Decreased expression and prognostic role of cytoplasmic BRSK1 in human breast carcinoma: correlation with Jab1 stability and PI3K/Akt pathway.

CONCLUSIONS: BRSK1 is a novel tumor suppressor in breast cancer which inversely correlated with Jab1 expression, may involve in the restoring Jab1-induced suppression of p27kip1 and may regulate cell cycle through PI3K⁄Akt pathway. PMID: 25036402 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/25036402?dopt=Abstract

Source: Experimental and Molecular Pathology - July 15, 2014 Category: Pathology Authors: Wang H, Liu XB, Chen JH, Wang QQ, Chen JP, Xu JF, Sheng CY, Ni QC Tags: Exp Mol Pathol Source Type: research