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Proinflammatory cytokines as serum biomarker in oral carcinoma —A prospective multi‐biomarker approach
BackgroundInflammation and cell‐mediated immunity have a key role in different stages of carcinogenesis. The aim of this prospective study was to assess serum levels of proinflammatory cytokines interleukin‐6 (IL‐6), interleukin‐8 (IL‐8), soluble interleukin‐2 receptor (sIL‐2R), tumor necrosis factor alpha (TNF‐α), and MHC class I polypeptide‐related sequence B (MICB) in patients with oral premalignant lesion (OPL), oral squamous cell carcinoma (OSCC), and healthy controls in a multi‐biomarker approach as a potential diagnostic and prognostic tool for OSCC. Material and MethodsA total of 205 patie...
Source: Journal of Oral Pathology and Medicine - January 22, 2018 Category: Pathology Authors: Eik Schiegnitz, Peer W. K ämmerer, Holger Schön, Sebastian Blatt, Manfred Berres, Keyvan Sagheb, Bilal Al‐Nawas Tags: ORIGINAL ARTICLE Source Type: research

2018: An update on JOPM progress over the last year
(Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - January 19, 2018 Category: Pathology Authors: Peter A. Brennan Tags: EDITORIAL Source Type: research

Cover Image
The cover image, by Simone Belobrov et al., is based on the Original Article The role of human papillomavirus in p16-positive oral cancers, DOI 10.1111/jop.12649. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - January 19, 2018 Category: Pathology Authors: Simone Belobrov, Alyssa M. Cornall, Richard J. Young, Kendrick Koo, Christopher Angel, David Wiesenfeld, Danny Rischin, Suzanne M. Garland, Michael McCullough Tags: COVER IMAGE Source Type: research

An immunohistochemical score to predict the outcome for oral squamous cell carcinoma
Abstract BackgroundOral cancer is a major public health problem worldwide, with a poor survival. Our aim was to evaluate several protein markers in oral squamous cell carcinomas (OSCC) and analyse their prognostic value on patient′s survival. MethodsWe analysed the expression of EGFR, p53, p27, p16, cyclin D1, cyclin A2, COX‐2, Ki‐67, Bcl‐2, VEGFR‐1, and VEGFR‐2, by immunohistochemistry on 67 primary OSCC. Cancer‐specific survival (CSS) analysis was evaluated by the Cox regression model. ResultsMarkers showed variable expression between 27.9% to 95.2%. In univariate analysis for CSS we found that fou...
Source: Journal of Oral Pathology and Medicine - January 18, 2018 Category: Pathology Authors: Lu ís Silva Monteiro, Márcio Diniz‐Freitas, Saman Warnakulasuriya, Tomás Garcia‐Caballero, Jerónimo Forteza, Máximo Fraga Tags: Original Article Source Type: research

Candida species in patients with oral dysesthesia: a comparison of carriage among oral disease states
ConclusionThere is no association between oral dysesthesia and the presence or load of oral Candida.This article is protected by copyright. All rights reserved. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - January 2, 2018 Category: Pathology Authors: Camile S Farah, Kate Amos, Rachel Leeson, Stephen Porter Tags: Original Article Source Type: research

Efficacy of photodynamic therapy in the treatment of  symptomatic oral lichen planus: a systematic review
ConclusionsThe limited available evidence suggests that PDT is an effective treatment option for the management of OLP. However, due to the limited number of studies included in this review and heterogeneity among these studies, more well‐designed clinical trials with adequate sample sizes are highly warranted.This article is protected by copyright. All rights reserved. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - January 1, 2018 Category: Pathology Authors: Sadeq Ali Al ‐Maweri, Sajna Ashraf, Butchibabu Kalakonda, Esam Halboub, Waleed Petro, Nader Ahmed AlAizari Tags: Review Source Type: research

