Announcements
(Source: Neuro-Oncology)
Source: Neuro-Oncology - December 26, 2016 Category: Cancer & Oncology Tags: Announcement Source Type: research

GlioVis data portal for visualization and analysis of brain tumor expression datasets
(Source: Neuro-Oncology)
Source: Neuro-Oncology - December 26, 2016 Category: Cancer & Oncology Authors: Bowman, R. L., Wang, Q., Carro, A., Verhaak, R. G. W., Squatrito, M. Tags: Letter to the Editor Source Type: research

Targeting tyrosine receptor kinase B in gliomas
(Source: Neuro-Oncology)
Source: Neuro-Oncology - December 26, 2016 Category: Cancer & Oncology Authors: Pinheiro, K. V., Alves, C., Buendia, M., Gil, M. S., Thomaz, A., Schwartsmann, G., de Farias, C. B., Roesler, R., Bowman, R. L., Wang, Q., Carro, A., Verhaak, R. G. W., Squatrito, M. Tags: Letter to the Editor Source Type: research

MR perfusion-weighted imaging in the evaluation of high-grade gliomas after treatment: a systematic review and meta-analysis
Conclusions. PWI-derived thresholds separating viable tumor from treatment changes demonstrate relatively good accuracy in individual studies. However, because of significant variability in optimal reported thresholds and other limitations in the existing body of literature, further investigation and standardization is needed before implementing any particular quantitative PWI strategy across institutions. (Source: Neuro-Oncology)
Source: Neuro-Oncology - December 26, 2016 Category: Cancer & Oncology Authors: Patel, P., Baradaran, H., Delgado, D., Askin, G., Christos, P., John Tsiouris, A., Gupta, A. Tags: Clinical Investigation Source Type: research

Multimodal MRI features predict isocitrate dehydrogenase genotype in high-grade gliomas
Conclusion. Using a machine-learning algorithm, we achieved accurate prediction of IDH genotype in high-grade gliomas with preoperative clinical and MRI features. (Source: Neuro-Oncology)
Source: Neuro-Oncology - December 26, 2016 Category: Cancer & Oncology Authors: Zhang, B., Chang, K., Ramkissoon, S., Tanguturi, S., Bi, W. L., Reardon, D. A., Ligon, K. L., Alexander, B. M., Wen, P. Y., Huang, R. Y. Tags: Clinical Investigations Source Type: research

Long-term survival in AIDS-related primary central nervous system lymphoma
Background. The optimal therapeutic approach for patients with AIDS-related primary central nervous system lymphoma (AR-PCNSL) remains undefined. While its incidence declined substantially with combination antiretroviral therapy (cART), AR-PCNSL remains a highly aggressive neoplasm for which whole brain radiotherapy (WBRT) is considered a standard first-line intervention. Methods. To identify therapy-related factors associated with favorable survival, we first retrospectively analyzed outcomes of AR-PCNSL patients treated at San Francisco General Hospital, a public hospital with a long history of dedicated care for patien...
Source: Neuro-Oncology - December 26, 2016 Category: Cancer & Oncology Authors: Gupta, N. K., Nolan, A., Omuro, A., Reid, E. G., Wang, C.-C., Mannis, G., Jaglal, M., Chavez, J. C., Rubinstein, P. G., Griffin, A., Abrams, D. I., Hwang, J., Kaplan, L. D., Luce, J. A., Volberding, P., Treseler, P. A., Rubenstein, J. L. Tags: Clinical Investigations Source Type: research

Baseline pretreatment contrast enhancing tumor volume including central necrosis is a prognostic factor in recurrent glioblastoma: evidence from single and multicenter trials
Background. The prognostic significance of baseline contrast enhancing tumor prior to second- or third-line therapy in recurrent glioblastoma (GBM) for overall survival (OS) remains controversial, particularly in the context of repeated surgical resection and/or use of anti-angiogenic therapy. In the current study, we examined recurrent GBM patients from both single and multicenter clinical trials to test whether baseline enhancing tumor volume, including central necrosis, is a significant prognostic factor for OS in recurrent GBM. Methods. Included were 497 patients with recurrent GBM from 4 data sources: 2 single-center...
Source: Neuro-Oncology - December 26, 2016 Category: Cancer & Oncology Authors: Ellingson, B. M., Harris, R. J., Woodworth, D. C., Leu, K., Zaw, O., Mason, W. P., Sahebjam, S., Abrey, L. E., Aftab, D. T., Schwab, G. M., Hessel, C., Lai, A., Nghiemphu, P. L., Pope, W. B., Wen, P. Y., Cloughesy, T. F. Tags: Clinical Investigations Source Type: research

