Impact Of "eHealth" in Allergic Diseases and Allergic Patients.
Impact Of "eHealth" in Allergic Diseases and Allergic Patients. J Investig Allergol Clin Immunol. 2019;29(2):94-102 Authors: Alvarez-Perea A, Sánchez-García S, Muñoz Cano R, Antolín-Amérigo D, Tsilochristou O, Stukus DR Abstract The emergence of new technology enables allergists and patients to compile data and receive feedback regarding key symptoms, risk behavior, and/or management. The term "eHealth" refers to a diverse group of tools that use computerized technologies to improve both the efficacy and the efficiency of the health care industry....
Source: Journal of Investigational Allergology and Clinical Immunology - August 10, 2019 Category: Allergy & Immunology Authors: Alvarez-Perea A, Sánchez-García S, Muñoz Cano R, Antolín-Amérigo D, Tsilochristou O, Stukus DR Tags: J Investig Allergol Clin Immunol Source Type: research

The safety and efficacy of aspirin desensitization combined with long-term aspirin therapy in Aspirin-exacerbated respiratory disease.
CONCLUSIONS: Clearly, aspirin desensitization and treatment are beneficial for AERD patients, with a reduction of nasal symptoms, improvements in asthma control and decrease of daily corticosteroid use, without fatal adverse events. However, long-term side effects of aspirin desensitization and optimal dosage of aspirin merit further investigation. PMID: 31283521 [PubMed - as supplied by publisher] (Source: Journal of Investigational Allergology and Clinical Immunology)
Source: Journal of Investigational Allergology and Clinical Immunology - July 8, 2019 Category: Allergy & Immunology Authors: Renjiao L, Fengming L Tags: J Investig Allergol Clin Immunol Source Type: research

Immunochemical and physical quantitation of grass and olive pollen allergens and correlation with asthma admitions in C áceres, Spain.
CONCLUSIONS: This study reveals a significant correlation between grass and olive pollination and the increase of the number of visits to the emergency room due to asthma crisis. The aerobiological pattern of allergen levels in the air is comparable to the pollen counts during the grass and olive pollination periods. PMID: 31283522 [PubMed - as supplied by publisher] (Source: Journal of Investigational Allergology and Clinical Immunology)
Source: Journal of Investigational Allergology and Clinical Immunology - July 8, 2019 Category: Allergy & Immunology Authors: Porcel Carreño S, Gómez Nieves E, Fernández-Caldas E, Abel Fernández E, Cases B, Tudela JI, Maghfour Martin Y, Domínguez Domínguez E, Alvarado Arenas M, Jiménez Timón S, Ahmida T, García Ponce JF, Jiménez Gallardo P, Alvarado Izquierdo MI, Hern Tags: J Investig Allergol Clin Immunol Source Type: research

Main contributory factors on asthma control and health-related quality of life (QoL) in elderly asthmatics.
CONCLUSIONS: Despite receiving anti-asthmatic therapy, almost one-third of elderly patients had uncontrolled asthma. Factors related to treatment adherence, exacerbations and health-related quality of life should be considered. Non-respiratory comorbid conditions in older patients does not seem to be associated with worse asthma control of symptoms but their influence in health-related quality of life could indirectly affect asthma control. PMID: 31283523 [PubMed - as supplied by publisher] (Source: Journal of Investigational Allergology and Clinical Immunology)
Source: Journal of Investigational Allergology and Clinical Immunology - July 8, 2019 Category: Allergy & Immunology Authors: Enríquez-Matas A, Fernández Rodríguez C, Andrés Esteban EM, Fernández Crespo J Tags: J Investig Allergol Clin Immunol Source Type: research

Molecular diagnosis in house dust mite allergic patients suggests clinical relevance of Der p 23 in asthmatic children.
CONCLUSIONS: Most of our population with mite allergy is sensitized to Der p 1, Der p 2 and Der p 23 major allergens; however, 5% were sensitized only to Der p 23 of the allergens evaluated. Sensitization to Der p 23 should be considered in the diagnosis and treatment of mite allergy, especially in patients with moderate and severe asthma because it may worsen the clinical phenotype. PMID: 31283524 [PubMed - as supplied by publisher] (Source: Journal of Investigational Allergology and Clinical Immunology)
Source: Journal of Investigational Allergology and Clinical Immunology - July 8, 2019 Category: Allergy & Immunology Authors: Jiménez-Feijoo R, Pascal M, Moya R, Riggioni C, Domínguez O, Lózano J, Álvaro-Lozano M, Piquert M, Machinena A, Folque M, Dias M, Carnés J, Plaza AM Tags: J Investig Allergol Clin Immunol Source Type: research

