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On-demand intermittent beclomethasone is effective for mild asthma in Brazil
ConclusionClinicians might consider intermittent inhaled steroid therapy as a therapeutic regimen for mild persistent asthma.Trial registration The Portuguese and English versions of the study protocol were submitted, approved, and registered in the Brazilian Network Platform for Clinical Trials (http://www.ensaiosclinicos.gov.br) under the primary identifier number “RBR-3gbyhk”. This platform is part of the Primary Registries in the World Health Organization Registry Network, where the trial is registered under the following Universal Trial Number: 1111-1149-4774
Source: Clinical and Translational Allergy - March 5, 2018 Category: Allergy & Immunology Source Type: research

A challenge ‐response endoscopic sinus surgery specific checklist as an add‐on to standard surgical checklist: an evaluation of potential safety and quality improvement issues
ConclusionThe design and integration of this checklist for endoscopic sinus surgery, has helped improve efficiency and patient safety in the operating room setting.
Source: International Forum of Allergy and Rhinology - February 27, 2018 Category: Allergy & Immunology Authors: Doron D. Sommer, Sadaf Arbab ‐Tafti, Forough Farrokhyar, Marc Tewfik, Allan Vescan, Ian J. Witterick, Brian Rotenberg, Rakesh Chandra, Erik k. Weitzel, Erin Wright, Jayant Ramakrishna Tags: ORIGINAL ARTICLE Source Type: research

Lessons of Drug Allergy Management Through the World Health Organization ’s International Classification of Diseases (ICD)-11
AbstractPurposes of reviewIn order to introduce the advances and use of the new sub-section addressed to the drug hypersensitivity reactions (DHRs) in the World Health Organizations ’ International Classification of Diseases (ICD)-11 revision, we here proposed a used case document and discuss the perspective of this new framework.Recent findingsWe expect that the construction of the new section addressed to DHRs in the ICD-11 will allow the collection of more accurate epidemiological data to support quality management of patients with drug allergies, and better facilitate health care planning to implement public health m...
Source: Current Treatment Options in Allergy - February 9, 2018 Category: Allergy & Immunology Source Type: research

Meeting report: Global vaccine and immunization research forum.
This report summarizes the discussions and conclusions from the forum participants. PMID: 29338876 [PubMed - as supplied by publisher]
Source: Vaccine - January 12, 2018 Category: Allergy & Immunology Authors: Ford AQ, Touchette N, Fenton Hall B, Hwang A, Hombach J Tags: Vaccine Source Type: research

Compositions and Methods for Blocking Transmission of Plasmodium
According to the World Health Organization, about 3.2 billion people – nearly half of the world ' s population – are at risk of infection by Plasmodium parasites, resulting in malaria. An estimated 214 million cases and 438,000 deaths were due to malaria in 2015.P47 protein expressed by Plasmodium species allow malaria parasites to evade the mosquito immune system, thereby facilitating the transmission of malaria parasites. NIAID inventors have discovered the region of P47 protein responsible for the immune evasion function of this protein. Specific sequences of protein fragments of P47 have proven to be both highly an...
Source: NIH OTT Licensing Opportunities - January 11, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

Advanced Proteomics and Systems Biology Applied to Study Food Allergy
Publication date: Available online 7 December 2017 Source:Current Opinion in Food Science Author(s): Mónica Carrera, Benito Cañas, José M. Gallardo Food allergy is considered to be the fourth most important public health problem by the World Health Organization (WHO). As a consequence, accurate, sensitive and fast detection methods for food allergy control and investigation are highly recommendable. In this work, we present a short overview of the applications of the Advanced Proteomics and Systems Biology approaches for the study and control of food allergy. For this purpose, two consecutive proteomics strategies (Dis...
Source: Current Opinion in Food Science - December 8, 2017 Category: Food Science Source Type: research

Fighting the flu, year after year
(NIH/National Institute of Allergy and Infectious Diseases) In a New England Journal of Medicine perspective, experts from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, and the World Health Organization (WHO) Collaborating Centre for Reference and Research on Influenza in Melbourne discuss how the process of preparing seasonal influenza vaccines in eggs may contribute to their limited effectiveness. The authors offer research strategies that might yield more protective vaccine candidates.
Source: EurekAlert! - Infectious and Emerging Diseases - November 29, 2017 Category: Infectious Diseases Source Type: news

