Medication Requirements for Disease Control Predict the Prognosis of Chronic Urticaria
Allergy Asthma Immunol Res. 2021 May;13(3):357-359. doi: 10.4168/aair.2021.13.3.357.NO ABSTRACTPMID:33733631 | PMC:PMC7984949 | DOI:10.4168/aair.2021.13.3.357 (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - March 18, 2021 Category: Allergy & Immunology Authors: Jeong Hee Choi Source Type: research

How do Host Genetic Factors Affect Gut Microbiome in the Development of Atopic Dermatitis?
Allergy Asthma Immunol Res. 2021 May;13(3):360-362. doi: 10.4168/aair.2021.13.3.360.NO ABSTRACTPMID:33733632 | PMC:PMC7984947 | DOI:10.4168/aair.2021.13.3.360 (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - March 18, 2021 Category: Allergy & Immunology Authors: Young Yoo Source Type: research

A Potential Role of Group 2 Innate Lymphoid Cells in Eosinophilic Chronic Rhinosinusitis With Nasal Polyps
Allergy Asthma Immunol Res. 2021 May;13(3):363-374. doi: 10.4168/aair.2021.13.3.363.ABSTRACTChronic rhinosinusitis with nasal polyps (CRSwNP), a type 2-based upper airway disease, is mainly characterized by high asthma comorbidity and recurrence after surgery. It has been shown that type 2 cytokines, including interleukin (IL)-4, IL-5, and IL-13 released from T helper 2 (Th2) cells as well as group 2 innate lymphoid cells (ILC2s), contribute to chronic inflammation of CRSwNP. This review summarizes recent progresses made in our understanding of ILC2 activity, particularly ILC2 accumulation at airway inflammation sites, coo...
Source: Allergy, Asthma and Immunology Research - March 18, 2021 Category: Allergy & Immunology Authors: Yan Li Wei Wang Sun Ying Feng Lan Luo Zhang Source Type: research

Biomarkers for Severe Asthma: Lessons From Longitudinal Cohort Studies
Allergy Asthma Immunol Res. 2021 May;13(3):375-389. doi: 10.4168/aair.2021.13.3.375.ABSTRACTSevere asthma (SA) is a heterogeneous disease characterized by uncontrolled symptoms, frequent exacerbations, and lung function decline. The discovery of phenotypes and endotypes of SA significantly improves our understanding of its pathophysiology and allows the advent of biologics blocking multiple molecular targets. The advances have mainly been made in type 2-high asthma associated with elevated type 2 inflammatory biomarkers such as immunoglobulin E (IgE), interleukins (IL)-4, IL-5, and IL-13. Previous clinical trials have demo...
Source: Allergy, Asthma and Immunology Research - March 18, 2021 Category: Allergy & Immunology Authors: Youngsoo Lee Quang Luu Quoc Hae Sim Park Source Type: research

Clustering the Clinical Course of Chronic Urticaria Using a Longitudinal Database: Effects on Urticaria Remission
Allergy Asthma Immunol Res. 2021 May;13(3):390-403. doi: 10.4168/aair.2021.13.3.390.ABSTRACTPURPOSE: Little is known about the clinical course of chronic urticaria (CU) and predictors of its prognosis. We evaluated CU patient clusters based on medication scores during the initial 3 months of treatment in an attempt to investigate time to remission and relapse rates for CU and to identify predictors for CU remission.METHODS: In total, 4,552 patients (57.9% female; mean age of 38.6 years) with CU were included in this retrospective cohort study. The K-medoids algorithm was used for clustering CU patients. Kaplan-Meier surviv...
Source: Allergy, Asthma and Immunology Research - March 18, 2021 Category: Allergy & Immunology Authors: Young Min Ye Jiwon Yoon Seong Dae Woo Jae Hyuk Jang Youngsoo Lee Hyun Young Lee Yoo Seob Shin Dong Ho Nahm Hae Sim Park Source Type: research

Interactions Between < em > IL-17 < /em > Variants and < em > Streptococcus < /em > in the Gut Contribute to the Development of Atopic Dermatitis in Infancy
CONCLUSIONS: These findings suggest that increased Streptococcus and A allele of IL-17 (rs2275913) may contribute to the pathogenesis of AD via modulation of the immune system in infancy.PMID:33733636 | PMC:PMC7984953 | DOI:10.4168/aair.2021.13.3.404 (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - March 18, 2021 Category: Allergy & Immunology Authors: Mi Jin Kang So Yeon Lee Yoon Mee Park Bong Soo Kim Min Jung Lee Jeong Hyun Kim Seonmi Jeong Seung Hwa Lee Min Jee Park Eun Sang Rhee Sungsu Jung Jisun Yoon Hyun Ju Cho Eun Lee Song I Yang Dong In Suh Kyung Won Kim Youn Ho Sheen Kangmo Ahn Soo Jong Hong Source Type: research

