Synergistic relationship between TSLP and IL ‐33/ST2 signaling pathways in allergic rhinitis and the effects of hypoxia

ConclusionOur data indicate that TSLP and IL ‐33/ST2 signaling pathways interact with each other in the pathogenesis and pathologic development of AR. TSLP inhibition is a key factor in AR treatment. Inhibiting hypoxia‐induced pathologic processes could represent a therapeutic effect by inhibiting IL‐33/ST2 expression via downregulating TSLP.

Source: International Forum of Allergy and Rhinology - January 9, 2020 Category: Allergy & Immunology Authors: Ruofei Huang, Wei Mao, Guoliang Wang, Jian Ding, Ying Sun, Gang Gao, Ping Dong, Zhenfeng Sun Tags: ORIGINAL ARTICLE Source Type: research