Corrigendum
(Source: Carcinogenesis)
Source: Carcinogenesis - January 5, 2017 Category: Cancer & Oncology Tags: Corrigendum Source Type: research
Eukaryotic translation initiation factor 5A2 promotes metabolic reprogramming in hepatocellular carcinoma cells
In conclusion, our findings demonstrate that EIF5A2 has a critical role in HCC cell metabolic reprogramming and may serve as a prominent novel therapeutic target for liver cancer treatment. (Source: Carcinogenesis)
Source: Carcinogenesis - January 5, 2017 Category: Cancer & Oncology Authors: Cao, T.-T., Lin, S.-H., Fu, L., Tang, Z., Che, C.-M., Zhang, L.-Y., Ming, X.-Y., Liu, T.-F., Tang, X.-M., Tan, B.-B., Xiang, D., Li, F., Chan, O.-Y., Xie, D., Cai, Z., Guan, X.-Y. Tags: Original Manuscript Source Type: research
Loss of free fatty acid receptor 2 enhances colonic adenoma development and reduces the chemopreventive effects of black raspberries in ApcMin/+ mice
We previously showed that black raspberries (BRBs) have beneficial effects in human colorectal cancer and a mouse model of colorectal cancer (ApcMin/+). The current study investigated the role of free fatty acid receptor 2 (FFAR2) in colon carcinogenesis and whether the FFAR2 signaling pathway contributes to BRB-mediated chemoprevention in mice. FFAR2 (also named GPR43) is a member of the G-protein-coupled receptor family that is expressed in leukocytes and colon. ApcMin/+ and ApcMin/+-FFAR2–/– mice were given a control diet or the control diet supplemented with 5% BRBs for 8 weeks. FFAR2 deficiency promoted co...
Source: Carcinogenesis - January 5, 2017 Category: Cancer & Oncology Authors: Pan, P., W.Skaer, C., Wang, H.-T., Oshima, K., Huang, Y.-W., Yu, J., Zhang, J., M.Yearsley, M., A.Agle, K., R.Drobyski, W., Chen, X., Wang, L.-S. Tags: Original Manuscript Source Type: research
Cancer-associated fibroblasts regulate keratinocyte cell-cell adhesion via TGF-{beta}-dependent pathways in genotype-specific oral cancer
The interrelationship between malignant epithelium and the underlying stroma is of fundamental importance in tumour development and progression. In the present study, we used cancer-associated fibroblasts (CAFs) derived from genetically unstable oral squamous cell carcinomas (GU-OSCC), tumours that are characterized by the loss of genes such as TP53 and p16INK4A and with extensive loss of heterozygosity, together with CAFs from their more genetically stable (GS) counterparts that have wild-type TP53 and p16INK4A and minimal loss of heterozygosity (GS-OSCC). Using a systems biology approach to interpret the genome-wide tran...
Source: Carcinogenesis - January 5, 2017 Category: Cancer & Oncology Authors: Cirillo, N., Hassona, Y., Celentano, A., Lim, K. P., Manchella, S., Parkinson, E. K., Prime, S. S. Tags: Original Manuscript Source Type: research
MCM7 and its hosted miR-25, 93 and 106b cluster elicit YAP/TAZ oncogenic activity in lung cancer
Lung cancer is the first cause of cancer death worldwide and the Hippo pathway transcriptional coactivators YAP/TAZ have a pro-oncogenic role in this context. In order to understand the mechanisms through which YAP/TAZ elicit their oncogenic role in different systems, many studies are focused on YAP/TAZ target genes involved in the regulation of cell proliferation/survival and migration. However, there is scarce evidence on the role of YAP/TAZ in microRNA regulation while there is increasing evidence supporting the role of microRNAs in the main oncogenic processes. Here, we showed that YAP/TAZ were able to regulate several...
Source: Carcinogenesis - January 5, 2017 Category: Cancer & Oncology Authors: Lo Sardo, F., Forcato, M., Sacconi, A., Capaci, V., Zanconato, F., Di Agostino, S., Del Sal, G., Pandolfi, P. P., Strano, S., Bicciato, S., Blandino, G. Tags: Original Manuscript Source Type: research
Anti-inflammatory natural product goniothalamin reduces colitis-associated and sporadic colorectal tumorigenesis
The tumor microenvironment offers multiple targets for cancer therapy, including pro-tumorigenic inflammation. Natural compounds represent an enormous source of new anti-inflammatory and anticancer agents. We previously showed that the styryl lactone goniothalamin (GTN) has promising antiproliferative and anti-inflammatory activities. Because inflammation is a major driver of colorectal cancer (CRC), we therefore evaluated the therapeutic and preventive potentials of GTN in colitis, colitis-associated cancer (CAC) and spontaneous CRC. First, in a simplistic model of inflammation in vitro, GTN was able to inhibit cytokine p...