Risk Factors Predicting Severe Asthma Exacerbations in Adult Asthmatics: A Real-World Clinical Evidence
In this study, 5,058 adult asthmatics were enrolled; 1,335 (28.64%) experienced ≥ 1 SAE during the initial 2 years of treatment. Female sex, higher peripheral eosinophil/basophil counts, and lower levels of forced expiratory volume in 1 second (FEV1; %) were factors predicting the risk of SAEs (P
Source: Allergy, Asthma and Immunology Research - March 18, 2021 Category: Allergy & Immunology Authors: Ga Young Ban Su Chin Kim Hyun Young Lee Young Min Ye Yoo Seob Shin Hae Sim Park Source Type: research

Inhaled Corticosteroid and Secondary Glaucoma: A Meta-analysis of 18 Studies
CONCLUSIONS: The ophthalmological side effects of ICSs, such as glaucoma and intraocular hypertension, should not be exaggerated.TRIAL REGISTRATION: University Hospital Medical Information Network Center Clinical Trial Registry Identifier: UMIN000040351.PMID:33733638 | PMC:PMC7984945 | DOI:10.4168/aair.2021.13.3.435 (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - March 18, 2021 Category: Allergy & Immunology Authors: Mai Ishii Nobuyuki Horita Masaki Takeuchi Hiromi Matsumoto Risa Ebina-Shibuya Yu Hara Nobuaki Kobayashi Nobuhisa Mizuki Takeshi Kaneko Source Type: research

Hemopexin: A Novel Anti-inflammatory Marker for Distinguishing COPD From Asthma
CONCLUSIONS: Hemopexin can be a novel biomarker with superior diagnostic ability in differentiating COPD and asthma. We propose an anti-inflammatory axis between the airways and systemic circulation, in which hemopexin is a protective component in airway disease.PMID:33733639 | PMC:PMC7984952 | DOI:10.4168/aair.2021.13.3.450 (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - March 18, 2021 Category: Allergy & Immunology Authors: Natasha A Winter Peter G Gibson Michael Fricker Jodie L Simpson Peter A Wark Vanessa M McDonald Source Type: research

Harmful Effect of Indoor Formaldehyde on Atopic Dermatitis in Children: A Longitudinal Study
Allergy Asthma Immunol Res. 2021 May;13(3):468-478. doi: 10.4168/aair.2021.13.3.468.ABSTRACTPURPOSE: Evidence supporting a link between indoor formaldehyde exposure and atopic dermatitis (AD) in humans is limited. The purpose of this longitudinal study was to investigate whether AD symptoms in children could be affected by indoor formaldehyde levels in ordinary households.METHODS: Fifty-five children with moderate-to-severe AD aged under 18 years were enrolled as a panel. They were followed up from February 2019 through February 2020. Indoor formaldehyde levels of patients' houses and their AD symptoms were repeatedly meas...
Source: Allergy, Asthma and Immunology Research - March 18, 2021 Category: Allergy & Immunology Authors: Young Min Kim Jihyun Kim Seoung Chul Ha Kangmo Ahn Source Type: research

ATP6V0d2 Suppresses Alveoli Macrophage Alternative Polarization and Allergic Asthma via Degradation of PU.1
CONCLUSIONS: Our results identify macrophage Atp6v0d2, as an induced feedback inhibitor of asthma disease severity by promoting Pu.1 lysosomal degradation, which may in turn leads to reduced AAM polarization and Ccl17 production.PMID:33733641 | PMC:PMC7984956 | DOI:10.4168/aair.2021.13.3.479 (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - March 18, 2021 Category: Allergy & Immunology Authors: Na Liu Yuchen Feng Huicheng Liu Wenliang Wu Yuxia Liang Pingfei Li Zhengping Wei Min Wu Zhao Hui Tang Junyan Han Xiang Cheng Zheng Liu Arian Laurence Huabin Li Guohua Zhen Xiang Ping Yang Source Type: research

Elevated MRGPRX2 Levels Related to Disease Severity in Patients With Chronic Spontaneous Urticaria
In conclusion, we suggest that serum MRGPRX2 could help indicate severe CSU.PMID:33733642 | PMC:PMC7984951 | DOI:10.4168/aair.2021.13.3.498 (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - March 18, 2021 Category: Allergy & Immunology Authors: Thi Bich Tra Cao Hyun Young Cha Eun Mi Yang Young Min Ye Source Type: research

