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Functional analysis of ESM1 by siRNA knockdown in primary and metastatic head and neck cancer cells
ConclusionThese findings suggest that ESM1 has roles on proliferation and migration of head and neck cancer cells.This article is protected by copyright. All rights reserved. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - October 11, 2017 Category: Pathology Authors: Onur Bender, Mehmet Gunduz, Sadik Cigdem, Omer Faruk Hatipoglu, Muradiye Acar, Mesut Kaya, Reidar Grenman, Esra Gunduz, Kadriye Serife Ugur Tags: Original Article Source Type: research

Should we be rethinking follow ‐up for oral cancer patients?
(Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - October 4, 2017 Category: Pathology Authors: Marieke T. Brands, Matthias A. W. Merkx, Sandra M. E. Geurts, Peter A. Brennan Tags: EDITORIAL Source Type: research

The role of human papillomavirus in p16 positive oral cancers
ConclusionWe have shown that the presence of transcriptionally active HPV rarely occurs in OSCC and that p16 is not an appropriate surrogate marker for HPV in OSCC cases. We propose that non‐viral mechanisms are responsible for the majority of IHC p16 overexpression in OSCC.This article is protected by copyright. All rights reserved. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - October 1, 2017 Category: Pathology Authors: Simone Belobrov, Alyssa M. Cornall, Richard J. Young, Kendrick Koo, Christopher Angel, David Wiesenfeld, Danny Rischin, Suzanne M. Garland, Michael McCullough Tags: Original Article Source Type: research

Odontogenic myxoma: a 63 ‐year retrospective multicenter study of 85 cases in a Brazil population and a review of 999 cases from literature
ConclusionsThe features of OM samples have strong similarity to that reported in studies from other continents. It is possible to infer that geographic variation does not help to explain some differences observed in the clinical features of OM.This article is protected by copyright. All rights reserved. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - October 1, 2017 Category: Pathology Authors: Ana Carolina Uchoa Vasconcelos, Felipe Martins Silveira, Ana Paula Neutzling Gomes, Sandra Beatriz Chaves Tarquinio, Ana Paula Veras Sobral, Jos é Alcides Almeida de Arruda, Leorik Pereira da Silva, Marcia Maria Fonseca da Silveira, Larissa Ferreira Barb Tags: Original Article Source Type: research

Denosumab ‐related osteonecrosis of the jaw: a retrospective study
ConclusionOur results raise important questions about the dental management of these patients, in particular concerning the healing period between dental extractions and the initiation of Denosumab.This article is protected by copyright. All rights reserved. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - October 1, 2017 Category: Pathology Authors: Egloff ‐Juras Claire, Gallois Aurélie, Salleron Julia, Massard Vincent, Dolivet Gilles, Guillet Julie, Phulpin Bérengère Tags: Original Article Source Type: research

Treatment resistance in potentially malignant disorders —‘Nature’ or ‘Nurture’…?
ConclusionDespite clinico‐pathological profiling of treatment resistant patients, the precise inter‐relationship between the inherent nature of potentially malignant disease and the external influence of treatment intervention remains obscure. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - September 18, 2017 Category: Pathology Authors: P. J. Thomson, M. L. Goodson, D. R. Smith Tags: ORIGINAL ARTICLE Source Type: research

Developing a quality ‐of‐life questionnaire for oral submucous fibrosis patients
(Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - September 15, 2017 Category: Pathology Authors: Arpita Rai Tags: LETTER TO THE EDITOR Source Type: research

Radiation ‐induced changes in the microstructure of epithelial cells of the oral mucosa: A comparative light and electron microscopic study
ConclusionScanning electron microscopy, in contrast to light microscopy, appears to be a useful tool to reveal the condition of superficial oral mucosal cells. In respect of the possible pathogenesis of osteoradionecrosis, the radiation‐induced damage of the microplicae and its influence on the mucosal salivary pellicle is discussed. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - September 15, 2017 Category: Pathology Authors: Pekka J. Asikainen, Hannah Dekker, Ellinoora Sirvi ö, Jopi Mikkonen, Engelbert A. J. M. Schulten, Elisabeth Bloemena, Arto Koistinen, Chris M. ten Bruggenkate, Arja M. Kullaa Tags: ORIGINAL ARTICLE Source Type: research

