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Cancer: Breast Carcinoma

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Total 244 results found since Jan 2013.

Inhibition of Lung Carcinoma A549 Cell Growth by Knockdown of Hexokinase 2 In Situ and In Vivo.
In this study, we explored the functional role of HK2 in lung cancer cell proliferation and tumorigenesis and determine its expression profile in lung cancer. HK2 expression was increased in primary lung cancer tissues of patients. Knocking down HK2 expression by small interfering RNA (siRNA) inhibited cell proliferation in lung cancer cells and nude mice. Thus, HK2 is required for sustained proliferation and survival of tumor cells in vitro and in vivo, and its aberrant expression may contribute to the pathogenesis of lung cancer. Thus, our study provided evidence that HK2 functions as a novel oncogene in lung cancer and ...
Source: Oncology Research - January 24, 2016 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Abstract B05: WHSC1L1 and estrogen-independent activation of estrogen receptor-alpha (ER{alpha}) in 8p11 amplicon-bearing cell lines
The 8p11-p12 genomic region is amplified in 15% of breast cancers and 21% of lung squamous cell carcinomas (LSCC) and is associated with poorer prognosis. This genomic region harbors several oncogenes, three of which are epigenetic modifiers of chromatin (WHSC1L1, KAT6A, ASH2L). WHSC1L1 is a histone methyltransferase (HMT) that is expressed in 2 isoforms. The long isoform (WH-long) encompasses the entire coding region and is associated with dimethylation of lysine 36 on histone 3 (H3K36me2) to facilitate transcriptional elongation. The short isoform (WH-short) is produced by alternative splicing at exon 10, resulting in a ...
Source: Cancer Research - January 14, 2016 Category: Cancer & Oncology Authors: Mills, J. N., Irish, J., Turner-Ivey, B., Ethier, S. P. Tags: Cancer Genomics and Epigenomics Source Type: research

pAT2R Gene Therapy Inhibits Lung Cancer via IV/IT Injection
Transfection efficiency and toxicity concerns remain a challenge for gene therapy. Cell-penetrating peptides (CPP) have been broadly investigated to improve the transfection of genetic material (e.g., pDNA and siRNA). Here, a synthetic CPP (polylysine, K9 peptide) was complexed with angiotensin II type 2 receptor (AT2R) plasmid DNA (pAT2R) and complexes were condensed using calcium chloride. The resulting complexes were small (~150 nm) and showed high levels of gene expression in vitro and in vivo. This simple nonviral formulation approach showed negligible cytotoxicity in four different human cell lines (cervix, breast, k...
Source: Molecular Cancer Therapeutics - January 7, 2016 Category: Cancer & Oncology Authors: Alhakamy, N. A., Ishiguro, S., Uppalapati, D., Berkland, C. J., Tamura, M. Tags: Models and Technologies Source Type: research

Down-regulation of BRMS1 by DNA hypermethylation and its association with metastatic progression in triple-negative breast cancer.
In this study, we found that BRMS1 was down-regulation in breast cancer cell lines and primary TNBC, while decreased expression of BRMS1 mRNA was significantly associated with lymph node metastasis. And this down-regulation was found to be in accordance with aberrant methylation of the gene. Hypermethylation of the gene was observed in 53.4% (62/116) of the TNBC primary breast carcinomas, while it was found in only 24.1% (28/116) of the corresponding nonmalignant tissues. In addition, BRMS1 expression was restored in MDA-MB-231 after treatment with the demethylating agent, 5-aza-2-deoxycytidine (5-Aza-dC), and demethylatio...
Source: Clinical Breast Cancer - December 2, 2015 Category: Cancer & Oncology Authors: Kong B, Lv ZD, Wang Y, Jin LY, Ding L, Yang ZC Tags: Int J Clin Exp Pathol Source Type: research

The expression level of the transcription factor Aryl hydrocarbon receptor nuclear translocator (ARNT) determines cellular survival after radiation treatment
Conclusions: These findings provide evidence to consider ARNT as a drug target and as a predictive marker in clinical applications concerning the response to radiation.
Source: Radiation Oncology - November 16, 2015 Category: Cancer & Oncology Authors: Markus MandlMaria- LieberumJuergen DunstReinhard Depping Source Type: research

