Alternative Immunomodulatory and Disease-Modifying Treatment for Atopic Dermatitis: Autologous Total Immunoglobulin G.
Authors: Kim SM, Park CO PMID: 32935484 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - September 18, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Understanding the Impact of Chronic Cough on the Quality of Life in the General Population.
Authors: Jin HJ, Kim CW PMID: 32935485 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - September 18, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Evaluation and Management of Difficult-to-Treat and Severe Asthma: An Expert Opinion From the Korean Academy of Asthma, Allergy and Clinical Immunology, the Working Group on Severe Asthma.
Authors: Kim BK, Park SY, Ban GY, Kim MA, Lee JH, An J, Shim JS, Lee Y, Won HK, Lee HY, Sohn KH, Kang SY, Park SY, Lee H, Kim MH, Kwon JW, Yoon SY, Lee JH, Rhee CK, Moon JY, Lee T, Kim SR, Park JS, Kim SH, Park HW, Jeong JW, Kim SH, Koh YI, Oh YM, Jang AS, Yoo KH, Cho YS, Korean Academy of Asthma, Allergy, and Clinical Immunology (KAACI), the Working Group on Severe Asthma Abstract Severe asthma (SA) presents in about 3%-5% of adult asthmatics and is responsible for over 60% of asthma-related medical expenses, posing a heavy socioeconomic burden. However, to date, a precise definition of or clear diagnostic criteri...
Source: Allergy, Asthma and Immunology Research - September 18, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Important Role of Immunological Responses to Environmental Exposure in the Development of Allergic Asthma.
Authors: Lin X, Ren X, Xiao X, Yang Z, Yao S, Wong GW, Liu Z, Wang C, Su Z, Li J Abstract Allergic asthma is a public health problem that affects human health and socioeconomic development. Studies have found that the prevalence of asthma has significantly increased in recent years, which has become particularly pronounced in developed countries. With rapid urbanization in China in the last 3 decades, the prevalence of asthma has increased significantly in urban areas. As changes in genetic backgrounds of human populations are limited, environmental exposure may be a major factor that is responsible for the increas...
Source: Allergy, Asthma and Immunology Research - September 18, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Efficacy, Safety, and Immunomodulatory Effect of the Intramuscular Administration of Autologous Total Immunoglobulin G for Atopic Dermatitis: A Randomized Clinical Trial.
Authors: Nahm DH, Ye YM, Shin YS, Park HS, Kim ME, Kwon B, Cho SM, Han J Abstract PURPOSE: The management of patients with atopic dermatitis (AD) is often difficult. We hypothesized that repeated intramuscular administration of autologous total immunoglobulin G (IgG) could induce clinical improvement in patients with AD through immune modulation. This clinical trial was conducted to evaluate the efficacy, safety, and immunomodulatory effect of the intramuscular administration of autologous total IgG in patients with AD. METHODS: In this randomized, double-blind, placebo-controlled trial, 51 adolescent and adult...
Source: Allergy, Asthma and Immunology Research - September 18, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Impact of Chronic Cough on Health-Related Quality of Life in the Korean Adult General Population: The Korean National Health and Nutrition Examination Survey 2010-2016.
This study analyzed cross-sectional datasets of adults (aged ≥ 40 years) in the Korean National Health and Nutrition Examination Survey 2010-2016. Health-related QoL was assessed using the 3-level EuroQoL 5-dimension component (EQ-5D-3L) index score. The presence of chronic cough and other conditions were defined using structured questionnaires. RESULTS: The prevalence of chronic cough was 3.48% ± 0.17% among adults aged ≥ 40 years. The overall EQ-5D-3L index score was significantly lower in subjects with than without chronic cough (0.79 ± 0.01 vs. 0.86 ± 0.00, P
Source: Allergy, Asthma and Immunology Research - September 18, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Enhanced Type 2 Immune Reactions by Increased IL-22/IL-22Ra1 Signaling in Chronic Rhinosinusitis With Nasal Polyps.