Proinflammatory cytokines as serum biomarker in oral carcinoma – a prospective multi‐biomarker approach
Abstract BackgroundInflammation and cell‐mediated immunity have a key role in different stages of carcinogenesis. The aim of this prospective study was to assess serum levels of proinflammatory cytokines interleukin‐6 (IL‐6), interleukin‐8 (IL‐8), soluble interleukin‐2 receptor (sIL‐2R), tumour necrosis factor alpha (TNF‐α) and MHC class I polypeptide‐related sequence B (MICB) in patients with oral premalignant lesion (OPL), oral squamous cell carcinoma (OSCC) and healthy controls in a multi‐biomarker approach as a potential diagnostic and prognostic tool for OSCC. Material and Methods205 patients...
Source: Journal of Oral Pathology and Medicine - December 22, 2017 Category: Pathology Authors: E. Schiegnitz, P. W. K ämmerer, H. Schön, S. Blatt, M. Berres, K. Sagheb, B. Al‐Nawas Tags: Original Article Source Type: research

Association between a single ‐nucleotide polymorphism in the GREM1 gene and non‐syndromic orofacial cleft in the Chinese population
ConclusionOur findings revealed that the GREM1 polymorphism was significantly associated with the risk of NSOC in the Chinese population. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - December 7, 2017 Category: Pathology Authors: Xiaotong Wang, Hongquan Song, Xiaohui Jiao, Yanru Hao, Wei Zhang, Yuwei Gao, Yong Li, Na Mi, Jiaqun Yan Tags: ORIGINAL ARTICLE Source Type: research

Ductal cells of minor salivary glands in Sj ögren's syndrome express LINE‐1 ORF2p and APOBEC3B
ConclusionsL1 ORF2p and APOBEC3B are expressed in the ductal epithelial cells of minor salivary glands that are among the key targets in Sjögren's syndrome. L1 ORF2p expression may promote the L1 ability to act as an intrinsic antigen in Sjögren's syndrome. The potential future use of L1 ORF2‐reverse transcriptase inhibitors in autoimmunity supports further investigation of L1 epigenetic regulation by APOBEC3 enzymes. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - November 28, 2017 Category: Pathology Authors: Eleni ‐Marina Kalogirou, Evangelia P. Piperi, Konstantinos I. Tosios, Evangelos Tsiambas, Galinos Fanourakis, Alexandra Sklavounou Tags: ORIGINAL ARTICLE Source Type: research

Epithelial disruptions, but not immune cell invasion, induced secretory dysfunction following innate immune activation in a novel model of acute salivary gland injury
ConclusionsIn the present study, we developed a novel injury model of the SGs, featuring acute secretory dysfunction and immediate structural disruptions. Our results ruled out the injurious role of aggressively infiltrating inflammatory cells.This article is protected by copyright. All rights reserved. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - November 21, 2017 Category: Pathology Authors: Abeer Shaalan, Guy Carpenter, Gordon Proctor Tags: Original Article Source Type: research

T cells are involved in the induction of macrophage phenotypes in oral leukoplakia and squamous cell carcinoma —a preliminary report
ConclusionsThe number and co‐localization of lymphocytes and macrophages in OLK and OSCC may indicate that infiltrating cells influence the early and subsequent stage of oral carcinogenesis. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - November 19, 2017 Category: Pathology Authors: Olga Stasikowska ‐Kanicka, Małgorzata Wągrowska‐Danilewicz, Marian Danilewicz Tags: ORIGINAL ARTICLE Source Type: research

Genetic study of the BRAF gene reveals new variants and high frequency of the V600E mutation among Iranian ameloblastoma patients
ConclusionsOur study confirms the role of BRAF mutations in ameloblastoma in the Iranian patients studied. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - November 7, 2017 Category: Pathology Authors: Maryam Soltani, Mohammad Amin Tabatabaiefar, Zhaleh Mohsenifar, Mohammad Reza Pourreza, Abbas Moridnia, Laleh Shariati, Seyyed Mohammad Razavi Tags: ORIGINAL ARTICLE Source Type: research

Evidence ‐based dentistry: Challenges and possibilities
(Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - November 2, 2017 Category: Pathology Authors: Paulo Ant ônio Martins‐Júnior, Ricardo Santiago Gomez, Peter A. Brennan, Lucas Guimarães Abreu Tags: EDITORIAL Source Type: research