CA1 contributes to microcalcification and tumourigenesis in breast cancer
Conclusion: The results of this study suggested that CA1 is a potential oncogene and that it contributes to abnormal cell calcification, apoptosis and migration in breast cancer.
Source: BMC Cancer - October 12, 2015 Category: Cancer & Oncology Authors: Yabing ZhengBing XuYan ZhaoHe GuChang LiYao WangXiaotian Chang Source Type: research

The adhesion G protein-coupled receptor G2 (ADGRG2/GPR64) constitutively activates SRE and NFκB and is involved in cell adhesion and migration.
Abstract Adhesion G protein-coupled receptors (ADGRs) are believed to be activated by auto-proteolytic cleavage of their very large extracellular N-terminal domains normally acting as a negative regulator of the intrinsically constitutively active seven transmembrane domain. ADGRG2 (or GPR64) which originally was described to be expressed in the epididymis and studied for its potential role in male fertility, is highly up-regulated in a number of carcinomas, including breast cancer. Here, we demonstrate that ADGRG2 is a functional receptor, which in transfected HEK293 cells signals with constitutive activity throu...
Source: Cellular Signalling - August 27, 2015 Category: Cytology Authors: Peeters MC, Fokkelman M, Boogaard B, Egerod KL, van de Water B, IJzerman AP, Schwartz TW Tags: Cell Signal Source Type: research

Silencing SOX2 Expression by RNA Interference Inhibits Proliferation, Invasion and Metastasis, and Induces Apoptosis through MAP4K4/JNK Signaling Pathway in Human Laryngeal Cancer TU212 Cells
SRY (sex determining region Y)-box 2 (SOX2) plays an important role in tumor cell metastasis and apoptosis. Laryngeal squamous cell carcinoma (LSCC), responsible for 1.5% of all cancers, is one of the most common head and neck malignancies. Accumulating evidence shows that SOX2 is overexpressed in several human tumors, including lung cancer, esophageal carcinoma, pancreatic carcinoma, breast cancer, ovarian carcinoma and glioma. Our study aimed to investigate the silencing effects of SOX2 expression using RNA interference (RNAi) on various biological processes in laryngeal cancer TU212 cells, including proliferation, apopt...
Source: Journal of Histochemistry and Cytochemistry - August 25, 2015 Category: Biochemistry Authors: Yang, N., Wang, Y., Hui, L., Li, X., Jiang, X. Tags: Articles Source Type: research

FOXA2 mRNA expression is associated with relapse in patients with Triple-Negative/Basal-like breast carcinoma
Abstract The FOXA family of transcription factors regulates chromatin structure and gene expression especially during embryonic development. In normal breast tissue FOXA1 acts throughout mammary development; whereas in breast carcinoma its expression promotes luminal phenotype and correlates with good prognosis. However, the role of FOXA2 has not been previously studied in breast cancer. Our purpose was to analyze the expression of FOXA2 in breast cancer cells, to explore its role in breast cancer stem cells, and to correlate its mRNA expression with clinicopathological features and outcome in a series of pati...
Source: Breast Cancer Research and Treatment - August 22, 2015 Category: Cancer & Oncology Source Type: research

Blockade of autophagy enhances proapoptotic potential of BI-69A11, a novel Akt inhibitor, in colon carcinoma.
Abstract BI-69A11, novel Akt inhibitor, is currently drawing much attention due to its intriguing effect in inducing apoptosis in melanoma, breast, prostate and colon cancer. However, earlier reports reveal that PI3K/Akt/ mTOR inhibitors promote autophagy at the early stage as a survival mechanism that might affect its apoptotic potential. It is necessary to investigate whether BI-69A11 mediated apoptosis is associated with autophagy for enhancing its therapeutic efficacy. Here, we found that BI-69A11 induced autophagy at earlier time point through the inhibition of Akt/mTOR/p70S6kinase pathway. Dose-dependent and...
Source: European Journal of Pharmacology - August 22, 2015 Category: Drugs & Pharmacology Authors: Pal I, Parida S, Prashanth Kumar BN, Banik P, Kumar Dey K, Chakraborty S, Bhutia SK, Mandal M Tags: Eur J Pharmacol Source Type: research