Profiling cancer risk in oral potentially malignant disorders —A patient cohort study
BackgroundOral potentially malignant disorders harbour variable and unpredictable risk for squamous carcinoma development. Whilst current management strategies utilise histopathological diagnoses, dysplasia grading and targeted intervention for “high‐risk” lesions, clinicians are unable to predict malignant potential. MethodsDetailed, retrospective clinico‐pathological analysis of potentially malignant lesions undergoing malignant transformation, from a 590 patient cohort treated by interventional laser surgery and followed for a mean of 7.3 years, was undertaken. Clinical outcome was documented at study ce...
Source: Journal of Oral Pathology and Medicine - September 5, 2017 Category: Pathology Authors: P. J. Thomson, M. L. Goodson, D. R. Smith Tags: ORIGINAL ARTICLE Source Type: research

Potentially malignant disorders —The case for intervention
Potentially malignant disorders (PMD) are recognisable mucosal conditions preceding invasive squamous carcinoma development. Established oral cancer remains a lethal and deforming disease, with a rising incidence. Management techniques for identifiable oral precursor lesions have traditionally been polarised between observational and interventional surgical techniques. By defining salient management goals for treating potentially malignant disease, and examining the evidence supporting the efficacy of treatment intervention, this paper presents the case for interventional laser surgery as a definitive diagnostic and treatm...
Source: Journal of Oral Pathology and Medicine - September 5, 2017 Category: Pathology Authors: P. J. Thomson Tags: REVIEW ARTICLE Source Type: research

Exciting news about the 2016 Impact Factor and JOPM performance
(Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - September 4, 2017 Category: Pathology Authors: Peter A. Brennan Tags: EDITORIAL Source Type: research

Chronic treatment with Zoledronic Acid increases inflammatory markers in periodontium of rats
Abstract BackgroundBisphosphonates (BF) rises proinflammatory markers and irreversibly binds to bone. Chronically BF can lead to an inflammatory status and can increase the local oxidative stress in periodontium. Therefore, the objective of this study was evaluated if the chronic infusion of Zoledronic Acid (ZA) increases inflammatory markers in periodontium of rats. Methods and resultsChronically infusion therapy was performed with ZA (0.04, 0.2 or 1 mg/kg or saline) by four doses in over a 70‐day period to analysis periodontium of the first right inferior molar using histologic, histochemical (toluidine blue) and immun...
Source: Journal of Oral Pathology and Medicine - September 2, 2017 Category: Pathology Authors: Paulo Goberl ânio de Barros Silva, Antonio Ernando Carlos Ferreira Junior, Camila Carvalho de Oliveira, Luiz André Cavalcante Brizeno, Deysi Viviana Tenazoa Wong, Roberto César Pereira Lima Júnior, Fabrício Bitú Sousa, Mário Rogério Lima Mota, Ana Tags: Original Article Source Type: research

Radiation ‐induced changes in the microstructure of epithelial cells of the oral mucosa a comparative light and electron microscopic study
ConclusionScanning electron microscopy, in contrast to light microscopy, appears to be a useful tool to reveal the condition of superficial oral mucosal cells. In respect of the possible pathogenesis of osteoradionecrosis, the radiation‐induced damage of the microplicae and its influence on the mucosal salivary pellicle is discussed.This article is protected by copyright. All rights reserved. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - September 2, 2017 Category: Pathology Authors: Pekka J. Asikainen, Hannah Dekker, Ellinoora Sirvi ö, Jopi Mikkonen, Engelbert A. J. M. Schulten, Elisabeth Bloemena, Arto Koistinen, Chris M. ten Bruggenkate, Arja M. Kullaa Tags: Original Article Source Type: research