CONCLUSION: IL-22 was associated with type 2 inflammatory reactions in NP. The IL-22/IL-22Ra1 axis was enhanced and might be involved in type 2 inflammatory reactions via TSLP production in NP. PMID: 32935490 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - September 18, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Chloroquine Treatment Suppresses Mucosal Inflammation in a Mouse Model of Eosinophilic Chronic Rhinosinusitis.
CONCLUSIONS: Chloroquine may be used for the treatment of patients with eosinophilic CRS. PMID: 32935491 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - September 18, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Chitinase 3-Like 1 Contributes to Food Allergy via M2 Macrophage Polarization.
CONCLUSIONS: CHI3L1 plays a pivotal role in Th2 inflammation and M2 macrophage polarization through MAPK/ERK and PI3K/AKT phosphorylation in food allergy. PMID: 32935492 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - September 18, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Aberrant Th2 Immune Responses Are Associated With a Reduced Frequency of IL-35-Induced Regulatory T Cells After Allergen Exposure in Patients With Allergic Asthma.
CONCLUSIONS: The results of our study suggest that iTr35 cells may play an important role in preventing Th2 responses to allergens by secreting IL-35 and that iTr35 cells may be a potential new immune regulator of allergic asthma. PMID: 32935493 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - September 18, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Does Carboplatin Rapid Desensitization Change Its Adverse Drug Reactions Other than Hypersensitivity and Efficacy in Patients With Ovarian Cancer?
CONCLUSIONS: Rapid desensitization of carboplatin can lower the risk of immediate hypersensitivity reactions without changing the inherent effect and severe ADRs. PMID: 32935494 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - September 18, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Spectrum of Allergen Sensitization to Food and Inhalant Allergens Across All Ages.
Authors: Kim JH, Cho W, An J, Ha EK, Lee W, Lee SW, Lee CH, Hwang S, Shin YH, Han MY PMID: 32935495 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - September 18, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Facial Redness in Atopic Dermatitis Patients Treated With Dupilumab: A Case Series.
Authors: Seok SH, An JH, Shin JU, Lee HJ, Kim DH, Yoon MS, Kim HJ PMID: 32935496 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - September 18, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Erratum: Allergenic Pollen Calendar in Korea Based on Probability Distribution Models and Up-to-Date Observations.
Authors: Shin JY, Han MJ, Cho C, Kim KR, Ha JC, Oh JW Abstract This corrects the article on p. 259 in vol. 12, PMID: 32009321. PMID: 32935497 [PubMed - in process] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - September 18, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Does the Serum Tell Us Something About the Host-Microbial Relations in Allergic Diseases?
Authors: Cho YS PMID: 32638555 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - July 10, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Joy of Ping-Pong: Genome-Wide and Phenome-Wide Association Studies.
Authors: Park HW PMID: 32638556 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - July 10, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

The KAAACI/KDA Evidence-Based Practice Guidelines for Chronic Spontaneous Urticaria in Korean Adults and Children: Part 2. Management of H1-Antihistamine-Refractory Chronic Urticaria.
Authors: Choi JH, Lee DH, Song WJ, Choi M, Kwon JW, Kim GW, Kim MH, Kim MA, Kim MH, Kim BK, Kim S, Kim JS, Kim JE, Kim JY, Kim JH, Kim HJ, Kim HO, Kim HB, Roh JY, Park KH, Park KY, Park HK, Park H, Bae JM, Byun JY, Song DJ, Ahn YM, Lee SE, Lee YB, Lee JS, Lee JH, Lim KH, Youn SW, Chang YS, Jeon YH, Jeon J, Jue MS, Choi SH, Hur GY, Lim DH, Ye YM, Park YM Abstract Quite a few patients with chronic spontaneous urticaria (CSU) are refractory to H₁-antihistamines, even though the dose of H₁-antihistamines is increased up to 4-fold. CSU that is not controlled with H₁-antihistamines results in increased disease burd...
Source: Allergy, Asthma and Immunology Research - July 10, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

An Overview of Rising CO ₂ and Climatic Change on Aeroallergens and Allergic Diseases.