Specialist Perception of Severe Asthma in Korea: A Questionnaire Survey
Allergy Asthma Immunol Res. 2021 May;13(3):507-514. doi: 10.4168/aair.2021.13.3.507.ABSTRACTThe Working Group on Severe Asthma of the Korean Academy of Allergy and Clinical Immunology recently published an expert opinion paper on the management of severe asthma in Korea. When developing a consensus, the working group encountered several diagnostic and treatment issues and decided to perform a questionnaire survey of Korean specialists with regard to severe asthma. An e-mail with a uniform resource locator link to the questionnaire was sent to 121 asthma specialists, of whom 44.6% responded. The most commonly accepted defin...
Source: Allergy, Asthma and Immunology Research - March 18, 2021 Category: Allergy & Immunology Authors: Mi Ae Kim Heung Woo Park Byung Keun Kim So Young Park Ga Young Ban Ji Hyang Lee Jin An Ji Su Shim Youngsoo Lee Ha Kyeong Won Hwa Young Lee Kyoung Hee Sohn Sung Yoon Kang So Young Park Hyun Lee Min Hye Kim Jae Woo Kwon Sun Young Yoon Jae Hyun Lee Chin Kook Source Type: research

Safety of Omalizumab During Pregnancy and Breast-Feeding With Assessment of Placental Transfer: A Case Report
Allergy Asthma Immunol Res. 2021 May;13(3):515-516. doi: 10.4168/aair.2021.13.3.515.NO ABSTRACTPMID:33733644 | PMC:PMC7984957 | DOI:10.4168/aair.2021.13.3.515 (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - March 18, 2021 Category: Allergy & Immunology Authors: Doriane Majou Baptiste Moreira Cl émence Martin St éphanie Chhun Jean Marc Treluyer Vassilis Tsatsaris Laurent Chouchana Source Type: research

Fatal anaphylaxis Due to Nafamostat Mesylate During Hemodialysis
Allergy Asthma Immunol Res. 2021 May;13(3):517-519. doi: 10.4168/aair.2021.13.3.517.NO ABSTRACTPMID:33733645 | PMC:PMC7984943 | DOI:10.4168/aair.2021.13.3.517 (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - March 18, 2021 Category: Allergy & Immunology Authors: Joo Hee Kim Ji Young Park Seung Hun Jang Jwa Kyung Kim Young Rim Song Hyung Seok Lee Sung Gyun Kim Source Type: research

Medication Requirements for Disease Control Predict the Prognosis of Chronic Urticaria
Allergy Asthma Immunol Res. 2021 May;13(3):357-359. doi: 10.4168/aair.2021.13.3.357.NO ABSTRACTPMID:33733631 | PMC:PMC7984949 | DOI:10.4168/aair.2021.13.3.357 (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - March 18, 2021 Category: Allergy & Immunology Authors: Jeong Hee Choi Source Type: research

How do Host Genetic Factors Affect Gut Microbiome in the Development of Atopic Dermatitis?
Allergy Asthma Immunol Res. 2021 May;13(3):360-362. doi: 10.4168/aair.2021.13.3.360.NO ABSTRACTPMID:33733632 | PMC:PMC7984947 | DOI:10.4168/aair.2021.13.3.360 (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - March 18, 2021 Category: Allergy & Immunology Authors: Young Yoo Source Type: research

A Potential Role of Group 2 Innate Lymphoid Cells in Eosinophilic Chronic Rhinosinusitis With Nasal Polyps
Allergy Asthma Immunol Res. 2021 May;13(3):363-374. doi: 10.4168/aair.2021.13.3.363.ABSTRACTChronic rhinosinusitis with nasal polyps (CRSwNP), a type 2-based upper airway disease, is mainly characterized by high asthma comorbidity and recurrence after surgery. It has been shown that type 2 cytokines, including interleukin (IL)-4, IL-5, and IL-13 released from T helper 2 (Th2) cells as well as group 2 innate lymphoid cells (ILC2s), contribute to chronic inflammation of CRSwNP. This review summarizes recent progresses made in our understanding of ILC2 activity, particularly ILC2 accumulation at airway inflammation sites, coo...
Source: Allergy, Asthma and Immunology Research - March 18, 2021 Category: Allergy & Immunology Authors: Yan Li Wei Wang Sun Ying Feng Lan Luo Zhang Source Type: research

Biomarkers for Severe Asthma: Lessons From Longitudinal Cohort Studies
Allergy Asthma Immunol Res. 2021 May;13(3):375-389. doi: 10.4168/aair.2021.13.3.375.ABSTRACTSevere asthma (SA) is a heterogeneous disease characterized by uncontrolled symptoms, frequent exacerbations, and lung function decline. The discovery of phenotypes and endotypes of SA significantly improves our understanding of its pathophysiology and allows the advent of biologics blocking multiple molecular targets. The advances have mainly been made in type 2-high asthma associated with elevated type 2 inflammatory biomarkers such as immunoglobulin E (IgE), interleukins (IL)-4, IL-5, and IL-13. Previous clinical trials have demo...
Source: Allergy, Asthma and Immunology Research - March 18, 2021 Category: Allergy & Immunology Authors: Youngsoo Lee Quang Luu Quoc Hae Sim Park Source Type: research