Histopathologic review of pineal parenchymal tumors identifies novel morphologic subtypes and prognostic factors for outcome
Conclusions. PPTIDs can be classified into 1 of 2 novel morphologic subtypes that are associated with distinct clinical outcomes. Tumor grade, neuraxis spread, and extent of resection also influence outcome for patients with PPT. (Source: Neuro-Oncology)
Source: Neuro-Oncology - December 26, 2016 Category: Cancer & Oncology Authors: Raleigh, D. R., Solomon, D. A., Lloyd, S. A., Lazar, A., Garcia, M. A., Sneed, P. K., Clarke, J. L., McDermott, M. W., Berger, M. S., Tihan, T., Haas-Kogan, D. A. Tags: Basic and Translational Investigations Source Type: research

CXCL12 mediates glioblastoma resistance to radiotherapy in the subventricular zone
Conclusion. Together, these data provide evidence on how the adult SVZ environment, through the release of CXCL12, supports GBM therapeutic failure and potential tumor relapse. (Source: Neuro-Oncology)
Source: Neuro-Oncology - December 26, 2016 Category: Cancer & Oncology Authors: Goffart, N., Lombard, A., Lallemand, F., Kroonen, J., Nassen, J., Di Valentin, E., Berendsen, S., Dedobbeleer, M., Willems, E., Robe, P., Bours, V., Martin, D., Martinive, P., Maquet, P., Rogister, B. Tags: Basic and Translational Investigations Source Type: research

miR-423-5p contributes to a malignant phenotype and temozolomide chemoresistance in glioblastomas
Conclusion This study establishes that miR-423-5p functions as an oncogene in glioma tissues by suppressing ING-4 and suggests that it has therapeutic potential for glioma. (Source: Neuro-Oncology)
Source: Neuro-Oncology - December 26, 2016 Category: Cancer & Oncology Authors: Li, S., Zeng, A., Hu, Q., Yan, W., Liu, Y., You, Y. Tags: Basic and Translational Investigations Source Type: research

Fatty acid oxidation is required for the respiration and proliferation of malignant glioma cells
Conclusions. Fatty acid oxidation enzymes are present and active within glioma tissues. Targeting this metabolic pathway reduces energy production and cellular proliferation in glioma cells. The drug etomoxir may provide therapeutic benefit to patients with malignant glioma. In addition, the expression of fatty acid oxidation enzymes may provide prognostic indicators for clinical practice. (Source: Neuro-Oncology)
Source: Neuro-Oncology - December 26, 2016 Category: Cancer & Oncology Authors: Lin, H., Patel, S., Affleck, V. S., Wilson, I., Turnbull, D. M., Joshi, A. R., Maxwell, R., Stoll, E. A. Tags: Basic and Translational Investigations Source Type: research

Tyrosine receptor kinase B is a drug target in astrocytomas
Conclusions. Our findings provide evidence that constitutively activated NTRK2 alleles, notably the human tumor-associated QKI-NTRK2 fusion, can cooperate with Ink4a/Arf loss to drive astrocytoma formation. Therefore, we propose NTRK2 as a potential therapeutic target in the subset of astrocytoma patients defined by QKI-NTRK2 fusion. (Source: Neuro-Oncology)
Source: Neuro-Oncology - December 26, 2016 Category: Cancer & Oncology Authors: Ni, J., Xie, S., Ramkissoon, S. H., Luu, V., Sun, Y., Bandopadhayay, P., Beroukhim, R., Roberts, T. M., Stiles, C. D., Segal, R. A., Ligon, K. L., Hahn, W. C., Zhao, J. J. Tags: Basic and Translational Investigations Source Type: research

Highlights from the Literature
(Source: Neuro-Oncology)
Source: Neuro-Oncology - December 26, 2016 Category: Cancer & Oncology Authors: Pope, W., Huse, J., Abounader, R., Purow, B., Wick, W., Aldape, K. Tags: Highlights Source Type: research

