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Total 244 results found since Jan 2013.

Abstract 5358: IL-4/IL-13 induce Duox2/DuoxA2 expression and reactive oxygen production in human pancreatic and colon cancer cells
NADPH oxidase (NOX)-derived reactive oxygen species (ROS) contribute significantly to inflammation-associated carcinogenesis. Expression of dual oxidase 2 (Duox2), one of seven members of the NOX gene family, is up-regulated in inflammatory bowel disease, chronic pancreatitis, and in many human malignancies including carcinomas of the prostate, lung, and breast. Previously, we demonstrated that Stat1 and/or NF-κB play a critical role in modulating the enhanced expression of Duox2, and its cognate maturation factor DuoxA2, by IFN-γ and lipopolysaccharide in human pancreatic cancer cells. This cytokine-mediated increase in...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Wu, Y., Doroshow, J. H. Tags: Carcinogenesis Source Type: research

Abstract 5203: Long non-coding RNA H19 as a novel therapeutic target for pancreatic cancer
Long non-coding RNAs (lncRNAs), non-protein coding transcripts longer than 200 nucleotides, have been recently reported to play important roles in carcinogenesis and cancer metastasis through epigenetic regulation. In the present study, we examined the expression levels and roles of lncRNA in pancreatic cancer to elucidate whether lncRNA could be a novel candidate for pancreatic cancer therapy. First, we injected PANC-1 and PK-45H, pancreatic ductal adenocarcinoma cells into the spleens of NOD/Shi-scid, IL-2Rγnull (NOG) mice, and then established novel cell lines from liver and lung metastatic nodules. Microarray analysis...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Yoshimura, H., Matsuda, Y., Suzuki, T., Naito, Z., Ishiwata, T. Tags: Molecular and Cellular Biology Source Type: research

Abstract 5145: KDM2B expression regulates ribosome biogenesis and cancer cell growth in a p53-dependent manner
In this study we aimed to define the contribution of KDM2B expression to the biological features of breast cancer, a tumor type whose clinical behavior is known to be related to the rate of ribosome biogenesis. We show that, in primary breast carcinomas, lower KDM2B expression correlates with an increased size of specifically stained nucleolar organizer regions, a morphological parameter directly related to the rate of ribosome biogenesis, and with a poorer prognosis. In vitro, in breast cancer-derived cell lines, siRNA mediated KDM2B knock-down (KD) induced an increase in H3K4 trimethylation and in rRNA transcription. How...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Penzo, M., Casoli, L., Sicuro, L., Galibiati, A., Pollutri, D., Govoni, M., Ceccarelli, C., Santini, D., Taffurelli, M., Trere, D., Montanaro, L. Tags: Molecular and Cellular Biology Source Type: research

Focal adhesion kinase and wnt signalling regulates human ductal carcinoma in situ stem cell activity and response to radiotherapy
Abstract Cancer stem cells (CSCs) can avoid or efficiently repair DNA damage from radio and chemotherapy, which suggests they play a role in disease recurrence. 20% of patients treated with surgery and radiotherapy for ductal carcinoma in Situ (DCIS) of the breast recur and our previous data shows that high grade DCIS have increased numbers of CSCs. Here, we investigate the role of Focal Adhesion Kinase (FAK) and Wnt pathways in DCIS stem cells and their capacity to survive irradiation. Using DCIS cell lines and patient samples we demonstrate that CSC‐enriched populations are relatively radioresistant and possess high FA...
Source: Stem Cells - September 3, 2014 Category: Stem Cells Authors: Kathryn E Williams, Nigel J Bundred, Göran Landberg, Robert B Clarke, Gillian Farnie Tags: Original Research Source Type: research

Identification and validation of genes with expression patterns inverse to multiple metastasis suppressor genes in breast cancer cell lines
This study demonstrates that previously unrecognized genes are inversely related to the expression of multiple MSGs, contribute to aspects of metastasis, and may stand as novel therapeutic targets.
Source: Clinical and Experimental Metastasis - August 3, 2014 Category: Cancer & Oncology Source Type: research