Clustering the Clinical Course of Chronic Urticaria Using a Longitudinal Database: Effects on Urticaria Remission
Allergy Asthma Immunol Res. 2021 May;13(3):390-403. doi: 10.4168/aair.2021.13.3.390.ABSTRACTPURPOSE: Little is known about the clinical course of chronic urticaria (CU) and predictors of its prognosis. We evaluated CU patient clusters based on medication scores during the initial 3 months of treatment in an attempt to investigate time to remission and relapse rates for CU and to identify predictors for CU remission.METHODS: In total, 4,552 patients (57.9% female; mean age of 38.6 years) with CU were included in this retrospective cohort study. The K-medoids algorithm was used for clustering CU patients. Kaplan-Meier surviv...
Source: Allergy, Asthma and Immunology Research - March 18, 2021 Category: Allergy & Immunology Authors: Young Min Ye Jiwon Yoon Seong Dae Woo Jae Hyuk Jang Youngsoo Lee Hyun Young Lee Yoo Seob Shin Dong Ho Nahm Hae Sim Park Source Type: research

Interactions Between < em > IL-17 < /em > Variants and < em > Streptococcus < /em > in the Gut Contribute to the Development of Atopic Dermatitis in Infancy
CONCLUSIONS: These findings suggest that increased Streptococcus and A allele of IL-17 (rs2275913) may contribute to the pathogenesis of AD via modulation of the immune system in infancy.PMID:33733636 | PMC:PMC7984953 | DOI:10.4168/aair.2021.13.3.404 (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - March 18, 2021 Category: Allergy & Immunology Authors: Mi Jin Kang So Yeon Lee Yoon Mee Park Bong Soo Kim Min Jung Lee Jeong Hyun Kim Seonmi Jeong Seung Hwa Lee Min Jee Park Eun Sang Rhee Sungsu Jung Jisun Yoon Hyun Ju Cho Eun Lee Song I Yang Dong In Suh Kyung Won Kim Youn Ho Sheen Kangmo Ahn Soo Jong Hong Source Type: research

Risk Factors Predicting Severe Asthma Exacerbations in Adult Asthmatics: A Real-World Clinical Evidence
In this study, 5,058 adult asthmatics were enrolled; 1,335 (28.64%) experienced ≥ 1 SAE during the initial 2 years of treatment. Female sex, higher peripheral eosinophil/basophil counts, and lower levels of forced expiratory volume in 1 second (FEV1; %) were factors predicting the risk of SAEs (P
Source: Allergy, Asthma and Immunology Research - March 18, 2021 Category: Allergy & Immunology Authors: Ga Young Ban Su Chin Kim Hyun Young Lee Young Min Ye Yoo Seob Shin Hae Sim Park Source Type: research

Inhaled Corticosteroid and Secondary Glaucoma: A Meta-analysis of 18 Studies
CONCLUSIONS: The ophthalmological side effects of ICSs, such as glaucoma and intraocular hypertension, should not be exaggerated.TRIAL REGISTRATION: University Hospital Medical Information Network Center Clinical Trial Registry Identifier: UMIN000040351.PMID:33733638 | PMC:PMC7984945 | DOI:10.4168/aair.2021.13.3.435 (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - March 18, 2021 Category: Allergy & Immunology Authors: Mai Ishii Nobuyuki Horita Masaki Takeuchi Hiromi Matsumoto Risa Ebina-Shibuya Yu Hara Nobuaki Kobayashi Nobuhisa Mizuki Takeshi Kaneko Source Type: research

Hemopexin: A Novel Anti-inflammatory Marker for Distinguishing COPD From Asthma
CONCLUSIONS: Hemopexin can be a novel biomarker with superior diagnostic ability in differentiating COPD and asthma. We propose an anti-inflammatory axis between the airways and systemic circulation, in which hemopexin is a protective component in airway disease.PMID:33733639 | PMC:PMC7984952 | DOI:10.4168/aair.2021.13.3.450 (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - March 18, 2021 Category: Allergy & Immunology Authors: Natasha A Winter Peter G Gibson Michael Fricker Jodie L Simpson Peter A Wark Vanessa M McDonald Source Type: research

Harmful Effect of Indoor Formaldehyde on Atopic Dermatitis in Children: A Longitudinal Study
Allergy Asthma Immunol Res. 2021 May;13(3):468-478. doi: 10.4168/aair.2021.13.3.468.ABSTRACTPURPOSE: Evidence supporting a link between indoor formaldehyde exposure and atopic dermatitis (AD) in humans is limited. The purpose of this longitudinal study was to investigate whether AD symptoms in children could be affected by indoor formaldehyde levels in ordinary households.METHODS: Fifty-five children with moderate-to-severe AD aged under 18 years were enrolled as a panel. They were followed up from February 2019 through February 2020. Indoor formaldehyde levels of patients' houses and their AD symptoms were repeatedly meas...
Source: Allergy, Asthma and Immunology Research - March 18, 2021 Category: Allergy & Immunology Authors: Young Min Kim Jihyun Kim Seoung Chul Ha Kangmo Ahn Source Type: research