An Overview of Rising CO₂ and Climatic Change on Aeroallergens and Allergic Diseases. Allergy Asthma Immunol Res. 2020 Sep;12(5):771-782 Authors: Ziska LH Abstract There are a number of implications of climate change in regard to human health. Among these, the role of rising carbon dioxide (CO₂) and temperature in aeroallergen exposure and associated changes in the start, duration and intensity of the pollen season, and associated consequences in aeroallergens and allergic disease are a primary concern. This review is intended to provide a synopsis of CO₂ and climate factors associated with likel...
Source: Allergy, Asthma and Immunology Research - July 10, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Management of Allergic Patients During the COVID-19 Pandemic in Asia.
We report this consensus to support allergists and clinical immunologists to make optimal decisions under the urgent situation in Asia. PMID: 32638559 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - July 10, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Diagnostic Models for Atopic Dermatitis Based on Serum Microbial Extracellular Vesicle Metagenomic Analysis: A Pilot Study.
CONCLUSIONS: In summary, microbial EVs demonstrated the potential in their use as novel biomarkers for AD diagnosis. Therefore, future work should investigate larger case and control groups with cross-sectional or longitudinal clinical data to explore the utility and validity of serum microbiota EV-based AD diagnosis. PMID: 32638560 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - July 10, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Phenotypic and Molecular Characterization of Risk Loci Associated With Asthma and Lung Function.
CONCLUSIONS: This study generated novel data regarding the genetics of respiratory diseases and their comorbidities, providing a deep characterization of loci associated with asthma and lung function. PMID: 32638561 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - July 10, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Coexisting COPD Increases Mortality in Patients With Corticosteroid-Dependent Asthma: A Nationwide Population-Based Study.
This study aimed to determine the impact of coexisting COPD on long-term mortality in patients with CS-dependent asthma. METHODS: A retrospective cohort of patients with CS-dependent asthma aged 40 years or older was established using records from the Korean National Health Insurance Service database for 2005 to 2015. We classified the subjects into 2 groups according to the presence of COPD and evaluated the hazard ratio (HR) for all-cause mortality in patients with COPD relative to those without COPD. RESULTS: Of 8,021 patients with CS-dependent asthma, 3,121 (38.9%) had COPD. All-cause mortality was significantl...
Source: Allergy, Asthma and Immunology Research - July 10, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Application of Impulse Oscillometry in Adult Asthmatic Patients With Preserved Lung Function.
Authors: Kim SR, Park KH, Son NH, Moon J, Park HJ, Kim K, Park JW, Lee JH Abstract PURPOSE: It is difficult to assess airway obstruction using spirometry in adult asthmatic patients with preserved lung function. Impulse oscillometry (IOS) can detect not only airway resistance but also reactance. Therefore, IOS may be useful in assessing pulmonary function in such patients. We investigated the applicability of IOS for asthma patients with preserved lung function. METHODS: Between 2015 and 2018, 1,248 adult asthmatic patients suspected of having asthma who visited the Allergy and Asthma Center of Severance Hospit...
Source: Allergy, Asthma and Immunology Research - July 10, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Effect of Dermatophagoides pteronyssinus Immunotherapy on Upper and Lower Airway Eosinophilic Inflammatory Response to Nasal Allergen Challenge.
Authors: Huang R, Qin R, Hu Q, Zhu Z, Liu Y, Luo T, Li J Abstract PURPOSE: It remains unknown whether allergen-specific immunotherapy (AIT) could attenuate airway inflammatory response triggered by allergen exposure. METHODS: We performed Dermatophagoides pteronyssinus (Der-p) nasal provocation tests (NPTs) in allergic rhinitis (AR) and/or asthma patients without AIT (non-AIT), or at 16, 52, 104, or 156 weeks after Der-p AIT. Rhinitis and asthma visual analog scale (VAS; VAS of nasal symptoms [VAS-NS], VAS of asthma symptoms), the rhinoconjunctivitis quality of life questionnaire (RQLQ), nasal lavage, sputum in...
Source: Allergy, Asthma and Immunology Research - July 10, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

MiR-1165-3p Suppresses Th2 Differentiation via Targeting IL-13 and PPM1A in a Mouse Model of Allergic Airway Inflammation.
CONCLUSIONS: MiR-1165-3p negatively may regulate Th2-cell differentiation by targeting IL-13 and PPM1A in allergic airway inflammation. PMID: 32638565 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - July 10, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Mitochondrial and Nuclear Mitochondrial Variants in Allergic Diseases.