Where size matters: imaging-based biomarkers for patient stratification
(Source: Neuro-Oncology)
Source: Neuro-Oncology - December 26, 2016 Category: Cancer & Oncology Authors: Erickson, B. J., Galanis, E. Tags: Editorial Source Type: research

How bad are your seizures and did the treatment help?
(Source: Neuro-Oncology)
Source: Neuro-Oncology - December 26, 2016 Category: Cancer & Oncology Authors: Grant, R. Tags: Editorial Source Type: research

Reviewer lists for Neuro-Oncology
(Source: Neuro-Oncology)
Source: Neuro-Oncology - December 26, 2016 Category: Cancer & Oncology Tags: List of reviewers Source Type: research

Systemic therapy of brain metastases: non-small cell lung cancer, breast cancer, and melanoma
Brain metastases (BM) occur frequently in many cancers, particularly non–small cell lung cancer (NSCLC), breast cancer, and melanoma. The development of BM is associated with poor prognosis and has an adverse impact on survival and quality of life. Commonly used therapies for BM such as surgery or radiotherapy are associated with only modest benefits. However, recent advances in systemic therapy of many cancers have generated considerable interest in exploration of those therapies for treatment of intracranial metastases. This review discusses the epidemiology of BM from the aforementioned primary tumors and the chal...
Source: Neuro-Oncology - December 26, 2016 Category: Cancer & Oncology Authors: Chamberlain, M. C., Baik, C. S., Gadi, V. K., Bhatia, S., Chow, L. Q. M. Tags: Review Source Type: research

Message from the Editor-in-Chief
(Source: Neuro-Oncology)
Source: Neuro-Oncology - December 26, 2016 Category: Cancer & Oncology Authors: Wen, P. Y. Tags: Editorial Source Type: research

Contents_Page
(Source: Neuro-Oncology)
Source: Neuro-Oncology - December 26, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research

Subscriptions
(Source: Neuro-Oncology)
Source: Neuro-Oncology - December 26, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research

Editorial_Board
(Source: Neuro-Oncology)
Source: Neuro-Oncology - December 26, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research

Cover
(Source: Neuro-Oncology)
Source: Neuro-Oncology - December 26, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research

Announcements
(Source: Neuro-Oncology)
Source: Neuro-Oncology - November 8, 2016 Category: Cancer & Oncology Tags: Announcements Source Type: research

Response to "Glioma resection and tumor recurrence: back to Semmelweis"
(Source: Neuro-Oncology)
Source: Neuro-Oncology - November 8, 2016 Category: Cancer & Oncology Authors: Menei, P., Clavreul, A., Lemee, J. M. Tags: Reply to Letter Source Type: research

Glioma resection and tumor recurrence: back to Semmelweis
(Source: Neuro-Oncology)
Source: Neuro-Oncology - November 8, 2016 Category: Cancer & Oncology Authors: Ratel, D., van der Sanden, B., Wion, D. Tags: Letter to the Editor Source Type: research

Multimodal imaging patterns predict survival in recurrent glioblastoma patients treated with bevacizumab
Background Bevacizumab is a humanized antibody against vascular endothelial growth factor approved for treatment of recurrent glioblastoma. There is a need to discover imaging biomarkers that can aid in the selection of patients who will likely derive the most survival benefit from bevacizumab. Methods The aim of the study was to examine if pre- and posttherapy multimodal MRI features could predict progression-free survival and overall survival (OS) for patients with recurrent glioblastoma treated with bevacizumab. The patient population included 84 patients in a training cohort and 42 patients in a testing cohort, separa...
Source: Neuro-Oncology - November 8, 2016 Category: Cancer & Oncology Authors: Chang, K., Zhang, B., Guo, X., Zong, M., Rahman, R., Sanchez, D., Winder, N., Reardon, D. A., Zhao, B., Wen, P. Y., Huang, R. Y. Tags: Clinical Investigation Source Type: research