DNA methylation patterns of genes related to immune response in the different clinical forms of oral lichen planus
ConclusionOur results show variations in the methylation profile of immune response‐related genes, according to the clinical type of oral lichen planus after comparing with the normal oral mucosa. Further studies are necessary to validate these findings using gene expression analysis.This article is protected by copyright. All rights reserved. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - September 1, 2017 Category: Pathology Authors: Aline Fernanda Cruz, Renata Gon çalves de Resende, Júlio César Tanos de Lacerda, Núbia Braga Pereira, Leonardo Augusto Melo, Marina Gonçalves Diniz, Carolina Cavalieri Gomes, Ricardo Santiago Gomez Tags: Original Article Source Type: research

Three ‐dimensional reconstruction with serial whole‐mount sections of oral tongue squamous cell carcinoma: a preliminary study
ConclusionsWhole‐mount histopathological 3D reconstruction of OTSCC was successfully generated, providing a solid foundation for comprehensive margin and invasion analysis. Though future study and improvement was needed, whole‐mount histopathological 3D reconstruction proved to be a promising method in OTSCC study.This article is protected by copyright. All rights reserved. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - September 1, 2017 Category: Pathology Authors: Yujia Wang, Sheng Chen, Yanhong Ni, Derek Magee, Yumei Pu, Qian Zhou, Zhiyong Wang, Lei Zhang, Xiaofeng Huang, Qingang Hu Tags: Original Article Source Type: research

Macrophages and prognosis of oral squamous cell carcinoma: a systematic review
In conclusion, macrophages are important to OSCC patients’ prognosis, however it is necessary to address in which tumor region the presence of polarized macrophage is more important to the outcome. This article is protected by copyright. All rights reserved. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - September 1, 2017 Category: Pathology Authors: Alessandro Menna Alves, Leonardo Francisco Diel, Marcelo Lazzaron Lamers Tags: Review Source Type: research

Molecular basis of oral squamous cell carcinoma in young patients: Is it any different from older patients?
This article is protected by copyright. All rights reserved. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - September 1, 2017 Category: Pathology Authors: Sara Ferreira dos Santos Costa, Peter A. Brennan, Ricardo Santiago Gomez, Eduardo Rodrigues Fregnani, Alan Roger Santos ‐Silva, Manoela Domingues Martins, Gilberto Castro‐Junior, Siavash Rahimi, Felipe Paiva Fonseca Tags: Review Source Type: research

Treatment Resistance in Potentially Malignant Disorders – ‘Nature’ or ‘Nurture’…?
ConclusionDespite clinico‐pathological profiling of treatment resistant patients, the precise inter‐relationship between the inherent nature of potentially malignant disease and the external influence of treatment intervention remains obscure.This article is protected by copyright. All rights reserved. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - September 1, 2017 Category: Pathology Authors: P J Thomson, M L Goodson, D R Smith Tags: Original Article Source Type: research

Efficacy of low ‐level laser therapy compared to steroid therapy in the treatment of oral lichen planus: A systematic review
ConclusionIt remains debatable whether LLLT is more effective as compared to corticosteroids in the treatment of OLP, given that the scientific evidence is weak. These findings are preliminary and further randomized clinical trials are recommended. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - August 21, 2017 Category: Pathology Authors: Zohaib Akram, Tariq Abduljabbar, Fahim Vohra, Fawad Javed Tags: REVIEW Source Type: research

Potentially Malignant Disorders – the Case for Intervention
This article is protected by copyright. All rights reserved. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - August 21, 2017 Category: Pathology Authors: P J Thomson Tags: Review Source Type: research

Surgical specimen handover from the operating theatre to laboratory —Can we improve patient safety by learning from aviation and other high‐risk organisations?
Essential communication between healthcare staff is considered one of the key requirements for both safety and quality care when patients are handed over from one clinical area to other. This is particularly important in environments such as the operating theatre and intensive care where mistakes can be devastating. Health care has learned from other high‐risk organisations (HRO) such as aviation where the use of checklists and human factors awareness has virtually eliminated human error and mistakes. To our knowledge, little has been published around ways to improve pathology specimen handover following surgery, with pa...
Source: Journal of Oral Pathology and Medicine - August 20, 2017 Category: Pathology Authors: Peter A. Brennan, Marieke T. Brands, Lucy Caldwell, Felipe Paiva Fonseca, Nic Turley, Susie Foley, Siavash Rahimi Tags: ORIGINAL ARTICLE Source Type: research

