What is the Optimal Method for Steroid Delivery in the Treatment of Chronic Rhinosinusitis With Nasal Polyps?
Authors: Hong SN, Kim DY PMID: 31172713 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - June 8, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Clinical and Laboratory Predictors of Egg Allergy Resolution in Children.
Authors: Kim JH PMID: 31172714 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - June 8, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

House Dust Mite Allergy Under Changing Environments.
Authors: Acevedo N, Zakzuk J, Caraballo L Abstract Environmental variations induced by industrialization and climate change partially explain the increase in prevalence and severity of allergic disease. One possible mechanism is the increase in allergen production leading to more exposure and sensitization in susceptible individuals. House dust mites (HDMs) are important sources of allergens inducing asthma and rhinitis, and experimentally they have been demonstrated to be very sensitive to microenvironment modifications; therefore, global or regional changes in temperature, humidity, air pollution or other environ...
Source: Allergy, Asthma and Immunology Research - June 8, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Emerging Therapies in Chronic Spontaneous Urticaria.
This article reviews its current status regarding pathogenesis and approach to treatment as well as therapeutic agents that are under development for the treatment of CSU. PMID: 31172716 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - June 8, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Comparison of Corticosteroids by 3 Approaches to the Treatment of Chronic Rhinosinusitis With Nasal Polyps.
Authors: Zhang Y, Lou H, Wang Y, Li Y, Zhang L, Wang C Abstract PURPOSE: Corticosteroids are regarded as the mainstay of medical treatment of eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP). To date, a head-to-head comparison of the efficacy and safety of glucocorticoid preparations administered via different routes for the treatment of chronic rhinosinusitis with nasal polyps has not been reported. To compare the efficacy and safety of steroids administered via the oral, intranasal spray and transnasal nebulization routes in the management of ECRSwNP over a short course. METHODS: Overall, 91 pa...
Source: Allergy, Asthma and Immunology Research - June 8, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Reduction Rate of Specific IgE Level as a Predictor of Persistent Egg Allergy in Children.
This study aimed to describe clinical characteristics and to identify prognostic factors associated with tolerance acquisition of immunoglobulin E (IgE)-mediated egg allergy in children. METHODS: Children who underwent more than 1 follow-up egg white-specific immunoglobulin E (EWsIgE) test between November 2005 and November 2015 at -Severance Children's Hospital were assessed. Children were diagnosed as having IgE-mediated egg allergy based on immediate allergic reaction after egg consumption and an EWsIgE level of> 0.35 kU/L. The children were divided into "tolerant" and "persistent" groups acco...
Source: Allergy, Asthma and Immunology Research - June 8, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Efficacy and Safety of Benralizumab for Korean Patients With Severe, Uncontrolled Eosinophilic Asthma.
Authors: Park HS, Lee SH, Lee SY, Kim MK, Lee BJ, Werkström V, Barker P, Zangrilli JG Abstract PURPOSE: In the Phase III SIROCCO trial (NCT01928771), benralizumab significantly reduced asthma exacerbations and improved lung function and symptoms for patients with severe, uncontrolled eosinophilic asthma. The aim of this subgroup analysis was to evaluate efficacy and safety of benralizumab for Korean patients in SIROCCO. METHODS: SIROCCO was a randomized, double-blind, parallel-group, placebo-controlled trial of 1,204 patients aged 12-75 years with severe asthma uncontrolled by high-dosage inhaled corticost...
Source: Allergy, Asthma and Immunology Research - June 8, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Add-on Tiotropium in Chinese Patients With Moderate Asthma: A Pooled Subgroup Analysis of MezzoTinA-Asthma 1 and 2.
This study aimed to assess the efficacy and safety of tiotropium in Chinese patients with moderate symptomatic asthma. METHODS: A post hoc subgroup analysis was conducted on 430 Chinese patients pooled from two 24-week, replicate phase 3 trials (NCT01172808 and NCT01172821), in which they received once-daily tiotropium 2.5 μg (Tio R2.5) or 5 μg (Tio R5) (n = 106 or 109, respectively), twice-daily salmeterol 50 μg (Sal 50) (n = 110), or placebo (n = 105), while maintaining inhaled corticosteroids (ICS). The co-primary endpoints assessed in week 24 were forced expiratory volume in 1 second (FEV1) peak0-3h respon...
Source: Allergy, Asthma and Immunology Research - June 8, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Underuse of Epinephrine for Pediatric Anaphylaxis Victims in the Emergency Department: A Population-based Study.
