Impact of Chronic Urticaria on the Self-Assessed Health Status.
Authors: Lee JH PMID: 32400123 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - May 15, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Is TLR4 Critical for Neutrophil Apoptosis in Occupational Asthma?
Authors: Choi Y, Sim S, Park HS PMID: 32400124 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - May 15, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

The KAAACI/KDA Evidence-Based Practice Guidelines for Chronic Spontaneous Urticaria in Korean Adults and Children: Part 1. Definition, Methodology and First-line Management.
Authors: Song WJ, Choi M, Lee DH, Kwon JW, Kim GW, Kim MH, Kim MA, Kim MH, Kim BK, Kim S, Kim JS, Kim JE, Kim JY, Kim JH, Kim HJ, Kim HO, Kim HB, Roh JY, Park KH, Park KY, Park HK, Park H, Bae JM, Byun JY, Song DJ, Ahn YM, Lee SE, Lee YB, Lee JS, Lee JH, Lim KH, Ye YM, Chang YS, Jeon YH, Jeon J, Jue MS, Choi SH, Choi JH, Hur GY, Park YM, Lim DH, Youn SW Abstract Chronic spontaneous urticaria (CSU) is defined as the occurrence of spontaneous wheals, angioedema, or both for>6 weeks in the absence of specific causes. It is a common condition associated with substantial disease burden both for affected individuals a...
Source: Allergy, Asthma and Immunology Research - May 15, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Skin Exposure Contributes to Chemical-Induced Asthma: What is the Evidence? A Systematic Review of Animal Models.
Authors: Tsui HC, Ronsmans S, De Sadeleer LJ, Hoet PHM, Nemery B, Vanoirbeek JAJ Abstract It is generally assumed that allergic asthma originates primarily through sensitization via the respiratory mucosa, but emerging clinical observations and experimental studies indicate that skin exposure to low molecular weight (LMW) agents, i.e. "chemicals," may lead to systemic sensitization and subsequently develop asthma when the chemical is inhaled. This review aims to evaluate the accumulating experimental evidence that adverse respiratory responses can be elicited upon inhalation of an LMW chemical sensitizer ...
Source: Allergy, Asthma and Immunology Research - May 15, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Health-Related Utility of EQ-5D in Korean Adults With Chronic Urticaria: Mapping From Urticaria Outcome Measures.
Authors: Lee MS, Yoon J, Kim J, Shin YS, Park HS, Lee HY, Ye YM Abstract PURPOSE: A need for useful measures reflective of the socio-economic burden of chronic urticaria (CU) has arisen. To obtain utility estimates for CU, we investigated EuroQol-5-Dimension (EQ-5D) indices according to urticaria control status and urticaria severity. METHODS: In this prospective observational study, we administered patient-oriented questionnaires on EQ-5D and urticaria outcomes, including Urticaria Activity Score over 7 days (UAS7), Urticaria Control Test (UCT), and CU-specific quality of life (CU-QOL). EQ-5D utility index sco...
Source: Allergy, Asthma and Immunology Research - May 15, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Toll-like Receptor 4 Deficiency Aggravates Airway Hyperresponsiveness and Inflammation by Impairing Neutrophil Apoptosis in a Toluene Diisocyanate-Induced Murine Asthma Model.
CONCLUSIONS: These data indicated that TLR4 deficiency promoted neutrophil infiltration by impairing its apoptosis via up-regulation of Bcl-2, thereby resulting in deteriorated AHR and airway inflammation, which suggests that TLR4 could be a negative regulator of TDI-induced neutrophilic inflammation. PMID: 32400128 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - May 15, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Genetic Signatures of Acute Asthma Exacerbation Related With Ineffective Response to Corticosteroid.
CONCLUSIONS: Many genes belong to the AE rate-associated and preserved module identified in blood cells from childhood and adults asthmatics showed no expression changes after in vitro Dex-treatment. These findings suggest that we may need alternative treatment options to corticosteroids to prevent AE. EIF2AK2, MSRA and MSRB2 expressions on blood cells may help us select AE-susceptible asthmatics and adjust treatments to prevent AE. PMID: 32400129 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - May 15, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Basophil Activation Test Based on CD203c Expression in the Diagnosis of Fish Allergy.