Artepillin C as a targeting survivin molecule in oral squamous cell carcinoma cells in vitro: a preliminary study
ConclusionsHSC‐3 cells are vulnerable to artepillin C in a dose‐ and time‐dependent manner. HSC‐3 cell death induced by artepillin C, at least in part, was a result of a decrease in survivin levels.This article is protected by copyright. All rights reserved. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - August 20, 2017 Category: Pathology Authors: Seokjoon Pang, Michael Yee, Yasmin Saba, Takahiro Chino Tags: Original Article Source Type: research

Immune response of patients with recurrent Aphthous Stomatitis challenged with a symbiotic
ConclusionsIn RAS, symbiotic treatment based on a fructooligosaccharide, Lactobacillus and Bifidobacterium composition produced an alteration in the Th2 serological immune profile in the direction of Th1 and improved pain symptomatology.This article is protected by copyright. All rights reserved. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - August 4, 2017 Category: Pathology Authors: Maria Angela Martins Mimura, Ricardo Carneiro Borra, Cleonice Hitomi Watashi Hirata, Norma Oliveira Penido Tags: Original Article Source Type: research

Impact of Oral Potentially Malignant Disorders on Quality of Life
ConclusionsOLP and OSF have a significant impact on the QoL of affected individuals: OL less so. Increasing stage of the disease is associated with worsening QoL.This article is protected by copyright. All rights reserved. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - August 2, 2017 Category: Pathology Authors: Jyothi Tadakamadla, Santhosh Kumar, Ratilal Lalloo, Gandhi Babu, Newell W Johnson Tags: Original Article Source Type: research

Developing a quality of life questionnaire for Oral submucous fibrosis patients
This article is protected by copyright. All rights reserved. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - August 1, 2017 Category: Pathology Authors: Arpita Rai Tags: Letter to the Editor Source Type: research

Efficacy of Oral Brush Biopsy in Potentially Malignant Disorder Management
ConclusionsOrcellex® brush cytology provides reliable diagnoses consistent with conventional histopathology and offers less invasive, adjunctive assessment appropriate for long‐term monitoring of patients in specialist clinics.This article is protected by copyright. All rights reserved. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - August 1, 2017 Category: Pathology Authors: M L Goodson, D R Smith, P J Thomson Tags: Original Article Source Type: research

Profiling Cancer Risk in Oral Potentially Malignant Disorders – a Patient Cohort Study
Abstract BackgroundOral potentially malignant disorders harbour variable and unpredictable risk for squamous carcinoma development. Whilst current management strategies utilise histopathological diagnoses, dysplasia grading and targeted intervention for ‘high risk’ lesions, clinicians are unable to predict malignant potential. MethodsDetailed, retrospective clinico‐pathological analysis of potentially malignant lesions undergoing malignant transformation, from a 590 patient cohort treated by interventional laser surgery and followed for a mean of 7.3 years, was undertaken. Clinical outcome was documented at s...
Source: Journal of Oral Pathology and Medicine - August 1, 2017 Category: Pathology Authors: P J Thomson, M L Goodson, D R Smith Tags: Original Article Source Type: research

Prognostic value of the immunohistochemical detection of cancer ‐associated fibroblasts in oral cancer: a systematic review and meta‐analysis
Abstract AimTo perform a meta‐analysis to assess whether the presence of cancer‐associated fibroblasts (CAF) is a prognostic marker of oral squamous cell carcinomas (OSCC). MethodsImmunohistochemical studies assessing the prognostic relevance of CAF (alpha smooth muscle actin (α‐SMA)‐positive fibroblasts) in patients with OSCC were systematically reviewed using Cochrane, Lilacs, PubMed, Scopus and Web of Science databases. The outcomes assessed were overall survival (OS) and disease‐free survival (DFS). The meta‐analysis was performed using the random and fixed effects model with adjusted hazard ratio (HR...
Source: Journal of Oral Pathology and Medicine - August 1, 2017 Category: Pathology Authors: Mauricio Rocha Dourado, Eliete N. S. Guerra, Tuula Salo, Daniel W. Lambert, Ricardo D. Coletta Tags: Review Source Type: research