Bibliometric analysis of a century of research on oral erythroplakia and leukoplakia
ConclusionsWe identified the leading journals as well as the leading authors and countries contributing to the research on OEL. International collaborative studies in the field are to be encouraged in order to refine strategies of oral cancer prevention.This article is protected by copyright. All rights reserved. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - November 1, 2017 Category: Pathology Authors: Jean ‐Philippe Foy, Chloé Bertolus, Patrick Goudot, Sophie Deneuve, Ellen Blanc, Christine Lasset, David Pérol, Pierre Saintigny Tags: Original Article Source Type: research

O ‐GlcNAcylation in Oral Squamous Cell Carcinoma
Abstract BackgroundTwo post‐translational mechanisms commonly demonstrated in various cancers are protein phosphorylation and glycosylation by O‐linked β‐N‐acetylglucosamine (O‐GlcNAc). However, only phosphorylation of the epidermal growth factor receptor (EGFR)/Akt pathway has been reported in oral squamous cell carcinoma (OSCC). Therefore, we aimed to determine both post‐translational modifications in OSCC tissues and in oral cancer cells compared to normal tissues and oral keratinocytes and to find correlations of these modifications with histological grading. MethodsThirty‐two OSCC and ten normal for...
Source: Journal of Oral Pathology and Medicine - November 1, 2017 Category: Pathology Authors: Tassaporn Kongkaew, Win Pa Pa Aung, Chayarop Supanchart, Anupong Makeudom, Sarawat Langsa ‐ard, Thanapat Sastraruji, Ponlatham Chaiyarit, Suttichai Krisanaprakornkit Tags: Original Article Source Type: research

Expression of CD163 in hereditary gingival fibromatosis: a possible association with TGF ‐β1
This study was directed to detect and outline the degree of relationship between the immunophenotyped macrophages (M2) expressing CD163 and TGF‐β1 in patients with gingival overgrowth due to HGF. MethodsBiopsies from 20 patients suffering from HGF and 20 normal control subjects were harvested, histologically and immunohistochemically stained then, analyzed and statistically compared and correlated for CD163 immunoexpression and TGF‐β1. ResultsAll HGF specimens expressed TGF‐β1 by most of the connective tissue fibroblasts, with statistically high significant mean of area % (2.61±0.41) compared to...
Source: Journal of Oral Pathology and Medicine - November 1, 2017 Category: Pathology Authors: Hala H. Hazzaa, Ossama M. Gouda, Naglaa M. Kamal, Shereen Abdel Moula Ali, Marwa A. M. ElShiekh, Marwa M. Tawfik Tags: Original Article Source Type: research

LINC00511 interacts with miR ‐765 and modulates tongue squamous cell carcinoma progression by targeting LAMC2
ConclusionsA novel molecular axis of LINC00511/miR‐765/LAMC2 was investigated to regulate the tumor development of TSCC. LINC00511 promoted the expression of LAMC2 via the ceRNA mechanism of sponging miR‐765. The ceRNA regulatory network provided a novel understanding of TSCC pathogenesis and also shed light on exploiting the new field of lncRNA‐directed therapy against TSCC.This article is protected by copyright. All rights reserved. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - November 1, 2017 Category: Pathology Authors: Junhai Ding, Changxi Yang, Sen Yang Tags: Original Article Source Type: research

Uncovering the potential of CD44v /SYNE1/miR34a axis in salivary fluids of oral cancer patients
ConclusionCollectively, these findings suggested a plausible role of CD44v/SYNE1/miR34a axis as non‐invasive salivary biomarkers to diagnose this disease at an early stage and predict the early onset of metastasis.This article is protected by copyright. All rights reserved. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - November 1, 2017 Category: Pathology Authors: Kavan Shah, Shanaya Patel, Bansri Modi, Franky Shah, Rakesh Rawal Tags: Original Article Source Type: research

