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Cancer: Breast Carcinoma

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Total 244 results found since Jan 2013.

P6.15 * peroxiredoxin 3 as a molecular therapeutic target in breast cancer
Conclusion: Our data suggests that PRDX3 promotes breast tumorigenesis and could be a potential therapeutic target in breast cancer.
Source: Annals of Oncology - March 20, 2015 Category: Cancer & Oncology Authors: Chua, P. J., Chin, J., Chee, S., Thike, A. A., Yip, G., Tan, P. H., Bay, B. H. Tags: Poster session 6: New drugs/targets: other Source Type: research

P8.08 * Roles of Nectin-4 in tumor progression
Nectin-4 is a transmembrane immunoglobulin weakly expressed in healthy tissues, in contrast with embryonic stage. Interestingly, an expression of nectin-4 is found in the breast, ovarian and lung tumors. This expression is correlated to the advanced stages of these cancerous pathologies. Furthermore, high levels of plasmatic form is also found at an important rate in the advanced stages of breast, ovarian and lung carcinomas. To identify the roles of nectin-4 expression in tumor progression, we used in our study MCF-7 & BT-474 cell lines expressing an endogenous nectin-4, but also MDA-MB213 cell lines transfected with ...
Source: Annals of Oncology - March 20, 2015 Category: Cancer & Oncology Authors: Ghidouche, A., Lopez, M., Olive, D. Tags: Poster session 8: Other topics Source Type: research

Decreased expression and prognostic role of EHD2 in human breast carcinoma: correlation with E-cadherin
Abstract Decreased expression of epithelial cadherin (E-cadherin) has been noted to associate with aggressiveness and metastasis of breast cancer. The aim of this study was to examine the effect of C-Terminal EH domain-containing protein 2 (EHD2) expression on E-cadherin and related mechanism in the metastasis of breast cancer. Immunohistochemical analysis was performed in 96 human breast carcinoma samples and the data were correlated with clinicopathologic characteristics. Furthermore, Western blot analysis was performed for EHD2 and E-cadherin in breast carcinoma samples and cell lines to evaluate their protein ...
Source: Journal of Molecular Histology - March 12, 2015 Category: Laboratory Medicine Source Type: research

The CCL2 chemokine is a negative regulator of autophagy and necrosis in luminal B breast cancer cells
Abstract Luminal A and B breast cancers are the most prevalent forms of breast cancer diagnosed in women. Compared to luminal A breast cancer patients, patients with luminal B breast cancers experience increased disease recurrence and lower overall survival. The mechanisms that regulate the luminal B subtype remain poorly understood. The chemokine CCL2 is overexpressed in breast cancer, correlating with poor patient prognosis. The purpose of this study was to determine the role of CCL2 expression in luminal B breast cancer cells. Breast tissues, MMTV-PyVmT and MMTV-Neu transgenic mammary tumors forming luminal B-l...
Source: Breast Cancer Research and Treatment - March 5, 2015 Category: Cancer & Oncology Source Type: research

Expression of BAF57 in ovarian cancer cells and drug sensitivity
In this study, we investigated BAF57 expression in ovarian cancer cell lines and their sensitivities to cisplatin, doxorubicin, paclitaxel, and 5‐fluorouracil. BAF57 expression was strongly correlated with sensitivities to cisplatin, doxorubicin, and 5‐fluorouracil in 10 ovarian cancer cell lines. Paclitaxel sensitivity was also correlated with BAF57 expression, but without significance. In A2780 ovarian cancer cells, knockdown of BAF57 using specific siRNA increased cell cycle arrest at G1 phase and the sensitivities to these anticancer agents. cDNA microarray analysis of A2780 cells transfected with BAF57 siRNA showe...
Source: Cancer Science - February 25, 2015 Category: Cancer & Oncology Authors: Takahiro Yamaguchi, Tomoko Kurita, Kazuto Nishio, Junichi Tsukada, Toru Hachisuga, Yasuo Morimoto, Yoshiko Iwai, Hiroto Izumi Tags: Original Article Source Type: research

