Recommended Immunization Schedule for Children and Adolescents: Committee on Infectious Diseases of the Korean Pediatric Society, 2018.
This report provides the revised recommendations made by the committee and summarizes several changes from the 2015 guideline. National immunization program (NIP) launched a human papillomavirus (HPV) immunization for girls aged 12 years in 2016. NIP has also expanded age indication for inactivated influenza vaccine (IIV) to 12 years of age in the 2018-2019 season. Quadrivalent IIVs with a full dose (0.5 mL) are approved for all children of 6 months or older. Recommendations of live attenuated influenza vaccine were removed. For inactivated Japanese encephalitis vaccine (JEV), first two doses are considered as the primary ...
Source: Korean Journal of Pediatrics - June 7, 2019 Category: Pediatrics Tags: Korean J Pediatr Source Type: research

Clinical impact of admission hypothermia in very low birth weight infants: Results from Korean neonatal network.
Authors: Lee NH, Nam SK, Lee J, Jun YH Abstract Background: Preterm infants have difficulty maintaining body temperature after birth. However, clinical guidelines advocate that neonatal body temperature should be maintained at 36.5-37.5°C. Purpose: We aimed to investigate the incidence of admission hypothermia in very low birth weight (VLBW) infants and to determine the association of admission temperature with in-hospital mortality and morbidities. Methods: A cohort study using prospectively collected data involving 70 neonatal intensive care units (NICUs) that participate in the Korean neonatal networ...
Source: Korean Journal of Pediatrics - May 29, 2019 Category: Pediatrics Tags: Korean J Pediatr Source Type: research

On the effect of omega-3 supplementation with methylphenidate as an alternative therapy to reduce Attention Deficit Hyperactivity Disorder (ADHD) in children.
Conclusion: The results of our study showed that a specific dose of omega-3 for eight weeks had no effect on the treatment of ADHD. PMID: 31122010 [PubMed - as supplied by publisher] (Source: Korean Journal of Pediatrics)
Source: Korean Journal of Pediatrics - May 29, 2019 Category: Pediatrics Tags: Korean J Pediatr Source Type: research

Bronchopulmonary dysplasia; what should we do to improve its outcomes?
Authors: Sung TJ Abstract Bronchopulmonary dysplasia (BPD) is a chronic lung disease of preterm infants with multiple factors affected from prenatal to postnatal periods. Despite the great advances in neonatal care over almost 50 years, the rates of BPD are not decreased and may even have risen. Since more preterm infants even in periviable gestational age are survived nowadays, different stages of lung development have an effect on the pathogenesis of BPD. Hence the definition of BPD had been changed from 'old' BPD and 'new' BPD. In this review, the various definition of BPD, risk factors from prenatal to postnata...
Source: Korean Journal of Pediatrics - May 29, 2019 Category: Pediatrics Tags: Korean J Pediatr Source Type: research

The role of Lactobacillus reuteri DSM 17938 for the absorption of iron preparations in children with iron deficiency anemia.
Authors: Manoppo J, Tasiringan H, Wahani A, Umboh A, Mantik M Abstract PURPOSE: To determine whether Lactobacillus reuteri DSM 17938 plays a role in absorption of iron preparations given to children with iron deficiency anemia (IDA). METHODS: We performed a quasi-experimental study involving pre- and postintervention tests using a control group in North Sulawesi province, Indonesia, between July and September 2017. We conducted a single-blind controlled trial that included primary school children who were diagnosed with IDA based on reticulocyte hemoglobin equivalent (Ret-He) levels
Source: Korean Journal of Pediatrics - May 22, 2019 Category: Pediatrics Tags: Korean J Pediatr Source Type: research

To give or not to give partially hydrolyzed infant formula to general population for primary prevention?
Authors: Song TW PMID: 31096738 [PubMed - as supplied by publisher] (Source: Korean Journal of Pediatrics)
Source: Korean Journal of Pediatrics - May 19, 2019 Category: Pediatrics Tags: Korean J Pediatr Source Type: research