CONCLUSIONS: The BAT score based on CD203c expression may be useful for fish allergy diagnosis, especially since a large variety of fish can be tested by the BAT using fish extracts prepared by a simple method. PMID: 32400130 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - May 15, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Altered Mitochondrial Functions and Morphologies in Epithelial Cells Are Associated With Pathogenesis of Chronic Rhinosinusitis With Nasal Polyps.
CONCLUSIONS: Production of mtROS, disrupted mitochondrial function, and structural changes in nasal epithelial cells might be involved in the pathogenesis of CRSwNP. PMID: 32400131 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - May 15, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Lung Disease Diagnostic Model Through IgG Sensitization to Microbial Extracellular Vesicles.
CONCLUSIONS: The results of this study suggest that ELISA-based analysis of anti-bacterial EV antibodies titers can be used as a diagnostic tool for lung disease. The present findings provide insights into the pathogenesis of lung disease as well as a foundation for developing a novel diagnostic methodology that synergizes microbial EV metagenomics and immune assays. PMID: 32400132 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - May 15, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Activation of Transient Receptor Potential Melastatin Family Member 8 (TRPM8) Receptors Induces Proinflammatory Cytokine Expressions in Bronchial Epithelial Cells.
Authors: Kim JH, Jang YS, Kim HI, Park JY, Park SH, Hwang YI, Jang SH, Jung KS, Park HS, Park CS Abstract PURPOSE: Cold air is a major environmental factor that exacerbates asthma. Transient receptor potential melastatin family member 8 (TRPM8) is a cold-sensing channel expressed in the airway epithelium. However, its role in airway inflammation remains unknown. We investigated the role of TRPM8 in innate immune responses in bronchial epithelial cells and asthmatic subjects. METHODS: The TRPM8 mRNA and protein expression on BEAS2B human bronchial epithelial cells was examined by real-time polymerase chain react...
Source: Allergy, Asthma and Immunology Research - May 15, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Combined Effects of Lactobacillus rhamnosus and Egg Oral Immunotherapy in a Mouse Model of Egg Allergy.
CONCLUSIONS: Lcr35 treatment during OIT had some synergic effect for protection against anaphylaxis in a mice model of egg allergy. These findings should be confirmed in future animal studies including more detailed immunological profiles and human studies. PMID: 32400134 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - May 15, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

In Vitro and In Vivo Validation of EP2-Receptor Agonism to Selectively Achieve Inhibition of Mast Cell Activity.
CONCLUSIONS: Selective EP2 agonism is a powerful pharmacological strategy to prevent MCs from being activated through IgE-mediated mechanisms and from causing deleterious effects. The MC EP2 receptor may be an effective pharmacological target in allergic and other MC-mediated conditions. PMID: 32400135 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - May 15, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Impact of Grilling Meat or Fish at Home on Peak Expiratory Flow Rate in Adults With Asthma.
Authors: Lee H, Chung SJ, Park JS, Kim S, Park DW, Sohn JW, Kim SH, Park CS, Yoon HJ Abstract Grilling, a common cooking method worldwide, can produce more toxic gases than other cooking methods. However, the impact of frequently grilling meat or fish at home on airflow limitation in adult asthma has not been well elucidated. We performed a prospective cohort study of 91 adult patients with asthma enrolled from 2 university hospitals. Of the patients, 39 (42.9%) grilled meat or fish at least once a week and 52 (57.1%) less than once a week. Patients who grilled at least once a week tended to have lower peak expirat...
Source: Allergy, Asthma and Immunology Research - May 15, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Management Practice of Allergic Rhinitis in China During the COVID-19 Pandemic.