Authors: Jang H, Kim M, Hong JY, Cho HJ, Kim CH, Kim YH, Sohn MH, Kim KW Abstract The mitochondrial genome encodes core catalytic peptides that affect major metabolic processes within a cell. Here, we investigated the association between mitochondrial DNA (mtDNA) variants and allergic diseases, including atopic dermatitis (AD) and asthma, alongside heteroplasmy within the mtDNA in subjects with allergic sensitization. We collected genotype data from 973 subjects with allergic sensitization, consisting of 632 children with AD, 498 children with asthma, and 481 healthy controls by extracting DNA from their blood samp...
Source: Allergy, Asthma and Immunology Research - July 10, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Low-Dose Mepolizumab Effectiveness in Patients Suffering From Eosinophilic Granulomatosis With Polyangiitis.
Authors: Vultaggio A, Nencini F, Bormioli S, Vivarelli E, Dies L, Rossi O, Parronchi P, Maggi E, Matucci A Abstract Eosinophilic granulomatosis with polyangiitis (EGPA) is a vasculitis characterized by multisystemic manifestations including asthma. Mepolizumab (300 mg/4 weeks) has recently been approved for EGPA. However, real-life data are scarce and report experiences with high doses of mepolizumab intravenously administered (750 mg/4 weeks). The aim of our study was to investigate in a real-life setting whether mepolizumab in EGPA patients at low doses would enable us 1) to control asthma symptoms, 2) to obtain ...
Source: Allergy, Asthma and Immunology Research - July 10, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Omalizumab Treatment in Patients With Cholinergic Urticaria: A Real-World Retrospective Study in Korea.
Authors: Kim JH, Park HS, Ye YM, Shin YS, Kang HR, Chung SJ, Choi JH PMID: 32638568 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - July 10, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Management of Severe Asthma During the COVID-19 Pandemic in Korea.
Authors: Kim S, Jin HJ, Kim SR PMID: 32638569 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - July 10, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Impact of Chronic Urticaria on the Self-Assessed Health Status.
Authors: Lee JH PMID: 32400123 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - May 15, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Is TLR4 Critical for Neutrophil Apoptosis in Occupational Asthma?
Authors: Choi Y, Sim S, Park HS PMID: 32400124 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - May 15, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

The KAAACI/KDA Evidence-Based Practice Guidelines for Chronic Spontaneous Urticaria in Korean Adults and Children: Part 1. Definition, Methodology and First-line Management.
Authors: Song WJ, Choi M, Lee DH, Kwon JW, Kim GW, Kim MH, Kim MA, Kim MH, Kim BK, Kim S, Kim JS, Kim JE, Kim JY, Kim JH, Kim HJ, Kim HO, Kim HB, Roh JY, Park KH, Park KY, Park HK, Park H, Bae JM, Byun JY, Song DJ, Ahn YM, Lee SE, Lee YB, Lee JS, Lee JH, Lim KH, Ye YM, Chang YS, Jeon YH, Jeon J, Jue MS, Choi SH, Choi JH, Hur GY, Park YM, Lim DH, Youn SW Abstract Chronic spontaneous urticaria (CSU) is defined as the occurrence of spontaneous wheals, angioedema, or both for>6 weeks in the absence of specific causes. It is a common condition associated with substantial disease burden both for affected individuals a...
Source: Allergy, Asthma and Immunology Research - May 15, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Skin Exposure Contributes to Chemical-Induced Asthma: What is the Evidence? A Systematic Review of Animal Models.
Authors: Tsui HC, Ronsmans S, De Sadeleer LJ, Hoet PHM, Nemery B, Vanoirbeek JAJ Abstract It is generally assumed that allergic asthma originates primarily through sensitization via the respiratory mucosa, but emerging clinical observations and experimental studies indicate that skin exposure to low molecular weight (LMW) agents, i.e. "chemicals," may lead to systemic sensitization and subsequently develop asthma when the chemical is inhaled. This review aims to evaluate the accumulating experimental evidence that adverse respiratory responses can be elicited upon inhalation of an LMW chemical sensitizer ...