The objective of this study was to compare epinephrine use between pediatric and adult patients who were treated with anaphylaxis in the emergency department (ED). METHODS: The data were retrieved from the National Sample Cohort of South Korea, which contains claim data from the National Health Insurance Service. We included patients who visited the ED with a discharge code of anaphylaxis between 2004 and 2013. We assessed prescription information of epinephrine, antihistamine and systemic steroid, previous medical history and discharge disposition from the ED. The study population was categorized based on age at the v...
Source: Allergy, Asthma and Immunology Research - June 8, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Cold Urticaria: Clinical Features and Natural Course in a Tropical Country.
CONCLUSIONS: The rate of anaphylaxis in patients with ColdU in a tropical country was lower than those reported by other studies conducted intemperate climates. On the other hand, the number of female patients, mean age at symptom onset, atopy rate, rate of concomitant chronic spontaneous urticaria and mean CTT were higher. PMID: 31172722 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - June 8, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Combination Effect of Titrated Extract of Centella asiatica and Astaxanthin in a Mouse Model of Phthalic Anhydride-Induced Atopic Dermatitis.
CONCLUSIONS: Our results demonstrate that the combination of TECA and AST could be a promising therapeutic agent for AD by inhibiting NF-κB signaling. PMID: 31172723 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - June 8, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Protease-Activated Receptors 2-Antagonist Suppresses Asthma by Inhibiting Reactive Oxygen Species-Thymic Stromal Lymphopoietin Inflammation and Epithelial Tight Junction Degradation.
CONCLUSIONS: ROS generation and epidermal tight junction degradation are triggered by protease, followed by the induction of TSLP in allergic asthma. Our findings could suggest that PAR2-ant or anti-oxidants could be considered for allergic diseases as preventive alternatives. PMID: 31172724 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - June 8, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Association of Sensitization to Different Aeroallergens With Airway Function and Nasal Patency in Urban Children.
Authors: Lee S, Koh HY, Yon DK, Lee SW, Ha EK, Sung M, Lee KS, Jee HM, Sheen YH, Han MY Abstract PURPOSE: Children with sensitization to aeroallergens have decreased lung function and nasal patency. Our purpose was to determine the association of sensitization to different aeroallergens with airway function and nasal patency. METHODS: Four hundred and eighty-six randomly selected 11 year-old children who lived in Seongnam City were examined. Serum specific immunoglobulin E (IgE) levels against 6 common allergens (Dermatophagoidesfarinae, birch, cat, dog, Japanese hop and Alternaria), impulse oscillometry (IOS) ...
Source: Allergy, Asthma and Immunology Research - June 8, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

The First Case Series of Cryopyrin-Associated Periodic Syndrome in Korea.
Authors: Han JH, Je YJ, Yoon HJ, Ahn JG, Lee JS, Park JW, Park HJ Abstract Cryopyrin-associated periodic syndrome (CAPS) is a hereditary autoinflammatory syndrome caused by mutations in NLRP3 (encoding cryopyrin), which presents with fever, fatigue and arthralgia. Thus far, however there have been no reports of CAPS in Korea. Herein, we report 3 cases of CAPS for the first time in Korea. The first case, a 28-year-old man with recurrent urticaria, arthralgia and fever induced by cold, all of which were observed in his father, showed elevated erythrocyte sedimentation rate and C-reactive protein. He exhibited a p.Gly...
Source: Allergy, Asthma and Immunology Research - June 8, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Sphingosine-1-Phosphate: Biomarker, Contributor, or Target for Asthma?
Authors: Kim SH PMID: 30912319 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - March 27, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Is Trabecular Bone Score a More Sensitive Marker for Osteoporosis in Asthmatics?
Authors: Kim CW PMID: 30912320 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - March 27, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Influence of Intranasal Drugs on Human Nasal Mucociliary Clearance and Ciliary Beat Frequency.
This article discusses the current literature on the effects of different classes of intranasal drugs including intranasal corticosteroids, antihistamines, decongestants, antimicrobials and antivirals, as well as various drug excipients and nasal irrigation solutions on human nasal mucociliary clearance and ciliary beat frequency. Available data indicate that some intranasal formulations tend to hamper nasal ciliary function and mucociliary clearance. Therefore, it is of great importance to assess the effects of intranasal drugs and additives on mucociliary function before they are recommended as therapy for different nasa...