Effect of 17 ‐allylamino‐17‐demethoxygeldanamycin (17‐AAG) on Akt protein expression is more effective in head and neck cancer cell lineages that retain PTEN protein expression
ConclusionThese data allow us to speculate on the particular utility of 17‐AAG for HNSCC treatment through the inhibition of Akt protein expression, especially in the cases that retain the expression of PTEN protein.This article is protected by copyright. All rights reserved. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - November 1, 2017 Category: Pathology Authors: Fl ávia Sirotheau Corrêa Pontes, Hélder Antônio Rebelo Pontes, Lucas Lacerda de Souza, Adriana Souza de Jesus, Andrea Maia Correa Joaquim, Ligia Akiko Ninokata Miyahara, Felipe Paiva Fonseca, Décio dos Santos Pinto Júnior Tags: Original Article Source Type: research

Focal adhesion kinases in head and neck squamous cell carcinoma
ConclusionsIncreased expression of FAK Tyr‐576 could enable identifcation of tumors with a more aggressive behavior and epithelial alterations before the appearance of clinical or histological manifestations.This article is protected by copyright. All rights reserved. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - November 1, 2017 Category: Pathology Authors: Anacl áudia Pereira Costa Flores, Kelly Bienk Dias, Laura de Campos Hildebrand, Márcia Gaiger Oliveira, Marcelo Lazzaron Lamers, Manoel Sant'Ana Filho Tags: Original Article Source Type: research

EZH2 overexpression in head and neck cancer is related to lymph node metastasis
ConclusionThe high prevalence of EZH2 expression in head and neck squamous cell carcinoma stresses its capability as a therapeutic target.This article is protected by copyright. All rights reserved. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - November 1, 2017 Category: Pathology Authors: Julie C. Nienstedt, Cornelia Schroeder, Till Clauditz, Ronald Simon, Guido Sauter, Adrian Muenscher, Marco Blessmann, Henning Hanken, Christina Pflug Tags: Original Article Source Type: research

Analytic survey of 57 cases of oral metastases
ConclusionsAs a departure from many previous case series, we found lung and breast metastases to be equally numerous in women and liver as the most common oral metastasis in men. Also, we identified a tendency for the patient to present with a previous history in certain malignancies, like breast cancer, whereas in other malignancies, such as renal cell carcinoma, our data demonstrated a propensity to present in the oral cavity without history of a primary tumor.This article is protected by copyright. All rights reserved. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - November 1, 2017 Category: Pathology Authors: Yingci Liu, Richard J. Vargo, Elizabeth A. Bilodeau Tags: Original Article Source Type: research

Absence of BRAFV600E mutation in odontogenic keratocysts
ConclusionOn the basis of our results, OKCs do not present recurrent hotspot mutations in these 50 genes commonly mutated in cancer. In addition, BRAFV600E does not play a central role in OKC pathogenesis.This article is protected by copyright. All rights reserved. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - November 1, 2017 Category: Pathology Authors: Josiane Alves Fran ça, Sílvia Ferreira de Sousa, Marina Gonçalves Diniz, Thaís dos Santos Fontes Pereira, Taynara Asevedo Campos de Resende, Jean Nunes dos Santos, Ricardo Santiago Gomez, Carolina Cavalieri Gomes Tags: Original Article Source Type: research

Type 1 diabetes mellitus effects on dental enamel formation revealed by microscopy and microanalysis
Abstract BackgroundType 1 diabetes mellitus (T1DM) largely affects children, occurring therefore at the same period of deciduous and permanent teeth development. The aim of the present work was to investigate birefringence and morphology of the secretory stage enamel organic extracellular matrix (EOECM), and structural and mechanical features of mature enamel from T1DM rats. MethodsAdult Wistar rats were maintained alive for a period of 56 days after the induction of experimental T1DM with a single dose of streptozotocin (60 mg/kg). After proper euthanasia of the animals, fixed upper incisors were accurately processed, and...
Source: Journal of Oral Pathology and Medicine - November 1, 2017 Category: Pathology Authors: Bruna Larissa Lago Silva, Danila Lima Medeiros, Ana Prates Soares, S érgio Roberto Peres Line, Maria das Graças Farias Pinto, Telma de Jesus Soares, Alexandre Ribeiro do Espírito Santo Tags: Original Article Source Type: research