Authors: Zhang Y, Zhang L PMID: 32400137 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - May 15, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Erratum: Factors Affecting Recovery Time of Pulmonary Function in Hospitalized Patients With Acute Asthma Exacerbations.
Authors: Kim HJ, Lee J, Kim JH, Park SY, Kwon HS, Kim TB, Moon HB, Cho YS Abstract This corrects the article on p. 499 in vol. 8, PMID: 27582400. PMID: 32400138 [PubMed - in process] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - May 15, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Erratum: In-Depth, Proteomic Analysis of Nasal Secretions from Patients With Chronic Rhinosinusitis and Nasal Polyps.
Authors: Kim YS, Han D, Kim J, Kim DW, Kim YM, Mo JH, Choi HG, Park JW, Shin HW Abstract This corrects the article on p. 691 in vol. 11, PMID: 31332980. PMID: 32400139 [PubMed - in process] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - May 15, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Does the Difference in Microbial Patterns in the Airways Induce Distinct Endotypes of Asthma?
Authors: Cho YJ PMID: 32141252 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - March 8, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Active Pharmacovigilance of Drug-Induced Liver Injury Using Electronic Health Records.
Authors: Kim SH PMID: 32141253 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - March 8, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Innate Lymphoid Cells in the Airways: Their Functions and Regulators.
Authors: Orimo K, Saito H, Matsumoto K, Morita H Abstract Since the airways are constantly exposed to various pathogens and foreign antigens, various kinds of cells in the airways-including structural cells and immune cells-interact to form a precise defense system against pathogens and antigens that involve both innate immunity and acquired immunity. Accumulating evidence suggests that innate lymphoid cells (ILCs) play critical roles in the maintenance of tissue homeostasis, defense against pathogens and the pathogenesis of inflammatory diseases, especially at body surface mucosal sites such as the airways. ILCs a...
Source: Allergy, Asthma and Immunology Research - March 8, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Understanding the Molecular Mechanisms of Asthma through Transcriptomics.
Authors: Park HW, Weiss ST Abstract The transcriptome represents the complete set of RNA transcripts that are produced by the genome under a specific circumstance or in a specific cell. High-throughput methods, including microarray and bulk RNA sequencing, as well as recent advances in biostatistics based on machine learning approaches provides a quick and effective way of identifying novel genes and pathways related to asthma, which is a heterogeneous disease with diverse pathophysiological mechanisms. In this manuscript, we briefly review how to analyze transcriptome data and then provide a summary of recent tran...
Source: Allergy, Asthma and Immunology Research - March 8, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Relationship of Microbial Profile With Airway Immune Response in Eosinophilic or Neutrophilic Inflammation of Asthmatics.
Authors: Son JH, Kim JH, Chang HS, Park JS, Park CS Abstract PURPOSE: Different characteristics of airway microbiome in asthmatics may lead to differential immune responses, which in turn cause eosinophilic or neutrophilic airway inflammation. However, the relationships among these factors have yet to be fully elucidated. METHODS: Microbes in induced sputum samples were subjected to sequence analysis of 16S rRNA. Airway inflammatory phenotypes were defined as neutrophils (>60%) and eosinophils (>3%), and inflammation endotypes were defined by levels of T helper (Th) 1 (interferon-γ), Th2 (interleuki...
Source: Allergy, Asthma and Immunology Research - March 8, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Evaluation of Drug-Induced Liver Injury Developed During Hospitalization Using Electronic Health Record (EHR)-Based Algorithm.
CONCLUSIONS: Using our EHR-based algorithm, we identified that approximately 0.14% of patients developed DILI during hospitalization. Further studies are needed to modify criteria for more accurate identification of DILI. PMID: 32141257 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - March 8, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Risk Factors for Acute Exacerbations in Elderly Asthma: What Makes Asthma in Older Adults Distinctive?
CONCLUSIONS: We suggest that fixed airway obstruction and CRS as the important clinical factors predicting acute exacerbations in EA, whereas in NEA, eosinophil count was the strong predictor of exacerbation. PMID: 32141258 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - March 8, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Efficacy and Safety of a Pressurized Metered-Dose Inhaler in Older Asthmatics: Comparison to a Dry Powder Inhaler in a 12-Week Randomized Trial.
