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Synergistic relationship between TSLP and IL ‐33/ST2 signaling pathways in allergic rhinitis and the effects of hypoxia
ConclusionOur data indicate that TSLP and IL ‐33/ST2 signaling pathways interact with each other in the pathogenesis and pathologic development of AR. TSLP inhibition is a key factor in AR treatment. Inhibiting hypoxia‐induced pathologic processes could represent a therapeutic effect by inhibiting IL‐33/ST2 expression via downregulating TSLP.
Source: International Forum of Allergy and Rhinology - January 9, 2020 Category: Allergy & Immunology Authors: Ruofei Huang, Wei Mao, Guoliang Wang, Jian Ding, Ying Sun, Gang Gao, Ping Dong, Zhenfeng Sun Tags: ORIGINAL ARTICLE Source Type: research

GINA Updated 2019: Landmark Changes Recommended for Asthma Management
GINA, Global Initiative for Asthma, was launched in 1993 in collaboration with the National Heart, Lung, and Blood Institute, National Institutes of Health, and the World Health Organization. to improve the prevention and management of asthma worldwide. Their science committee updates asthma guidelines yearly and the 20191 report ’s goals were to reduce the risk of serious asthma-related exacerbations: to avoid patient reliance on quick-relief medication: and to update asthma treatment goals. In the U.S., the NHLBI EPR-3 guidelines have not been updated since 2007.
Source: Annals of Allergy, Asthma and Immunology - November 13, 2019 Category: Allergy & Immunology Authors: Angela Duff Hogan, Jonathan A. Bernstein Tags: Perspective Source Type: research

GINA updated 2019
The Global Initiative for Asthma (GINA) was launched in 1993 in collaboration with the National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health, and the World Health Organization, to improve the prevention and management of asthma worldwide. Their science committee updates asthma guidelines yearly, and the 20191 report ’s goals were to reduce the risk of serious asthma-related exacerbations, to avoid patient reliance on quick-relief medication, and to update asthma treatment goals.
Source: Annals of Allergy, Asthma and Immunology - November 13, 2019 Category: Allergy & Immunology Authors: Angela Duff Hogan, Jonathan A. Bernstein Tags: Perspective Source Type: research

Defining Polysaccharide Antibody Deficiency: Measurement of Anti-Pneumococcal Antibodies and Anti- Salmonella typhi Antibodies in a Cohort of Patients with Recurrent Infections
ConclusionThe lack of evidence-based gold standards for the diagnosis of SAD represents a challenge in clinical practice. In our cohort, we confirmed the insufficient correlation between different methods of specific PPV response measurement, and showed that theS. typhi Vi response was not contributive. Caution in the interpretation of results is warranted until more reliable diagnostic methods can be validated.
Source: Journal of Clinical Immunology - November 7, 2019 Category: Allergy & Immunology Source Type: research

Outdoor air pollution and the burden of childhood asthma across Europe
Conclusions A significant proportion of childhood asthma cases may be attributable to outdoor air pollution and these cases could be prevented. Our estimates underline an urgent need to reduce children's exposure to air pollution.
Source: European Respiratory Journal - October 30, 2019 Category: Respiratory Medicine Authors: Khreis, H., Cirach, M., Mueller, N., de Hoogh, K., Hoek, G., Nieuwenhuijsen, M. J., Rojas-Rueda, D. Tags: Epidemiology, occupational and environmental lung disease, Asthma and allergy Original Articles: Asthma and epidemiology Source Type: research

Cow ’s Milk and Vitamin D Supplementation in Infants
In this issue of JAMA Pediatrics, Urashima and colleagues ask whether very early (within 3 days of birth) exposure to cow ’s milk formula (CMF) (a common practice in Japan) and vitamin D supplementation (uncommon in Japan) lowers or increases the risk of developing food allergy (as determined by cow’s milk–specific IgE [CM-IgE] sensitization at 5 months and 2 years of age) in infants at risk of atopy (risk was de fined as having ≥1 of the father, mother, and/or siblings with current and/or past atopic diseases [eg, asthma]). In recent years, the approach for primary prevention of food allergy has changed dramatical...
Source: JAMA Pediatrics - October 21, 2019 Category: Pediatrics Source Type: research

Benefits and harms of aspirin desensitization for aspirin ‐exacerbated respiratory disease: a systematic review and meta‐analysis
ConclusionIn patients with AERD, moderate ‐certainty and high‐certainty evidence shows that aspirin desensitization meaningfully reduces symptoms of rhinosinusitis and improves quality of life, but results in a significant increase in adverse events.
Source: International Forum of Allergy and Rhinology - September 12, 2019 Category: Allergy & Immunology Authors: Derek K. Chu, Daniel J. Lee, Keith M. Lee, Holger J. Sch ünemann, Wojciech Szczeklik, John M. Lee Tags: REVIEW ARTICLE Source Type: research

Fast track concepts in total knee arthroplasty: use of tranexamic acid and local intra-articular anesthesia technique.
Abstract OBJECTIVE: Fast track concepts are used to reduce the risk of perioperative and postoperative complications after total knee arthroplasty. INDICATIONS: The described concepts are used for patients with indications for the implantation of a total knee prosthesis. CONTRAINDICATIONS: Contraindications for fast track concepts are aged patients, dementia, American Society of Anesthesiologists (ASA) grade IV and implantation of large revision or tumor prostheses. Contraindications for tranexamic acid are bleeding in the urinary tract, caution in cases of known epilepsy, individual risk assessment in e...
Source: Operative Orthopadie und Traumatologie - September 12, 2019 Category: Orthopaedics Authors: Petersen W, Bierke S, Hees T, Karpinski K, Häner M Tags: Oper Orthop Traumatol Source Type: research