Clinical parameters outweigh diffusion- and perfusion-derived MRI parameters in predicting survival in newly diagnosed glioblastoma
Conclusions MRI parameters help to predict OS in a univariate Cox regression analysis, and increased rCBVCE is associated with shorter PFS in the multivariable model. In summary, however, our findings suggest that the relevance of MRI parameters is outperformed by clinical parameters in a multivariable analysis, which limits their prognostic value for survival prediction at the time of initial diagnosis. (Source: Neuro-Oncology)
Source: Neuro-Oncology - November 8, 2016 Category: Cancer & Oncology Authors: Burth, S., Kickingereder, P., Eidel, O., Tichy, D., Bonekamp, D., Weberling, L., Wick, A., Löw, S., Hertenstein, A., Nowosielski, M., Schlemmer, H.-P., Wick, W., Bendszus, M., Radbruch, A. Tags: Basic and Translational Investigation Source Type: research

Frequent occurrence of therapeutically reversible CMV-associated encephalopathy during radiotherapy of the brain
Conclusion CMV reactivation frequently causes encephalopathy during radio(chemo)therapy of the brain. The unexpected high incidence of this infection makes it highly clinically relevant for every treating physician. (Source: Neuro-Oncology)
Source: Neuro-Oncology - November 8, 2016 Category: Cancer & Oncology Authors: Goerig, N. L., Frey, B., Korn, K., Fleckenstein, B., Überla, K., Schmidt, M. A., Dörfler, A., Engelhorn, T., Eyüpoglu, I., Rühle, P. F., Putz, F., Semrau, S., Gaipl, U. S., Fietkau, R. Tags: Clinical Investigation Source Type: research

Neurocognitive function varies by IDH1 genetic mutation status in patients with malignant glioma prior to surgical resection
Conclusion. Patients with IDH1-WT show reduced NCF compared with those with IDH1-M malignant gliomas. Lesion volume is inversely associated with NCF for patients with IDH1-WT, but not IDH1-M tumors. These findings are consistent with the hypothesis that patients with IDH1-WT tumors present with more severe NCF impairment due to greater lesion momentum, which may impede compensatory neuroplasticity and cerebral reorganization. (Source: Neuro-Oncology)
Source: Neuro-Oncology - November 8, 2016 Category: Cancer & Oncology Authors: Wefel, J. S., Noll, K. R., Rao, G., Cahill, D. P. Tags: Clinical Investigations Source Type: research

Electrophysiology of glioma: a Rho GTPase-activating protein reduces tumor growth and spares neuron structure and function
Conclusions Our findings demonstrate that CNF1 reduces glioma volume while at the same time maintaining the physiological and structural properties of peritumoral neurons. These data indicate a promising strategy for the development of more effective antiglioma therapies. (Source: Neuro-Oncology)
Source: Neuro-Oncology - November 8, 2016 Category: Cancer & Oncology Authors: Vannini, E., Olimpico, F., Middei, S., Ammassari-Teule, M., de Graaf, E. L., McDonnell, L., Schmidt, G., Fabbri, A., Fiorentini, C., Baroncelli, L., Costa, M., Caleo, M. Tags: Basic and Translational Investigation Source Type: research

Reactive astrocytes potentiate tumor aggressiveness in a murine glioma resection and recurrence model
Conclusions This study demonstrates a unique syngeneic model of glioma resection and recurrence in immune-competent mice. Furthermore, this model provided insights into the pattern of postsurgical tumor recurrence and changes in the peritumoral microenvironment, as well as the impact of injured astrocytes on glioma growth and invasion. A better understanding of the postsurgical tumor microenvironment will allow development of targeted anticancer agents that improve surgery-mediated effects on tumor biology. (Source: Neuro-Oncology)
Source: Neuro-Oncology - November 8, 2016 Category: Cancer & Oncology Authors: Okolie, O., Bago, J. R., Schmid, R. S., Irvin, D. M., Bash, R. E., Miller, C. R., Hingtgen, S. D. Tags: Basic and Translational Investigation Source Type: research

Limited role for transforming growth factor-{beta} pathway activation-mediated escape from VEGF inhibition in murine glioma models
Conclusions Our study highlights the biological heterogeneity of murine glioma models and illustrates that cotargeting of the VEGF and TGF-β pathways might lead to improved tumor control only in subsets of glioblastoma. (Source: Neuro-Oncology)
Source: Neuro-Oncology - November 8, 2016 Category: Cancer & Oncology Authors: Mangani, D., Weller, M., Seyed Sadr, E., Willscher, E., Seystahl, K., Reifenberger, G., Tabatabai, G., Binder, H., Schneider, H. Tags: Basic and Translational Investigation Source Type: research