Authors: Woo SD, Ye YM, Lee Y, Lee SH, Shin YS, Park JH, Choi H, Lee HY, Shin HJ, Park HS Abstract PURPOSE: Asthma control in older asthmatics is often less effective, which may be attributed to small airway dysfunction and poor inhalation technique. We compared the efficacy of 2 inhalers (fluticasone propionate/formoterol treatment using a pressurized metered-dose inhaler [p-MDI group] vs. fluticasone propionate/salmeterol treatment using a dry powder inhaler [DPI group]) in older asthmatics. METHODS: We conducted a 12-week, randomized, open-label, parallel-designed trial in older patients (over 55 years old) ...
Source: Allergy, Asthma and Immunology Research - March 8, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Increasing Prevalence and Mortality of Asthma With Age in Korea, 2002-2015: A Nationwide, Population-Based Study.
CONCLUSIONS: The prevalence and mortality of asthma as well as SA increases along with the burden of health care uses/costs. More active interventions, including changes in health care policies, are needed to reduce the prevalence and mortality of asthma, especially SA. PMID: 32141260 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - March 8, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Hospitalization Due to Asthma Exacerbation: A China Asthma Research Network (CARN) Retrospective Study in 29 Provinces Across Mainland China.
CONCLUSIONS: Despite enhanced education on asthma self-management in China during recent years, few patients were using daily controller medications before the onset of their exacerbation, indicating that more educational efforts and considerations are needed. The findings of this study may improve our understanding of hospital admission for asthma exacerbation in mainland China and provide evidence for decision-making. PMID: 32141261 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - March 8, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

A Prospective Observation of Psychological Distress in Patients With Anaphylaxis.
Authors: Lee Y, Chang HY, Kim SH, Yang MS, Koh YI, Kang HR, Choi JH, Kim CW, Park HK, Kim JH, Nam YH, Kim TB, Hur GY, Jung JW, Park KH, Kim MA, Kim J, Yoon J, Ye YM Abstract PURPOSE: Anaphylaxis is an immediate allergic reaction characterized by potentially life-threatening, severe, systemic manifestations. While studies have evaluated links between serious illness and posttraumatic stress disorder (PTSD), few have investigated PTSD after anaphylaxis in adults. We sought to investigate the psychosocial burden of recent anaphylaxis in Korean adults. METHODS: A total of 203 (mean age of 44 years, 120 females) pat...
Source: Allergy, Asthma and Immunology Research - March 8, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Role of IL-17A in Chronic Rhinosinusitis With Nasal Polyp.
CONCLUSIONS: IL-17A possibly plays a role in the pathogenesis of CRSwNP, the major cellular source being M1 macrophage in NP tissues. Targeting IL-17A directly or indirectly may be an effective therapeutic strategy for CRSwNP. PMID: 32141263 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - March 8, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Oxidative Stress Modulates the Expression Pattern of Peroxiredoxin-6 in Peripheral Blood Mononuclear Cells of Asthmatic Patients and Bronchial Epithelial Cells.
CONCLUSIONS: The expression of peroxiredoxin-6, which is down-regulated in the immune cells of asthmatic patients and BECs, can be modified by oxidative stress. This phenomenon may have an effect on asthmatic airway inflammation. PMID: 32141264 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - March 8, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

An Alternative Dendritic Cell-Induced Murine Model of Asthma Exhibiting a Robust Th2/Th17-Skewed Response.
CONCLUSIONS: A reliable murine model of asthma by intravenous (i.v.) transfer of OVA-BMDCs was successfully established without anesthesia. This model more accurately reflects heterogeneous human asthma, exhibiting a robust Th2/Th17-skewed response and eosinophilic/neutrophilic infiltration with good reproducibility and low variation among individuals. This model will be useful for understanding the pathogenesis of asthma and would serve as an alternative tool for immunological studies on the function of DCs, T-cell responses and new drugs. PMID: 32141265 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - March 8, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Revised Pollen Calendar in Korea.
