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Total 244 results found since Jan 2013.

The prognostic value of DAAM2 in lower grade glioma, liver cancer, and breast cancer
ConclusionDAAM2 had a specific value in foretelling the prognosis of LGG, LIHC, and BRCA. High expression level of DAAM2 has longer survival rates in LGG and LIHC. The knockdown of DAAM2 retards the proliferation, invasion, and migration of BRCA cells. This study provides a novel sight of DAAM2 into the exploration of a potential biomarker in pan-cancer.
Source: Clinical and Translational Oncology - February 15, 2023 Category: Cancer & Oncology Source Type: research

MicroRNA-122 targets δ-catenin to suppress the tumorigenic potential of prostate cancer cells
Am J Cancer Res. 2022 Oct 15;12(10):4853-4864. eCollection 2022.ABSTRACTδ-Catenin is expressed abundantly in various human cancers, including prostate, brain, breast, and lung carcinomas, and is recognized as an oncogene that promotes cancer cell growth and tumorigenesis. Although several transcriptional and post-translational pathways for δ-catenin regulation have been identified in cancer cells, the potential effects of microRNA-mediated regulation remain elusive. Here, we used a δ-catenin 3'-UTR luciferase reporter assay to identify regulatory microRNAs. Subsequent bioinformatics analyses and molecular studies reveal...
Source: Cell Research - November 16, 2022 Category: Cytology Authors: So-Yeon Park Sung Jin Kim Phuong Kim To Rui Zhou Kwonseop Kim Kyung Keun Kim Chaeyong Jung Hangun Kim Source Type: research

Cyclin ‐dependent kinase subunit2 (CKS2) promotes malignant phenotypes and epithelial‐mesenchymal transition‐like process in glioma by activating TGFβ/SMAD signaling
ConclusionsWe identified CKS2 as a critical contributor to the gliomagenesis, which might provide a novel therapeutic target for inhibiting the spread and infiltration of glioma.
Source: Cancer Medicine - October 26, 2022 Category: Cancer & Oncology Authors: Fan Feng, Zongqing Zhao, Xuechang Cai, Xueyuan Heng, Ximeng Ma Tags: RESEARCH ARTICLE Source Type: research

Microenvironment-tailored micelles restrain carcinoma-astrocyte crosstalk for brain metastasis
This study indicates that the micelle system can serve as a hopeful strategy to treat breast-to-brain metastasis.PMID:35820539 | DOI:10.1016/j.jconrel.2022.07.009
Source: Cancer Control - July 12, 2022 Category: Cancer & Oncology Authors: Zhenhao Zhao Yujie Zhang Chao Li Xuwen Li Yongchao Chu Qin Guo Yiwen Zhang Weiyi Xia Peixin Liu Hongyi Chen Yu Wang Chufeng Li Tao Sun Chen Jiang Source Type: research

Abstracts of Presentations at the Association of Clinical Scientists 143 < sup > rd < /sup > Meeting Louisville, KY May 11-14,2022
Conclusion: These assays are suitable for routine diagnostic. The UltraFast NextGenPCR is the fastest with average time (30mins), followed by Agilent (2 hrs) and MassArray (6hrs). Upon completion of this activity, participants should be able to examine, measure and compare results from different assays for SARS detection, evaluate and diagnose accurately, as well as being able to plan, organize and recommend a diagnostic procedure for diagnostic laboratory. Key words: SARS-CoV-2, RNA extraction, RT-PCR, limit of detection, quantification cycle, COVID-19, in vitro diagnostic tests, Agilent, Massarray, Ultrafast. [20] From t...
Source: Annals of Clinical and Laboratory Science - July 1, 2022 Category: Laboratory Medicine Source Type: research

The heparan sulphate proteoglycan Syndecan ‐1 (CD138) regulates tumour progression in a 3D model of ductal carcinoma in situ of the breast
In this study, we employed a siRNA knockdown approach in the DCIS model cell line MCF10A DCIS.com to investigate a potential connection between Sdc-1 and epithelial mesenchymal transition (EMT), proteolysis and the Rho kinase pathway. Analysis of gene expression data of the TNMplot.com database revealed that Sdc-1 expression was higher in primary breast tumours compared to metastases. The impact of Sdc-1-depletion on the cellular phenotype was investigated in a Matrigel-based three-dimensional cell culture model. Sdc-1 depletion resulted in the formation of larger spheroids and the formation of invasive protrusions. Applic...
Source: IUBMB Life - May 20, 2022 Category: Research Authors: Christopher D'Arcy, Clarissa Constanze Zimmermann, Nancy Adriana Espinoza ‐Sanchez, Burkhard Greve, Annika Schmidt, Ludwig Kiesel, Marie‐Kristin von Wahlde, Martin Götte Tags: SPECIAL ISSUE Source Type: research