Identification and validation of genes with expression patterns inverse to multiple metastasis suppressor genes in breast cancer cell lines.
This study demonstrates that previously unrecognized genes are inversely related to the expression of multiple MSGs, contribute to aspects of metastasis, and may stand as novel therapeutic targets. PMID: 25086928 [PubMed - as supplied by publisher]
Source: Clinical Genitourinary Cancer - August 3, 2014 Category: Cancer & Oncology Authors: Marino N, Collins JW, Shen C, Caplen NJ, Merchant AS, Gökmen-Polar Y, Goswami CP, Hoshino T, Qian Y, Sledge GW, Steeg PS Tags: Clin Exp Metastasis Source Type: research

Potential role of hematopoietic pre‐B‐cell leukemia transcription factor‐interacting protein in oral carcinogenesis
ConclusionHPIP may play a critical role in oral carcinogenesis and is thus a potential target for anticancer therapy, with particular emphasis on its involvement in differentiation and migration/metastasis.
Source: Journal of Oral Pathology and Medicine - July 24, 2014 Category: Pathology Authors: Seiji Okada, Tarou Irié, Junichi Tanaka, Rika Yasuhara, Gou Yamamoto, Tomohide Isobe, Chie Hokazono, Tetsuhiko Tachikawa, Yohko Kohno, Kenji Mishima Tags: Original Article Source Type: research

Decreased expression and prognostic role of cytoplasmic BRSK1 in human breast carcinoma: correlation with Jab1 stability and PI3K/Akt pathway.
CONCLUSIONS: BRSK1 is a novel tumor suppressor in breast cancer which inversely correlated with Jab1 expression, may involve in the restoring Jab1-induced suppression of p27kip1 and may regulate cell cycle through PI3K⁄Akt pathway. PMID: 25036402 [PubMed - as supplied by publisher]
Source: Experimental and Molecular Pathology - July 15, 2014 Category: Pathology Authors: Wang H, Liu XB, Chen JH, Wang QQ, Chen JP, Xu JF, Sheng CY, Ni QC Tags: Exp Mol Pathol Source Type: research

Targeting Fyn in Ras‐transformed cells induces F‐actin to promote adherens junction‐mediated cell–cell adhesion
Fyn, a member of the Src family kinases (SFK), is an oncogene in murine epidermis and is associated with cell–cell adhesion turnover and induction of cell migration. Additionally, Fyn upregulation has been reported in multiple tumor types, including cutaneous squamous cell carcinoma (cSCC). Introduction of active H‐Ras(G12V) into the HaCaT human keratinocyte cell line resulted in upregulation of Fyn mRNA (200‐fold) and protein, while expression of other SFKs remained unaltered. Transduction of active Ras or Fyn was sufficient to induce an epithelial‐to‐mesenchymal transition in HaCaT cells. Inhibition of Fyn acti...
Source: Molecular Carcinogenesis - June 29, 2014 Category: Molecular Biology Authors: Sarah E. Fenton, Kelli A. Hutchens, Mitchell F. Denning Tags: Research Article Source Type: research

Sp1 is necessary for gene activation of Adamts17 by estrogen
In this report, we show that knockdown of Adamts17 expression induces apoptosis and inhibits breast cancer cell growth. Adamts17 expression can rapidly be induced by estrogens. siRNA knockdown of Sp1 or Myc demonstrated that Sp1 is required to induce Adamts17 gene expression in response to estrogen. Moreover, reporter assays showed that the proximal promoter and the upstream sequences were not capable of conferring estrogen responsiveness, suggesting that Sp1 elements may be located in the downstream intronic region. We further demonstrated that Sp1 and Myc binding in the proximal promoter region contributed to the Adamts1...
Source: Journal of Cellular Biochemistry - June 6, 2014 Category: Biochemistry Authors: Zanhui Jia, Shuping Gao, Nadira M’Rabet, Christian De Geyter, Hong Zhang Tags: Article Source Type: research

