Filtered By:
Cancer: Breast Carcinoma

This page shows you your search results in order of date. This is page number 16.

Order by Relevance | Date

Total 244 results found since Jan 2013.

Beta-naphthoflavone (DB06732) mediates estrogen receptor-positive breast cancer cell cycle arrest through AhR-dependent regulation of PI3K/AKT and MAPK/ERK signaling
This study showed that BNF suppressed cell proliferation and induced cell cycle arrest in the G0/G1 phase with downregulation of cyclin D1/D3 and CDK4 and upregulation of p21Cip1/Waf1, leading to a senescence-like phenotype in estrogen receptor (ER)-positive MCF-7 cells, but not in ER-negative MDA-MB-231 cells. In addition, BNF inhibited PI3K/AKT signaling, and the PI3K inhibitor, LY294,002, exhibited the same inhibitory effects on cyclinD1/D3, CDK4 and the cell cycle as BNF. Interestingly, BNF activated mitogen-activated protein kinase-extracellular signal-regulated kinase (MAPK-ERK) signaling, and more notably, MEK inhib...
Source: Carcinogenesis - March 1, 2014 Category: Cancer & Oncology Authors: Wang, C., Xu, C.-X., Bu, Y., Bottum, K. M., Tischkau, S. A. Tags: Original Manuscript Source Type: research

Decorin Evokes Mitostatin-dependent Mitophagy Cell Biology
Tumor cell mitochondria are key biosynthetic hubs that provide macromolecules for cancer progression and angiogenesis. Soluble decorin protein core, hereafter referred to as decorin, potently attenuated mitochondrial respiratory complexes and mitochondrial DNA (mtDNA) in MDA-MB-231 breast carcinoma cells. We found a rapid and dynamic interplay between peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) and the decorin-induced tumor suppressor gene, mitostatin. This interaction stabilized mitostatin mRNA with concurrent accumulation of mitostatin protein. In contrast, siRNA-mediated abrogation of PGC-1α...
Source: Journal of Biological Chemistry - February 21, 2014 Category: Chemistry Authors: Neill, T., Torres, A., Buraschi, S., Owens, R. T., Hoek, J. B., Baffa, R., Iozzo, R. V. Tags: Glycobiology and Extracellular Matrices Source Type: research

Low-voltage-activated T-type Ca(2+) channel inhibitors as new tools in the treatment of glioblastoma: the role of endostatin.
Abstract Ca(2+) plays a key role in intracellular signaling and controls various cellular processes such as proliferation, differentiation, cell growth, death, and apoptosis. Aberrant changes in intracellular Ca(2+) levels can promote undesired cell proliferation and migration and are therefore associated with certain tumor types. Many research groups have suggested a potential role for voltage-gated Ca(2+) channels in the regulation of tumor growth and progression, particularly T-type channels due to their unique biophysical properties. T-type channels are expressed in normal tissues throughout the body and in di...
Source: Pflugers Archiv : European Journal of Physiology - January 10, 2014 Category: Physiology Authors: Zhang Y, Wang H, Qian Z, Feng B, Zhao X, Jiang X, Tao J Tags: Pflugers Arch Source Type: research

Early animal research into blocking breast cancer
"'An injection that prevents breast cancer is being developed by scientists," is the news on the Mail Online website. This news seems a heartening way to start the year, but a caveat is that the research is in the very early stages – as yet only tested in mice. The researchers were interested in a type of breast cancer known as ductal carcinoma in situ (DCIS). In DCIS the cancerous cells are contained within the ducts in the breast, and not spread to other breast tissue. The problem with DCIS is that it is currently impossible to predict whether the cancer will remain inside the duct (so will not require tr...
Source: NHS News Feed - January 2, 2014 Category: Consumer Health News Tags: Cancer Source Type: news

Overexpression of GNAO1 correlates with poor prognosis in patients with gastric cancer and plays a role in gastric cancer cell proliferation and apoptosis.
Abstract Guanine nucleotide-binding protein (G protein), alpha activating activity polypeptide O (GNAO1) encodes an alpha subunit of the heterotrimeric guanine nucleotide-binding proteins (Gαo), which plays a significant role in the development of various types of cancer, including breast cancer and hepatocellular carcinoma. However, its role in gastric cancer (GC) has not yet been elucidated. In the current study, the expression of Gαo was analyzed by immunohistochemistry in paraffin-embedded tissue sections from 70 patients with GC and its cellular role was examined by small interfering RNA (siRNA)-mediated...
Source: International Journal of Molecular Medicine - December 20, 2013 Category: Molecular Biology Authors: Liu Z, Zhang J, Wu L, Liu J, Zhang M Tags: Int J Mol Med Source Type: research