Understanding the importance of cerebrovascular involvement in Kawasaki disease.
Authors: Yeom JS, Cho JY, Woo HO Abstract Kawasaki disease (KD) is a systemic vasculitis in infants and young children. The natural history of KD has not been fully elucidated because the first case of KD was reported in late 1960s and patients who have recovered will just now entering middle age. Nevertheless, several evidences have raised concerns regarding the subclinical vascular changes in post-KD patients. KD have focused on the coronary artery aneurysms because which are directly associated with fatality. However, aneurysms have been reported in other extra-cardiac muscular arteries and their fate seems to r...
Source: Korean Journal of Pediatrics - May 19, 2019 Category: Pediatrics Tags: Korean J Pediatr Source Type: research

Correlation Of Serum S100B Levels With MRI Abnormalities In Children With Status Epilepticus.
Authors: Gunawan PI, Saharso D, Sari DP Abstract Purpose: To evaluate the association of elevated S100B levels with brain tissue damage seen in abnormalities of head MRI (Diffusiion-Tensor Imaging (DTI) sequence) in patients with Status Epilepticus. Methods: an analytical observational study was conducted in children hospitalized at Dr Soetomo hospital, Surabaya from July 2016 to December 2016. The patients were divided into two groups. The SE groups consisted of all children with a history of SE and the control group consisted of all children with febrile seizure. Blood samples of patients were drawn within 24...
Source: Korean Journal of Pediatrics - May 19, 2019 Category: Pediatrics Tags: Korean J Pediatr Source Type: research

Importance of Coronary Artery Dominance in children to determined coronary artery dilatation.
Authors: Choi HJ PMID: 31096741 [PubMed - as supplied by publisher] (Source: Korean Journal of Pediatrics)
Source: Korean Journal of Pediatrics - May 19, 2019 Category: Pediatrics Tags: Korean J Pediatr Source Type: research

Is there any specific infection that causes Kawasaki disease?
Authors: Lee DS PMID: 31096742 [PubMed - as supplied by publisher] (Source: Korean Journal of Pediatrics)
Source: Korean Journal of Pediatrics - May 19, 2019 Category: Pediatrics Tags: Korean J Pediatr Source Type: research

Nasal eosinophilia and eosinophil peroxidase in children and adolescents with rhinitis.
Authors: Choi Y, Jeon H, Yang EA, Yoon JS, Kim HH Abstract Background: Researcher showed that EPO is a relatively accurate marker of eosinophilia and eosinophil activity and that EPO has a higher correlation to them. However, it's use as markers of eosinophilic inflammation in nasal secretions is limited because the diagnostic cut-off values of EPO for use as one-time tests for allergic diseases such as allergic rhinitis have not been established. Purpose: To identify the correlation between nasal eosinophil and eosinophil peroxidase (EPO) in children and adolescents with rhinitis. Methods: We recruited pat...
Source: Korean Journal of Pediatrics - May 19, 2019 Category: Pediatrics Tags: Korean J Pediatr Source Type: research

Prevalence of Obesity and Overweight in Iranian Children under 5 Years: A Systematic Review and Meta-analysis.
Conclusion: Although, there was a high heterogeneity among the results of the articles included in the meta-analysis, however, the prevalence of obesity and overweigh is higher in Iranian children under 5 years. Therefore, parents and the health system need to pay more attention to lifestyle, nutritional habits and physical activity of these children. PMID: 31096744 [PubMed - as supplied by publisher] (Source: Korean Journal of Pediatrics)
Source: Korean Journal of Pediatrics - May 19, 2019 Category: Pediatrics Tags: Korean J Pediatr Source Type: research

Phenotypes of allergic diseases in children and their application in clinical situations.
Authors: Lee E, Hong SJ Abstract Allergic disease, including allergic rhinitis, asthma, and atopic dermatitis, are huge heterogeneous diseases, encompassing diverse phenotypes with different pathogenesis. Phenotype studies on allergic diseases are important in that they can facilitate the identification of risk factors and the underlying pathophysiologies, resulting in the application of more effective treatment, selection of better response to the treatment, and prediction of prognosis for each phenotype. In the early phase of phenotype studies in allergic diseases, artificial classifications were usually performe...
Source: Korean Journal of Pediatrics - May 19, 2019 Category: Pediatrics Tags: Korean J Pediatr Source Type: research