Source: Allergy, Asthma and Immunology Research - March 27, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Which Factors Associated With Activated Eosinophils Contribute to the Pathogenesis of Aspirin-Exacerbated Respiratory Disease?
Authors: Choi Y, Lee Y, Park HS Abstract Eosinophils have long been recognized as a central effector cell in the lungs of asthmatic patients. They contribute to airway inflammation and remodeling through releasing several molecules such as cytokines, granule proteins, lipid mediators and extracellular traps/vesicles. Repeated evidence reveals that intense eosinophil infiltration in upper and lower airway mucosae contributes to the pathogenesis of aspirin-exacerbated respiratory disease (AERD). Persistent eosinophilia is found to be associated with type 2 immune responses, cysteinyl leukotriene overproduction and eo...
Source: Allergy, Asthma and Immunology Research - March 27, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Altered Sphingolipid Metabolism Is Associated With Asthma Phenotype in House Dust Mite-Allergic Patients.
CONCLUSIONS: Altered sphingolipid metabolism, with augmented synthesis of S1P and impaired de novo sphingolipid synthesis in response to allergen challenge, may participate in the development of asthma phenotype in HDM-APs. PMID: 30912323 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - March 27, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Trabecular Bone Score Is More Sensitive to Asthma Severity and Glucocorticoid Treatment Than Bone Mineral Density in Asthmatics.
This study aimed to evaluate TBS in asthmatics in comparison to propensity score-matched controls and to investigate correlations between TBS and cumulative systemic and inhaled corticosteroid doses 1 year prior to bone mineral density (BMD) measurement in patients with asthma. METHODS: In total, 627 patients with asthma and the same number of non-asthmatic controls matched for sex and age were included in this retrospective cohort study. TBS was calculated in the lumbar region, based on 2 dimensional projections of dual-energy X-ray absorptiometry. RESULTS: Patients with severe asthma exhibited lower vertebral TBS...
Source: Allergy, Asthma and Immunology Research - March 27, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Leukocyte Telomere Length Reflects Prenatal Stress Exposure, But Does Not Predict Atopic Dermatitis Development at 1 Year.
CONCLUSIONS: Cord-blood LTL may reflect subjects' exposure to maternal prenatal stress. However, the LTL shortening is not a risk factor of increasing AD development until the age of 1, and a longer investigation may be necessary for validation. Currently, the results doubt the role of LTL shortening as a marker for risk assessment tool for the prenatal stress associated with AD development in the offspring. PMID: 30912325 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - March 27, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Nasal Nitric Oxide Is Correlated With Nasal Patency and Nasal Symptoms.
CONCLUSIONS: The nNO level can be significantly different between healthy and AR patients and may be significantly correlated with nasal symptoms and nasal patency of rhinitis patients. However, the clinical value of nNO is still in the exploration stage. PMID: 30912326 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - March 27, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Evaluation of Neutrophil Activation Status According to the Phenotypes of Adult Asthma.
This study assessed the activation status of neutrophils in adult asthmatics, and the therapeutic potential of FTY720, a synthetic sphingosine-1-phosphate analog, on activated neutrophils using an in vitro stimulation model. METHODS: We isolated peripheral blood neutrophils (PBNs) from 59 asthmatic patients (including 20 aspirin-exacerbated respiratory disease [AERD] and 39 aspirin-tolerant asthma [ATA] groups). PBNs were stimulated with N-formyl-methionyl-leucyl-phenylalanine (fMLP) or lipopolysaccharide (LPS) and their activation status was determined based on reactive oxygen species (ROS) production, cell surface ex...
Source: Allergy, Asthma and Immunology Research - March 27, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Serum Levels of Eosinophil-Derived Neurotoxin: A Biomarker for Asthma Severity in Adult Asthmatics.
Authors: Lee Y, Lee JH, Yang EM, Kwon E, Jung CG, Kim SC, Choi Y, Cho YS, Kim CK, Park HS Abstract PURPOSE: Eosinophilic inflammation is a key component of severe asthma (SA). However, there has been no reliable serum biomarker for the eosinophilic inflammation of SA. We hypothesized that serum eosinophil-derived neurotoxin (EDN) could predict the eosinophilic inflammation of SA in adult asthmatics. METHODS: Severe asthmatics (n = 235), nonsevere asthmatics (n = 898), and healthy controls (n = 125) were enrolled from Ajou University Hospital, South Korea. The serum levels of EDN and periostin were measured by e...