Genome-wide study of hypomethylated and induced genes in liver cancer patients unravels novel anticancer targets.
CONCLUSIONS: Our results prove that genes that are hypomethylated and induced in tumors are candidate targets for anticancer therapeutics in multiple cancer cell types. Since these genes are particularly activated in cancer they constitute a group of targets for specific pharmacological inhibitors of cancer and cancer metastasis. PMID: 24763612 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - April 24, 2014 Category: Cancer & Oncology Authors: Stefanska B, Cheishvili D, Suderman M, Arakelian A, Huang J, Hallett M, Han ZG, Al-Mahtab M, Akbar SM, Khan WA, Raqib R, Tanvir I, Khan HA, Rabbani SA, Szyf M Tags: Clin Cancer Res Source Type: research

PDGFRβ and FGFR2 mediate endothelial cell differentiation capability of triple negative breast carcinoma cells
In this study we investigated the possibility that TNBC cells contribute to the establishment of tumor vascular network by the process known as vasculogenic mimicry, through endothelial cell differentiation.Vascular-like functional properties of breast cancer cell lines were investigated in vitro by tube formation assay and in vivo by confocal microscopy, immunofluorescence or immunohistochemistry on frozen tumor sections. TNBCs express endothelial markers and acquire the ability to form vascular-like channels in vitro and in vivo, both in xenograft models and in human specimens, generating blood lacunae surrounded by ...
Source: Molecular Oncology - April 2, 2014 Category: Cancer & Oncology Authors: Ilaria Plantamura, Patrizia Casalini, Erica Dugnani, Marianna Sasso, Elvira D'Ippolito, Monica Tortoreto, Matilde Cacciatore, Carla Guarnotta, Cristina Ghirelli, Isabella Barajon, Francesca Bianchi, Tiziana Triulzi, Roberto Agresti, Andrea Balsari, Manuel Tags: Research articles Source Type: research

Ziyuglycoside II induces cell cycle arrest and apoptosis through activation of ROS/JNK pathway in human breast cancer cells.
In this study, the anti-proliferative effect of ziyuglycoside II in two classic human breast cancer cell lines, MCF-7 and MDA-MB-231, was extensively investigated. Our study indicated that ziyuglycoside II could effectively induce G2/M phase arrest and apoptosis in both cell lines. Cell cycle blocking was associated with the down-regulation of Cdc25C, Cdc2, cyclin A and cyclin B1 as well as the up-regulation of p21/WAF1, phospho-Cdc25C and phospho-Cdc2. Ziyuglycoside II treatment also induced reactive oxygen species (ROS) production and apoptosis by activating the extrinsic/Fas/FasL pathway as well as the intrinsic/mitocho...
Source: Toxicology Letters - March 27, 2014 Category: Toxicology Authors: Zhu X, Wang K, Zhang K, Zhu L, Zhou F Tags: Toxicol Lett Source Type: research

EIF5A2 is a novel chemoresistance gene in breast cancer.
CONCLUSION: This study shows that eIF-5A2 plays an important role in doxorubicin chemoresistance in breast cancer cells. PMID: 24638963 [PubMed - as supplied by publisher]
Source: Breast Cancer - March 18, 2014 Category: Cancer & Oncology Authors: Liu Y, Du F, Chen W, Yao M, Lv K, Fu P Tags: Breast Cancer Source Type: research

Silencing of ETS1 reverses adriamycin resistance in MCF-7/ADR cells via downregulation of MDR1
Conclusions: This study demonstrates that drug resistance can be effectively reversed in adriamycin-resistant breast carcinoma cells through delivery of siRNAs targeting ETS1.
Source: Cancer Cell International - March 7, 2014 Category: Cancer & Oncology Authors: Jinrong WeiYong ZhouGuo-Qin JiangDong Xiao Source Type: research