Filtered By:
Cancer: Breast Carcinoma

This page shows you your search results in order of date. This is page number 5.

Order by Relevance | Date

Total 244 results found since Jan 2013.

Docetaxel-triggered SIDT2/NOX4/JNK/HuR signaling axis is associated with TNF- α-mediated apoptosis of cancer cells
Biochem Pharmacol. 2021 Dec 2:114865. doi: 10.1016/j.bcp.2021.114865. Online ahead of print.ABSTRACTPrevious studies have confirmed that docetaxel (DTX) treatment increases TNF-α production in cancer cells, but its mechanism of action remains unclear. Therefore, this study aimed to determine the signaling axis by which DTX induced the expression of TNF-α in U937 leukemia and MCF-7 breast carcinoma cells. DTX treatment promoted Ca2+-controlled autophagy and SIDT2 expression, resulting in lysosomal degradation of miR-25 in U937 cells. Downregulation of miR-25 increased NOX4 mRNA stability and protein expression. NOX4-stimu...
Source: Biochemical Pharmacology - December 5, 2021 Category: Drugs & Pharmacology Authors: Liang-Jun Wang Jing-Ting Chiou Yuan-Chin Lee Long-Sen Chang Source Type: research

GALNT14 promotes cancer stem cell-like characteristics and metastasis of nasopharyngeal carcinoma cells through upregulating SOX4
ConclusionGALNT14 promoted the cancer stem cell-like characteristics and metastasis of nasopharyngeal carcinoma cells through upregulating SOX4, providing a potential therapeutic target for nasopharyngeal carcinoma treatment.
Source: Molecular and Cellular Toxicology - November 17, 2021 Category: Cytology Source Type: research

KIF21A regulates breast cancer aggressiveness and is prognostic of patient survival and tumor recurrence
CONCLUSION: The data demonstrates that KIF21A is an important regulator of breast cancer aggressiveness and may be useful in refining prognostication of this malignant disease.PMID:34698969 | DOI:10.1007/s10549-021-06426-x
Source: Cell Research - October 26, 2021 Category: Cytology Authors: Anton J Lucanus Aye Aye Thike Xing Fei Tan Kee Wah Lee Shiyuan Guo Victoria P C King Von Bing Yap Boon Huat Bay Puay Hoon Tan George W Yip Source Type: research

Fluid flow exposure promotes epithelial-to-mesenchymal transition and adhesion of breast cancer cells to endothelial cells
CONCLUSIONS: This study shows that fluid forces on the order of 1 Pa promote EMT and adhesion of breast cancer cells to an endothelial monolayer and identified biomarkers were distinctly expressed in patient populations. A better understanding of how biophysical forces such as shear stress affect cellular processes involved in metastatic progression of breast cancer is important for identifying new molecular markers for disease progression, and for predicting metastatic risk.PMID:34641959 | DOI:10.1186/s13058-021-01473-0
Source: Cell Research - October 13, 2021 Category: Cytology Authors: Kenneth F Fuh Robert D Shepherd Jessica S Withell Brayden K Kooistra Kristina D Rinker Source Type: research

PCSK9 and cancer: Rethinking the link
Biomed Pharmacother. 2021 May 28;140:111758. doi: 10.1016/j.biopha.2021.111758. Online ahead of print.ABSTRACTBACKGROUND: Cancer is emerging as a major problem globally, as it accounts for the second cause of death despite medical advances. According to epidemiological and basic studies, cholesterol is involved in cancer progression and there are abnormalities in cholesterol metabolism of cancer cells including prostate, breast, and colorectal carcinomas. However, the importance of cholesterol in carcinogenesis and thereby the role of cholesterol homeostasis as a therapeutic target is still a debated area in cancer therapy...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 31, 2021 Category: Drugs & Pharmacology Authors: Khadijeh Mahboobnia Matteo Pirro Ettore Marini Francesco Grignani Evgeny E Bezsonov Tannaz Jamialahmadi Amirhossein Sahebkar Source Type: research

LncRNA RUSC1-AS1 promotes osteosarcoma progression through regulating the miR-340-5p and PI3K/AKT pathway
In conclusion, our study demonstrated that RUSC1-AS1 promoted osteosarcoma development both in vitro and in vivo through sponging to miR-340-5p and activating the PI3K/AKT signaling pathway. Therefore, RUSC1-AS1 becomes a potential therapeutic target for osteosarcoma.PMID:34048366 | DOI:10.18632/aging.203047
Source: Aging - May 28, 2021 Category: Biomedical Science Authors: Chang-Jun Tong Qing-Chun Deng Di-Jun Ou Xia Long He Liu Kang Huang Source Type: research

A Novel Role for Brain and Acute Leukemia Cytoplasmic (BAALC) in Human Breast Cancer Metastasis
This study investigates BAALC expression in human breast cancers with the aim of determining if it plays a role in the pathogenesis of the disease. BAALC protein expression was examined by immunohistochemistry in breast cancer, and matched lymph node and normal breast tissue samples. The effect of gene expression on overall survival (OS), disease-free and distant metastasis free survival (DMFS) was assessed in silico using the Kaplan-Meier Plotter (n=3,935), the TCGA invasive breast carcinoma (n=960) and GOBO (n=821) data sets. Functional effects of BAALC expression on breast cancer proliferation, migration and invasion we...
Source: Frontiers in Oncology - April 22, 2021 Category: Cancer & Oncology Source Type: research