Source: Allergy, Asthma and Immunology Research - May 15, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Health-Related Utility of EQ-5D in Korean Adults With Chronic Urticaria: Mapping From Urticaria Outcome Measures.
Authors: Lee MS, Yoon J, Kim J, Shin YS, Park HS, Lee HY, Ye YM Abstract PURPOSE: A need for useful measures reflective of the socio-economic burden of chronic urticaria (CU) has arisen. To obtain utility estimates for CU, we investigated EuroQol-5-Dimension (EQ-5D) indices according to urticaria control status and urticaria severity. METHODS: In this prospective observational study, we administered patient-oriented questionnaires on EQ-5D and urticaria outcomes, including Urticaria Activity Score over 7 days (UAS7), Urticaria Control Test (UCT), and CU-specific quality of life (CU-QOL). EQ-5D utility index sco...
Source: Allergy, Asthma and Immunology Research - May 15, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Toll-like Receptor 4 Deficiency Aggravates Airway Hyperresponsiveness and Inflammation by Impairing Neutrophil Apoptosis in a Toluene Diisocyanate-Induced Murine Asthma Model.
CONCLUSIONS: These data indicated that TLR4 deficiency promoted neutrophil infiltration by impairing its apoptosis via up-regulation of Bcl-2, thereby resulting in deteriorated AHR and airway inflammation, which suggests that TLR4 could be a negative regulator of TDI-induced neutrophilic inflammation. PMID: 32400128 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - May 15, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Genetic Signatures of Acute Asthma Exacerbation Related With Ineffective Response to Corticosteroid.
CONCLUSIONS: Many genes belong to the AE rate-associated and preserved module identified in blood cells from childhood and adults asthmatics showed no expression changes after in vitro Dex-treatment. These findings suggest that we may need alternative treatment options to corticosteroids to prevent AE. EIF2AK2, MSRA and MSRB2 expressions on blood cells may help us select AE-susceptible asthmatics and adjust treatments to prevent AE. PMID: 32400129 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - May 15, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Basophil Activation Test Based on CD203c Expression in the Diagnosis of Fish Allergy.
CONCLUSIONS: The BAT score based on CD203c expression may be useful for fish allergy diagnosis, especially since a large variety of fish can be tested by the BAT using fish extracts prepared by a simple method. PMID: 32400130 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - May 15, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Altered Mitochondrial Functions and Morphologies in Epithelial Cells Are Associated With Pathogenesis of Chronic Rhinosinusitis With Nasal Polyps.
CONCLUSIONS: Production of mtROS, disrupted mitochondrial function, and structural changes in nasal epithelial cells might be involved in the pathogenesis of CRSwNP. PMID: 32400131 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - May 15, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Lung Disease Diagnostic Model Through IgG Sensitization to Microbial Extracellular Vesicles.
CONCLUSIONS: The results of this study suggest that ELISA-based analysis of anti-bacterial EV antibodies titers can be used as a diagnostic tool for lung disease. The present findings provide insights into the pathogenesis of lung disease as well as a foundation for developing a novel diagnostic methodology that synergizes microbial EV metagenomics and immune assays. PMID: 32400132 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - May 15, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Activation of Transient Receptor Potential Melastatin Family Member 8 (TRPM8) Receptors Induces Proinflammatory Cytokine Expressions in Bronchial Epithelial Cells.
Authors: Kim JH, Jang YS, Kim HI, Park JY, Park SH, Hwang YI, Jang SH, Jung KS, Park HS, Park CS Abstract PURPOSE: Cold air is a major environmental factor that exacerbates asthma. Transient receptor potential melastatin family member 8 (TRPM8) is a cold-sensing channel expressed in the airway epithelium. However, its role in airway inflammation remains unknown. We investigated the role of TRPM8 in innate immune responses in bronchial epithelial cells and asthmatic subjects. METHODS: The TRPM8 mRNA and protein expression on BEAS2B human bronchial epithelial cells was examined by real-time polymerase chain react...
Source: Allergy, Asthma and Immunology Research - May 15, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Combined Effects of Lactobacillus rhamnosus and Egg Oral Immunotherapy in a Mouse Model of Egg Allergy.
