Next-Generation Therapeutic Approaches for Uncontrolled Asthma: Insights Into the Heterogeneity of Non-Type 2 Inflammation
Allergy Asthma Immunol Res. 2024 Jan;16(1):1-5. doi: 10.4168/aair.2024.16.1.1.NO ABSTRACTPMID:38262386 | PMC:PMC10823145 | DOI:10.4168/aair.2024.16.1.1 (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - January 23, 2024 Category: Allergy & Immunology Authors: So Ri Kim Source Type: research

Considerations for Developing Diagnostic Artificial Intelligence: Towards Real-World Application of an Asthma Detection Model
Allergy Asthma Immunol Res. 2024 Jan;16(1):6-8. doi: 10.4168/aair.2024.16.1.6.NO ABSTRACTPMID:38262387 | PMC:PMC10823146 | DOI:10.4168/aair.2024.16.1.6 (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - January 23, 2024 Category: Allergy & Immunology Authors: Taeyoung Kim Myung Jin Chung Source Type: research

The KAAACI Guidelines for Sublingual Immunotherapy
Allergy Asthma Immunol Res. 2024 Jan;16(1):9-21. doi: 10.4168/aair.2024.16.1.9.ABSTRACTAllergen immunotherapy is regarded as the only disease-modifying treatment option for various allergic conditions, including allergic rhinitis and asthma. Among the routes of administration of allergens, sublingual immunotherapy (SLIT) has gained clinical interest recently, and the prescription of SLIT is increasing among patients with allergies. After 30 years of SLIT use, numerous pieces of evidence supporting its efficacy, safety, and mechanism allows SLIT to be considered as an alternative option to subcutaneous immunotherapy. Based ...
Source: Allergy, Asthma and Immunology Research - January 23, 2024 Category: Allergy & Immunology Authors: Jin-Young Min Hye Mi Jee Hwa Young Lee Sung-Yoon Kang Kyunghoon Kim Ju Hee Kim Kyung Hee Park So-Young Park Myongsoon Sung Youngsoo Lee Eun-Ae Yang Gwanghui Ryu Eun Kyo Ha Sang Min Lee Yong Won Lee Eun Hee Chung Sun Hee Choi Young-Il Koh Seon Tae Kim Dong Source Type: research

ST2-Mediated Neutrophilic Airway Inflammation: A Therapeutic Target for Patients With Uncontrolled Asthma
CONCLUSIONS: These results suggest that IL-33 induces the activation of neutrophils and Mϕ via ST2 receptors, leading to neutrophilic airway inflammation and poor control status of asthma. ST2 could be a therapeutic target for neutrophilic airway inflammation in patients with UA.PMID:38262389 | PMC:PMC10823144 | DOI:10.4168/aair.2024.16.1.22 (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - January 23, 2024 Category: Allergy & Immunology Authors: Quang Luu Quoc Thi Bich Tra Cao Jae-Hyuk Jang Yoo Seob Shin Youngwoo Choi Hae-Sim Park Source Type: research

Novel Artificial Intelligence-Based Technology to Diagnose Asthma Using Methacholine Challenge Tests
CONCLUSIONS: Artificial intelligence-based models showed excellent performance in asthma prediction compared to using PC20 ≤ 16 mg/mL. The novel technology could be used to enhance the clinical diagnosis of asthma.PMID:38262390 | PMC:PMC10823143 | DOI:10.4168/aair.2024.16.1.42 (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - January 23, 2024 Category: Allergy & Immunology Authors: Noeul Kang KyungHyun Lee Sangwon Byun Jin-Young Lee Dong-Chull Choi Byung-Jae Lee Source Type: research

Sputum Transcriptomics Reveals FCN1+ Macrophage Activation in Mild Eosinophilic Asthma Compared to Non-Asthmatic Eosinophilic Bronchitis
CONCLUSIONS: FCN1+ macrophage activation associated with airway remodeling processes was upregulated in EA compared to that in EB, which may contribute to airway hyperresponsiveness and airflow obstruction.PMID:38262391 | PMC:PMC10823142 | DOI:10.4168/aair.2024.16.1.55 (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - January 23, 2024 Category: Allergy & Immunology Authors: Wenzhi Zhan Wei Luo Yulong Zhang Keheng Xiang Xiaomei Chen Shuirong Shen Chuqing Huang Tingting Xu Wenbin Ding Yuehan Chen Mingtong Lin Xinghua Pan Kefang Lai Source Type: research

LincR-PPP2R5C Promotes Th2 Cell Differentiation Through PPP2R5C/PP2A by Forming an RNA-DNA Triplex in Allergic Asthma
CONCLUSIONS: LincR-PPP2R5C regulated PPP2R5C expression and PP2A activity by forming an RNA-DNA triplex with the PPP2R5C promoter, leading to Th2 polarization in a mouse model of acute asthma. Our data presented the first definitive evidence of lncRNAs in the regulation of Th2 cells in asthma.PMID:38262392 | PMC:PMC10823138 | DOI:10.4168/aair.2024.16.1.71 (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - January 23, 2024 Category: Allergy & Immunology Authors: Ningfei Ji Zhongqi Chen Zhengxia Wang Wei Sun Qi Yuan Xijie Zhang Xinyu Jia Jingjing Wu Jingxian Jiang Meijuan Song Tingting Xu Yanan Liu Qiyun Ma Zhixiao Sun Yanmin Bao Mingshun Zhang Mao Huang Source Type: research