STRO ‐1 confers myofibroblast transdifferentiation in fibroblasts derived from oral submucous fibrosis
Abstract BackgroundSTRO‐1 is a mesenchymal cell marker present on all clonogenic stromal precursors. Current evidence has indicated that the pathogenesis of fibrotic changes may be mediated by stemness properties. The aim of this study was to investigate the role of STRO‐1 in areca quid chewing‐associated oral submucous fibrosis (OSF). MethodsThirty OSF specimens and ten normal buccal mucosa were examined by immunohistochemistry. The activity of STRO‐1 from fibroblasts cultured from normal buccal mucosa (BMFs) and OSF (OSFFs) were measureed and the effects of arecoline, a major areca nut alkaloid, on STRO‐1 in BM...
Source: Journal of Oral Pathology and Medicine - November 1, 2017 Category: Pathology Authors: Cheng ‐Chia Yu, Yi‐Wen Liao, Chuan‐Hang Yu, Yu‐Chao Chang Tags: Original Article Source Type: research

Plasma IL ‐8 signature correlates with pain and depressive symptomatology in patients with Burning Mouth Syndrome: results from a pilot study
ConclusionsOverall, these findings indicate that plasma IL‐8 profiles are dysregulated in BMS and that modulation of IL‐8 production in the disorder may be a tool in the management of BMS symptomatology.This article is protected by copyright. All rights reserved. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - November 1, 2017 Category: Pathology Authors: Alison Barry, Ken D. O'Halloran, Joseph P. McKenna, Christine McCreary, Eric J. Downer Tags: Original Article Source Type: research

Oral cancer databases: a comprehensive review
This article is protected by copyright. All rights reserved. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - November 1, 2017 Category: Pathology Authors: Gargi S Sarode, Sachin C Sarode, Nikunj Maniyar, Rahul Anand, Shankargouda Patil Tags: Review Source Type: research

Upregulation of angiogenesis in oral lichen planus
Abstract ObjectivesSince angiogenesis is fundamental to the pathogenesis of many chronic inflammatory disorders this study investigated the expression of various vascular markers in oral lichen planus and non‐specific oral mucosal inflammatory tissues. MethodsArchival specimens of oral lichen planus (n=15) and inflamed tissues (n=13) were stained using immunohistochemistry with antibodies to CD34, vascular endothelial growth factor, vascular endothelial growth factor receptor and vasohibin. Nine representative sites at the epithelial‐connective tissue junction and through the fibrous connective tissue were selected and...
Source: Journal of Oral Pathology and Medicine - November 1, 2017 Category: Pathology Authors: A Al ‐Hassiny, L T Friedlander, V PB Parachuru, B Seo, H M Hussaini, A M Rich Tags: Original Article Source Type: research

Smoking cessation leads to changes in survivin expression in oral mucosa
ConclusionsThe extension and intensity of survivin expression in the cytological smears were related to the smoking cessation in the group with OSCC. However, the smoking history (packs/years) did not influence the survivin expression.This article is protected by copyright. All rights reserved. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - November 1, 2017 Category: Pathology Authors: Celina Faig Lima, Erica Crastechini, Nathalia Curto dos Santos, Ana Carolina Prado Ribeiro, Thais Bianca Brand ão, Félix Cristiano Ferreira de Castro, Jaqueline Scholz Issa, Janete Dias Almeida Tags: Original Article Source Type: research

Association between a single ‐nucleotide polymorphism in the GREM1 gene and nonsyndromic orofacial cleft in the Chinese population
ConclusionOur findings revealed that the GREM1 polymorphism was significantly associated with the risk of NSOC in the Chinese population.This article is protected by copyright. All rights reserved. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - November 1, 2017 Category: Pathology Authors: Xiaotong Wang, Hongquan Song, Xiaohui Jiao, Yanru Hao, Wei Zhang, Yuwei Gao, Yong Li, Na Mi, Jiaqun Yan Tags: Original Article Source Type: research