Ameloblastic fibroma and ameloblastic fibrosarcoma: a systematic review
ConclusionsVery long follow‐up is recommended for AF lesions, due to the risk of recurrence and malignant change into AFS. Segmental resection is the most recommended therapy for AFS.This article is protected by copyright. All rights reserved. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - August 1, 2017 Category: Pathology Authors: Bruno Ramos Chrcanovic, Peter A. Brennan, Siavash Rahimi, Ricardo Santiago Gomez Tags: Review Source Type: research

Advances toward fully automated in vivo assessment of oral epithelial dysplasia by nuclear endomicroscopy —A pilot study
ConclusionsNuclear‐to‐image ratios are applicable for automated optical in vivo diagnostics for oral potentially malignant disorders. Nuclear endomicroscopy may promote non‐invasive, early detection of dys‐/neoplastic lesions by reducing sampling error. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - July 28, 2017 Category: Pathology Authors: Jan Liese, Karsten Winter, Änne Glass, Julia Bertolini, Peer Wolfgang Kämmerer, Bernhard Frerich, Ingolf Schiefke, Torsten W. Remmerbach Tags: ORIGINAL ARTICLE Source Type: research

Ki67, CD105, and α‐SMA expressions better relate the binary oral epithelial dysplasia grading system of World Health Organization
ConclusionThe expressions of ki67, CD105, and α‐SMA markers compliment binary grading system of OED in OPMDS, thus justifying its use in clinical practice. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - July 25, 2017 Category: Pathology Authors: Amol Ramchandra Gadbail, Minal S. Chaudhary, Sachin C. Sarode, Madhuri Gawande, Sheetal Korde, Satyajit Ashok Tekade, Shailesh Gondivkar, Alka Hande, Rupesh Maladhari Tags: ORIGINAL ARTICLE Source Type: research

Circulating high mobility group AT ‐hook 2 and pleomorphic adenoma gene 1 in blood of patients with oral squamous cell carcinoma
BackgroundHigh mobility group AT‐hook 2 (HMGA2) and pleomorphic adenoma gene 1(PLAG1) have been demonstrated to be elevated in many malignant tumors. However, the aim of this study was to evaluate HMGA2 and PLAG1 levels in blood as a non‐invasive biomarker for oral squamous cell carcinoma (OSCC) diagnosis. MethodsqRT‐PCR was performed to measure circulating HMGA2 and PLAG1 levels in OSCC patients (n=43) and matched cancer‐free blood control group (n=21). Clinical data of all patients were recorded. ResultsCirculating HMGA2 and PLAG1 in the 43 OSCC patients was significantly higher than in control group (P
Source: Journal of Oral Pathology and Medicine - July 24, 2017 Category: Pathology Authors: Wenhao Ren, Ling Gao, Fan Li, Cui Qiang, Shaoming Li, Jingjing Zheng, Xinjuan Kong, Jing Deng, Guangfeng Cai, Hao Zhang, Minzhan Zhou, Keqian Zhi Tags: ORIGINAL ARTICLE Source Type: research

