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< em > Capsicum < /em > Allergy: Involvement of Cap a 7, a New Clinically Relevant Gibberellin-Regulated Protein Cross-Reactive With Cry j 7, the Gibberellin-Regulated Protein From Japanese Cedar Pollen
Allergy Asthma Immunol Res. 2022 May;14(3):328-338. doi: 10.4168/aair.2022.14.3.328.ABSTRACTThe Capsicum genus belongs to the Solanaceae family. Bell or chili peppers are consumed worldwide, but allergy to Capsicum is rare. It is involved in the celery-birch-mugwort-spice syndrome and cross-reactivities were reported with latex. Several allergens have been described, but only 2 are referenced in the World Health Organization/International Union of Immunological Societies allergen data bank, a thaumatin-like protein and a profilin. A patient allergic to bell/chili pepper, peach, orange and Japanese cedar pollen was clinical...
Source: Allergy, Asthma and Immunology Research - May 13, 2022 Category: Allergy & Immunology Authors: Mari Takei Charles Nin Tomona Iizuka Marine Pawlikowski Marie-Ange Selva Yannick Chantran Yurie Nakajima Jingkang Zheng Tomoyasu Aizawa Motohiro Ebisawa H élène Sénéchal Pascal Poncet Source Type: research

Why Acupuncture Is Going Mainstream in Medicine
When the opioid addiction crisis began to surge in the U.S. about a decade ago, Dr. Medhat Mikhael spent a lot of time talking to his patients about other ways to heal pain besides opioids, from other types of medications to alternative treatments. As a pain management specialist at MemorialCare Orange Coast Medical Center in Fountain Valley, Calif., he didn’t anticipate leaving behind the short-term use of opioids altogether, since they work so well for post-surgical pain. But he wanted to recommend a remedy that was safer and still effective. That turned out to be acupuncture. “Like any treatment, acupuncture...
Source: TIME: Health - April 29, 2022 Category: Consumer Health News Authors: Elizabeth Millard Tags: Uncategorized healthscienceclimate medicine Source Type: news

Beta-lactam allergy and drug challenge test in children: a systematic review and meta-analysis
CONCLUSIONS: The prevalence of children with suspected beta-lactam allergy with true-positive results and false-negative results from the drug challenge test was very low. Serious adverse events resulting from drug challenge tests were also very rare.IMPACT: Most children with suspected beta-lactam allergy were likely to be mislabeled. Serious adverse events caused by the drug challenge test were rare. Few false-negative results were obtained from the drug challenge test.PMID:35449396 | DOI:10.1038/s41390-022-02076-x
Source: Pediatric Research - April 22, 2022 Category: Pediatrics Authors: Yasutaka Kuniyoshi Yasushi Tsujimoto Masahiro Banno Shunsuke Taito Takashi Ariie Takafumi Kubota Natsuki Takahashi Haruka Tokutake Source Type: research

The Current COVID-19 Booster-Shot Strategy is Not Sustainable, Says FDA ’s Expert Panel
While the currently available COVID-19 vaccines remain effective in protecting people from serious disease, public health experts still face a handful of important questions about the shots and their ability to continue to protect against the virus in coming years. Will a new version of the vaccine be more effective? How long does protection last? Are boosters the only way to extend that protection? Is there a better, more coordinated way to give vaccines and boosters to maximize immunity in the face of an ever-changing virus? Those were the discussion topics that the U.S. Food and Drug Administration’s Vaccines and ...
Source: TIME: Health - April 7, 2022 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized COVID-19 healthscienceclimate Source Type: news

Asthma and COVID-19 risk: a systematic review and meta-analysis
Background Individual case series and cohort studies have reported conflicting results in people with asthma on the vulnerability to and risk of mortality from coronavirus disease 2019 (COVID-19). Research question Are people with asthma at a higher risk of being infected or hospitalised or poorer clinical outcomes from COVID-19? Methods A systematic review and meta-analysis based on five main databases including the World Health Organization COVID-19 database between 1 December 2019 and 11 July 2021 on studies with a control (non-asthma) group was conducted. Prevalence and risk ratios were pooled using Sidik–Jonkm...
Source: European Respiratory Journal - March 31, 2022 Category: Respiratory Medicine Authors: Sunjaya, A. P., Allida, S. M., Di Tanna, G. L., Jenkins, C. R. Tags: Asthma and allergy, Respiratory infections and tuberculosis Original Articles: Asthma and infection Source Type: research