Authors: Park JW PMID: 32009317 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - February 7, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Impact of the Long-Lived Plasma Cells in Patients With Chronic Rhinosinusitis With Nasal Polyps.
Authors: Khalmuratova R, Shin HW PMID: 32009318 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - February 7, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Chinese Society of Allergy and Chinese Society of Otorhinolaryngology-Head and Neck Surgery Guideline for Chronic Rhinosinusitis.
In conclusion, these guidelines will help select therapies, such as pharmacotherapy, surgical approaches and innovative biotherapeutics, which are tailored to each of the individual CRS endotypes. PMID: 32009319 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - February 7, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Aligning the Good Practice MASK With the Objectives of the European Innovation Partnership on Active and Healthy Ageing.
Authors: Bousquet J, Farrell J, Illario M, ARIA-MASK study group Abstract The reference sites of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) were renewed in 2019. The DG Santé good practice Mobile Airways Sentinel networK was reviewed to meet the objectives of the EIP on AHA. It included 1) Management of care process, 2) Blueprint of digital transformation, 3) EIP on AHA, innovation to market, 4) Community for monitoring and assessment framework, 5) Political, organizational, technological and financial readiness, 6) Contributing to European co-operation and transferability,...
Source: Allergy, Asthma and Immunology Research - February 7, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Allergenic Pollen Calendar in Korea Based on Probability Distribution Models and Up-to-Date Observations.
CONCLUSIONS: A new methodology for the creation of a pollen calendar was developed to attenuate the impact of large temporal and spatial variability in pollen concentrations. This revised calendar should be available to the public and allergic patients to prevent aggravation of pollen allergy. PMID: 32009321 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - February 7, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Evidence for the Presence of Long-Lived Plasma Cells in Nasal Polyps.
CONCLUSIONS: Human nasal polyps harbor a population of LLPCs and NGF may be involved in their prolonged survival. LLPCs may be a novel therapeutic target for suppressing the local Ig production in nasal polyps. PMID: 32009322 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - February 7, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Flow Cytometry for the Diagnosis of Primary Immunodeficiency Diseases: A Single Center Experience.
CONCLUSIONS: The initial application of FCM, particularly with known protein targets on immune cells, would facilitate the timely diagnosis of PIDs and thus would support clinical decisions and improve the clinical outcome. PMID: 32009323 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - February 7, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Evaluation of Neo-Osteogenesis in Eosinophilic Chronic Rhinosinusitis Using a Nasal Polyp Murine Model.
CONCLUSIONS: In the present study, we found the histopathological and radiographic evidence of osteogenesis using a previously established murine eosinophilic CRS NP model. This animal model could provide new insights into the pathophysiology of neo-osteogenesis and provide a basis for developing new therapeutics. PMID: 32009324 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - February 7, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Imbalance of Gut Streptococcus, Clostridium, and Akkermansia Determines the Natural Course of Atopic Dermatitis in Infant.
CONCLUSIONS: Compositions, functions and metabolites of the early gut microbiome are related to natural courses of AD in infants. PMID: 32009325 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - February 7, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Epithelial PI3K- δ Promotes House Dust Mite-Induced Allergic Asthma in NLRP3 Inflammasome-Dependent and -Independent Manners.
CONCLUSIONS: The results of this study suggest that PI3K-δ-isoform can promote HDM-induced allergic airway inflammation via NLRP3 inflammasome-dependent response as well as via NLRP3 inflammasome-independent epithelial cell activation. PMID: 32009326 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - February 7, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Delayed-Onset Anaphylaxis Caused by IgE Response to Influenza Vaccination.