Suppression of SPARC Ameliorates Ovalbumin-induced Airway Remodeling via TGF β1/Smad2 in Chronic Asthma
CONCLUSIONS: Our studies provided evidence for the involvement of SPARC in the airway remodeling of asthma via the TGFβ1/Smad2 pathway.PMID:38262393 | PMC:PMC10823139 | DOI:10.4168/aair.2024.16.1.91 (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - January 23, 2024 Category: Allergy & Immunology Authors: Yun Pan Dong Zhang Jintao Zhang Xiaofei Liu Jiawei Xu Rong Zeng Wenjing Cui Tian Liu Junfei Wang Liang Dong Source Type: research

Prediction Model for Annual Variation in Total Pollen by Allergenic Trees in Korean Cities
CONCLUSIONS: The annual variation model in this study can be integrated with the daily pollen forecast model by controlling the annual pollen potential, and the accuracy of the daily forecast can be improved accordingly.PMID:38262394 | PMC:PMC10823140 | DOI:10.4168/aair.2024.16.1.109 (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - January 23, 2024 Category: Allergy & Immunology Authors: Kyu Rang Kim Mae Ja Han Young Jong Han Yong Hee Lee Jae-Won Oh Source Type: research

Next-Generation Therapeutic Approaches for Uncontrolled Asthma: Insights Into the Heterogeneity of Non-Type 2 Inflammation
Allergy Asthma Immunol Res. 2024 Jan;16(1):1-5. doi: 10.4168/aair.2024.16.1.1.NO ABSTRACTPMID:38262386 | PMC:PMC10823145 | DOI:10.4168/aair.2024.16.1.1 (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - January 23, 2024 Category: Allergy & Immunology Authors: So Ri Kim Source Type: research

Considerations for Developing Diagnostic Artificial Intelligence: Towards Real-World Application of an Asthma Detection Model
Allergy Asthma Immunol Res. 2024 Jan;16(1):6-8. doi: 10.4168/aair.2024.16.1.6.NO ABSTRACTPMID:38262387 | PMC:PMC10823146 | DOI:10.4168/aair.2024.16.1.6 (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - January 23, 2024 Category: Allergy & Immunology Authors: Taeyoung Kim Myung Jin Chung Source Type: research

The KAAACI Guidelines for Sublingual Immunotherapy
Allergy Asthma Immunol Res. 2024 Jan;16(1):9-21. doi: 10.4168/aair.2024.16.1.9.ABSTRACTAllergen immunotherapy is regarded as the only disease-modifying treatment option for various allergic conditions, including allergic rhinitis and asthma. Among the routes of administration of allergens, sublingual immunotherapy (SLIT) has gained clinical interest recently, and the prescription of SLIT is increasing among patients with allergies. After 30 years of SLIT use, numerous pieces of evidence supporting its efficacy, safety, and mechanism allows SLIT to be considered as an alternative option to subcutaneous immunotherapy. Based ...
Source: Allergy, Asthma and Immunology Research - January 23, 2024 Category: Allergy & Immunology Authors: Jin-Young Min Hye Mi Jee Hwa Young Lee Sung-Yoon Kang Kyunghoon Kim Ju Hee Kim Kyung Hee Park So-Young Park Myongsoon Sung Youngsoo Lee Eun-Ae Yang Gwanghui Ryu Eun Kyo Ha Sang Min Lee Yong Won Lee Eun Hee Chung Sun Hee Choi Young-Il Koh Seon Tae Kim Dong Source Type: research

ST2-Mediated Neutrophilic Airway Inflammation: A Therapeutic Target for Patients With Uncontrolled Asthma
CONCLUSIONS: These results suggest that IL-33 induces the activation of neutrophils and Mϕ via ST2 receptors, leading to neutrophilic airway inflammation and poor control status of asthma. ST2 could be a therapeutic target for neutrophilic airway inflammation in patients with UA.PMID:38262389 | PMC:PMC10823144 | DOI:10.4168/aair.2024.16.1.22 (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - January 23, 2024 Category: Allergy & Immunology Authors: Quang Luu Quoc Thi Bich Tra Cao Jae-Hyuk Jang Yoo Seob Shin Youngwoo Choi Hae-Sim Park Source Type: research

Novel Artificial Intelligence-Based Technology to Diagnose Asthma Using Methacholine Challenge Tests
CONCLUSIONS: Artificial intelligence-based models showed excellent performance in asthma prediction compared to using PC20 ≤ 16 mg/mL. The novel technology could be used to enhance the clinical diagnosis of asthma.PMID:38262390 | PMC:PMC10823143 | DOI:10.4168/aair.2024.16.1.42 (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - January 23, 2024 Category: Allergy & Immunology Authors: Noeul Kang KyungHyun Lee Sangwon Byun Jin-Young Lee Dong-Chull Choi Byung-Jae Lee Source Type: research

Sputum Transcriptomics Reveals FCN1+ Macrophage Activation in Mild Eosinophilic Asthma Compared to Non-Asthmatic Eosinophilic Bronchitis
CONCLUSIONS: FCN1+ macrophage activation associated with airway remodeling processes was upregulated in EA compared to that in EB, which may contribute to airway hyperresponsiveness and airflow obstruction.PMID:38262391 | PMC:PMC10823142 | DOI:10.4168/aair.2024.16.1.55 (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - January 23, 2024 Category: Allergy & Immunology Authors: Wenzhi Zhan Wei Luo Yulong Zhang Keheng Xiang Xiaomei Chen Shuirong Shen Chuqing Huang Tingting Xu Wenbin Ding Yuehan Chen Mingtong Lin Xinghua Pan Kefang Lai Source Type: research