Occupational asthma induced by quinoa exposure.
PMID: 31283525 [PubMed - as supplied by publisher] (Source: Journal of Investigational Allergology and Clinical Immunology)
Source: Journal of Investigational Allergology and Clinical Immunology - July 8, 2019 Category: Allergy & Immunology Authors: Guarnieri G, Bonadonna P, Olivieri E, Schiappoli M Tags: J Investig Allergol Clin Immunol Source Type: research

Does Rapid Drug Desensitization to chemotherapy affect survival outcomes?
CONCLUSIONS: Survival outcomes of oxaliplatin-hypersensitive patients who received oxaliplatin via RDD were not significantly different compared to those of control patients who received oxaliplatin via standard administration. Receiving oxaliplatin by means of RDD might be an effective therapeutic alternative for oxaliplatin-hypersensitive patients. PMID: 31188129 [PubMed - as supplied by publisher] (Source: Journal of Investigational Allergology and Clinical Immunology)
Source: Journal of Investigational Allergology and Clinical Immunology - June 12, 2019 Category: Allergy & Immunology Authors: Berges-Gimeno MP, Carpio-Escalona LV, Longo-Muñoz F, Bernal-Rubio L, Lopez-Gonzalez P, Gehlhaar P, Pachon V, Ferreiro-Monteagudo R, Madrigal-Burgaleta R, Alvarez-Cuesta E Tags: J Investig Allergol Clin Immunol Source Type: research

Survey of opinion of Spanish physicians on the role of eosinophils in asthma and other pathologies.
M, Molina J PMID: 31172950 [PubMed - as supplied by publisher] (Source: Journal of Investigational Allergology and Clinical Immunology)
Source: Journal of Investigational Allergology and Clinical Immunology - June 7, 2019 Category: Allergy & Immunology Authors: Plaza V, Blanco M, Delgado J, Martínez I, Zubeldía JM, Molina J Tags: J Investig Allergol Clin Immunol Source Type: research

FOXP3 expression, vitamins D and C in the prediction of tolerance acquisition in infants with cow's milk allergy.
Abstract BACKGROUND AND OBJECTIVE: Treg cells and dietetic factors may play a significant role in the natural acquisition of tolerance in children with cow's milk allergy (CMA). The best marker for Treg lymphocytes is the transcription factor-forkhead boxP3 (FOXP3). Objective: The paper examines the relationship between Foxp3mRNA expression and serum concentration of vitamins D and C, and the development of different phenotypes of tolerance in children with CMA. MATERIAL AND METHODS: The study group comprised 138 infants with CMA and 101 healthy infants. All children underwent oral food challenge, first with ...
Source: Journal of Investigational Allergology and Clinical Immunology - June 7, 2019 Category: Allergy & Immunology Authors: Sardecka I, Łoś-Rycharska E, Gawryjołek J, Toporowska-Kowalska E, Krogulska A Tags: J Investig Allergol Clin Immunol Source Type: research

Chronic Pulmonary Aspergillosis Succesfully Treated With Isavuconazole.
ndez-Rodríguez C PMID: 31172952 [PubMed - as supplied by publisher] (Source: Journal of Investigational Allergology and Clinical Immunology)
Source: Journal of Investigational Allergology and Clinical Immunology - June 7, 2019 Category: Allergy & Immunology Authors: Guillen-Vera D, Ruiz-Ruigómez M, García-Moguel I, Morales-Ruiz R, Corbella L, Fernández-Rodríguez C Tags: J Investig Allergol Clin Immunol Source Type: research

Celiac disease and wheat allergy may coexist: two case reports.
PMID: 31172953 [PubMed - as supplied by publisher] (Source: Journal of Investigational Allergology and Clinical Immunology)
Source: Journal of Investigational Allergology and Clinical Immunology - June 7, 2019 Category: Allergy & Immunology Authors: Lombardi C, Savi E, Passalacqua G Tags: J Investig Allergol Clin Immunol Source Type: research

Adaptation to Spanish and validation of the Rhinitis Control Assessment Test (RCAT) questionnaire.
ero A Abstract BACKGROUND AND OBJECTIVE: The Rhinitis Control Assessment Test (RCAT) is a widely used patient-based questionnaire developed to evaluate control of rhinitis. Objective: To develop and validate a Spanish version of the RCAT (RCATe). METHODS: After translation and cultural adaptation of the original RCAT, this multicentric observational, prospective study evaluated the properties/attributes of the RCATe assessing its validity, reliability, responsiveness, size effect, minimal important difference and cut point score. RESULTS: A total of 252 allergic rhinitis (AR) patients from 27 allergy and...
Source: Journal of Investigational Allergology and Clinical Immunology - May 28, 2019 Category: Allergy & Immunology Authors: Del Cuvillo A, Sastre J, Colás C, Navarro AM, Mullol J, Valero A Tags: J Investig Allergol Clin Immunol Source Type: research