Stereotactic modulation of blood-brain barrier permeability to enhance drug delivery
Drug delivery in the CNS is limited by endothelial tight junctions forming the impermeable blood-brain barrier. The development of new treatment paradigms has previously been hampered by the restrictiveness of the blood-brain barrier to systemically administered therapeutics. With recent advances in stereotactic localization and noninvasive imaging, we have honed the ability to modulate, ablate, and rewire millimetric brain structures to precisely permeate the impregnable barrier. The wide range of focused radiations offers endless possibilities to disrupt endothelial permeability with different patterns and intensity foll...
Source: Neuro-Oncology - November 8, 2016 Category: Cancer & Oncology Authors: Appelboom, G., Detappe, A., LoPresti, M., Kunjachan, S., Mitrasinovic, S., Goldman, S., Chang, S. D., Tillement, O. Tags: Review Source Type: research

Highlights from the Literature
(Source: Neuro-Oncology)
Source: Neuro-Oncology - November 8, 2016 Category: Cancer & Oncology Authors: Schiff, D., Lawler, S., Chamberlain, M., Wright, K., Bhat, K. Tags: Highlights Source Type: research

Lesion momentum as explanation for preoperative neurocognitive function in patients with malignant glioma
(Source: Neuro-Oncology)
Source: Neuro-Oncology - November 8, 2016 Category: Cancer & Oncology Authors: Klein, M. Tags: Editorial Source Type: research

Molecular profiling optimizes the treatment of low-grade glioma
(Source: Neuro-Oncology)
Source: Neuro-Oncology - November 8, 2016 Category: Cancer & Oncology Authors: Schiff, D. Tags: Editorial Source Type: research

Corrigendum
(Source: Neuro-Oncology)
Source: Neuro-Oncology - November 8, 2016 Category: Cancer & Oncology Tags: Corrigendum Source Type: research

Contents_Page
(Source: Neuro-Oncology)
Source: Neuro-Oncology - November 8, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research

Subscriptions
(Source: Neuro-Oncology)
Source: Neuro-Oncology - November 8, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research

Editorial_Board
(Source: Neuro-Oncology)
Source: Neuro-Oncology - November 8, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research

Cover
(Source: Neuro-Oncology)
Source: Neuro-Oncology - November 8, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research

Author index
(Source: Neuro-Oncology)
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Tags: Author Index Source Type: research

Tmod-39. a novel ex vivo tumor slice culture system as a tool for basic and clinical research
Many cytotoxic and targeted therapies show promising activity in cultured cells but most fail to show equivalent efficacy in patients, indicating that the predictive power of cell culture models is limited. While patient derived xenograft (PDX) models are more faithful models of human cancer, they are very expensive and time consuming to generate and maintain, rendering them impractical models for most studies. To bridge the gap between in vitro cell culture and in vivo animal models, we developed a tumor slice culture system from PDX models and patient tumors. While other studies have described the use of tumor tissue sli...
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Gopalan, A., Wood, S., Yamamoto, K., Keck, J., Airhart, S., Shopland, L., Rueter, J., Yun, K. Tags: TUMOR MODELS Source Type: research

Tmod-38. development of an in vitro glioblastoma cancer stem cell bank
The Preston A. Wells Jr. Glioma Cell Line Bank began collecting tissue from UF glioma neurosurgical operations in 2014 and has established an organized repository of immortalized glioma cell lines that have been collected and maintained in a manner useful for a wide range of studies. Copies of patient’s consent to donate their tissue is obtained and clinical data from each case is logged into a secured computer database. Tissue is placed in culture as soon as it is received and the line is founded using the serum-free neurosphere method. Once a line is established, it is expanded and 100 vials are cryopreserved ...
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Reynolds, B., Vedam-mai, V., Deleyrolle, L. Tags: TUMOR MODELS Source Type: research

Tmod-37. characterization of a unique bmic population in human brain metastases
Brain Metastases (BM) are the most common neoplasm to affect the adult central nervous system, occurring at a rate 10 times greater than that of primary brain cancers. Despite the prevalence and severe lethality of BM, the current available in vivo models of metastasis neither fully recapitulate the clinical progression of BM nor allow for proper examination of metastatic cells. Not every cell within a primary tumour possess the ability to survive metastasis, and studies typical investigate large macro-metastases formed by cells that have already exited the metastatic cycle. We hypothesize that within primary tumours exist...
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Singh, M., Venugopal, C., Tokar, T., McFarlane, N., Bakhshinyan, D., Murty, N., Hassell, J., Jurisica, I., Singh, S. Tags: TUMOR MODELS Source Type: research