ATP6V0d2 Suppresses Alveoli Macrophage Alternative Polarization and Allergic Asthma via Degradation of PU.1
CONCLUSIONS: Our results identify macrophage Atp6v0d2, as an induced feedback inhibitor of asthma disease severity by promoting Pu.1 lysosomal degradation, which may in turn leads to reduced AAM polarization and Ccl17 production.PMID:33733641 | PMC:PMC7984956 | DOI:10.4168/aair.2021.13.3.479 (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - March 18, 2021 Category: Allergy & Immunology Authors: Na Liu Yuchen Feng Huicheng Liu Wenliang Wu Yuxia Liang Pingfei Li Zhengping Wei Min Wu Zhao Hui Tang Junyan Han Xiang Cheng Zheng Liu Arian Laurence Huabin Li Guohua Zhen Xiang Ping Yang Source Type: research

Elevated MRGPRX2 Levels Related to Disease Severity in Patients With Chronic Spontaneous Urticaria
In conclusion, we suggest that serum MRGPRX2 could help indicate severe CSU.PMID:33733642 | PMC:PMC7984951 | DOI:10.4168/aair.2021.13.3.498 (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - March 18, 2021 Category: Allergy & Immunology Authors: Thi Bich Tra Cao Hyun Young Cha Eun Mi Yang Young Min Ye Source Type: research

Specialist Perception of Severe Asthma in Korea: A Questionnaire Survey
Allergy Asthma Immunol Res. 2021 May;13(3):507-514. doi: 10.4168/aair.2021.13.3.507.ABSTRACTThe Working Group on Severe Asthma of the Korean Academy of Allergy and Clinical Immunology recently published an expert opinion paper on the management of severe asthma in Korea. When developing a consensus, the working group encountered several diagnostic and treatment issues and decided to perform a questionnaire survey of Korean specialists with regard to severe asthma. An e-mail with a uniform resource locator link to the questionnaire was sent to 121 asthma specialists, of whom 44.6% responded. The most commonly accepted defin...
Source: Allergy, Asthma and Immunology Research - March 18, 2021 Category: Allergy & Immunology Authors: Mi Ae Kim Heung Woo Park Byung Keun Kim So Young Park Ga Young Ban Ji Hyang Lee Jin An Ji Su Shim Youngsoo Lee Ha Kyeong Won Hwa Young Lee Kyoung Hee Sohn Sung Yoon Kang So Young Park Hyun Lee Min Hye Kim Jae Woo Kwon Sun Young Yoon Jae Hyun Lee Chin Kook Source Type: research

Safety of Omalizumab During Pregnancy and Breast-Feeding With Assessment of Placental Transfer: A Case Report
Allergy Asthma Immunol Res. 2021 May;13(3):515-516. doi: 10.4168/aair.2021.13.3.515.NO ABSTRACTPMID:33733644 | PMC:PMC7984957 | DOI:10.4168/aair.2021.13.3.515 (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - March 18, 2021 Category: Allergy & Immunology Authors: Doriane Majou Baptiste Moreira Cl émence Martin St éphanie Chhun Jean Marc Treluyer Vassilis Tsatsaris Laurent Chouchana Source Type: research

Fatal anaphylaxis Due to Nafamostat Mesylate During Hemodialysis
Allergy Asthma Immunol Res. 2021 May;13(3):517-519. doi: 10.4168/aair.2021.13.3.517.NO ABSTRACTPMID:33733645 | PMC:PMC7984943 | DOI:10.4168/aair.2021.13.3.517 (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - March 18, 2021 Category: Allergy & Immunology Authors: Joo Hee Kim Ji Young Park Seung Hun Jang Jwa Kyung Kim Young Rim Song Hyung Seok Lee Sung Gyun Kim Source Type: research

Medication Requirements for Disease Control Predict the Prognosis of Chronic Urticaria
Allergy Asthma Immunol Res. 2021 May;13(3):357-359. doi: 10.4168/aair.2021.13.3.357.NO ABSTRACTPMID:33733631 | PMC:PMC7984949 | DOI:10.4168/aair.2021.13.3.357 (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - March 18, 2021 Category: Allergy & Immunology Authors: Jeong Hee Choi Source Type: research

How do Host Genetic Factors Affect Gut Microbiome in the Development of Atopic Dermatitis?
Allergy Asthma Immunol Res. 2021 May;13(3):360-362. doi: 10.4168/aair.2021.13.3.360.NO ABSTRACTPMID:33733632 | PMC:PMC7984947 | DOI:10.4168/aair.2021.13.3.360 (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - March 18, 2021 Category: Allergy & Immunology Authors: Young Yoo Source Type: research