Role of the EphB2 receptor in autophagy, apoptosis and invasion in human breast cancer cells.
Abstract The Eph and Ephrin proteins, which constitute the largest family of receptor tyrosine kinases, are involved in normal tissue development and cancer progression. Here, we examined the expression and role of the B-type Eph receptor EphB2 in breast cancers. By immunohistochemistry using a progression tissue microarray of human clinical samples, we found EphB2 to be expressed in benign tissues, but strongly increased in cancers particularly in invasive and metastatic carcinomas. Subsequently, we found evidence that EphB2, whose expression varies in established cell breast lines, possesses multiple functions. ...
Source: Experimental Cell Research - November 6, 2013 Category: Cytology Authors: Chukkapalli S, Amessou M, Kumar Dilly A, Dekhil H, Zhao J, Liu Q, Bejna A, Thomas RD, Bandyopadhyay S, Bismar TA, Neill D, Azoulay L, Batist G, Kandouz M Tags: Exp Cell Res Source Type: research

Novel XBP1-regulated Endoplasmic Stress Response Element Gene Regulation
Understanding the regulatory mechanisms mediating PRNP gene expression is highly relevant to elucidating normal cellular prion protein (PrP) function(s) and the transmissibility of prion protein neurodegenerative diseases. Here, luciferase reporter assays showed that an endoplasmic reticulum stress element (ERSE)-like element, CCAAT-N26-CCACG in the human PRNP promoter, is regulated by ER stress and X-box-binding protein 1 (XBP1) but not by activating transcription factor 6 α (ATF6α). Bioinformatics identified the ERSE-26 motif in 37 other human genes in the absence of canonical ERSE sites except for three genes. Several...
Source: Journal of Biological Chemistry - July 12, 2013 Category: Chemistry Authors: Misiewicz, M., Dery, M., Foveau, B., Jodoin, J., Ruths, D., LeBlanc, A. C. Tags: Gene Regulation Source Type: research

In Vitro and In Vivo Effects of Phenethyl Isothiocyanate Treatment on Vimentin Protein Expression in Cancer Cells.
Abstract We have shown previously that cancer prevention by cruciferous vegetable constituent phenethyl isothiocyanate (PEITC) in a transgenic mouse model of prostate cancer is associated with induction of E-cadherin protein expression. Because suppression of E-cadherin protein concomitant with induction of mesenchymal markers (e.g., vimentin) is a biochemical hallmark of epithelial-mesenchymal transition, a process implicated in cancer metastasis, we hypothesized that PEITC treatment was likely to suppress vimentin protein expression. Contrary to this prediction, exposure of human breast (MDA-MB-231) and prostate...
Source: Nutrition and Cancer - May 29, 2013 Category: Cancer & Oncology Authors: Sakao K, Hahm ER, Singh SV Tags: Nutr Cancer Source Type: research

In vitro and in vivo effects of phenethyl isothiocyanate treatment on vimentin protein expression in cancer cells.
Abstract We have shown previously that cancer prevention by cruciferous vegetable constituent phenethyl isothiocyanate (PEITC) in a transgenic mouse model of prostate cancer is associated with induction of E-cadherin protein expression. Because suppression of E-cadherin protein concomitant with induction of mesenchymal markers (e.g., vimentin) is a biochemical hallmark of epithelial-mesenchymal transition, a process implicated in cancer metastasis, we hypothesized that PEITC treatment was likely to suppress vimentin protein expression. Contrary to this prediction, exposure of human breast (MDA-MB-231) and prostate...
Source: Nutrition and Cancer - May 29, 2013 Category: Cancer & Oncology Authors: Sakao K, Hahm ER, Singh SV Tags: Nutr Cancer Source Type: research

CD44/cellular prion protein interact in multidrug resistant breast cancer cells and correlate with responses to neoadjuvant chemotherapy in breast cancer patients
Abstract Multidrug resistance (MDR) is one of the most important factors leading to chemotherapeutic failure in patients with breast cancer. The invasive/metastatic ability of MDR cells is strengthened compared with their parental cells. However, the mechanisms underlying MDR have not been fully elucidated. We found that CD44 and the cellular prion protein (PrPc) were both overexpressed in MDR cells (MCF7/Adr and H69AR). Subsequently, we chose the human breast cancer cell line MCF7/Adr, which is resistant to adriamycin, for further research. We discovered that PrPc physically and functionally interacted with CD44. The knoc...
Source: Molecular Carcinogenesis - May 16, 2013 Category: Molecular Biology Authors: Yuanyuan Cheng, Lili Tao, Jiawen Xu, Qingquan Li, Juan Yu, Yiting Jin, Qi Chen, Zude Xu, Qiang Zou, Xiuping Liu Tags: Research Article Source Type: research