Cancers, Vol. 13, Pages 1469: The Epithelial –Mesenchymal Transcription Factor SNAI1 Represses Transcription of the Tumor Suppressor miRNA let-7 in Cancer
In conclusion, the SNAI1/let-7 axis is an important component of stemness pathways in cancer cells, and this study provides a rationale for future work examining this axis as a potential target for cancer stem cell-specific therapies.
Source: Cancers - March 23, 2021 Category: Cancer & Oncology Authors: Hanmin Wang Evgeny Chirshev Nozomi Hojo Tise Suzuki Antonella Bertucci Michael Pierce Christopher Perry Ruining Wang Jeffrey Zink Carlotta A. Glackin Yevgeniya J. Ioffe Juli J. Unternaehrer Tags: Article Source Type: research

Cancers, Vol. 13, Pages 82: STAT3 Stabilizes IKK α Protein through Direct Interaction in Transformed and Cancerous Human Breast Epithelial Cells
In this study, we observed overexpression and co-localization of IKKα and STAT3 in human breast cancer tissues as well as in H-Ras transformed human breast epithelial (H-Ras MCF-10A) and breast cancer (MDA-MB-231) cells. By utilizing small interfering RNA (siRNA) technology, we were able to demonstrate that STAT3 up-regulated IKKα, but not IKKβ or IKKγ, in these cells. This was attributable to direct binding to and subsequent stabilization of IKKα protein by blocking the ubiquitin-proteasome system. Notably, we identified the lysine 44 residue of IKK&...
Source: Cancers - December 30, 2020 Category: Cancer & Oncology Authors: Young-Il Hahn Soma Saeidi Su-Jung Kim Se-Young Park Na-Young Song Jie Zheng Do-Hee Kim Han-Byoel Lee Wonshik Han Dong-Young Noh Hye-Kyung Na Young-Joon Surh Tags: Article Source Type: research

Cancers, Vol. 13, Pages 80: The ITIM-Containing Receptor: Leukocyte-Associated Immunoglobulin-Like Receptor-1 (LAIR-1) Modulates Immune Response and Confers Poor Prognosis in Invasive Breast Carcinoma
Conclusion: High expression of LAIR-1 is associated with poor clinical outcome in BC. Association with immune cells and immune checkpoint markers warrant further studies to assess the underlying mechanistic roles.
Source: Cancers - December 30, 2020 Category: Cancer & Oncology Authors: Chitra Joseph Mansour A. Alsaleem Michael S. Toss Yousif A. Kariri Maryam Althobiti Sami Alsaeed Abrar I. Aljohani Pavan L. Narasimha Nigel P. Mongan Andrew R. Green Emad A. Rakha Tags: Article Source Type: research

High expression of ZNF652 promotes carcinogenesis and progression of breast cancer.
CONCLUSIONS: ZNF652 is highly expressed in breast cancer tissues and cells to promote the development and progression of breast cancer and may serve as a potential molecular target for diagnosis and treatment of the malignancy. PMID: 33380394 [PubMed - in process]
Source: Journal of Southern Medical University - December 30, 2020 Category: Universities & Medical Training Authors: Lei T, Xiao B, He Y, Sun Z, Li L Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

ASMT Regulates Tumor Metastasis Through the Circadian Clock System in Triple-Negative Breast Cancer
ConclusionOur study suggests that ASMT regulates the circadian clock system in breast cancer and inhibition of ASMT reduces the invasiveness of triple-negative breast cancer cells by downregulating clock protein in a certain extent, indicating the potential value of ASMT as a drug target for TNBC treatment.
Source: Frontiers in Oncology - October 21, 2020 Category: Cancer & Oncology Source Type: research

Role of ARID1A in epithelial ‑mesenchymal transition in breast cancer and its effect on cell sensitivity to 5‑FU.
Role of ARID1A in epithelial‑mesenchymal transition in breast cancer and its effect on cell sensitivity to 5‑FU. Int J Mol Med. 2020 Nov;46(5):1683-1694 Authors: Wang T, Gao X, Zhou K, Jiang T, Gao S, Liu P, Zuo X, Shi X Abstract The loss of function mutation of AT‑rich interactive domain 1A (ARID1A) often occurs in patients with breast cancer. It has been found that ARID1A knockout can enhance both the migratory activity of renal carcinoma cells and their sensitivity to therapeutic drugs by promoting epithelial-mesenchymal transition (EMT); however, its mechanisms of action in breast cancer r...
Source: International Journal of Molecular Medicine - October 3, 2020 Category: Molecular Biology Authors: Wang T, Gao X, Zhou K, Jiang T, Gao S, Liu P, Zuo X, Shi X Tags: Int J Mol Med Source Type: research

Prognostic and therapeutic relevance of phosphofructokinase platelet-type (PFKP) in breast cancer.
Abstract In the present study, we have explored the prognostic value of the Phosphofructokinase Platelet-type (PFKP) expression and its therapeutic relevance in metastatic breast cancer. PFKP immunohistochemistry was performed on Invasive ductal carcinomas (IDCs; n = 87) of breast, and its association with clinicopathological parameters were evaluated. Using online meta-analysis tools, PFKP's prognostic value was investigated in overall breast cancer as well as in triple negative subtype (TNBCs). For in vitro analysis, MDA-MB-231 cells model was used in order to elucidate mechanisms behind PFKP regulated gly...
Source: Experimental Cell Research - September 9, 2020 Category: Cytology Authors: Umar SM, Kashyap A, Kahol S, Mathur S, Gogia A, Deo SVS, Prasad CP Tags: Exp Cell Res Source Type: research