A Potential Role of Group 2 Innate Lymphoid Cells in Eosinophilic Chronic Rhinosinusitis With Nasal Polyps
Allergy Asthma Immunol Res. 2021 May;13(3):363-374. doi: 10.4168/aair.2021.13.3.363.ABSTRACTChronic rhinosinusitis with nasal polyps (CRSwNP), a type 2-based upper airway disease, is mainly characterized by high asthma comorbidity and recurrence after surgery. It has been shown that type 2 cytokines, including interleukin (IL)-4, IL-5, and IL-13 released from T helper 2 (Th2) cells as well as group 2 innate lymphoid cells (ILC2s), contribute to chronic inflammation of CRSwNP. This review summarizes recent progresses made in our understanding of ILC2 activity, particularly ILC2 accumulation at airway inflammation sites, coo...
Source: Allergy, Asthma and Immunology Research - March 18, 2021 Category: Allergy & Immunology Authors: Yan Li Wei Wang Sun Ying Feng Lan Luo Zhang Source Type: research

Biomarkers for Severe Asthma: Lessons From Longitudinal Cohort Studies
Allergy Asthma Immunol Res. 2021 May;13(3):375-389. doi: 10.4168/aair.2021.13.3.375.ABSTRACTSevere asthma (SA) is a heterogeneous disease characterized by uncontrolled symptoms, frequent exacerbations, and lung function decline. The discovery of phenotypes and endotypes of SA significantly improves our understanding of its pathophysiology and allows the advent of biologics blocking multiple molecular targets. The advances have mainly been made in type 2-high asthma associated with elevated type 2 inflammatory biomarkers such as immunoglobulin E (IgE), interleukins (IL)-4, IL-5, and IL-13. Previous clinical trials have demo...
Source: Allergy, Asthma and Immunology Research - March 18, 2021 Category: Allergy & Immunology Authors: Youngsoo Lee Quang Luu Quoc Hae Sim Park Source Type: research

Clustering the Clinical Course of Chronic Urticaria Using a Longitudinal Database: Effects on Urticaria Remission
Allergy Asthma Immunol Res. 2021 May;13(3):390-403. doi: 10.4168/aair.2021.13.3.390.ABSTRACTPURPOSE: Little is known about the clinical course of chronic urticaria (CU) and predictors of its prognosis. We evaluated CU patient clusters based on medication scores during the initial 3 months of treatment in an attempt to investigate time to remission and relapse rates for CU and to identify predictors for CU remission.METHODS: In total, 4,552 patients (57.9% female; mean age of 38.6 years) with CU were included in this retrospective cohort study. The K-medoids algorithm was used for clustering CU patients. Kaplan-Meier surviv...
Source: Allergy, Asthma and Immunology Research - March 18, 2021 Category: Allergy & Immunology Authors: Young Min Ye Jiwon Yoon Seong Dae Woo Jae Hyuk Jang Youngsoo Lee Hyun Young Lee Yoo Seob Shin Dong Ho Nahm Hae Sim Park Source Type: research

Interactions Between < em > IL-17 < /em > Variants and < em > Streptococcus < /em > in the Gut Contribute to the Development of Atopic Dermatitis in Infancy
CONCLUSIONS: These findings suggest that increased Streptococcus and A allele of IL-17 (rs2275913) may contribute to the pathogenesis of AD via modulation of the immune system in infancy.PMID:33733636 | PMC:PMC7984953 | DOI:10.4168/aair.2021.13.3.404 (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - March 18, 2021 Category: Allergy & Immunology Authors: Mi Jin Kang So Yeon Lee Yoon Mee Park Bong Soo Kim Min Jung Lee Jeong Hyun Kim Seonmi Jeong Seung Hwa Lee Min Jee Park Eun Sang Rhee Sungsu Jung Jisun Yoon Hyun Ju Cho Eun Lee Song I Yang Dong In Suh Kyung Won Kim Youn Ho Sheen Kangmo Ahn Soo Jong Hong Source Type: research

Risk Factors Predicting Severe Asthma Exacerbations in Adult Asthmatics: A Real-World Clinical Evidence
In this study, 5,058 adult asthmatics were enrolled; 1,335 (28.64%) experienced ≥ 1 SAE during the initial 2 years of treatment. Female sex, higher peripheral eosinophil/basophil counts, and lower levels of forced expiratory volume in 1 second (FEV1; %) were factors predicting the risk of SAEs (P
Source: Allergy, Asthma and Immunology Research - March 18, 2021 Category: Allergy & Immunology Authors: Ga Young Ban Su Chin Kim Hyun Young Lee Young Min Ye Yoo Seob Shin Hae Sim Park Source Type: research