In this study, we analyzed the immunoglobulin E (IgE) response to whole influenza vaccines in a pediatric case of delayed-onset anaphylaxis after influenza vaccination. The patient showed elevated specific IgE levels against whole influenza vaccines, especially with split virion from egg-based manufacturing process. Specific IgE levels to influenza vaccines showed decreased over. We evaluated a causal relationship between influenza vaccine and anaphylaxis event by enzyme-linked immunosorbent assay. Delayed-onset anaphylaxis after influenza vaccination can occur in children without predisposing allergic diseases. In additio...
Source: Allergy, Asthma and Immunology Research - February 7, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Primary Nasal Epithelial Cells From Allergic and Non-allergic Individuals Show Comparable Barrier Function.
Authors: Waltl EE, Stanek V, Mueller CA, Kiss R, Eckl-Dorna J, Valenta R, Niederberger V Abstract Previous reports suggested that ex vivo cultured primary nasal epithelial cells from allergic patients differ from those from non-allergic individuals by genuinely reduced barrier function. By contrast, we found that primary nasal epithelial cells from allergic and non-allergic individuals showed comparable barrier function and secretion of cytokines. PMID: 32009328 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - February 7, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Non-episodic Angioedema With Eosinophilia Successfully Treated With Reslizumab.
Authors: Chu H, Youn DY, Park HS, Ye YM, Park YB, Ban GY PMID: 32009329 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - February 7, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Understanding the Role of Neutrophils in Refractoriness of Chronic Rhinosinusitis With Nasal Polyps.
Authors: Lan F, Zhang L PMID: 31743960 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - November 20, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

MicroRNAs in Asthma and Respiratory Infections: Identifying Common Pathways.
We describe recent findings on miR expression and function in asthma and their role in the regulation of viral ARIs, according to cell tissue specificity and asthma severity. By combining the above information, we identify miRs that may be important in virus-induced asthma exacerbations. This is the first attempt to link miR profiles of asthmatic patients and ARI-induced miRs, addressing the question of whether there might be a specific miR deficit in asthmatic subjects that make them more susceptible and/or reactive to infection. PMID: 31743961 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - November 20, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Critical Points on the Use of Biologicals in Allergic Diseases and Asthma.
Authors: Agache I, Cojanu C, Laculiceanu A, Rogozea L Abstract Improved understanding of the contribution of immune-inflammatory mechanisms in allergic diseases and asthma has encouraged development of biologicals and small molecules specifically targeting the innate and adaptive immune response. There are several critical points impacting the efficacy of this stratified approach, from the complexity of disease endotypes to the effectiveness in real-world settings. We discuss here how these barriers can be overcome to facilitate the development of implementation science for allergic diseases and asthma. PMID: 3...
Source: Allergy, Asthma and Immunology Research - November 20, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Elastase-Positive Neutrophils Are Associated With Refractoriness of Chronic Rhinosinusitis With Nasal Polyps in an Asian Population.
CONCLUSIONS: Tissue neutrophilia had an influence on treatment outcomes in the Asian CRSwNP patients. HNE-positive cells and IL-36α may be biomarkers for predicting refractoriness in Asians with CRSwNP. Additionally, imbalances in HNE and α1 anti-trypsin may be associated with pathophysiology of neutrophilic chronic rhinosinusitis. PMID: 31743963 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - November 20, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Particulate Matter 2.5 Causes Deficiency in Barrier Integrity in Human Nasal Epithelial Cells.
CONCLUSIONS: Exposure to PM2.5 may lead to loss of barrier function in human nasal epithelium through decreased expression of TJ proteins and increased release of proinflammatory cytokines. These results suggest an important mechanism of susceptibility to rhinitis and rhinosinusitis in highly PM2.5-polluted areas. PMID: 31743964 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - November 20, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Risk Factors and Comorbidities Associated With the Allergic Rhinitis Phenotype in Children According to the ARIA Classification.
CONCLUSIONS: Moderate to severe-persistent AR is more closely related to respiratory comorbidities and sensitizations than mild AR. Stratifying the AR phenotype by ARIA classification may assist in disease management. PMID: 31743965 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - November 20, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research