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Total 401 results found since Jan 2013.

Evaluation of the measurement properties of the Brazilian version of two quality-of-life questionnaires in food allergy - for children and their parents.
CONCLUSIONS: The specific questionnaires to evaluate the health-related quality of life of children with food allergy and of their parents were satisfactorily validated to be used in Brazil. PMID: 31176692 [PubMed - as supplied by publisher]
Source: Jornal de Pediatria - June 5, 2019 Category: Pediatrics Authors: Mendonça RB, Solé D, DunnGalvin A, Len CA, Sarni ROS Tags: J Pediatr (Rio J) Source Type: research

Antibiotic therapy for adults with neurosyphilis.
CONCLUSIONS: Due to low quality and insufficient evidence, it was not possible to determine whether there was a difference between treatment with ceftriaxone or Penicillin G. Also, the benefits to people without HIV and neurosyphilis are unknown, as is the ceftriaxone safety profile.Therefore, these results should be interpreted with caution. This conclusion does not mean that antibiotics should not be used for treating this clinical entity. This Cochrane Review has identified the need of adequately powered trials, which should be planned according to Standard Protocol Items: Recommendations for Interventional Trials (SPIR...
Source: Cochrane Database of Systematic Reviews - May 26, 2019 Category: General Medicine Authors: Buitrago-Garcia D, Martí-Carvajal AJ, Jimenez A, Conterno LO, Pardo R Tags: Cochrane Database Syst Rev Source Type: research

A Critical View of Specific Antibody Deficiencies
Ricardo U. Sorensen1,2,3* 1Professor Emeritus of Pediatrics, Department of Pediatrics, Louisiana State University Health Science Center, New Orleans, LA, United States 2Louisiana Primary Immunodeficiency Network, New Orleans, LA, United States 3Honorary Professor, Faculty of Medicine, University of La Frontera, Temuco, Chile In thisopinion manuscript the author postulates that the present definition of Specific Antibody Deficiency (SAD) needs to be revised and expanded. It is presently defined as a syndrome of low IgG antibody responses to purified Streptococcus pneumoniae capsular polysaccharides vaccine...
Source: Frontiers in Immunology - April 30, 2019 Category: Allergy & Immunology Source Type: research

Surface (S) Layer Proteins of Lactobacillus acidophilus Block Virus Infection via DC-SIGN Interaction
We describe the unexpected binding of S-layer to cells devoid of DC-SIGN but also confirm that the presence of DC-SIGN was essential for S-layer’s antiviral activity. S-layer protein exerted its antiviral effect with different kinetics than mannan, a known viral inhibitor that also acts on DC-SIGN (Yu et al., 2017). Together our results suggest that inhibition of viral entry by S-layer occurs via a novel S-layer/DC-SIGN interaction. Materials and Methods Isolation of S-Layer Proteins S-layer proteins were extracted from overnight cultures of L. acidophilus ATCC 4356 cells grown in MRS medium at 37°C by usi...
Source: Frontiers in Microbiology - April 15, 2019 Category: Microbiology Source Type: research

Expanding Research Capacity in Sub-Saharan Africa Through Informatics, Bioinformatics, and Data Science Training Programs in Mali
Conclusion Bioinformatics and data science training programs in developing countries necessitate incremental and collaborative strategies for their feasible and sustainable development. The progress described here covered decades of collaborative efforts centered on training and research on computationally intensive topics. These efforts laid the groundwork and platforms conducive for hosting a bioinformatics and data science training program in Mali. Training programs are perhaps best facilitated through Africa’s university systems as they are perhaps best positioned to maintain core resources during lapses in sho...
Source: Frontiers in Genetics - April 11, 2019 Category: Genetics & Stem Cells Source Type: research

Sequential Immunization With Live-Attenuated Chimeric Hemagglutinin-Based Vaccines Confers Heterosubtypic Immunity Against Influenza A Viruses in a Preclinical Ferret Model
This study was also partly funded by a research contract from GSK. The findings and conclusions contained within are those of the authors and do not necessarily reflect positions or policies of the funders. Conflict of Interest Statement AG-S, FK, and PP are inventors in patent applications filed and owned b
Source: Frontiers in Immunology - April 9, 2019 Category: Allergy & Immunology Source Type: research

Developing an Intervention to Improve the Health Related Quality of Life in Children and Young People With Serious Parental Mental Illness
Conclusion: Young SMILES captures a broad age range and level of need for CAPRI and can be evaluated with quantifiable child-centered outcomes. In line with current policy directives, this is the first UK-based, multi-context intervention to improve QoL in this population. Implementation and referral mechanisms are currently being evaluated in a multi-site feasibility trial. Introduction Children and adolescents living with parental mental illness (CAPRI) are poorly provided for in current social care and educational settings (1, 2). Children and young people (CYP) growing up in families affected by parental mental h...
Source: Frontiers in Psychiatry - April 8, 2019 Category: Psychiatry Source Type: research