Suppression of miR-184 in malignant gliomas upregulates SND1 and promotes tumor aggressiveness
Conclusions Our study is the first to show a novel regulatory role of SND1, a direct target of miR-184, in glioma progression, suggesting that the miR-184/SND1 axis may be a useful diagnostic and therapeutic tool for malignant glioma.
Source: Neuro-Oncology - February 18, 2015 Category: Cancer & Oncology Authors: Emdad, L., Janjic, A., Alzubi, M. A., Hu, B., Santhekadur, P. K., Menezes, M. E., Shen, X.-N., Das, S. K., Sarkar, D., Fisher, P. B. Tags: Basic and Translational Investigations Source Type: research

Overexpression of deubiquitinating enzyme USP28 promoted non-small cell lung cancer growth.
Abstract Non-small cell lung cancer (NSCLC) accounts for most lung cancer. To develop new therapy required the elucidation of NSCLC pathogenesis. The deubiquitinating enzymes USP 28 has been identified and studied in colon and breast carcinomas. However, the role of USP28 in NSCLC is unknown. The level mRNA or protein level of USP28 were measured by qRT-PCR or immunohistochemistry (IHC). The role of USP28 in patient survival was revealed by Kaplan-Meier plot of overall survival in NSCLC patients. USP28 was up or down regulated by overexpression plasmid or siRNA transfection. Cell proliferation and apoptosis was as...
Source: J Cell Mol Med - February 5, 2015 Category: Molecular Biology Authors: Zhang L, Xu B, Qiang Y, Huang H, Wang C, Li D, Qian J Tags: J Cell Mol Med Source Type: research

Overexpression of deubiquitinating enzyme USP28 promoted non‐small cell lung cancer growth
Abstract Non‐small cell lung cancer (NSCLC) accounts for most lung cancer. To develop new therapy required the elucidation of NSCLC pathogenesis. The deubiquitinating enzymes USP 28 has been identified and studied in colon and breast carcinomas. However, the role of USP28 in NSCLC is unknown. The level mRNA or protein level of USP28 were measured by qRT‐PCR or immunohistochemistry (IHC). The role of USP28 in patient survival was revealed by Kaplan–Meier plot of overall survival in NSCLC patients. USP28 was up or down regulated by overexpression plasmid or siRNA transfection. Cell proliferation and apoptosis was assay...
Source: Journal of Cellular and Molecular Medicine - February 5, 2015 Category: Molecular Biology Authors: Lei Zhang, Biao Xu, Yong Qiang, Hairong Huang, Changtian Wang, Demin Li, Jianjun Qian Tags: Original Article Source Type: research

Cell surface heparan sulfate proteoglycans control adhesion and invasion of breast carcinoma cells
Conclusion: Cell surface proteoglycans, notably syndecan-2, may be important regulators of breast carcinoma progression through regulation of cytoskeleton, cell adhesion and invasion.
Source: Molecular Cancer - January 27, 2015 Category: Cancer & Oncology Authors: Hooi LimHinke MulthauptJohn Couchman Source Type: research

BAF57 expression of ovarian cancer cells and drug sensitivity
This article is protected by copyright. All rights reserved.
Source: Cancer Science - January 22, 2015 Category: Cancer & Oncology Authors: Takahiro Yamaguchi, Tomoko Kurita, Kazuto Nishio, Junichi Tsukada, Toru Hachisuga, Yasuo Morimoto, Yoshiko Iwai, Hiroto Izumi Tags: Original Article Source Type: research