The utility of oral brush cytology in the early detection of oral cancer and oral potentially malignant disorders: A systematic review
ConclusionsFindings from this paper indicate that meaningful evidence‐based recommendations for the implementation of a minimally‐invasive technique to be utilized as an adjunctive tool for screening and early detection of oral cancer and OPMDs are complicated from the reported studies in the literature. There is need for well‐designed clinical studies to assess the accuracy of oral brush cytology utilizing validated cytological assessment criteria for the diagnosis and prediction of OPMDs.This article is protected by copyright. All rights reserved. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - November 1, 2017 Category: Pathology Authors: Abdulhameed Husain, Omar Kujan, Camile S. Farah Tags: Review Article Source Type: research

The effects of Icariin on wound healing of extraction sites with administration of Zoledronic and Dexamethasone: A rat model study
ConclusionConcurrent use of Zoledronic and Dexamethasone inhibits expression of VEGF, OCN and wound healing; and increases the number of osteoclast cells, serum CTX‐1 and TRACP‐5b after discontinuation for ten weeks. Icariin weakens those effects at a dose‐dependent manner but does not influence onset of BRONJ.This article is protected by copyright. All rights reserved. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - November 1, 2017 Category: Pathology Authors: Jie Liu, Nikos Mattheos, Cheng Su, Chuanxi Deng, Nanyu Luo, Zekun Wang, Hua Tang Tags: Original Article Source Type: research

Assessment of biologically aggressive, recurrent glandular odontogenic cysts for mastermind ‐like 2 (MAML2) rearrangements: histopathologic and fluorescent in situ hybridization (FISH) Findings in eleven cases
ConclusionFindings in the current study are in concert with previous investigations, and although this study finds ONLY LIMITED molecular evidence to support the premise that recurrent biologically aggressive GOCs are a precursor to IMEC, detection of MAML2 rearrangements in one case suggests that such a theoretic transition, while rare, is possible.This article is protected by copyright. All rights reserved. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - November 1, 2017 Category: Pathology Authors: Robert O. Greer, Jeffrey Eskendri, Paul Freedman, Moni Ahmadian, Aline Murakami ‐Walter, Marileila Varella‐Garcia Tags: Original Article Source Type: research

T cells are involve in the induction of macrophage phenotypes in oral leukoplakia and squamous cell carcinoma – a preliminary report
ConclusionsThe number and co‐localization of lymphocytes and macrophages in OLK and OSCC, may indicate that infiltrating cells influence the early and subsequent stage of oral carcinogenesis.This article is protected by copyright. All rights reserved. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - November 1, 2017 Category: Pathology Authors: Olga Stasikowska ‐Kanicka, Małgorzata Wągrowska‐Danilewicz, Marian Danilewicz Tags: Original Article Source Type: research

Mutations in the genes for keratin ‐4 and keratin‐13 in Swedish patients with white sponge nevus
ConclusionWe describe a novel heterozygous missense mutation in the keratin‐4 gene of a Swedish family with white sponge nevus. Our results support the notion that mutations in keratin‐4 and keratin‐13 are the underlying cause of white sponge nevus. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - November 1, 2017 Category: Pathology Authors: Maria Westin, Elham Rekabdar, Lena Blomstrand, Per Klintberg, Mats Jontell, Jairo Robledo ‐Sierra Tags: ORIGINAL ARTICLE Source Type: research

The role of human papillomavirus in p16 ‐positive oral cancers
ConclusionWe have shown that the presence of transcriptionally active HPV rarely occurs in OSCC and that p16 is not an appropriate surrogate marker for HPV in OSCC cases. We propose that non‐viral mechanisms are responsible for the majority of IHC p16 overexpression in OSCC. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - October 30, 2017 Category: Pathology Authors: Simone Belobrov, Alyssa M. Cornall, Richard J. Young, Kendrick Koo, Christopher Angel, David Wiesenfeld, Danny Rischin, Suzanne M. Garland, Michael McCullough Tags: ORIGINAL ARTICLE Source Type: research