Source: Carcinogenesis - January 5, 2017 Category: Cancer & Oncology Authors: Vendramini-Costa, D. B., Francescone, R., Posocco, D., Hou, V., Dmitrieva, O., Hensley, H., de Carvalho, J. E., Pilli, R. A., Grivennikov, S. I. Tags: Original Manuscript Source Type: research
Role of p53 in silibinin-mediated inhibition of ultraviolet B radiation-induced DNA damage, inflammation and skin carcinogenesis
Non-melanoma skin cancers (NMSC) are a growing problem given that solar ultraviolet B (UVB) radiation exposure is increasing most likely due to depletion of the atmospheric ozone layer and lack of adequate sun protection. Better preventive methods are urgently required to reduce UV-caused photodamage and NMSC incidence. Earlier, we have reported that silibinin treatment activates p53 and reduces photodamage and NMSC, both in vitro and in vivo; but whether silibinin exerts its protective effects primarily through p53 remains unknown. To address this question, we generated p53 heterozygous (p53+/–) and p53 knockout (p5...
Source: Carcinogenesis - January 5, 2017 Category: Cancer & Oncology Authors: Rigby, C. M., Roy, S., Deep, G., Guillermo-Lagae, R., Jain, A. K., Dhar, D., Orlicky, D. J., Agarwal, C., Agarwal, R. Tags: Original Manuscript Source Type: research
Polymorphisms in microRNA binding sites of mucin genes as predictors of clinical outcome in colorectal cancer patients
In this study, we analyzed the association of single nucleotide polymorphisms in predicted miRNA target sites (miRSNPs) of mucin genes with colorectal cancer (CRC) risk and clinical outcome. Thirteen miRSNPs in 9 genes were assessed in 1111 cases and 1469 controls. No strongly significant associations were observed in the case–control study. Patients carrying the CC genotype of rs886403 in MUC21 displayed a shorter survival and higher recurrence risk when compared with TT carriers [overall survival (OS): hazard ratios (HR) 1.69; 95% confidence intervals (CI) 1.13–2.46; P = 0.01 and event-free survival (EFS): HR...
Source: Carcinogenesis - January 5, 2017 Category: Cancer & Oncology Authors: Vymetalkova, V., Pardini, B., Rosa, F., Jiraskova, K., Di Gaetano, C., Bendova, P., Levy, M., Veskrnova, V., Buchler, T., Vodickova, L., Naccarati, A., Vodicka, P. Tags: Original Manuscript Source Type: research
Short leukocyte telomere length, alone and in combination with smoking, contributes to increased risk of gastric cancer or esophageal squamous cell carcinoma
In humans, telomeres shorten along with division of somatic cells. Shortened telomere length might result in genomic instability and has been associated with several malignancies. However, the findings in different populations remain conflicting. Therefore, we assessed the association of telomere length in peripheral blood leukocytes with risk of gastric cancer (GC) or esophageal squamous cell carcinoma (ESCC) in a Chinese Han population. A total of 574 GC cases, 740 ESCC cases and 774 age- and sex-matched healthy controls were included in this analysis. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated ...
Source: Carcinogenesis - January 5, 2017 Category: Cancer & Oncology Authors: Pan, W., Du, J., Shi, M., Jin, G., Yang, M. Tags: Original Manuscript Source Type: research
Frequently mutated genes/pathways and genomic instability as prevention targets in liver cancer
The incidence of liver cancer has increased in recent years. Worldwide, liver cancer is common: more than 600000 related deaths are estimated each year. In the USA, about 27170 deaths due to liver cancer are estimated for 2016. Liver cancer is highly resistant to conventional chemotherapy and radiotherapy. For all stages combined, the 5-year survival rate is 15–17%, leaving much to be desired for liver cancer prevention and therapy. Heterogeneity, which can originate from genomic instability, is one reason for poor outcome. About 80–90% of liver cancers are hepatocellular carcinoma (HCC), and recent cancer geno...
Source: Carcinogenesis - January 5, 2017 Category: Cancer & Oncology Authors: Rao, C. V., Asch, A. S., Yamada, H. Y. Tags: Review Source Type: research
Editorial
(Source: Carcinogenesis)
Source: Carcinogenesis - January 5, 2017 Category: Cancer & Oncology Authors: Harris, C. C. Tags: Editorial Source Type: research
Table_of_Contents
(Source: Carcinogenesis)
Source: Carcinogenesis - January 5, 2017 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Subscriptions
(Source: Carcinogenesis)
Source: Carcinogenesis - January 5, 2017 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Instructions_to_Authors
(Source: Carcinogenesis)
Source: Carcinogenesis - January 5, 2017 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Front_Cover
(Source: Carcinogenesis)
Source: Carcinogenesis - January 5, 2017 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