Inhaled Corticosteroid and Secondary Glaucoma: A Meta-analysis of 18 Studies
CONCLUSIONS: The ophthalmological side effects of ICSs, such as glaucoma and intraocular hypertension, should not be exaggerated.TRIAL REGISTRATION: University Hospital Medical Information Network Center Clinical Trial Registry Identifier: UMIN000040351.PMID:33733638 | PMC:PMC7984945 | DOI:10.4168/aair.2021.13.3.435 (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - March 18, 2021 Category: Allergy & Immunology Authors: Mai Ishii Nobuyuki Horita Masaki Takeuchi Hiromi Matsumoto Risa Ebina-Shibuya Yu Hara Nobuaki Kobayashi Nobuhisa Mizuki Takeshi Kaneko Source Type: research

Hemopexin: A Novel Anti-inflammatory Marker for Distinguishing COPD From Asthma
CONCLUSIONS: Hemopexin can be a novel biomarker with superior diagnostic ability in differentiating COPD and asthma. We propose an anti-inflammatory axis between the airways and systemic circulation, in which hemopexin is a protective component in airway disease.PMID:33733639 | PMC:PMC7984952 | DOI:10.4168/aair.2021.13.3.450 (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - March 18, 2021 Category: Allergy & Immunology Authors: Natasha A Winter Peter G Gibson Michael Fricker Jodie L Simpson Peter A Wark Vanessa M McDonald Source Type: research

Harmful Effect of Indoor Formaldehyde on Atopic Dermatitis in Children: A Longitudinal Study
Allergy Asthma Immunol Res. 2021 May;13(3):468-478. doi: 10.4168/aair.2021.13.3.468.ABSTRACTPURPOSE: Evidence supporting a link between indoor formaldehyde exposure and atopic dermatitis (AD) in humans is limited. The purpose of this longitudinal study was to investigate whether AD symptoms in children could be affected by indoor formaldehyde levels in ordinary households.METHODS: Fifty-five children with moderate-to-severe AD aged under 18 years were enrolled as a panel. They were followed up from February 2019 through February 2020. Indoor formaldehyde levels of patients' houses and their AD symptoms were repeatedly meas...
Source: Allergy, Asthma and Immunology Research - March 18, 2021 Category: Allergy & Immunology Authors: Young Min Kim Jihyun Kim Seoung Chul Ha Kangmo Ahn Source Type: research

ATP6V0d2 Suppresses Alveoli Macrophage Alternative Polarization and Allergic Asthma via Degradation of PU.1
CONCLUSIONS: Our results identify macrophage Atp6v0d2, as an induced feedback inhibitor of asthma disease severity by promoting Pu.1 lysosomal degradation, which may in turn leads to reduced AAM polarization and Ccl17 production.PMID:33733641 | PMC:PMC7984956 | DOI:10.4168/aair.2021.13.3.479 (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - March 18, 2021 Category: Allergy & Immunology Authors: Na Liu Yuchen Feng Huicheng Liu Wenliang Wu Yuxia Liang Pingfei Li Zhengping Wei Min Wu Zhao Hui Tang Junyan Han Xiang Cheng Zheng Liu Arian Laurence Huabin Li Guohua Zhen Xiang Ping Yang Source Type: research

Elevated MRGPRX2 Levels Related to Disease Severity in Patients With Chronic Spontaneous Urticaria
In conclusion, we suggest that serum MRGPRX2 could help indicate severe CSU.PMID:33733642 | PMC:PMC7984951 | DOI:10.4168/aair.2021.13.3.498 (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - March 18, 2021 Category: Allergy & Immunology Authors: Thi Bich Tra Cao Hyun Young Cha Eun Mi Yang Young Min Ye Source Type: research

Specialist Perception of Severe Asthma in Korea: A Questionnaire Survey
Allergy Asthma Immunol Res. 2021 May;13(3):507-514. doi: 10.4168/aair.2021.13.3.507.ABSTRACTThe Working Group on Severe Asthma of the Korean Academy of Allergy and Clinical Immunology recently published an expert opinion paper on the management of severe asthma in Korea. When developing a consensus, the working group encountered several diagnostic and treatment issues and decided to perform a questionnaire survey of Korean specialists with regard to severe asthma. An e-mail with a uniform resource locator link to the questionnaire was sent to 121 asthma specialists, of whom 44.6% responded. The most commonly accepted defin...
Source: Allergy, Asthma and Immunology Research - March 18, 2021 Category: Allergy & Immunology Authors: Mi Ae Kim Heung Woo Park Byung Keun Kim So Young Park Ga Young Ban Ji Hyang Lee Jin An Ji Su Shim Youngsoo Lee Ha Kyeong Won Hwa Young Lee Kyoung Hee Sohn Sung Yoon Kang So Young Park Hyun Lee Min Hye Kim Jae Woo Kwon Sun Young Yoon Jae Hyun Lee Chin Kook Source Type: research