Source: Allergy, Asthma and Immunology Research - March 27, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Sputum Autoantibodies Are More Relevant in Autoimmune Responses in Asthma than Are Serum Autoantibodies.
Authors: Qin R, Long F, Xiao X, Xiao J, Zheng Z, Feng M, Huang R, Peng T, Li J Abstract PURPOSE: The data on the differences between sputum autoantibodies (Sp-Abs) and serum autoantibodies (Se-Abs) in reflection of autoimmune responses to lungs is still lacking. METHODS: Ten types of Abs were investigated in matched Se and Sp samples collected from recruited subjects. Correlations between Ab levels and airway inflammatory parameters and measures of pulmonary function were assessed. The network-based and inter-correlated analysis was performed to explore the patterns of Sp- and Se-Ab profiles. RESULTS: Fifty...
Source: Allergy, Asthma and Immunology Research - March 27, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Validation of PROTIA ™ Allergy-Q 64 Atopy® as a Specific IgE Measurement Assay for 10 Major Allergen Components.
CONCLUSIONS: PROTIA™ Allergy-Q 64 Atopy® is reliable and comparable to the ImmunoCAP® assay for component-resolved diagnosis. PMID: 30912330 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - March 27, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Hyperresponsiveness to Boiled Egg Yolk in Early Life Leads to Prolonged Egg Allergy.
Authors: Horino S, Kitazawa H, Satou T, Miura K Abstract Hen's egg is the most common allergen in IgE-mediated food allergy among children in Japan. Although the majority of patients with egg allergy can eat heated egg yolk safely because of its low allergenicity, severely allergic patients show an immediate-type reaction to heated egg yolk. We hypothesized that patients with hyperresponsiveness to boiled egg yolk may have difficulty in acquiring tolerance to egg. The purpose of this study was to examine the prognosis of patients with hyperresponsiveness to boiled egg yolk. Data from 121 patients with egg allergy w...
Source: Allergy, Asthma and Immunology Research - March 27, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Sublingual Immunotherapy for Japanese Cedar Pollinosis Attenuates Asthma Exacerbation.
Authors: Kikkawa S, Nakagome K, Kobayashi T, Soma T, Kamijo A, Nagata M PMID: 30912332 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - March 27, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Erratum: Pollen-Food Allergy Syndrome in Korean Pollinosis Patients: A Nationwide Survey.
Authors: Kim MA, Kim DK, Yang HJ, Yoo Y, Ahn Y, Park HS, Lee HJ, Jeong YY, Kim BS, Bae WY, Jang AS, Park Y, Koh YI, Lee J, Lim DH, Kim JH, Lee SM, Kim YM, Jun YJ, Kim HY, Kim Y, Choi JH, Work Group for Rhinitis, the Korean Academy of Asthma, Allergy and Clinical Immunology Abstract This corrects the article on p. 648 in vol. 10, PMID: 30306747. PMID: 30912333 [PubMed - in process] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - March 27, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Does Inflammatory Endotype can Change in Patients With Chronic Rhinosinusitis?
Authors: Kim DK, Kim DW PMID: 30661308 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - January 22, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Increasing Prevalence of Allergic Rhinitis in China.
Authors: Zhang Y, Zhang L Abstract Allergic rhinitis (AR) is a critical public health, medical and economic problem in China. AR is also an important risk factor which will cause many diseases or disorders, especially in children. The trend of AR incidence is still on the rise in recent years and has had a significant effect on the general public. This significant increase is alarming, which highlights an urgent need for better understanding of the prevalence status and characteristics, sensitization patterns, and the associated risk factors of AR in order to improve treatment and develop effective prevention strat...
Source: Allergy, Asthma and Immunology Research - January 22, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Lessons Learned From GWAS of Asthma.
Authors: Kim KW, Ober C Abstract Asthma is a common complex disease of the airways. Genome-wide association studies (GWASs) of asthma have identified many risk alleles and loci that have been replicated in worldwide populations. Although the risk alleles identified by GWAS have small effects and explain only a small portion of prevalence, the discovery of asthma loci can provide an understanding of its genetic architecture and the molecular pathways involved in disease pathogenesis. These discoveries can translate into advances in clinical care by identifying therapeutic targets, preventive strategies and ultimatel...
Source: Allergy, Asthma and Immunology Research - January 22, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Update on the Management of Occupational Asthma and Work-Exacerbated Asthma.