MicroRNA-205 inhibits the proliferation and invasion of breast cancer by regulating AMOT expression.
Authors: Zhang H, Fan Q Abstract It has been reported that the expression of angiomotin (AMOT) is upre-gulated in breast cancer. However, the regulatory mechanism remains unknown. In the present study, we aimed to ascertain whether the expression of AMOT is regulated by microRNAs (miRNAs) in breast cancer. In the present study, miR-205 was significantly downregulated in breast cancer samples and it was identified to directly target the 3'-untranslated region (3'-UTR) of AMOT in breast cancer MCF-7 cells by luciferase assay. miR-205 and small interfering RNA (siRNA)-mediated AMOT-knockdown experiments revealed that...
Source: Oncology Reports - August 7, 2015 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Abstract 1429: Contribution of membrane-bound carboxypeptidase M to tumor growth and metastasis by regulating epithelial mesenchymal transition in esophageal squamous carcinoma
In this study, we examined the properties of CPM for tumor growth and metastasis in human esophageal carcinoma cells. In order to investigate the expression of CPM on human tumor cells, we established the monoclonal antibody specific for human CPM and found the constitutive expression of CPM on various human carcinomas by flow cytometry and confocal laser microscopy. Treatment of cancer cells with EMT-mediated cytokines, including TGF-beta, IL-6 and OSM, increased CPM expression on their cell surface followed by enhancement of cell migration and change of cell shapes from epithelial to mesenchymal type. Silencing CPM expre...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Kudo, Y., Fukuda, J., Harigai, R., Kato, K. Tags: Tumor Biology Source Type: research

Abstract 1942: Regulation of GRNMB transcription and cellular effects by chondroitin 4-sulfation
Increased expression of glycoprotein (transmembrane) NMB (GPNMB; osteoactivin) has been identified in triple negative breast cancer, melanoma, glioma, and hepatocellular carcinoma, and followed decline in expression of the enzyme arylsulfatase B (ARSB; N-acetylgalactosamine 4-sulfatase). The expression and regulation of GPNMB was evaluated in HepG2 cells and in ARSB-deficient and control C57BL/6J mouse hepatic tissue. Increased expression of GPNMB was attributable to promoter activation by phospho(Ser)MITF (microphthalmia-associated transcription factor), the phosphorylation of which was activated by phospho(Ser)-p38 MAPK....
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Tobacman, J. K., Feferman, L., Bhattacharyya, S. Tags: Molecular and Cellular Biology Source Type: research

Abstract 1980: Identification of the transcription factor ZNF217 in ER+ subset of BC: A functional relationship with the PI3K-AKT-mTOR pathway
ZNF217 gene encodes for a Krüppel-like finger protein transcription factor. Here we report an amplification of ZNF217 gene in breast cancer (BC) patients. Retrospective study of 72 BC patients showed that ZNF217 gene was amplified in 12.5% of patients enrolled in our center over last ten months from February 2014 through November 2014. We found a similar level of amplification of ZNF217 gene at 20q13 in different epithelial cancers including lung, uterus, ovary, stomach, bladder and breast using data from c-Bioportal. The observed percentage of the amplification of ZNF217 gene in our patients (12.5%) was comparable to the...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Dey, N., Williams, C., Krie, A., Solomon, B., Starks, D., Rojas, L., Carlson, J. H., Sun, Y., Lin, X., Abramovitz, M., Metzger-Nelson, T., Williams, K., Klein, J., De, P., Leyland-Jones, B. Tags: Molecular and Cellular Biology Source Type: research

Abstract LB-200: Loss of the scaffold protein Kibra in a mouse model of triple-negative breast cancer
Introduction: Targeted therapies in breast cancer rely on tumor cell expression of Estrogen and/or HER2 receptors. Triple negative breast cancers (TNBCs), lacking these receptors, have no targeted therapies. We have developed a preclinical murine model expressing a naturally occurring oncogenic variant of the Met receptor in the mammary gland combined with loss of function of the tumour suppressor p53 (MMTV-Met;Trp53fl/+;Cre). This model recapitulates many features of TNBC at the level of gene expression, pathological markers and genomic alterations. Notably, this model spontaneously undergoes loss of a genomic region synt...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Knight, J. F., Gruosso, T., de Verteuil, D. A., Saleh, S., Lesurf, R., Zhao, H., Davis, R., Zuo, D., Cardiff, R., Gregg, J., Hallett, M., Park, M. Tags: Tumor Biology Source Type: research