Predictors and management of intravenous immunoglobulin-resistant Kawasaki disease.
Authors: Song MS Abstract Kawasaki disease (KD) is a systemic vasculitis that mainly affects younger children. Intravenous immunoglobulin (IVIG) resistant cases are at increasing risk for coronary artery complications. The strategy on prediction of potential nonresponders and treatment of IVIG-resistant patients is now controversial. In this review the definition and predictors of IVIG-resistant KD and current evidence to guide management are discussed. PMID: 30999718 [PubMed] (Source: Korean Journal of Pediatrics)
Source: Korean Journal of Pediatrics - April 21, 2019 Category: Pediatrics Tags: Korean J Pediatr Source Type: research

Evaluation of hematologic profile may be needed for patients treated with oxcarbazepine.
Authors: Jung GH, You SJ Abstract Purpose: The major side effects of treatment with oxcarbazepine (OXC) are skin rash and hyponatremia. Hematologic side effects are reported to be rare. The aim of this study was to investigate the rate and types of hematologic side effects of OXC. Methods: The medical records of 184 patients who were diagnosed with epilepsy or movement disorder and treated with OXC monotherapy at the Department of Pediatrics of Sanggye Paik Hospital from July 2001 to July 2018 were retrospectively reviewed. Results: Of the 184 patients, 10 (5.4%) developed leukopenia including pancytopenia ...
Source: Korean Journal of Pediatrics - April 21, 2019 Category: Pediatrics Tags: Korean J Pediatr Source Type: research

The Association of vitamin D status at birth and respiratory outcomes in preterm infants.
Authors: Park SH PMID: 30999725 [PubMed - as supplied by publisher] (Source: Korean Journal of Pediatrics)
Source: Korean Journal of Pediatrics - April 21, 2019 Category: Pediatrics Tags: Korean J Pediatr Source Type: research

Practice for Preterm Patent Ductus Arteriosus; Focusing on the Hemodynamic Significance and the Impact on the Neonatal Outcomes.
Authors: Lee JA Abstract Hemodynamically significant preterm patent ductus arteriosus (PDA) has been known to affect mortality, morbidities such as necrotizing enterocolitis, intra-ventricular hemorrhage, bronchopulmonary dysplasia, and adverse long-term neurodevelopmental outcomes in preterm infants, especially in very low birth weight infants. However, recent researches indicate that there is no consensus about the causal relationship between the PDA and neonatal outcomes, the benefit or lack of treatment, the factors guiding the need to treat, and about the optimal treatment strategies. Such uncertainty made the...
Source: Korean Journal of Pediatrics - April 21, 2019 Category: Pediatrics Tags: Korean J Pediatr Source Type: research

The effect of high fat dietary modification and nutritional status on the outcome of critically ill ventilated children: Single-center study.
Conclusion: The high-fat enteral feeding protocol may contribute to the reduction of carbon dioxide tension with mild hypertriglyceridemia and negligible gastrointestinal intolerances as potential adverse effects. Optimization of nutritional status rather than dietary modification may improve ventilatory and survival outcomes in critically ill ventilated children. PMID: 30999727 [PubMed - as supplied by publisher] (Source: Korean Journal of Pediatrics)
Source: Korean Journal of Pediatrics - April 21, 2019 Category: Pediatrics Tags: Korean J Pediatr Source Type: research

Simple Universal cut-point of Waist-Height Ratio for Metabolic Risk in Korean Children and Adolescents.
Authors: Kim HS PMID: 30999728 [PubMed - as supplied by publisher] (Source: Korean Journal of Pediatrics)
Source: Korean Journal of Pediatrics - April 21, 2019 Category: Pediatrics Tags: Korean J Pediatr Source Type: research

The Role of Fecal Calprotectin in Pediatric Disease.
This article summarizes the current literature on the use of fecal calprotectin in clinical practice. PMID: 30999729 [PubMed - as supplied by publisher] (Source: Korean Journal of Pediatrics)
Source: Korean Journal of Pediatrics - April 21, 2019 Category: Pediatrics Tags: Korean J Pediatr Source Type: research