Long-Term Exposure to Transportation Noise in Relation to Development of Obesity —a Cohort Study
Conclusion: Our results link transportation noise exposure to development of obesity and suggest that combined exposure from different sources may be particularly harmful. https://doi.org/10.1289/EHP1910 Received: 17 March 2017 Revised: 5 October 2017 Accepted: 9 October 2017 Published: 20 November 2017 Address correspondence to A. Pyko, Institute of Environmental Medicine, Karolinska Institutet, SE-171 77 Stockholm, Sweden. Telephone: 46(0) 852487561. Email: Andrei.pyko@ki.se Supplemental Material is available online (https://doi.org/10.1289/EHP1910). The authors declare they have no actual or potential competing fina...
Source: EHP Research - November 20, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

What can we learn in drug allergy management from World Health Organization's international classifications?
Allergy, EarlyView.
Source: Allergy - November 20, 2017 Category: Allergy & Immunology Source Type: research

Breast-feeding and risk of asthma, hay fever, and eczema
The World Health Organization recommends breast-feeding for at least 6  months after delivery because of general health benefits for the child.1 However, studies on breast-feeding have yielded inconsistent results regarding its association with the risks for developing asthma, hay fever, and eczema.2-4 A large homogeneous population-based cohort, such as the one used in this study (UK Biobank; N = 502,682), provides statistical power to fill in unaddressed gaps in the knowledge on the effects of breast-feeding on the risks of developing asthma, hay fever, and eczema.
Source: Journal of Allergy and Clinical Immunology - November 10, 2017 Category: Allergy & Immunology Authors: Weronica E. Ek, Torgny Karlsson, Carlos Azuaje Hern ándes, Mathias Rask-Andersen, Åsa Johansson Tags: Letter to the Editor Source Type: research

What can we learn in drug allergy management from World Health Organization's International Classifications?
This article is protected by copyright. All rights reserved.
Source: Allergy - November 1, 2017 Category: Allergy & Immunology Authors: Luciana Kase Tanno, Maria Jose Torres, Mariana Castells, Pascal Demoly, Tags: Review Article Source Type: research

Omalizumab Rapidly Improves Angioedema ‐Related Quality of Life in Adult Patients with Chronic Spontaneous Urticaria: X‐ACT Study Data
ConclusionsOur findings support omalizumab treatment in patients with severe H1‐antihistamine‐refractory CSU with angioedema.This article is protected by copyright. All rights reserved.
Source: Allergy - October 23, 2017 Category: Allergy & Immunology Authors: Petra Staubach, Martin Metz, Nadine Chapman ‐Rothe, Christian Sieder, Matthias Bräutigam, Marcus Maurer, Karsten Weller Tags: Original Article: Experimental Allergy and Immunology Source Type: research

Impact of pediatric obesity on acute asthma exacerbation in Japan
ConclusionThese findings demonstrated that obesity was a risk factor for repeated admissions caused by asthma in children, indicating the importance for the prevention of pediatric obesity.
Source: Pediatric Allergy and Immunology - October 18, 2017 Category: Allergy & Immunology Authors: Yusuke Okubo, Nobuaki Michihata, Koichi Yoshida, Naho Morisaki, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga Tags: ORIGINAL ARTICLE Source Type: research

Variation in DNA-Damage Responses to an Inhalational Carcinogen (1,3-Butadiene) in Relation to Strain-Specific Differences in Chromatin Accessibility and Gene Transcription Profiles in C57BL/6J and CAST/EiJ Mice
Conclusions: These results suggest that strain-specific changes in chromatin and transcription in response to chemical exposure lead to a “compensation” for underlying genetic-driven interindividual differences in the baseline chromatin and transcriptional state. This work represents an example of how chemical and environmental exposures can be evaluated to better understand gene-by-environment interactions, and it demonstrates the important role of chromatin response in transcriptomic changes and, potentially, in deleterious effects of exposure. https://doi.org/10.1289/EHP1937 Received: 21 March 2017 Revis...
Source: EHP Research - October 17, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research