Effects of endoscopic sinus surgery on objective and subjective measures of cognitive dysfunction in chronic rhinosinusitis
ConclusionESS is associated with improvement in subjective and some aspects of objective cognition.
Source: International Forum of Allergy and Rhinology - August 25, 2019 Category: Allergy & Immunology Authors: Frederick Yoo, Rodney J. Schlosser, Kristina A. Storck, Kimia G. Ganjaei, Nicholas R. Rowan, Zachary M. Soler Tags: ORIGINAL ARTICLE Source Type: research

A ‘Cure’ for Ebola but Will it Stop the Outbreak if People Won’t Get Treatment?
Health workers inside a "CUBE" talk to an Ebola patient, while a nurse consults a chart outside. ALIMA Ebola Treatment Centre, Beni, Democratic Republic of the Congo. Two drugs have been found to successfully treat the Ebola virus. Aid agencies have welcomed the news saying it allows communities to access early treatment. Courtesy: World Health Organisation (WHO)By Issa Sikiti da SilvaCOTONOU, Benin, Aug 20 2019 (IPS) While people in the Democratic Republic of Congo (DRC) are slowly being made aware that scientists have discovered two drugs that are effective in treating Ebola, letting go of the fear and anxiety that has p...
Source: IPS Inter Press Service - Health - August 20, 2019 Category: International Medicine & Public Health Authors: Issa Sikiti da Silva Tags: Africa Development & Aid Editors' Choice Featured Health Human Rights Humanitarian Emergencies Population Poverty & SDGs Regional Categories TerraViva United Nations Democratic Republic of Congo (DRC) ebola Source Type: news

Safety assessment of miraculin using in silico and in vitro digestibility analyses.
Abstract Miraculin is a glycoprotein with the ability to make sour substances taste sweet. The safety of miraculin has been evaluated using an approach proposed by the Food and Agriculture Organization of the United Nations and the World Health Organization for assessing the safety of novel proteins. Miraculin was shown to be fully and rapidly digested by pepsin in an in vitro digestibility assay. The proteomic analysis of miraculin's pepsin digests further corroborated that it is highly unlikely that any of the protein will remain intact within the gastrointestinal tract for potential absorption. The potential al...
Source: Food and Chemical Toxicology - August 13, 2019 Category: Food Science Authors: Tafazoli S, Vo TD, Roberts A, Rodriguez C, Viñas R, Madonna ME, Chiang YH, Noronha JW, Holguin JC, Ryder JA, Perlstein A Tags: Food Chem Toxicol Source Type: research

A Cure for Ebola? Two New Treatments Prove Highly Effective in Congo
The therapies saved roughly 90 percent of the patients who were newly infected, a turning point in the decades-long fight against the virus.
Source: NYT Health - August 13, 2019 Category: Consumer Health News Authors: Donald G. McNeil Jr. Tags: Ebola Virus Epidemics ZMapp (Drug) National Institute of Allergy and Infectious Diseases World Health Organization Fauci, Anthony S Congo, Democratic Republic of (Congo-Kinshasa) Source Type: news

Two New Ebola Treatments Prove Highly Effective in Congo Epidemic
The therapies saved roughly 90 percent of the patients who received them early in the course of infection. Doctors hope patients will seek out the cures, ending the outbreak.
Source: NYT Health - August 12, 2019 Category: Consumer Health News Authors: Donald G. McNeil Jr. Tags: Ebola Virus Epidemics ZMapp (Drug) National Institute of Allergy and Infectious Diseases World Health Organization Fauci, Anthony S Congo, Democratic Republic of (Congo-Kinshasa) Source Type: news

Ebola now curable after trials of drugs in DRC, say scientists
Congo results show good survival rates for patients treated quickly with antibodiesEbola can no longer be called an incurable disease, scientists have said, after two of four drugs being trialled in themajor outbreak in the Democratic Republic of the Congo were found to have significantly reduced the death rate.ZMapp, used during the massive Ebola epidemic in Sierra Leone, Liberia and Guinea, has been dropped along with Remdesivir after two monoclonal antibodies, which block the virus, had substantially more effect, said the World Health Organization and the US National Institute of Allergy and Infectious Diseases, which w...
Source: Guardian Unlimited Science - August 12, 2019 Category: Science Authors: Sarah Boseley Health editor Tags: Ebola Democratic Republic of the Congo Africa World news Infectious diseases Medical research Microbiology Science Pharmaceuticals industry World Health Organization Source Type: news

Changing the history of anaphylaxis mortality statistics through the World Health Organization's International Classification of Diseases –11
We review the history of the classification and coding changes for anaphylaxis and provide current and perspective information in the field. In 2012, an analysis of Brazilian data demonstrated undernotification of anaphylaxis-related deaths because of the difficulties of coding using the International Classification of Diseases, 10th Revision. This work triggered strategic international actions supported by the Joint Allergy Academies and the International Classification of Diseases World Health Organization (WHO) leadership to update the classification of allergic disorders for the International Classification of Diseases...
Source: Journal of Allergy and Clinical Immunology - June 18, 2019 Category: Allergy & Immunology Authors: Luciana Kase Tanno, Robert Chalmers, Ana Luiza Bierrenbach, F. Estelle R. Simons, Bryan Martin, Nicolas Molinari, Isabella Annesi-Maesano, Margitta Worm, Victoria Cardona, Nikolaos G. Papadopoulos, Mario Sanchez-Borges, Lanny J. Rosenwasser, Ignacio Anson Tags: Review article Source Type: research