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Total 401 results found since Jan 2013.
Emergence of Marburg virus: a global perspective on fatal outbreaks and clinical challenges
The Marburg virus (MV), identified in 1967, has caused deadly outbreaks worldwide, the mortality rate of Marburg virus disease (MVD) varies depending on the outbreak and virus strain, but the average case fatality rate is around 50%. However, case fatality rates have varied from 24 to 88% in past outbreaks depending on virus strain and case management. Designated a priority pathogen by the National Institute of Allergy and Infectious Diseases (NIAID), MV induces hemorrhagic fever, organ failure, and coagulation issues in both humans and non-human primates. This review presents an extensive exploration of MVD outbreak evolu...
Source: Frontiers in Microbiology - September 13, 2023 Category: Microbiology Source Type: research
Tachycardia and fever after packed red cell (PRC) infusion: A case report
J Family Med Prim Care. 2023 Jul;12(7):1457-1459. doi: 10.4103/jfmpc.jfmpc_647_22. Epub 2023 Jul 14.ABSTRACTA 56-year-old female patient with a body weight of 60 kg was brought to the hospital with hematemesis and received one unit of packed red cells (PRCs) for this condition. After 30 min, the patient experienced tachycardia of 120 beats/min and an increased body temperature of 102°F. The patient had no relevant medical history of allergy or similar episodes in the past. The patient was not suffering from any coagulopathies or sickle cell anaemia, which is a prevalent condition in the region. The patient was receiving t...
Source: Primary Care - August 31, 2023 Category: Primary Care Authors: Swanand S Pathak Shailesh R Nagpure Rupesh A Warbhe Dattaprasad N Kumbhakarna Source Type: research
News at a glance: A win for obesity drugs, NIH unionization roadblocks, and Mexican fireflies under threat
CONSERVATION
Researchers raise alarm over threat to Mexican fireflies
Scientists from the International Union for Conservation of Nature (IUCN) last week delivered a letter to the Mexican government requesting it regulate tourism centered on the threatened firefly species
Photinus palaciosi
. Endemic to Mexico’s Tlaxcala forests,
P. palaciosi
is one of the few species that glow in synchrony, offering an annual spectacle that attracts thousands of visitors during summer mating season. The letter describes how littering, artificial light, and noise interfere with the insects’ courtship and eg...
Source: ScienceNOW - August 10, 2023 Category: Science Source Type: news
News at a glance: A win for obesity drugs, a new infectious disease institute head, and Mexican fireflies under threat
CONSERVATION
Researchers raise alarm over threat to Mexican fireflies
Scientists from the International Union for Conservation of Nature (IUCN) last week delivered a letter to the Mexican government requesting it regulate tourism centered on the threatened firefly species
Photinus palaciosi
. Endemic to Mexico’s Tlaxcala forests,
P. palaciosi
is one of the few species that glow in synchrony, offering an annual spectacle that attracts thousands of visitors during summer mating season. The letter describes how littering, artificial light, and noise interfere with the insects’ courtship and eg...
Source: Science of Aging Knowledge Environment - August 10, 2023 Category: Geriatrics Source Type: research
World Health Organization Classification and Diagnosis of Mastocytosis
This article discusses the revised classification of mastocytosis in light of a rapidly moving field and the advent of new diagnostic parameters, new prognostication tools, and new therapies.
Source: Immunology and Allergy Clinics of North America - July 17, 2023 Category: Allergy & Immunology Authors: Peter Valent, Karl Sotlar, Hans-Peter Horny, Michel Arock, Cem Akin Source Type: research
The U.S. Scientist At the Heart of COVID-19 Lab Leak Conspiracies Is Still Trying to Save the World From the Next Pandemic
Ralph Baric stepped onto the auditorium stage at the University of North Carolina, Chapel Hill, and looked out at the sparse audience that had come to hear him speak. On the large projector screen hanging behind him, the following words appeared: How Bad the Next Pandemic Could Be, What Might It Look Like, and Will We be Ready. The date was May 29, 2018.
“Well, I have to admit I’m a little worried about giving this talk,” Baric said. “The reason is being labelled a harbinger of doom.” The screen shifted, and images of the four horsemen of the apocalypse—Death, Famine, War, and Plague&mda...