Uncovering the role of brain ‐derived neurotrophic factor/tyrosine kinase receptor B signaling in head and neck malignancies
Brain‐derived neurotrophic factor (BDNF) is a member of the neurotrophin family of growth factors that was first known as responsible for sustain the growth, function, and plasticity of neural cells. BDNF exerts its effects by binding to the tyrosine kinase receptor B (TrkB). The BDNF/TrkB axis has been reported to be overexpressed in several neurogenic and non‐neurogenic tumors. Its higher expression was associated with a poor prognosis to patients affected by different human malignancies, tumor growth, invasion, and metastasis; epithelial‐mesenchymal transition and resistance to chemotherapy. BDNF/TrkB represent pr...
Source: Journal of Oral Pathology and Medicine - July 22, 2017 Category: Pathology Authors: Juliana Kern Moraes, Vivian Petersen Wagner, Felipe Paiva Fonseca, Pablo Agustin Vargas, Caroline Brunetto Farias, Rafael Roesler, Manoela Domingues Martins Tags: REVIEW ARTICLE Source Type: research

An in  vitro study of the long non‐coding RNA TUG1 in tongue squamous cell carcinoma
This study sought to study the expression of the long non‐coding RNA (lncRNA) taurine‐upregulated gene 1 (TUG1) in tongue squamous cell carcinoma (TSCC) and reveal its possible function. MethodsqRT‐PCR was used to evaluate 27 samples of fresh TSCC tissues and adjacent normal tongue tissues. siRNA technology was employed to downregulate TUG1 expression in CAL‐27 and SCC‐9 cell lines. The 3‐(4,5‐dimethyl‐2‐thiazolyl)‐2,5‐diphenyl‐2‐H‐tetrazolium bromide (MTT) assay was utilized to assess cell proliferation ability; apoptosis and cell‐cycle phases were analysed via flow cytometry. ResultsqRT‐PC...
Source: Journal of Oral Pathology and Medicine - July 16, 2017 Category: Pathology Authors: Zhi ‐qiang Li, Rui Zou, Ke‐Xiong Ouyang, Wei‐Jian Ai Tags: ORIGINAL ARTICLE Source Type: research

Peritumoral cuffing by T ‐cell tumor‐infiltrating lymphocytes distinguishes HPV‐related oropharyngeal squamous cell carcinoma from oral cavity squamous cell carcinoma
ConclusionsFor the first time, we show an architectural pattern of immune infiltrate in HNSCC is seen exclusively in HPV‐positive patients with improved recurrence‐free survival and suggests an organized host immunological response contributes to disease control. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - July 14, 2017 Category: Pathology Authors: Kate Poropatich, David Hernandez, Joel Fontanarosa, Koshonna Brown, Gayle Woloschak, Ajit Paintal, Kirtee Raparia, Sandeep Samant Tags: ORIGINAL ARTICLE Source Type: research

Patient ‐reported outcome measures in oral lichen planus: A comprehensive review of the literature with focus on psychometric properties and interpretability
ConclusionThe range of PROMs used in clinical studies of patients with OLP is wide and include instruments for oral symptoms, psychosocial status and quality of life. The vast majority of these instruments have no evidence of psychometric properties and interpretability for patients with OLP. Further qualitative and validation studies are required to investigate whether these instruments are appropriate for use in this patient population. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - July 11, 2017 Category: Pathology Authors: P. Wiriyakijja, S. Fedele, S. Porter, V. Mercadante, R. Ni Riordain Tags: REVIEW ARTICLE Source Type: research

High ‐level βIII‐tubulin overexpression occurs in most head and neck cancers but is unrelated to clinical outcome
ConclusionDespite lacking prognostic utility in HNSCC, the remarkable high prevalence of TUBB3 expression in HNSCC emphasizes its putative relevance as a target for future drugs targeting TUBB3. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - July 9, 2017 Category: Pathology Authors: Julie C. Nienstedt, Alexander Gr öbe, Till Clauditz, Ronald Simon, Adrian Muenscher, Rainald Knecht, Guido Sauter, Christoph Moebius, Marco Blessmann, Max Heiland, Christina Pflug Tags: ORIGINAL ARTICLE Source Type: research