ADAM12 is expressed in the tumour vasculature and mediates ectodomain shedding of several membrane-anchored endothelial proteins.
In conclusion, the results of the present study demonstrate a role for ADAM12 in ectodomain shedding of several membrane-anchored endothelial proteins. We speculate that this process may have importance in tumour neovascularization or/and tumour cell extravasation. PMID: 23458101 [PubMed - in process]
Source: The Biochemical Journal - May 15, 2013 Category: Biochemistry Authors: Fröhlich C, Klitgaard M, Noer JB, Kotzsch A, Nehammer C, Kronqvist P, Berthelsen J, Blobel C, Kveiborg M, Albrechtsen R, Wewer UM Tags: Biochem J Source Type: research

Identification of upregulated phosphoinositide 3-kinase γ as a target to suppress breast cancer cell migration and invasion.
Abstract Metastasis is the major cause of breast cancer mortality. We recently reported that aberrant G-protein coupled receptor (GPCR) signaling promotes breast cancer metastasis by enhancing cancer cell migration and invasion. Phosphatidylinositol 3-kinase γ (PI3Kγ) is specifically activated by GPCRs. The goal of the present study was to determine the role of PI3Kγ in breast cancer cell migration and invasion. Immunohistochemical staining showed that the expression of PI3Kγ protein was significantly increased in invasive human breast carcinoma when compared to adjacent benign breast tissue or ductal carcinom...
Source: Biochemical Pharmacology - May 15, 2013 Category: Drugs & Pharmacology Authors: Xie Y, Abel PW, Kirui JK, Deng C, Sharma P, Wolff DW, Toews ML, Tu Y Tags: Biochem Pharmacol Source Type: research

WNT-5A triggers Cdc42 activation leading to an ERK1/2 dependent decrease in MMP9 activity and invasive migration of breast cancer cells
Abstract: An important role for WNT-5A is implicated in a variety of tumors, including breast carcinoma. We previously showed that WNT-5A signaling inhibits migration and metastasis of breast cancer cells, and that patients with primary breast cancer in which WNT-5A was expressed have a better prognosis. Despite the fact that RhoGTPase Cdc42 is commonly associated with increased cell migration, we here show that recombinant WNT-5A activates the Cdc42 in breast cancer cells (lines MDA-MB468 and MDA-MB231) in a time-dependent manner. Activation of Cdc42 was also observed in MDA-MB468 cells that were stably transfected with a...
Source: Molecular Oncology - May 3, 2013 Category: Cancer & Oncology Authors: Chandra Prakash Prasad, Shivendra Kumar Chaurasiya, Lena Axelsson, Tommy Andersson Tags: Research Articles Source Type: research

Annexin A3 is associated with a poor prognosis in breast cancer and participates in the modulation of apoptosis in vitro by affecting the Bcl-2/Bax balance.
CONCLUSION: Our findings indicated that Annexin A3 might be a novel and potential prognostic marker for patients with breast cancer and be involved in regulating apoptosis by affecting Bcl-2/Bax balance. PMID: 23631820 [PubMed - as supplied by publisher]
Source: Experimental and Molecular Pathology - April 28, 2013 Category: Pathology Authors: Zeng C, Ke Z, Song Y, Yao Y, Hu X, Zhang M, Li H, Yin J Tags: Exp Mol Pathol Source Type: research

ADAM12 is expressed in the tumour vasculature and mediates ectodomain shedding of several membrane-anchored endothelial proteins
In conclusion, our data demonstrate a role for ADAM12 in ectodomain shedding of several membrane-anchored endothelial proteins. We speculate that this process may have importance in tumour neovascularization or/and tumour-cell extravasation.
Source: BJ Cell - March 5, 2013 Category: Biochemistry Authors: C Fröhlich, M Klitgaard, J B Noer, A Kotzsch, C Nehammer, P Kronqvist, J Berthelsen, C Blobel, M Kveiborg, R Albrechtsen, U M Wewer Tags: BJ Cell Source Type: research