Allergy to Spathiphyllum wallisii, an indoor allergen.
elandia D, Gaig Jané P PMID: 31135378 [PubMed - as supplied by publisher] (Source: Journal of Investigational Allergology and Clinical Immunology)
Source: Journal of Investigational Allergology and Clinical Immunology - May 28, 2019 Category: Allergy & Immunology Authors: Herrera-Lasso Regás V, Dalmau Duch G, Gázquez García V, Pineda De La Losa F, Castillo Fernández M, Garnica Velandia D, Gaig Jané P Tags: J Investig Allergol Clin Immunol Source Type: research

Atopic dermatitis phenotypes in preschool and school-age children: a latent class analysis.
Abstract BACKGROUND: Atopic dermatitis (AD) represents the most common chronic inflammatory skin disease in childhood. Few data are available about the different AD phenotypes and their nationwide distribution. METHODS: We performed a cross-sectional multicentre study involving some of the main Italian paediatric allergy centres in 9 Italian cities. A structured questionnaire was administered to 371 children with AD. Patients were divided in two groups: preschool children (aged
Source: Journal of Investigational Allergology and Clinical Immunology - May 27, 2019 Category: Allergy & Immunology Authors: Galli E, Maiello N, Cipriani F, La Grutta S, Fasola S, Carello R, Caminiti L, Licari A, Landi M, Di Mauro D, Ricci G, Panel of the Italian Society of Pediatric Allergy and Immunology (SIAIP) Tags: J Investig Allergol Clin Immunol Source Type: research

Subcutaneous immunotherapy with high-dose cat and dog extracts: a real-life study.
CONCLUSIONS: High-dose SCIT has substantial clinical value in many cat and dog allergic patients. PMID: 31132032 [PubMed - as supplied by publisher] (Source: Journal of Investigational Allergology and Clinical Immunology)
Source: Journal of Investigational Allergology and Clinical Immunology - May 27, 2019 Category: Allergy & Immunology Authors: Uriarte SA, Sastre J Tags: J Investig Allergol Clin Immunol Source Type: research

A Novel TTC37 Mutation Causing Remarkable Trichohepatoenteric Syndrome Clinical Findings Such as Pyoderma Gangrenosum and Immunodeficiency without Severe Diarrhea.
PMID: 31132033 [PubMed - as supplied by publisher] (Source: Journal of Investigational Allergology and Clinical Immunology)
Source: Journal of Investigational Allergology and Clinical Immunology - May 27, 2019 Category: Allergy & Immunology Authors: Karaca NE, Aykut A, Pariltay E, Aksu G, Cogulu O, Kutukculer N Tags: J Investig Allergol Clin Immunol Source Type: research

Treating "asthma" with a scalpel - achalasia in a patient impersonating asthmatic condition.
Treating "asthma" with a scalpel - achalasia in a patient impersonating asthmatic condition. J Investig Allergol Clin Immunol. 2019 May 27;:0 Authors: Nittner-Marszalska N, Kopeć A, Jędrzejewska J, Pawłowicz R PMID: 31132034 [PubMed - as supplied by publisher] (Source: Journal of Investigational Allergology and Clinical Immunology)
Source: Journal of Investigational Allergology and Clinical Immunology - May 27, 2019 Category: Allergy & Immunology Authors: Nittner-Marszalska N, Kopeć A, Jędrzejewska J, Pawłowicz R Tags: J Investig Allergol Clin Immunol Source Type: research

Stability of asthma control implies no changes in microRNAs expression.
ozo V PMID: 31062689 [PubMed - as supplied by publisher] (Source: Journal of Investigational Allergology and Clinical Immunology)
Source: Journal of Investigational Allergology and Clinical Immunology - May 7, 2019 Category: Allergy & Immunology Authors: Rial MJ, Rodrigo-Muñoz JM, Sastre B, Sastre J, Del Pozo V Tags: J Investig Allergol Clin Immunol Source Type: research