Squamous cell carcinoma antigen as a prognostic marker and  its correlation with clinicopathological features in head and neck squamous cell carcinoma: Systematic review and meta‐analysis
BackgroundSeveral studies investigate the prognostic value of squamous cell carcinoma antigen (SCC‐Ag) in head and neck squamous cell carcinoma (HNSCC) patients, with contradicting findings. Considering this, the aim of this study was to evaluate the prognostic value of high SCC‐Ag levels and its association with clinicopathological features of HNSCC. Material and MethodsPubMed, SCOPUS, and Cochrane Library were searched for relevant studies up to December 2015. English‐language publications assessing clinicopathological features of HNSCC and the prognostic significance of SCC‐Ag in this disease were included. A me...
Source: Journal of Oral Pathology and Medicine - July 5, 2017 Category: Pathology Authors: Daphine Caxias Travassos, Darcy Fernandes, Elaine Maria Sgavioli Massucato, Cl áudia Maria Navarro, Andreia Bufalino Tags: REVIEW ARTICLE Source Type: research

Oral submucous fibrosis —an increasing global healthcare problem
(Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - July 3, 2017 Category: Pathology Authors: Peter A Brennan, Gururaj Arakeri Tags: EDITORIAL Source Type: research

Efficacy of low level laser therapy compared to steroid therapy in the treatment of oral lichen planus: A systematic review
ConclusionIt remains debatable whether LLLT is more effective as compared to corticosteroids in the treatment of OLP, given that the scientific evidence is weak. These findings are preliminary and further randomized clinical trials are recommended.This article is protected by copyright. All rights reserved. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - July 1, 2017 Category: Pathology Authors: Zohaib Akram, Tariq Abduljabbar, Fahim Vohra, Fawad Javed Tags: Review Source Type: research

Participation of osteoclastogenic factors in immunopathogenesis of human chronic periapical lesions
The objective of this study was to investigate the participation of RANKL, TNF‐α, cathepsin K, IL‐33 and OPG in the development of radicular cysts (RCs) and periapical granulomas (PGs). MethodsParaffin‐embedded sections of 30 RCs and 22 PGs were submitted to immunohistochemistry. ResultsImmunoexpression of the proteins studied was observed in the epithelium and capsule of RCs, as well as in connective tissue of PGs. The expression of the osteoclastogenic factors studied differed significantly in RCs and PGs (p
Source: Journal of Oral Pathology and Medicine - July 1, 2017 Category: Pathology Authors: S.C.L.T. Santos, L.A. Couto, J.M. Fonseca, F.C.A. Xavier, A.C.L. Figueiredo, V.S Freitas, R.A. Freitas, J.N. Santos, A.C.G. Henriques Tags: Original Article Source Type: research

Is DNA ploidy related to smoking?
ConclusionSmoking was not associated with changes in DNA content or the incidence of aneuploidy in normal oral mucosa.This article is protected by copyright. All rights reserved. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - July 1, 2017 Category: Pathology Authors: Celina Faig Lima, Monica Ghislaine Oliveira Alves, Bruna Fernandes do Carmo Carvalho, Thaynara Alves de Lima, Cl áudia Malheiros Coutinho‐Camillo, Fernando Augusto Soares, Jaqueline Scholz, Janete Dias Almeida Tags: Original Article Source Type: research

Immunohistochemical Expression of MYB in Salivary Gland Basal Cell Adenocarcinoma and Basal Cell Adenoma
ConclusionsMYB expression does not help separate basal cell adenocarcinomas from basal cell adenomas and our data suggest it does not differentiate between either of these neoplasms and adenoid cystic carcinoma.This article is protected by copyright. All rights reserved. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - July 1, 2017 Category: Pathology Authors: Sydney L. Rooney, Robert A. Robinson Tags: Original Article Source Type: research

The Origins of Oral Medicine in the Hippocratic Collected Works
This article is protected by copyright. All rights reserved. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - July 1, 2017 Category: Pathology Authors: Helen Askitopoulou, Vasileia Nyktari, Alexandra Papaioannou, Georgios Stefanakis, Elina Konsolaki Tags: Review Article Source Type: research

