cell renal cell carcinomas.
In conclusion, our data demonstrated CADM1-AS1 is a new tumor suppressor in ccRCC which regulates cell proliferation, apoptosis and migration via the expression pattern of "CADM1-AS1/CADM1 mRNA gene pairs". CADM1-AS1 may be a potential biomarker and therapeutic target in patients with ccRCC. PMID: 25031695 [PubMed - in process]
Source: International Journal of Clinical and Experimental Pathology - July 19, 2014 Category: Pathology Authors: Yao J, Chen Y, Wang Y, Liu S, Yuan X, Pan F, Geng P Tags: Int J Clin Exp Pathol Source Type: research

Expression of Wip1 in Kidney Carcinoma and its Correlation with Tumor Metastasis and Clinical Significance.
This study aimed to analyze the expression, clinical significance of proto-oncogene in kidney carcinoma and the biological effect in its cell line by siRNA targeting wild-type p53-induced phosphatase 1 (Wip1). Immunohistochemistry and western blot were respectively used to analyze Wip1 protein expression in 78 cases of kidney cancer and normal tissues to study the relationship between Wip1 expression and clinical factors. Wip1 siRNA was transiently transfected into papillary kidney carcinoma cell by liposome-mediated method and was detected by Quantitative real-time RT-PCR (qRT-PCR) and western blot. MTT assay, cell apopto...
Source: Pathology Oncology Research - June 28, 2014 Category: Pathology Authors: Sun GG, Wang YD, Liu Q, Hu WN Tags: Pathol Oncol Res Source Type: research

HDAC-inhibition counteracts everolimus resistance in renal cell carcinoma in vitro by diminishing cdk2 and cyclin A
Conclusion: It is concluded that non-response to everolimus is characterized by increased cdk2/cyclin A, driving RCC cells into the G2/M-phase. VPA hinders everolimus non-response by diminishing cdk2/cyclin A. Therefore, treatment with HDAC-inhibitors might be an option for patients with advanced renal cell carcinoma and acquired everolimus resistance.
Source: Epidemiologic Perspectives and Innovations - June 16, 2014 Category: Epidemiology Authors: Eva JuengelSnigdha NowazJasmina Makarevi¿Iyad NatshehIsabella WernerKaren NelsonMichael ReiterIgor TsaurJens ManiSebastian HarderGeorg BartschAxel HaferkampRoman A Blaheta Source Type: research

Improvement of Doxorubicin Efficacy Using Liposomal Anti-Polo-like Kinase 1 siRNA in Human Renal Cell Carcinomas
Molecular PharmaceuticsDOI: 10.1021/mp500245z
Source: Molecular Pharmaceutics - May 12, 2014 Category: Drugs & Pharmacology Authors: Yu Sakurai, Hiroto Hatakeyama, Hidetaka Akita and Hideyoshi Harashima Source Type: research

Abrogation of STAT3 signaling cascade by zerumbone inhibits proliferation and induces apoptosis in renal cell carcinoma xenograft mouse model
Persistent activation of signal transducer and activator of transcription 3 (STAT3) is one of the characteristic features of renal cell carcinoma (RCC) and often linked to its deregulated proliferation, survival, and angiogenesis. In the present report, we investigated whether zerumbone, a sesquiterpene, exerts its anticancer effect through modulation of STAT3 activation pathway. The pharmacological effect of zerumbone on STAT3 activation, associated protein kinases and phosphatase, and apoptosis was investigated using both RCC cell lines and xenograft mouse model. We observed that zerumbone suppressed STAT3 activation in ...
Source: Molecular Carcinogenesis - May 3, 2014 Category: Molecular Biology Authors: Muthu K. Shanmugam, Peramaiyan Rajendran, Feng Li, Chulwon Kim, Sakshi Sikka, Kodappully Sivaraman Siveen, Alan Prem Kumar, Kwang Seok Ahn, Gautam Sethi Tags: Research Article Source Type: research

Evidence for aldosterone‐dependent growth of renal cell carcinoma
Summary The aim if this study was to investigate the hypothesis that K‐RAS 4A is upregulated in a mineralocorticoid‐dependent manner in renal cell carcinoma and that this supports the proliferation and survival of some renal cancers. Expression of the K‐RAS in renal tumour tissues and cell lines was examined by real‐time PCR and Western blot and mineralocorticoid receptor, and its gatekeeper enzyme 11β‐hydroxysteroid dehydrogenase‐2 was examined by immunocytochemistry on a tissue microarray of 27 cases of renal cell carcinoma. Renal cancer cells lines 04A018 (RCC4 plus VHL) and 04A019 (RCC4 plus vector alone) ...
Source: International Journal of Experimental Pathology - April 1, 2014 Category: Pathology Authors: Sharon King, Susan Bray, Sarah Galbraith, Lesley Christie, Stewart Fleming Tags: Original Article Source Type: research

Increased expression of transglutaminase 2 drives glycolytic metabolism in renal carcinoma cells.
Abstract Transglutaminase 2 (TGase 2) expression and glycolysis are increased in most renal cell carcinoma (RCC) cell lines compared to the HEK293 kidney cell line. Although increased glycolysis and altered tricarboxylic acid cycle are common in RCC, the detailed mechanism by which this phenomenon occurs remains to be elucidated. In the present study, TGase 2 siRNA treatment lowered glucose consumption and lactate levels by about 20-30 % in RCC cells; conversely, high expression of TGase 2 increased glucose consumption and lactate production together with decreased mitochondrial aconitase (Aco 2) levels. In addit...
Source: Amino Acids - March 19, 2014 Category: Biochemistry Authors: Ku BM, Lee CH, Lee SH, Kim SY Tags: Amino Acids Source Type: research