Selective allergy to conger fish due to parvalbumin.
PMID: 31062690 [PubMed - as supplied by publisher] (Source: Journal of Investigational Allergology and Clinical Immunology)
Source: Journal of Investigational Allergology and Clinical Immunology - May 7, 2019 Category: Allergy & Immunology Authors: Argiz L, Vega F, Castillo M, Pineda F, Blanco C Tags: J Investig Allergol Clin Immunol Source Type: research

Promoter genotyping and mRNA expression analysis of PTGDR gene in allergy.
CONCLUSIONS: The results indicate that PTGDR overexpression is associated with allergy. In addition, polymorphisms -1289G>A and -1122T>C contribute to explain some of the observed expression variation. PTGDR expression could have a potential role as biomarker and pharmacogenetic factor in Allergy. PMID: 31062691 [PubMed - as supplied by publisher] (Source: Journal of Investigational Allergology and Clinical Immunology)
Source: Journal of Investigational Allergology and Clinical Immunology - May 7, 2019 Category: Allergy & Immunology Authors: San Segundo-Val I, García-Sánchez A, Sanz C, Cornejo-García JA, Isidoro-García M, Dávila I Tags: J Investig Allergol Clin Immunol Source Type: research

General anesthetics drug challenge tests: predictive value of skin tests.
CONCLUSIONS: After assessing risks and benefits and considering the importance of this group of drugs, we conclude that drug challenge test with general anesthetics are necessary. We propose a diagnostic protocol for perioperative drug reactions that allows to reach an etiological diagnosis as accurate as possible with the minimum risks for the patient. PMID: 31058590 [PubMed - as supplied by publisher] (Source: Journal of Investigational Allergology and Clinical Immunology)
Source: Journal of Investigational Allergology and Clinical Immunology - May 6, 2019 Category: Allergy & Immunology Authors: Tornero Molina P, Rojas-Perez-Ezquerra P, Noguerado-Mellado B, Baeza Ochoa de Ocáriz ML, Garrido Sánchez A, Alonso Mateos M, Zubeldia Ortuño JM Tags: J Investig Allergol Clin Immunol Source Type: research

Usefulness of basophil activation test in the diagnosis of amiodarone hypersensitivity.
Gancedo S, Cabañas Moreno R PMID: 31017105 [PubMed - as supplied by publisher] (Source: Journal of Investigational Allergology and Clinical Immunology)
Source: Journal of Investigational Allergology and Clinical Immunology - April 24, 2019 Category: Allergy & Immunology Authors: Vílchez Sánchez F, Lluch Bernal M, González Muñoz M, Marques Mejías MA, Quirce Gancedo S, Cabañas Moreno R Tags: J Investig Allergol Clin Immunol Source Type: research

Loquat (Eriobotrya japonica) allergy, including anaphylaxis, is induced by a Bet v1 homolog.
PMID: 31017106 [PubMed - as supplied by publisher] (Source: Journal of Investigational Allergology and Clinical Immunology)
Source: Journal of Investigational Allergology and Clinical Immunology - April 24, 2019 Category: Allergy & Immunology Authors: Takaoka Y, Kondo Y, Matsunaga K, Aoki Y, Hasegawa E, Tokuda R, Fujisawa T, Morikawa A, Doi S Tags: J Investig Allergol Clin Immunol Source Type: research

Responses to biological therapies in eosinophilic severe asthma.
PMID: 30990776 [PubMed - as supplied by publisher] (Source: Journal of Investigational Allergology and Clinical Immunology)
Source: Journal of Investigational Allergology and Clinical Immunology - April 16, 2019 Category: Allergy & Immunology Authors: Alvarez-Puebla MJ, Arroabarren E, Zavala MJ, Corcuera A, Olaguibel A, Olaguibel JM Tags: J Investig Allergol Clin Immunol Source Type: research

Ebastine in the treatment of allergic rhinitis and urticaria: 30 years of clinical studies and real-world experience.
Abstract Histamine, acting predominantly via the H1-receptor, is an important mediator of the symptoms of allergy, and H1-antihistamines, which stabilise the receptor in its inactive form, are the treatment of choice for some chronic allergic conditions. Ebastine is a well-established oral second-generation H1-antihistamine. It is administered once daily at a dose of 10-20 mg and is available as a standard tablet and also as a fast-dissolving tablet that disintegrates in the mouth. Ebastine has demonstrated to be efficacious at relieving symptoms in patients with allergic rhinitis or urticaria in multiple clinical...
Source: Journal of Investigational Allergology and Clinical Immunology - April 12, 2019 Category: Allergy & Immunology Authors: Sastre J Tags: J Investig Allergol Clin Immunol Source Type: research