Surgical specimen handover from the operating theatre to laboratory ‐ can we improve patient safety by learning from aviation and other high‐risk organisations?
This article is protected by copyright. All rights reserved. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - July 1, 2017 Category: Pathology Authors: Peter A Brennan, Marieke T Brands, Lucy Caldwell, Felipe Paiva Fonseca, Nic Turley, Susie Foley, Siavash Rahimi Tags: Original Article Source Type: research

Advances towards fully automated in vivo assessment of oral epithelial dysplasia by nuclear endomicroscopy – A pilot study
Conclusionsnuclear‐to‐image ratios are applicable for automated optical in vivo diagnostics for oral potentially malignant disorders. Nuclear endomicroscopy may promote non‐invasive, early detection of dys‐/neoplastic lesions by reducing sampling error.This article is protected by copyright. All rights reserved. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - July 1, 2017 Category: Pathology Authors: Jan Liese, Karsten Winter, Änne Glass, Julia Bertolini, Peer Wolfgang Kämmerer, Bernhard Frerich, Ingolf Schiefke, Torsten Remmerbach Tags: Original Article Source Type: research

Ki67, CD105, and α‐SMA expression better relates the binary oral epithelial dysplasia grading system of World Health Organization
ConclusionThe expressions of ki67, CD105 and α‐SMA markers compliment binary grading system of OED in OPMDS, thus justifying its use in clinical practice.This article is protected by copyright. All rights reserved. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - July 1, 2017 Category: Pathology Authors: Amol Ramchandra Gadbail, Minal S. Chaudhary, Sachin C Sarode, Madhuri Gawande, Sheetal Korde, Satyajit Ashok Tekade, Shailesh Gondivkar, Alka Hande, Rupesh Maladhari Tags: Original Article Source Type: research

Next ‐generation sequencing of oncogenes and tumor suppressor genes in odontogenic myxomas
ConclusionThese aggressive tumors do not harbor pathogenic mutations in genes commonly mutated in human cancers or if they do, these mutations probably occur in a low proportion of cases. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - June 28, 2017 Category: Pathology Authors: Jean Nunes Santos, Ernesto Santos Sousa Neto, Josiane Alves Fran ça, Marina Gonçalves Diniz, Rennan Garcias Moreira, Wagner Henriques Castro, Ricardo Santiago Gomez, Silvia Ferreira Sousa, Carolina Cavalieri Gomes Tags: ORIGINAL ARTICLE Source Type: research

Circulating HMGA2 and PLAG1 in blood of patients with oral squamous cell carcinoma
Abstracrt BackgroundHigh mobility group AT‐hook 2 (HMGA2) and pleomorphic adenoma gene 1(PLAG1) have been demonstrated to be elevated in many malignant tumors. However, the aim of this study was to evaluate HMGA2 and PLAG1 levels in blood as a non‐invasive biomarker for oral squamous cell carcinoma (OSCC) diagnosis. MethodsqRT‐PCR was performed to measure circulating HMGA2 and PLAG1 levels in OSCC patients (n=43) and matched cancer‐free blood control group (n=21). Clinical data of all patients were recorded. ResultsCirculating HMGA2 and PLAG1 in the 43 OSCC patients was significantly higher than in control group (p
Source: Journal of Oral Pathology and Medicine - June 26, 2017 Category: Pathology Authors: Wenhao Ren, Ling Gao, Fan Li, Cui Qiang, Shaoming Li, Jingjing Zheng, Xinjuan Kong, Jing Deng, Guangfeng Cai, Hao Zhang, Minzhan Zhou, Keqian Zhi Tags: Original Article Source Type: research

Genetic study of the BRAF gene reveals a new variants and high frequency of the V600E mutation among Iranian ameloblastoma patients
ConclusionsOur study confirms the role of BRAF mutations in ameloblastoma in the Iranian patients studied.This article is protected by copyright. All rights reserved. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - June 26, 2017 Category: Pathology Authors: Maryam Soltani, Mohammad Amin Tabatabaiefar, Zhaleh Mohsenifar, Mohammad Reza Pourreza, Abbas Moridnia, Laleh Shariati, Seyyed Mohammad Razavi Tags: Original Article Source Type: research