Porphyromonas gingivalis lipopolysaccharide induces over production of CC chemokine ligand 2 via toll ‐like receptor‐4 in oral lichen planus
ConclusionIncreased TLR‐4 expression contributes to the upregulated expression of CCL2 in the epithelium of OLP lesions, which suggests that oral bacteria participate in the pathogenesis of OLP via the TLR‐4 pathway.This article is protected by copyright. All rights reserved. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - October 23, 2017 Category: Pathology Authors: Qi Zeng, Xi Yang, Xiaobing Chen, Juan Xia, Bin Cheng, Xiaoan Tao Tags: Original Article Source Type: research

Tumor ‐derived exosomes enhance invasion and metastasis of salivary adenoid cystic carcinoma cells
ConclusionThe results suggested that SACC cells‐derived exosomes were loaded with individual components that could enhance invasiveness and induce microenvironment changes, thus promoting SACC aggression.This article is protected by copyright. All rights reserved. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - October 23, 2017 Category: Pathology Authors: Jin Hou, Fangyuan Wang, Xiaohao Liu, Mengyang Song, Xuemin Yin Tags: Original Article Source Type: research

Cell proliferation is associated with intensity of tumor budding in oral squamous cell carcinoma
This study aimed to evaluate the association between intensity of tumor budding and cell proliferation in oral squamous cell carcinoma (OSCC). MethodsImmunohistochemistry was employed in 163 OSCC samples to detect the cell proliferation marker Ki‐67 and multi‐cytokeratin (to identify OSCC cells in tumor budding evaluation). The Mann‐Whitney test was used to evaluate differences in the cell proliferation index between samples with high‐intensity tumor budding and samples with low‐intensity or no tumor budding. In samples with high‐intensity tumor budding, the Wilcoxon test was used to evaluate differences in the...
Source: Journal of Oral Pathology and Medicine - October 20, 2017 Category: Pathology Authors: Helv écio Marangon Junior, Priscila Laiza Rubim Leão, Victória Vasconcellos Moreira Melo, Ângela Braga Caixeta, Paulo Eduardo Alencar Souza, Maria Cássia Ferreira Aguiar, Martinho Campolina Rebello Horta Tags: Original Article Source Type: research

Functional analysis of ESM1 by siRNA knockdown in primary and metastatic head and neck cancer cells
ConclusionThese findings suggest that ESM1 has roles on proliferation and migration of head and neck cancer cells.This article is protected by copyright. All rights reserved. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - October 11, 2017 Category: Pathology Authors: Onur Bender, Mehmet Gunduz, Sadik Cigdem, Omer Faruk Hatipoglu, Muradiye Acar, Mesut Kaya, Reidar Grenman, Esra Gunduz, Kadriye Serife Ugur Tags: Original Article Source Type: research

Should we be rethinking follow ‐up for oral cancer patients?
(Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - October 4, 2017 Category: Pathology Authors: Marieke T. Brands, Matthias A. W. Merkx, Sandra M. E. Geurts, Peter A. Brennan Tags: EDITORIAL Source Type: research

Ductal cells of minor salivary glands in Sj ögren's syndrome patients express LINE‐1 ORF2p and APOBEC3B
ConclusionsL1 ORF2p and APOBEC3B are expressed in the ductal epithelial cells of minor salivary glands that are among the key targets in Sjögren's syndrome. L1 ORF2p expression may promote the L1 ability to act as an intrinsic antigen in Sjögren's syndrome. The potential future use of L1 ORF2‐reverse transcriptase inhibitors in autoimmunity supports further investigation of L1 epigenetic regulation by APOBEC3 enzymes.This article is protected by copyright. All rights reserved. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - October 1, 2017 Category: Pathology Authors: Eleni ‐Marina Kalogirou, Evangelia P. Piperi, Konstantinos I. Tosios, Evangelos Tsiambas, Galinos Fanourakis, Alexandra Sklavounou Tags: Original Article Source Type: research

Clinicopathologic significance of ROCK2 expression in oral squamous cell carcinomas
ConclusionsThe findings suggest that high ROCK2 expression in OSCC is associated with advanced disease and follows the increase in CAF density, which may be important for tumor progression.This article is protected by copyright. All rights reserved. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - October 1, 2017 Category: Pathology Authors: Mauricio Rocha Dourado, Carine Ervolino Oliveira, Iris Sawazaki ‐Calone, Elias Sundquist, Ricardo D. Coletta, Tuula Salo Tags: Original Article Source Type: research