Selection of biologics in severe asthma: a multifaceted algorithm.
el JM PMID: 30969172 [PubMed - as supplied by publisher] (Source: Journal of Investigational Allergology and Clinical Immunology)
Source: Journal of Investigational Allergology and Clinical Immunology - April 10, 2019 Category: Allergy & Immunology Authors: Dávila I, Quirce S, Olaguibel JM Tags: J Investig Allergol Clin Immunol Source Type: research

Usefulness of Omalizumab and Sting Challenge Test in Hymenoptera Venom Allergy and Mastocytosis.
spesa M, de-la-Hoz-Caballer B PMID: 30957757 [PubMed - as supplied by publisher] (Source: Journal of Investigational Allergology and Clinical Immunology)
Source: Journal of Investigational Allergology and Clinical Immunology - April 8, 2019 Category: Allergy & Immunology Authors: González-de-Olano D, Padial-Vilchez MA, Núñez-Acevedo B, de-Calzada-Bustingorri MP, de-Andrés-Martín A, Caldas C, Piris-Villaespesa M, de-la-Hoz-Caballer B Tags: J Investig Allergol Clin Immunol Source Type: research

Occupational asthma caused by powder paint in the automotive industry.
PMID: 30957758 [PubMed - as supplied by publisher] (Source: Journal of Investigational Allergology and Clinical Immunology)
Source: Journal of Investigational Allergology and Clinical Immunology - April 8, 2019 Category: Allergy & Immunology Authors: Tiotiu A, Thaon I, Poussel M, Penven E Tags: J Investig Allergol Clin Immunol Source Type: research

A reoccurring drug induced liver injury (DILI) with cetirizine and amoxicillin-clavulanate potassium.
Sánchez M PMID: 30957759 [PubMed - as supplied by publisher] (Source: Journal of Investigational Allergology and Clinical Immunology)
Source: Journal of Investigational Allergology and Clinical Immunology - April 8, 2019 Category: Allergy & Immunology Authors: Vilà-Nadal G, Lleonart Bellfill R, Martí Garrido J, Baliellas Comellas C, Corominas Sánchez M Tags: J Investig Allergol Clin Immunol Source Type: research

Anaphylaxis to clavulanic acid: seven-year survey.
PMID: 30957760 [PubMed - as supplied by publisher] (Source: Journal of Investigational Allergology and Clinical Immunology)
Source: Journal of Investigational Allergology and Clinical Immunology - April 8, 2019 Category: Allergy & Immunology Authors: Silveira AM, Gaspar A, Benito-Garcia F, Couto S, Matias J, Chambel M, Morais-Almeida M Tags: J Investig Allergol Clin Immunol Source Type: research

Angioedema-induced by nonsteroidal anti-inflammatory drugs: a genotype-phenotype correlation in a Brazilian population.
PMID: 30957761 [PubMed - as supplied by publisher] (Source: Journal of Investigational Allergology and Clinical Immunology)
Source: Journal of Investigational Allergology and Clinical Immunology - April 8, 2019 Category: Allergy & Immunology Authors: Ensina LF, Martin RP, Filippelli-Silva R, Lopes Veronez C, Sole D, Bosco Pesquero J Tags: J Investig Allergol Clin Immunol Source Type: research

Der p 23 - clinical relevance of molecular monosensitisation in House Dust Mite allergy.
nta R PMID: 30957762 [PubMed - as supplied by publisher] (Source: Journal of Investigational Allergology and Clinical Immunology)
Source: Journal of Investigational Allergology and Clinical Immunology - April 8, 2019 Category: Allergy & Immunology Authors: Matos Semedo F, Dorofeeva Y, Pires AP, Tomaz E, Taborda Barata L, Inácio F, Valenta R Tags: J Investig Allergol Clin Immunol Source Type: research

Impact of low dose chlorine inhalation in healthy humans: a pilot study.
PMID: 30957763 [PubMed - as supplied by publisher] (Source: Journal of Investigational Allergology and Clinical Immunology)
Source: Journal of Investigational Allergology and Clinical Immunology - April 8, 2019 Category: Allergy & Immunology Authors: Ojanguren I, Chaboillez S, Cloutier Y, Panariti A, McGovern TK, Martin JG, Lemiere C Tags: J Investig Allergol Clin Immunol Source Type: research

Omalizumab's effectiveness in severe allergic asthma and nasal polyps: a real-life study.
CONCLUSIONS: The treatment by omalizumab in SAA improves the associated CRSNP+ outcomes supporting the concept of the one airway disease. PMID: 30931917 [PubMed - as supplied by publisher] (Source: Journal of Investigational Allergology and Clinical Immunology)
Source: Journal of Investigational Allergology and Clinical Immunology - April 1, 2019 Category: Allergy & Immunology Authors: Tiotiu A, Oster JP, Roux P, Nguyen Thi PL, Peiffer G, Bonniaud P, Dalphin JC, de Blay F Tags: J Investig Allergol Clin Immunol Source Type: research