Authors: Lau A, Tarlo SM Abstract Work-related asthma is the most common occupational lung disease encountered in clinical practice. In adult asthmatics, work-relatedness can account for 15%-33% of cases, but delays in diagnosis remain common and lead to worse outcomes. Accurate diagnosis of asthma is the first step to managing occupational asthma, which can be sensitizer-induced or irritant-induced asthma. While latency has traditionally been recognized as a hallmark of sensitizer-induced asthma and rapid-onset a defining feature of irritant-induced asthma (as in Reactive Airway Dysfunction Syndrome), there is epi...
Source: Allergy, Asthma and Immunology Research - January 22, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Comparison Between Signature Cytokines of Nasal Tissues in Subtypes of Chronic Rhinosinusitis.
CONCLUSIONS: Commonly upregulated mediators in NP were Th2-associated, compared with UP regardless of CRS subtypes, whereas signature markers were distinct in each NP subtype. These findings imply that Th2 inflammatory responses may play a role in the development of NP regardless of CRSwNP subtypes. PMID: 30661312 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - January 22, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Phenotypes of Severe Cutaneous Adverse Reactions Caused by Nonsteroidal Anti-inflammatory Drugs.
CONCLUSIONS: The present study indicates that the phenotypes of SCARs may differ according to the chemical classifications of NSAIDs. To establish the mechanisms and incidences of NSAID-induced SCARs, further prospective studies are needed. PMID: 30661313 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - January 22, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Multicenter Adherence Study of Asthma Medication for Children in Korea.
Authors: Kim CK, Callaway Z, Choi J, Kim HB, Kwon EM, Chang YS, Rha YH, Hong SJ, Oh JW, Kim HH, Lim DH, Kim SW, Park KS, Cho YH, Chung HL, Park HJ, Jung SG, Kang IJ, Hyun MC, Oh MY, Jung JA, Kim MS, Shim JY, Kim JT, Koh YY, KAPARD Work Group on Asthma Medication Compliance Abstract PURPOSE: Adherence is a major component of successful medical treatment. However, non-adherence remains a barrier to effective delivery of healthcare worldwide. METHODS: Twenty healthcare facilities (secondary or tertiary hospitals) belonging to the Korean Academy of Pediatric Allergy and Respiratory Diseases (KAPARD) participated. Q...
Source: Allergy, Asthma and Immunology Research - January 22, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Eperisone-Induced Anaphylaxis: Pharmacovigilance Data and Results of Allergy Testing.
CONCLUSIONS: Incidence of eperisone-induced anaphylaxis calculated from the KIDS-KAERS database was 0.001%. Eperisone can cause hypersensitive reactions, including anaphylaxis, possibly by inducing non-immunoglobulin E-mediated immediate hypersensitivity. PMID: 30661315 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - January 22, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Severe Cutaneous Adverse Reactions in Korean Pediatric Patients: A Study From the Korea SCAR Registry.
CONCLUSIONS: In patients with pediatric SCARs, including those with DRESS, SJS and TEN, clinical presentations were variable. Thus, there was no clear continuous disease spectrum. Although the mortality rate was low (2.1%), clinical suspicion may be the best tool for proactive SCAR management. PMID: 30661316 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - January 22, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

A Fusion Protein of Derp2 Allergen and Flagellin Suppresses Experimental Allergic Asthma.
CONCLUSIONS: The Derp2-FlaB fusion protein showed a strong anti-asthma immunomodulatory capacity, leading to the prevention of airway inflammatory responses in a murine disease model through the inhibition of Th2 responses. These findings suggest that the Derp2-FlaB fusion protein would be a promising vaccine candidate for HDM-mediated allergic asthma therapy. PMID: 30661317 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - January 22, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Intranasal Treatment With 1, 25-Dihydroxyvitamin D3 Alleviates Allergic Rhinitis Symptoms in a Mouse Model.
CONCLUSIONS: The results confirm the antiallergic effect of intranasal 1,25-dihydroxyvitamin D3. It decreases CD 86 expression among CD11c⁺MHCIIhigh cells and T-helper type 2-mediated inflammation in the cervical LNs. Therefore, topically applied 1,25-dihydroxyvitamin D3 can be a future therapeutic agent for allergic rhinitis. PMID: 30661318 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - January 22, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Prescription Patterns and Burden of Pediatric Asthma in Korea.