Mutations in the genes for keratin ‐4 and ‐13 in Swedish patients with white sponge nevus
ConclusionWe describe a novel heterozygous missense mutation in the keratin‐4 gene of a Swedish family with white sponge nevus. Our results support the notion that mutations in keratin‐4 and ‐13 are the underlying cause of white sponge nevus.This article is protected by copyright. All rights reserved. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - October 1, 2017 Category: Pathology Authors: Maria Westin, Elham Rekabdar, Lena Blomstrand, Per Klintberg, Mats Jontell, Jairo Robledo ‐Sierra Tags: Original Article Source Type: research

MicroRNA profiling reveals dysregulated microRNAs and their target gene regulatory networks in cemento ‐ossifying fibroma
ConclusionmiRNA dysregulation occurs in COF and EZH2, XIAP, MET and TGFBR1 are potential targets for functional analysis validation.This article is protected by copyright. All rights reserved. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - October 1, 2017 Category: Pathology Authors: Tha ís dos Santos Fontes Pereira, João Artur Ricieri Brito, André Luiz Sena Guimarães, Carolina Cavaliéri Gomes, Júlio Cesar Tanos de Lacerda, Wagner Henriques de Castro, Roney Santos Coimbra, Marina Gonçalves Diniz, Ricardo Santiago Gomez Tags: Original Article Source Type: research

The role of human papillomavirus in p16 positive oral cancers
ConclusionWe have shown that the presence of transcriptionally active HPV rarely occurs in OSCC and that p16 is not an appropriate surrogate marker for HPV in OSCC cases. We propose that non‐viral mechanisms are responsible for the majority of IHC p16 overexpression in OSCC.This article is protected by copyright. All rights reserved. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - October 1, 2017 Category: Pathology Authors: Simone Belobrov, Alyssa M. Cornall, Richard J. Young, Kendrick Koo, Christopher Angel, David Wiesenfeld, Danny Rischin, Suzanne M. Garland, Michael McCullough Tags: Original Article Source Type: research

Odontogenic myxoma: a 63 ‐year retrospective multicenter study of 85 cases in a Brazil population and a review of 999 cases from literature
ConclusionsThe features of OM samples have strong similarity to that reported in studies from other continents. It is possible to infer that geographic variation does not help to explain some differences observed in the clinical features of OM.This article is protected by copyright. All rights reserved. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - October 1, 2017 Category: Pathology Authors: Ana Carolina Uchoa Vasconcelos, Felipe Martins Silveira, Ana Paula Neutzling Gomes, Sandra Beatriz Chaves Tarquinio, Ana Paula Veras Sobral, Jos é Alcides Almeida de Arruda, Leorik Pereira da Silva, Marcia Maria Fonseca da Silveira, Larissa Ferreira Barb Tags: Original Article Source Type: research

Denosumab ‐related osteonecrosis of the jaw: a retrospective study
ConclusionOur results raise important questions about the dental management of these patients, in particular concerning the healing period between dental extractions and the initiation of Denosumab.This article is protected by copyright. All rights reserved. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - October 1, 2017 Category: Pathology Authors: Egloff ‐Juras Claire, Gallois Aurélie, Salleron Julia, Massard Vincent, Dolivet Gilles, Guillet Julie, Phulpin Bérengère Tags: Original Article Source Type: research

Treatment resistance in potentially malignant disorders —‘Nature’ or ‘Nurture’…?
ConclusionDespite clinico‐pathological profiling of treatment resistant patients, the precise inter‐relationship between the inherent nature of potentially malignant disease and the external influence of treatment intervention remains obscure. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - September 18, 2017 Category: Pathology Authors: P. J. Thomson, M. L. Goodson, D. R. Smith Tags: ORIGINAL ARTICLE Source Type: research

Developing a quality ‐of‐life questionnaire for oral submucous fibrosis patients
(Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - September 15, 2017 Category: Pathology Authors: Arpita Rai Tags: LETTER TO THE EDITOR Source Type: research