Referral criteria for asthma: Consensus document.
as Ortega DA, Álvarez Puebla MJ, Carretero Gracia JA Abstract Asthma is one of the most prevalent chronic diseases in Spain. Current treatments ensure that the disease is controlled in most cases. However, disease is often uncontrolled in daily clinical practice, mainly owing to underdiagnosis, loss to follow-up, and poor adherence to therapy. In order to improve this situation, we must coordinate all those health professionals who intervene in patient care. Therefore, the Spanish Society of Allergology and Clinical Immunology (SEAIC), the Spanish Society of Primary Care Physicians (SEMERGEN), the Spanish S...
Source: Journal of Investigational Allergology and Clinical Immunology - April 1, 2019 Category: Allergy & Immunology Authors: Blanco Aparicio M, Delgado Romero J, Molina París J, Tomás Gómez J, Gómez Ruiz F, Álvarez Gutiérrez FJ, Domínguez Ortega J, Núñez Palomo S, Hidalgo Requena A, Vargas Ortega DA, Álvarez Puebla MJ, Carretero Gracia JA Tags: J Investig Allergol Clin Immunol Source Type: research

Diagnostic Approach for Suspected Allergic Cutaneous Reaction to a Permanent Tattoo.
eva I Abstract The last few decades have seen a notable increase in the number of people who have a tattoo. This practice is not free from complications. Most adverse effects appear early and are temporary, although they can occasionally develop later and be permanent and serious. Recent research has generated new knowledge on the composition of inks, their degradation over time, the immune activity that is stimulated, and the various clinical disorders that can arise. This information enables better approaches to diagnosis and management when complications arise. Diagnosing allergic reactions to permanent tattoo ...
Source: Journal of Investigational Allergology and Clinical Immunology - April 1, 2019 Category: Allergy & Immunology Authors: Silvestre JF, González-Villanueva I Tags: J Investig Allergol Clin Immunol Source Type: research

What we know about fish allergy by the end of the decade?
Abstract Fish allergy is one of the most common food allergies. It is usually considered to be immunoglobulin (Ig) E-mediated and correlated well with diagnostic tests such as prick tests and/or specific IgE. Recommended treatment is avoidance, generally extended to all fishes. However, new clinical presentations have been described, including non-IgE-mediated disease, mono-sensitization, and new syndromes that are sometimes associated with surprising cross-reactivity. Advances in molecular allergy have provided insights into new allergens and have increased our understanding of cross-reactivity. This paper focuse...
Source: Journal of Investigational Allergology and Clinical Immunology - February 11, 2019 Category: Allergy & Immunology Authors: Kourani E, Corazza F, Michel O, Doyen V Tags: J Investig Allergol Clin Immunol Source Type: research

Common Variable Immunodeficiency: Epidemiology, Pathogenesis, Clinical manifestations, Diagnosis, Classification and Management.
Abstract Common variable immunodeficiency (CVID) is a heterogeneous disorder characterized by hypogammaglobulinemia and increased susceptibility to recurrent bacterial infections. It is the most frequent symptomatic antibody deficiency with a wide variety of infectious and non-infectious complications. Numerous studies demonstrated that different immunological and genetic defects are involved in the pathogenesis of CVID. However, in most cases, the genetic background of the disease remains unidentified. This review aims to discuss different aspects of CVID including epidemiology, pathogenesis, symptoms, diagnosis,...
Source: Journal of Investigational Allergology and Clinical Immunology - February 11, 2019 Category: Allergy & Immunology Authors: Yazdani R, Habibi S, Sharifi L, Azizi G, Abolhassani H, Olbrich P, Aghamohammadi A Tags: J Investig Allergol Clin Immunol Source Type: research

Clinical factors associated with the overuse of asthma rescue medication.
vestigators Group Abstract BACKGROUND AND OBJECTIVE: Our aim was to evaluate the relationship between asthma clinical factors and use of relief medication. METHODS: This was an observational cross-sectional study conducted in Spain. The study recruited patients ≥ 12 years of age diagnosed with persistent asthma according to the GINA criteria and receiving maintenance treatment for at least 12 months. Use of relief medication was dichotomized: low use of rescue medication (LURM) (≤ twice/week) or high use of rescue medication (HURM) (≥ three times/week). A variety of clinical variables and patient rep...
Source: Journal of Investigational Allergology and Clinical Immunology - February 11, 2019 Category: Allergy & Immunology Authors: Urrutia I, Delgado J, Domínguez-Ortega J, Mascarós E, Pérez M, Resler G, Plaza V, on behalf on the MISTRAL Investigators Group Tags: J Investig Allergol Clin Immunol Source Type: research