With All Eyes on BA.2, Here ’s What Experts Say Might Happen in the U.S.
For the last two years, the U.S. has been stuck in a cycle of COVID-19 case spikes and lulls. Cases rise dramatically, then drop off—and the process repeats. Several times, these surges have been preceded by rising case rates in Europe—such as before last year’s Delta wave and the start of last winter’s Omicron spike—which is why experts have been carefully monitoring a recent increase in cases there. More than 5.2 million COVID-19 infections were reported across Europe during the week ending March 20, according to World Health Organization data, and countries including the U.K. have also repo...
Source: TIME: Health - March 25, 2022 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized COVID-19 healthscienceclimate Source Type: news

With All Eyes on BA.2, Here ’ s What Experts Say Might Happen in the U.S.
For the last two years, the U.S. has been stuck in a cycle of COVID-19 case spikes and lulls. Cases rise dramatically, then drop off—and the process repeats. Several times, these surges have been preceded by rising case rates in Europe—such as before last year’s Delta wave and the start of last winter’s Omicron spike—which is why experts have been carefully monitoring a recent increase in cases there. More than 5.2 million COVID-19 infections were reported across Europe during the week ending March 20, according to World Health Organization data, and countries including the U.K. have also repo...
Source: TIME: Health - March 25, 2022 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized COVID-19 healthscienceclimate Source Type: news

More Than Half of Ukrainians Vulnerable to Health Risks More Than Half of Ukrainians Vulnerable to Health Risks
The World Health Organization says that, in addition to the refugees, those displaced within Ukraine face challenges to their health.Medscape Medical News
Source: Medscape Allergy Headlines - March 24, 2022 Category: Allergy & Immunology Tags: Infectious Diseases News Source Type: news

Ebola vaccine being used in Congo produces lasting antibody response, study finds
FINDINGSA new study by UCLA researchers and colleagues demonstrates that the Ebola vaccine known as rVSV ΔG-ZEBOV-GP results in a robust and enduring antibody response among vaccinated individuals in areas of the Democratic Republic of Congo that are experiencing outbreaks of the disease. Among the more than 600 study participants, 95.6% demonstrated antibody persistence six months after they received the vaccine.The study is the first published research examining post –Ebola-vaccination antibody response in the DRC, a nation of nearly 90 million. While long-term analyses of the study cohort continue, the findings will ...
Source: UCLA Newsroom: Health Sciences - February 8, 2022 Category: Universities & Medical Training Source Type: news

A Phase 2/3 Study of BLU-263 in Patients with Indolent Systemic Mastocytosis or Monoclonal Mast Cell Activation Syndrome
Systemic mastocytosis (SM) is a rare, clonal mast cell neoplasm driven by the KIT D816V mutation in ∼95% of cases. Indolent SM (ISM) is characterized by mast cell aggregates in skin, bone marrow, and multiple internal organs, and is often associated with chronic, debilitating, and potentially life-threatening symptoms. Monoclonal mast cell activation syndrome (mMCAS) is a clonal mast cell expans ion, defined by the presence of 1 or 2 minor World Health Organization SM criteria, including D816V KIT mutation.
Source: Journal of Allergy and Clinical Immunology - February 1, 2022 Category: Allergy & Immunology Authors: Mariana Castells, Tuan Dong Si, Vishwa Bhavsar, Kevin He, Cem Akin Source Type: research

Abnormal sperm morphology is associated with sensitization to inhaled allergens
CONCLUSION: Allergy due to inhalation allergens had an influence on the quality of male semen. Further research is necessary to establish the immunological bases of this phenomenon.PMID:34984934 | PMC:PMC8743921 | DOI:10.1177/20587384211066718
Source: International Journal of Immunopathology and Pharmacology - January 5, 2022 Category: Allergy & Immunology Authors: Rafa ł Adamczak Natalia Ukleja-Soko łowska Magdalena Pasi ńska Joanna Zieli ńska Mateusz Le śny Mariusz Dubiel Source Type: research

Johnson & Johnson Announces Positive CHMP Opinion for a Booster Shot of its COVID-19 Vaccine
NEW BRUNSWICK, N.J., December 15, 2021 – Johnson & Johnson (NYSE: JNJ) (the Company) today announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) issued a Positive Opinion for use of the Company’s COVID-19 vaccine as a booster for adults aged 18 and older at least two months after primary vaccination with a single-shot of the Johnson & Johnson COVID-19 vaccine, and as a ‘mix and match’ booster following primary vaccination with an approved two-shot mRNA COVID-19 vaccine regimen (known as heterologous boosting). “We are pleased with today’s Positiv...
Source: Johnson and Johnson - December 15, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news