Focal Adhesion Kinase and Wnt Signaling Regulate Human Ductal Carcinoma In Situ Stem Cell Activity and Response to Radiotherapy
Abstract Cancer stem cells (CSCs) can avoid or efficiently repair DNA damage from radio and chemotherapy, which suggests they play a role in disease recurrence. Twenty percentage of patients treated with surgery and radiotherapy for ductal carcinoma in situ (DCIS) of the breast recur and our previous data show that high grade DCIS have increased numbers of CSCs. Here, we investigate the role of focal adhesion kinase (FAK) and Wnt pathways in DCIS stem cells and their capacity to survive irradiation. Using DCIS cell lines and patient samples, we demonstrate that CSC‐enriched populations are relatively radioresistant and p...
Source: Stem Cells - January 22, 2015 Category: Stem Cells Authors: Kathryn E. Williams, Nigel J. Bundred, Göran Landberg, Robert B. Clarke, Gillian Farnie Tags: Cancer Stem Cells Source Type: research

Carnosic acid sensitized TRAIL-mediated apoptosis through down-regulation of c-FLIP and Bcl-2 expression at the post translational levels and CHOP-dependent up-regulation of DR5, Bim, and PUMA expression in human carcinoma caki cells.
In this study, we examined whether carnosic acid could sensitize TRAIL-mediated apoptosis in human renal carcinoma Caki cells. We found that carnosic acid markedly induced TRAIL-mediated apoptosis in human renal carcinoma (Caki, ACHN, and A498), and human hepatocellular carcinoma (SK-HEP-1), and human breast carcinoma (MDA-MB-231) cells, but not normal cells (TMCK-1 and HSF). Carnosic acid induced down-regulation of c-FLIP and Bcl-2 expression at the post-translational levels, and the over-expression of c-FLIP and Bcl-2 markedly blocked carnosic acid-induced TRAIL sensitization. Furthermore, carnosic acid induced death rec...
Source: Oncotarget - January 21, 2015 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Abstract A62: TGF-{beta} regulates CXCL1 expression in mammary carcinoma associated fibroblasts through novel Smad2/3- and HGF/c-Met-dependent mechanisms.
CXCL1 is a chemokine secreted by macrophages, neutrophils, epithelial cells and fibroblasts, and plays a role in inflammation and wound healing. Enhanced expression of CXCL1 in tumor epithelium is associated with cell invasion, angiogenesis in melanoma, bladder, ovarian and breast cancer. However, little is known about CXCL1 expression in tumor stroma. Through analysis of gene expression data, our studies reveal that high RNA levels of CXCL1 in breast tumor stroma is associated with increased rate of recurrence and shorter relapse-free survival. We noticed decreased secretion levels of TGF-β and increased secretion of CXC...
Source: Cancer Research - January 12, 2015 Category: Cancer & Oncology Authors: Zou, A., Lambert, D., Yeh, H., Fang, W. B., Cheng, N. Tags: Translational and Therapeutic Potential of the Tumor Microenvironment Source Type: research

The induction of activating transcription factor 3 (ATF3) contributes to anti-cancer activity of Abeliophyllum distichum Nakai in human colorectal cancer cells
Conclusion: These findings suggest that the anti-cancer activity of EAFAD-B may be a result of ATF3 promoter activation and subsequent increase of ATF3 expression.
Source: BMC Complementary and Alternative Medicine - December 15, 2014 Category: Complementary Medicine Authors: Gwang Hun ParkJae Ho ParkHyun Ji EoHun Min SongSo Hee WooMi Kyoung KimJin Wook LeeMan Hyo LeeJeong Rak LeeJin Suk KooJin Boo Jeong Source Type: research

Downregulation of clusterin mediates sensitivity to protein kinase inhibitors in breast cancer cells
We describe the use of clusterin-specific antisense oligonucleotides and siRNA to sensitize breast carcinoma cells to several PKIs. MCF-7 and MDA-MB-231 cells were treated with antisense oligonucleotide or siRNA to clusterin and the following PKIs: H-89, chelerythrine and genistein. The three inhibitors used in this study upregulated clusterin expression and treatments that included antisense oligonucleotide or siRNA to clusterin reduced the number of viable cells more effectively than did treatment with the drugs alone. Therefore, treatment with such combinations may benefit patients with breast cancer.
Source: Anti-Cancer Drugs - November 27, 2014 Category: Cancer & Oncology Tags: Preclinical Reports Source Type: research