IgE-mediated sensitization to galactose-alpha-1,3-galactose ( α-gal) in urticaria and anaphylaxis in Spain: geographical variations and risk factors.
CONCLUSIONS: Sensitization to α-gal in patients with urticaria or anaphylaxis differs considerably between the three geographical areas studied and is related to tick bites. PMID: 30676319 [PubMed - as supplied by publisher] (Source: Journal of Investigational Allergology and Clinical Immunology)
Source: Journal of Investigational Allergology and Clinical Immunology - January 24, 2019 Category: Allergy & Immunology Authors: Mateo-Borrega MB, Garcia B, Hernando Larramendi C, Azofra J, González-Mancebo E, Alvarado MI, Alonso Díaz de Durana MD, Núñez-Orjales R, Diéguez MC, Guilarte M, Soriano-Galarraga AM, Sosa G, Ferrer A, García-Moral A, Beristain AM, Bartra J Tags: J Investig Allergol Clin Immunol Source Type: research

Incidence and risk factors of low-osmolar iodinated contrast media related immediate hypersensitivity reactions: A longitudinal study based on a real-time monitoring system.
Abstract BACKGROUND: We investigated the incidence of immediate hypersensitivity reaction (HSR) focusing on the types of low osmolar contrast media (LOCM) and accumulated exposures to LOCM. METHODS: This cohort study included all consecutive patients who underwent LOCM-enhanced computed tomography scan from 2012 through 2014. Five LOCMs (iobitridol, iohexol, iomeprol, iopamidol, and iopromide) were used. All patients were monitored for adverse events and new symptoms and signs were recorded in the Contrast Safety Monitoring and Management System (CoSM2oS) in real-time. RESULTS: The overall incidence of i...
Source: Journal of Investigational Allergology and Clinical Immunology - January 24, 2019 Category: Allergy & Immunology Authors: Suh-Young L, Dong Yoon K, Ju-Young K, Soon Ho Y, Young-Hoon C, Whal L, Sang Heon C, Hye-Ryun K Tags: J Investig Allergol Clin Immunol Source Type: research

Relevance of Th2 markers in the assessment and therapeutic management of severe allergic asthma: a real life perspective.
Abstract BACKGROUND: Although blood eosinophils are currently recognized as the main clinical marker of Th2 inflammation, their relevance in identifying asthma severity is still matter of debate. METHODS: Our retrospective real-life study on severe asthmatics included in the NEONet Italian database, aimed at investigating the relevance of blood eosinophil count and FeNO in severe asthma clinical assessment and their role as a potential predictor of responsiveness to anti-IgE therapy. As cut-off values 300 blood eosinophils/mm3 and 30 ppm for FeNO were chosen. RESULTS: Overall 132 adult patients were eval...
Source: Journal of Investigational Allergology and Clinical Immunology - January 24, 2019 Category: Allergy & Immunology Authors: Caminati M, Vianello A, Chieco Bianchi F, Festi G, Guarnieri G, Marchi MR, Micheletto C, Olivieri M, Tognella S, Guerriero M, Senna G, NEONET Study Group Tags: J Investig Allergol Clin Immunol Source Type: research

VEGF -2549 -2567 del18 polymorphism and irreversible bronchoconstriction in asthmatics.
CONCLUSIONS: Our results showed that the presence of del18 genotype at -2549 -2567 position in the promoter of VEGF gene, along with disease duration and other factors like cigarette smoking, associate with the risk of irreversible bronchoconstriction in asthmatics. PMID: 30574871 [PubMed - as supplied by publisher] (Source: Journal of Investigational Allergology and Clinical Immunology)
Source: Journal of Investigational Allergology and Clinical Immunology - December 21, 2018 Category: Allergy & Immunology Authors: Gomulka K, Liebhart J, Jaskula E, Lange A, Medrala W Tags: J Investig Allergol Clin Immunol Source Type: research