Tmod-36. gene expression analysis of short and long survival groups of glioblastoma patient-derived orthotopic xenografts
Few molecular markers predictive of glioblastoma patient prognosis are MGMT promoter methylation, IDH1/2 mutation and G-CIMP status. Gene expression, on the other hand, has been less robust in predicting survival, in part due to the influence and variability of the hosts. Here we present analysis of gene expression patterns in relation to glioblastoma tumor aggressivity in uniform murine hosts, using glioblastoma patient-derived xenograft (PDX) models. Neurosphere cultures established from IDH1/2 wildtype glioblastomas were implanted orthotopically in cohorts of 10 to 15 nude mice, for development of PDX. Mice were monitor...
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Cherba, D., Poisson, L., Winn, M., Kim, H., Verhaak, R. G. W., Mikkelsen, T., deCarvalho, A. C. Tags: TUMOR MODELS Source Type: research

Tmod-35. primary and recurrent sacral chordoma affects the hind limbs motor and nociceptive function in rats: an orthotopic spine model
CONCLUSIONS:We have developed an orthotopic human chordoma model in rats that reproduces cardinal clinical signs of the human pathology. Such signs include locomotor and sensory deficits present in human patients. The use of a reliable animal model of CHO will be essential for pathophysiology research and the development of new therapeutic strategies. (Source: Neuro-Oncology)
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Sarabia-Estrada, R., Ruiz-Valls, A., R Sha, S., Guerrero-Cazares, H., Jimenez-Estrada, I., Tyler, B., Gallia, G., Gokaslan, Z., Quinones-Hinojosa, A., Sciubba, D. Tags: TUMOR MODELS Source Type: research

Tmod-34. reactive astrocytes potentiate tumor aggressiveness in a murine glioma resection and recurrence model
CONCLUSIONS:This study demonstrates that peri-tumoral astrocytes undergo temporal and spatial changes after surgical tumor resection, and that surgery-induced changes influence the aggressiveness of residual tumor. Gaining a better understanding of the post-surgical microenvironment will allow optimization of therapeutic strategies and facilitate the development of new approaches that ameliorate surgery-mediated effects on recurrent tumors. (Source: Neuro-Oncology)
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Okolie, O., Bago, J., Schmid, R., Irvin, D., Bash, R., Miller, C. R., Hingtgen, S. Tags: TUMOR MODELS Source Type: research

Tmod-32. mathematically modeling perineural spread along peripheral nerves
The perineural spread of cancers to and along the peripheral nerve system is an emerging explanation for neoplastic plexopathy and underestimated source of patient morbidity and mortality. The perineural spread is a slowly growing process and can be difficult to detect without diligence for those at risk. This can lead to significant loss of mobility, function, and reduced quality of life for patients affected. Building on previous results in modeling glioblastoma multiforme, we present a mathematical model for predicting the course and extent of the perineural spread of recurrent tumors. By tracking cancer growth in the l...
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Jacobs, J., Capek, S., Spinner, R., Swanson, K. Tags: TUMOR MODELS Source Type: research

TMOD-31. AN INFLAMMATION RESPONSE GENE SIGNATURE IS ASSOCIATED WITH PROGNOSIS OF GLIOMA PATIENTS WITH 1p/19q CO-DELETION TUMORS
Meta-analysis of glioma patients revealed that LOH of 1p/19q (IDH mutant-codel) is associated with favorable progression-free survival (PFS) and overall survival (OS). Heterogeneity in clinical outcomes exists within this subset of glioma. To determine transcriptional biomarkers associated with treatment response, we developed and independently validated a method to determine codel status using gene expression. We screened the transcriptional profiles from 1,828 gliomas to identify 333 cases predicted to harbor 1p/19 co-deletion. In order to identify a prognostic gene signature, we split this dataset into a training datase...
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Hu, X., Martinez-Ledesma, E., Zheng, S., Kim, H., Barthel, F., Jiang, T., R Hess, K., Verhaak, R. Tags: TUMOR MODELS Source Type: research