CONCLUSIONS: The prevalence of pediatric asthma increased annually and decreased with age. Individual cost of asthma showed a decreasing trend in Korean children. PMID: 30661319 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - January 22, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Higher Binding Affinity and in vitro Potency of Reslizumab for Interleukin-5 Compared With Mepolizumab.
In conclusion, comparative assays show that reslizumab has higher affinity binding for and in vitro potency against human IL-5 compared with mepolizumab. However, these results do not take into consideration the different methods of administration of reslizumab and mepolizumab. PMID: 30661320 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - January 22, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Anti-TPO IgE Autoantibody in Chronic Urticaria: Is It Clinically Relevant?
Authors: Ulambayar B, Park HS PMID: 30479072 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - November 29, 2018 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Mechanisms by Which Atopic Dermatitis Predisposes to Food Allergy and the Atopic March.
Authors: Tham EH, Leung DY Abstract The Atopic march denotes the progression from atopic dermatitis (AD) to the development of other allergic disorders such as immunoglobulin (Ig) E-mediated food allergy, allergic rhinitis and asthma in later childhood. There is increasing evidence from prospective birth cohort studies that early-onset AD is a risk factor for other allergic diseases or is found in strong association with them. Animal studies now provide mechanistic insights into the pathways that may be responsible for triggering the progression from the skin barrier dysfunction seen in AD to epicutaneous sensitiza...
Source: Allergy, Asthma and Immunology Research - November 29, 2018 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Biomarkers for Recurrent Wheezing and Asthma in Preschool Children.
Authors: Lee YJ, Fujisawa T, Kim CK Abstract Wheezing is one of the characteristic symptoms of asthma, but all preschool children with wheezing are not diagnosed with asthma. Preschool children are not cooperative enough to participate in spirometry and invasive tests. Thus, there is no conventional method to diagnose asthma in preschool children. We reviewed studies on non-invasive biomarkers for assessing asthma in preschool children. Specimens that can be easily obtained by non-invasive methods are blood, exhaled breath and urine. Eosinophils, eosinophil cationic protein and eosinophil-derived neurotoxin (EDN) i...
Source: Allergy, Asthma and Immunology Research - November 29, 2018 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Characteristics of Adult Severe Refractory Asthma in Korea Analyzed From the Severe Asthma Registry.
CONCLUSIONS: The baseline characteristics of severe asthma patients in the Korea Severe Asthma Registry were analyzed and reported for the first time. With this cohort, further prospective studies should be performed to search for ways to improve management of severe refractory asthma. PMID: 30479076 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - November 29, 2018 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Adaptation and Validation of the Korean Version of the Urticaria Control Test and Its Correlation With Salivary Cortisone.
CONCLUSIONS: This study demonstrated that the K-UCT can be a valid instrument with which to gauge CU control status in Korean patients. Further studies are needed to validate salivary cortisone as a biomarker for CU control. PMID: 30479077 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - November 29, 2018 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Comparison of Long-term Efficacy of Subcutaneous Immunotherapy in Pediatric and Adult Patients With Allergic Rhinitis.
This study aimed to compare the long-term effects of HDM-SCIT in a cohort of Chinese pediatric and adult patients with AR. METHODS: A total of 124 pediatric and adult AR patients received HDM-SCIT for 3 years, with 118 patients being followed-up for 2 years. Prior to treatment (baseline), at the end of the 3-year treatment periods (third year) and 2 years after the discontinuation of treatment (fifth year), all patients were evaluated for total nasal symptom scores (TNSS), daily medication score (DMS), total combined score (TCS; symptoms [nasal + ocular] + DMS) and quality of life (QoL). Safety was assessed according t...
Source: Allergy, Asthma and Immunology Research - November 29, 2018 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Prevalence and Clinical Features of Drug Reactions With Eosinophilia and Systemic Symptoms Syndrome Caused by Antituberculosis Drugs: A Retrospective Cohort Study.
CONCLUSIONS: This study confirmed the prevalence of DRESS syndrome in a cohort of adult patients with tuberculosis. PMID: 30479080 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - November 29, 2018 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Different Biological Pathways Are Up-regulated in the Elderly With Asthma: Sputum Transcriptomic Analysis.
CONCLUSIONS: The findings of 2 distinct gene clusters in EA and different biological pathways in each gene cluster suggest 2 different pathogenesis mechanisms underlying EA. PMID: 30479081 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - November 29, 2018 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research