Relationship between air pollution, meteorological factors and grass pollen counts, with seasonal allergic rhinitis in Madrid (1996 and 2009).
CONCLUSIONS: The effect of the temperature and pollution (mainly O3, even at lower atmospheric concentrations than the established guidelines about its effects on health), could contributed to the observed higher seasonal allergic rhinitis symptom score in 2009. PMID: 30574872 [PubMed - as supplied by publisher] (Source: Journal of Investigational Allergology and Clinical Immunology)
Source: Journal of Investigational Allergology and Clinical Immunology - December 21, 2018 Category: Allergy & Immunology Authors: Cabrera M, Garzón García B, Moreno Grau S, Subiza J Tags: J Investig Allergol Clin Immunol Source Type: research

Asthma Exacerbations in the Pediatric Emergency Department at a Tertiary Hospi-tal: Relationship with Environmental Factors.
z I, López I, Quirce S Abstract BACKGROUND: Children with asthma suffer from recurrent respiratory symptoms and exacerbations due to multiple environmental factors. The aim of this study is to describe the prevalence and triggers of asthma exacerbations and their management in cohort of pediatric patients attended in an emergency department (ED). METHODS: This was an observational, retrospective, single center study, conducted in the pediatric ED of the Hospital Universitario La Paz (Madrid, Spain) in 2015. Children with asthma exacerbations attending the ED were included in the study after a thorough ...
Source: Journal of Investigational Allergology and Clinical Immunology - December 18, 2018 Category: Allergy & Immunology Authors: Marques-Mejías MA, Tomás-Pérez M, Hernández I, López I, Quirce S Tags: J Investig Allergol Clin Immunol Source Type: research

Early Life Origins of Asthma: A Review of Potential Effectors.
te; A Abstract There is currently growing evidence that events occurring early in life, both before and after birth, are significantly associated with the risk of asthma, COPD and low lung function later in life. In fact, from conception to death there are continuous, dynamic numbers of gene-environment interactions that determine two fundamental biologic processes, lung development and lung ageing. Over 130 birth cohorts have been initiated in the last 30 years. These birth cohorts have improved our understanding of asthma inception, progression and persistency. In this review, we summarize the main data upon tho...
Source: Journal of Investigational Allergology and Clinical Immunology - December 18, 2018 Category: Allergy & Immunology Authors: Bobolea I, Arismendi E, Valero A, Agustí A Tags: J Investig Allergol Clin Immunol Source Type: research

Mast Cells as Key Players in Allergy and Inflammation.
This article provides a comprehensive overview of MC biology, focusing predominantly on mechanisms of MC activation and the role of MCs in the pathogenesis of allergic diseases. PMID: 30530385 [PubMed - in process] (Source: Journal of Investigational Allergology and Clinical Immunology)
Source: Journal of Investigational Allergology and Clinical Immunology - December 1, 2018 Category: Allergy & Immunology Authors: González-de-Olano D, Álvarez-Twose I Tags: J Investig Allergol Clin Immunol Source Type: research

Skin Reactivity to Aeroallergens in Schistosoma mansoni-Infected Brazilian Individuals and Modulation of CCL2 and IL-10.
ria Oliveira de Souza V PMID: 30530386 [PubMed - in process] (Source: Journal of Investigational Allergology and Clinical Immunology)
Source: Journal of Investigational Allergology and Clinical Immunology - December 1, 2018 Category: Allergy & Immunology Authors: Correia do Nascimento WR, de Oliveira Nóbrega CG, Barros Lorena V, Alves Dos Santos P, de Souza Fernandes E, Maria Assis Costa V, Simões Barbosa C, Medeiros D, Sávio Sarinho E, Solé D, Maria Oliveira de Souza V Tags: J Investig Allergol Clin Immunol Source Type: research

Leukocytoclastic Vasculitis After Influenza Vaccination: An Allergy Assessment.
z-Rodríguez M, Alvarez-Mon M PMID: 30530387 [PubMed - in process] (Source: Journal of Investigational Allergology and Clinical Immunology)
Source: Journal of Investigational Allergology and Clinical Immunology - December 1, 2018 Category: Allergy & Immunology Authors: Barbarroja-Escudero J, Sánchez-González MJ, Vélez D, Aboín S, Rodríguez-Rodríguez M, Alvarez-Mon M Tags: J Investig Allergol Clin Immunol Source Type: research

Anaphylaxis Due to Poloxamer 238.
eda F PMID: 30530388 [PubMed - in process] (Source: Journal of Investigational Allergology and Clinical Immunology)
Source: Journal of Investigational Allergology and Clinical Immunology - December 1, 2018 Category: Allergy & Immunology Authors: Carbonell A, Escudero AI, Miralles JC, González A, Navarro C, Cardona P, Jimeno L, Pineda F Tags: J Investig Allergol Clin Immunol Source Type: research