Source: TIME: Health - July 11, 2023 Category: Consumer Health News Authors: Dan Werb Tags: Uncategorized COVID-19 feature freelance Source Type: news
Mastocytosis: Aiming for the Right Targets
We have witnessed important and historic developments in mastocytosis in the last year. Diagnostic criteria and classification of mastocytosis have been revised by the World Health Organization and International Consensus Classification groups. FDA approved avapritinib for the treatment of indolent systemic mastocytosis, the first cytoreductive targeted therapy with selectivity against D816V KIT mutation. Availability of new drugs made us think harder about coming up with symptom scores and quality-of-life measures to document response to therapies.
Source: Immunology and Allergy Clinics of North America - July 11, 2023 Category: Allergy & Immunology Authors: Cem Akin Tags: Preface Source Type: research
Case studies expose deadly risk of mpox to people with untreated HIV
In June 2022, a young man in his 30s severely sick with mpox, the viral disease formerly known as monkeypox, was admitted to the Salvador Zubirán National Institute of Health Sciences and Nutrition hospital in Mexico City. Tests showed the patient was also HIV-positive, which he had not known, and that his blood had few CD4 cells, critical immune cells that HIV attacks. The man’s immune system was so weak it could not keep mpox in check and painful lesions kept spreading across his body, eating away at, or necrotizing, the flesh, according to HIV researcher Brenda Crabtree Ramirez, who was on his care team. Then the vir...
Source: Science of Aging Knowledge Environment - February 21, 2023 Category: Geriatrics Source Type: research
Case studies expose deadly risk of mpox in people with untreated HIV
In June 2022, a young man in his 30s severely sick with mpox, the viral disease formerly known as monkeypox, was admitted to the Salvador Zubirán National Institute of Health Sciences and Nutrition hospital in Mexico City. Tests showed the patient was also HIV-positive, which he had not known, and that his blood had few CD4 cells, critical immune cells that HIV attacks. The man’s immune system was so weak it could not keep mpox in check and painful lesions kept spreading across his body, eating away at, or necrotizing, the flesh, according to HIV researcher Brenda Crabtree Ramirez, who was on his care team. Then the vir...
Source: ScienceNOW - February 21, 2023 Category: Science Source Type: news
Can Use of A Novel Nasal Cleansing Kit Impact Relief of Allergy Symptoms?
We examined whether an antiseptic nasal cleansing kit could help relieve symptoms in patients with chronic allergy symptoms.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Arman Kalamkarian, Ewen Tseng, Kenny Carter, Keith Matheny Source Type: research
Janssen and Global Partners to Discontinue Phase 3 Mosaico HIV Vaccine Clinical Trial
LEIDEN, THE NETHERLANDS, (January 18, 2023) – The Janssen Pharmaceutical Companies of Johnson & Johnson, together with a consortium of global partners, today announced the results of an independent, scheduled data review of the Phase 3 Mosaico study (also known as HPX3002/HVTN706) of Janssen’s investigational HIV vaccine regimen. The study’s independent Data and Safety Monitoring Board (DSMB) determined that the regimen was not effective in preventing HIV infection compared to placebo among study participants. No safety issues with the vaccine regimen were identified.In light of the DSMB’s determination, the Mo...
Source: Johnson and Johnson - January 18, 2023 Category: Pharmaceuticals Tags: Latest News Source Type: news
Eleven science stories likely to make big news in 2023
As the COVID-19 pandemic enters its fourth year as a global health emergency, researchers will continue pushing to help make the disease manageable and ordinary. They will track hundreds of subvariants of Omicron, the highly transmissible but seemingly less lethal strain of SARSCoV-2 that dominated in 2022. Virologists will watch the virus’ evolution this year to see whether it has finally slowed or a more dangerous variant pops up, evading much of the immunity that humanity has built up to previous ones. Vaccine researchers hope to develop new shots that provide broad protection against a variety of coronaviruses. Ano...
Source: ScienceNOW - January 4, 2023 Category: Science Source Type: news
Anthony Fauci: a scientific adviser's role from HIV to COVID-19
Bull World Health Organ. 2023 Jan 1;101(1):8-9. doi: 10.2471/BLT.23.030123.ABSTRACTAnthony Fauci talks to Gary Humphreys about his achievements at the National Institute of Allergy and Infectious Diseases (NIAID), his experiences advising seven consecutive United States presidents, and the challenges faced in communicating scientific evidence.PMID:36593776 | PMC:PMC9795384 | DOI:10.2471/BLT.23.030123
Source: Bulletin of the World Health Organization - January 3, 2023 Category: International Medicine & Public Health Source Type: research