Safety of Omalizumab During Pregnancy and Breast-Feeding With Assessment of Placental Transfer: A Case Report
Allergy Asthma Immunol Res. 2021 May;13(3):515-516. doi: 10.4168/aair.2021.13.3.515.NO ABSTRACTPMID:33733644 | PMC:PMC7984957 | DOI:10.4168/aair.2021.13.3.515 (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - March 18, 2021 Category: Allergy & Immunology Authors: Doriane Majou Baptiste Moreira Cl émence Martin St éphanie Chhun Jean Marc Treluyer Vassilis Tsatsaris Laurent Chouchana Source Type: research

Fatal anaphylaxis Due to Nafamostat Mesylate During Hemodialysis
Allergy Asthma Immunol Res. 2021 May;13(3):517-519. doi: 10.4168/aair.2021.13.3.517.NO ABSTRACTPMID:33733645 | PMC:PMC7984943 | DOI:10.4168/aair.2021.13.3.517 (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - March 18, 2021 Category: Allergy & Immunology Authors: Joo Hee Kim Ji Young Park Seung Hun Jang Jwa Kyung Kim Young Rim Song Hyung Seok Lee Sung Gyun Kim Source Type: research

Medication Requirements for Disease Control Predict the Prognosis of Chronic Urticaria
Allergy Asthma Immunol Res. 2021 May;13(3):357-359. doi: 10.4168/aair.2021.13.3.357.NO ABSTRACTPMID:33733631 | PMC:PMC7984949 | DOI:10.4168/aair.2021.13.3.357 (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - March 18, 2021 Category: Allergy & Immunology Authors: Jeong Hee Choi Source Type: research

How do Host Genetic Factors Affect Gut Microbiome in the Development of Atopic Dermatitis?
Allergy Asthma Immunol Res. 2021 May;13(3):360-362. doi: 10.4168/aair.2021.13.3.360.NO ABSTRACTPMID:33733632 | PMC:PMC7984947 | DOI:10.4168/aair.2021.13.3.360 (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - March 18, 2021 Category: Allergy & Immunology Authors: Young Yoo Source Type: research

A Potential Role of Group 2 Innate Lymphoid Cells in Eosinophilic Chronic Rhinosinusitis With Nasal Polyps
Allergy Asthma Immunol Res. 2021 May;13(3):363-374. doi: 10.4168/aair.2021.13.3.363.ABSTRACTChronic rhinosinusitis with nasal polyps (CRSwNP), a type 2-based upper airway disease, is mainly characterized by high asthma comorbidity and recurrence after surgery. It has been shown that type 2 cytokines, including interleukin (IL)-4, IL-5, and IL-13 released from T helper 2 (Th2) cells as well as group 2 innate lymphoid cells (ILC2s), contribute to chronic inflammation of CRSwNP. This review summarizes recent progresses made in our understanding of ILC2 activity, particularly ILC2 accumulation at airway inflammation sites, coo...
Source: Allergy, Asthma and Immunology Research - March 18, 2021 Category: Allergy & Immunology Authors: Yan Li Wei Wang Sun Ying Feng Lan Luo Zhang Source Type: research

Biomarkers for Severe Asthma: Lessons From Longitudinal Cohort Studies
Allergy Asthma Immunol Res. 2021 May;13(3):375-389. doi: 10.4168/aair.2021.13.3.375.ABSTRACTSevere asthma (SA) is a heterogeneous disease characterized by uncontrolled symptoms, frequent exacerbations, and lung function decline. The discovery of phenotypes and endotypes of SA significantly improves our understanding of its pathophysiology and allows the advent of biologics blocking multiple molecular targets. The advances have mainly been made in type 2-high asthma associated with elevated type 2 inflammatory biomarkers such as immunoglobulin E (IgE), interleukins (IL)-4, IL-5, and IL-13. Previous clinical trials have demo...
Source: Allergy, Asthma and Immunology Research - March 18, 2021 Category: Allergy & Immunology Authors: Youngsoo Lee Quang Luu Quoc Hae Sim Park Source Type: research

Clustering the Clinical Course of Chronic Urticaria Using a Longitudinal Database: Effects on Urticaria Remission
Allergy Asthma Immunol Res. 2021 May;13(3):390-403. doi: 10.4168/aair.2021.13.3.390.ABSTRACTPURPOSE: Little is known about the clinical course of chronic urticaria (CU) and predictors of its prognosis. We evaluated CU patient clusters based on medication scores during the initial 3 months of treatment in an attempt to investigate time to remission and relapse rates for CU and to identify predictors for CU remission.METHODS: In total, 4,552 patients (57.9% female; mean age of 38.6 years) with CU were included in this retrospective cohort study. The K-medoids algorithm was used for clustering CU patients. Kaplan-Meier surviv...
Source: Allergy, Asthma and Immunology Research - March 18, 2021 Category: Allergy & Immunology Authors: Young Min Ye Jiwon Yoon Seong Dae Woo Jae Hyuk Jang Youngsoo Lee Hyun Young Lee Yoo Seob Shin Dong Ho Nahm Hae Sim Park Source Type: research