Risks and Benefits of Dolutegravir- and Efavirenz-Based Strategies for South African Women With HIV of Child-Bearing Potential: A Modeling Study.
Conclusion: Although NTD risks may be higher with dolutegravir than efavirenz, dolutegravir will lead to many fewer deaths among women, as well as fewer overall HIV transmissions. These results argue against a uniform policy of avoiding dolutegravir in women of child-bearing potential. Primary Funding Source: National Institutes of Health, National Institute of Allergy and Infectious Diseases and Eunice Kennedy Shriver National Institute of Child Health and Human Development; Massachusetts General Hospital; and Harvard University Center for AIDS Research. PMID: 30934067 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - April 1, 2019 Category: Internal Medicine Authors: Dugdale CM, Ciaranello AL, Bekker LG, Stern ME, Myer L, Wood R, Sax PE, Abrams EJ, Freedberg KA, Walensky RP Tags: Ann Intern Med Source Type: research

Asthma, Copd And Home Environments: Interventions With Older Adults
The World Health Organization estimates that at least 300 million people suffer from asthma worldwide.1 Over 17.7 million adults suffer from asthma compared to the 6.3 million children who are also afflicted with asthma in the United States (U.S.).2 Older adults ages 65 and over with asthma are the fastest growing age-group in the U.S.3 Studies in the United States show that asthma and other reactive airway diseases are under-diagnosed among the elderly, that asthma-related morbidity and mortality among the elderly is increasing4 and that nationally the number of older adults dying from asthma is 14 times higher compared t...
Source: Annals of Allergy, Asthma and Immunology - February 28, 2019 Category: Allergy & Immunology Authors: David A. Turcotte, Susan Woskie, Rebecca Gore, Emily Chaves, Kelechi L. Adejumo Source Type: research

The impact of medical therapy on cognitive dysfunction in chronic rhinosinusitis
ConclusionAppropriate medical therapy improves several measures of cognitive dysfunction in patients with CRS. Sustainability of results should be evaluated with larger, prolonged studies.
Source: International Forum of Allergy and Rhinology - February 27, 2019 Category: Allergy & Immunology Authors: Nicholas R. Rowan, Rodney J. Schlosser, Kristina A. Storck, Kimia G. Ganjaei, Zachary M. Soler Tags: ORIGINAL ARTICLE Source Type: research

A Perspective on Partially Hydrolyzed Protein Infant Formula In Non-Exclusively Breastfed Infants.
The objectives of this paper were to review the evidence of pHF whey formula for non-breastfed infants, not only to prevent of atopic disease in high-risk infants but also as routine starter formula regardless of the allergic risk status. PMID: 30651423 [PubMed - as supplied by publisher]
Source: Korean Journal of Pediatrics - January 18, 2019 Category: Pediatrics Tags: Korean J Pediatr Source Type: research

Demonstrating vaccine effectiveness during a waning epidemic: A WHO/NIH meeting report on approaches to development and licensure of Zika vaccine candidates.
Abstract Since its peak in early 2016, the incidence of Zika virus (ZIKV) cases has declined to such low levels that Phase 3 field efficacy trials may be infeasible. While great progress was made to rapidly advance several vaccine candidates into Phase 1 and 2 clinical trials, in the absence of sustained viral transmission it may be difficult to evaluate the effectiveness of ZIKV vaccine candidates by conducting traditional clinical disease endpoint efficacy studies. However, ZIKV is still circulating at low levels in some areas and is likely to re-emerge in naïve populations or in sites of prior epidemics once p...
Source: Vaccine - January 10, 2019 Category: Allergy & Immunology Authors: Vannice KS, Cassetti MC, Eisinger RW, Hombach J, Knezevic I, Marston HD, Wilder-Smith A, Cavaleri M, Krause PR Tags: Vaccine Source Type: research

Action Plan to Reach the Global Availability of Adrenaline Auto-Injectors.
Abstract Adrenaline is the first-line treatment for anaphylaxis and, therefore, listed as an essential medication for the treatment of anaphylaxis by the World Health Organization (WHO). However, the availability of auto-injector (AAI) forms for use in the first-aid treatment is limited to only 32% of all 195-world countries, mostly high-income countries. The key issues leading to the lack of availability of AAIs include cost but also national regulations, lack of regional evidence about the value of epinephrine and the limited accurate data about the epidemiology of anaphylaxis. For these reasons, regional and in...
Source: Journal of Investigational Allergology and Clinical Immunology - November 13, 2018 Category: Allergy & Immunology Authors: Kase Tanno L, Demoly P, Joint Allergy Academies Tags: J Investig Allergol Clin Immunol Source Type: research

Antibodies and Methods for the Diagnosis and Treatment of Epstein-Barr Virus Infection
According to the World Health Organization, over 90% of the worldwide population is infected with Epstein-Barr virus by adulthood. In most cases, the disease accompanying initial infection is subclinical though some individuals who are infected as adolescents or adults do experience infectious mononucleosis. However, once infected, individuals carry latent EBV for their remaining lifespan. In such individuals, immune suppression can result in reactivation of the EBV and consequently, EBV-associated lymphoproliferative disease. Currently, there is no prophylactic to prevent primary EBV infection and additional therapeutics ...
Source: NIH OTT Licensing Opportunities - November 5, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research