CONCLUSIONS: Lcr35 treatment during OIT had some synergic effect for protection against anaphylaxis in a mice model of egg allergy. These findings should be confirmed in future animal studies including more detailed immunological profiles and human studies. PMID: 32400134 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - May 15, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

In Vitro and In Vivo Validation of EP2-Receptor Agonism to Selectively Achieve Inhibition of Mast Cell Activity.
CONCLUSIONS: Selective EP2 agonism is a powerful pharmacological strategy to prevent MCs from being activated through IgE-mediated mechanisms and from causing deleterious effects. The MC EP2 receptor may be an effective pharmacological target in allergic and other MC-mediated conditions. PMID: 32400135 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - May 15, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Impact of Grilling Meat or Fish at Home on Peak Expiratory Flow Rate in Adults With Asthma.
Authors: Lee H, Chung SJ, Park JS, Kim S, Park DW, Sohn JW, Kim SH, Park CS, Yoon HJ Abstract Grilling, a common cooking method worldwide, can produce more toxic gases than other cooking methods. However, the impact of frequently grilling meat or fish at home on airflow limitation in adult asthma has not been well elucidated. We performed a prospective cohort study of 91 adult patients with asthma enrolled from 2 university hospitals. Of the patients, 39 (42.9%) grilled meat or fish at least once a week and 52 (57.1%) less than once a week. Patients who grilled at least once a week tended to have lower peak expirat...
Source: Allergy, Asthma and Immunology Research - May 15, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Management Practice of Allergic Rhinitis in China During the COVID-19 Pandemic.
Authors: Zhang Y, Zhang L PMID: 32400137 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - May 15, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Erratum: Factors Affecting Recovery Time of Pulmonary Function in Hospitalized Patients With Acute Asthma Exacerbations.
Authors: Kim HJ, Lee J, Kim JH, Park SY, Kwon HS, Kim TB, Moon HB, Cho YS Abstract This corrects the article on p. 499 in vol. 8, PMID: 27582400. PMID: 32400138 [PubMed - in process] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - May 15, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Erratum: In-Depth, Proteomic Analysis of Nasal Secretions from Patients With Chronic Rhinosinusitis and Nasal Polyps.
Authors: Kim YS, Han D, Kim J, Kim DW, Kim YM, Mo JH, Choi HG, Park JW, Shin HW Abstract This corrects the article on p. 691 in vol. 11, PMID: 31332980. PMID: 32400139 [PubMed - in process] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - May 15, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Does the Difference in Microbial Patterns in the Airways Induce Distinct Endotypes of Asthma?
Authors: Cho YJ PMID: 32141252 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - March 8, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Active Pharmacovigilance of Drug-Induced Liver Injury Using Electronic Health Records.
Authors: Kim SH PMID: 32141253 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - March 8, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Innate Lymphoid Cells in the Airways: Their Functions and Regulators.
Authors: Orimo K, Saito H, Matsumoto K, Morita H Abstract Since the airways are constantly exposed to various pathogens and foreign antigens, various kinds of cells in the airways-including structural cells and immune cells-interact to form a precise defense system against pathogens and antigens that involve both innate immunity and acquired immunity. Accumulating evidence suggests that innate lymphoid cells (ILCs) play critical roles in the maintenance of tissue homeostasis, defense against pathogens and the pathogenesis of inflammatory diseases, especially at body surface mucosal sites such as the airways. ILCs a...
Source: Allergy, Asthma and Immunology Research - March 8, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Understanding the Molecular Mechanisms of Asthma through Transcriptomics.
Authors: Park HW, Weiss ST Abstract The transcriptome represents the complete set of RNA transcripts that are produced by the genome under a specific circumstance or in a specific cell. High-throughput methods, including microarray and bulk RNA sequencing, as well as recent advances in biostatistics based on machine learning approaches provides a quick and effective way of identifying novel genes and pathways related to asthma, which is a heterogeneous disease with diverse pathophysiological mechanisms. In this manuscript, we briefly review how to analyze transcriptome data and then provide a summary of recent tran...
Source: Allergy, Asthma and Immunology Research - March 8, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research