Validity of the Korean Developmental Screening Test for Very Low Birth Weight Infants.
This study wanted to assess the validity of the Korean Developmental Screening Test (K-DST), a developmental screening tool acknowledged by Korean Society of Pediatrics, for timely diagnosis of neurodevelopmental delay in VLBW infants. Methods: Subjects included VLBW infants enrolled in Korean Neonatal Network database from January 2012 to December 2014. The collected data was analyzed for sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of K-DST compared to Bayley Scales of Infant Development-II (BSID-II) in VLBW infants. Results: A total of 173 patients were enrolled....
Source: Korean Journal of Pediatrics - April 21, 2019 Category: Pediatrics Tags: Korean J Pediatr Source Type: research

The relation between serum levels of Epidermal Growth Factor (EGF) and necrotizing enterocolitis in preterm neonates.
Authors: Ahmed H, Kamel N Abstract Purpose: Necrotizing enterocolitis (NEC) is one of the most serious complications of prematurity. There are many risk factors can contribute to the development of NEC .Epidermal growth factor (EGF) plays a major role in the intestinal barrier function, increases intestinal enzyme activity, and improves nutrient transport . The aim of study is to assess the role of epidermal growth factor in the development of NEC in preterm neonates. Methods: 130 preterm neonates were included in the study and were divided into three groups; group 1 (40 preterms with NEC) group 2( 50 preterms ...
Source: Korean Journal of Pediatrics - April 21, 2019 Category: Pediatrics Tags: Korean J Pediatr Source Type: research

Benefits and risks of therapeutic alternatives for macrolide resistant Mycoplasma Pneumoniae pneumonia in children.
Authors: Yang HJ Abstract Mycoplasma pneumoniae pneumonia (MPP) has been generally susceptible to macrolides, however emergence of macrolide-resistant Mycoplasma pneumoniae pneumonia (MRMP) has made the treatment of MPP challenging. MRMP rapidly spread after 2000s, especially in the Eastern Asia. MRMPs are more common in children and adolescents than in adults, which is likely related to the frequent use of macrolides for treatments of MP infections in children. The MRMP is unlikely to be related with clinical, laboratory, or radiological- severity, although it is likely to cause longer persistence of symptoms and ...
Source: Korean Journal of Pediatrics - April 21, 2019 Category: Pediatrics Tags: Korean J Pediatr Source Type: research

Perampanel is also a useful adjunctive treatment option in children.
Authors: Kim JS, Kim WS PMID: 30852883 [PubMed - as supplied by publisher] (Source: Korean Journal of Pediatrics)
Source: Korean Journal of Pediatrics - March 13, 2019 Category: Pediatrics Tags: Korean J Pediatr Source Type: research

Trend in the use of antibiotics in Korean children.
Authors: Choe YJ, Shin JY Abstract Inappropriate use of antibiotics is the most important factor that causes an increase in bacterial resistance to antibiotics, thus affecting patient outcomes. Multidrug-resistant bacteria have become a serious public health threat causing significant morbidity and mortality worldwide. In Korea, the burden of antibiotic resistant bacteria have become an important public health issues. There is increasing evidence of overuse and misuse of antibiotics in Korea observed from cohorts of large sample size. In specific, antibiotic use in children should be highlighted because of the freq...
Source: Korean Journal of Pediatrics - March 13, 2019 Category: Pediatrics Tags: Korean J Pediatr Source Type: research

Predictive risk factors of coronary artery aneurysms in Kawasaki disease.
Authors: Woo HO PMID: 30776881 [PubMed - as supplied by publisher] (Source: Korean Journal of Pediatrics)
Source: Korean Journal of Pediatrics - February 21, 2019 Category: Pediatrics Tags: Korean J Pediatr Source Type: research

Prevalence and associates of obesity and overweight among school-age children in a rural community of Thailand.
Conclusion: The findings of this study identified many socio-demographic predictors and dietary and behavioral factors were related to overweight and obesity among school-age children not only in the urban but also in the rural community of Thailand. PMID: 30744316 [PubMed - as supplied by publisher] (Source: Korean Journal of Pediatrics)
Source: Korean Journal of Pediatrics - February 14, 2019 Category: Pediatrics Tags: Korean J Pediatr Source Type: research

Iron deficiency anemia as a predictor of coronary artery abnormalities in Kawasaki disease.
Conclusion: The indicators of IDA, especially ferritin, were highly associated with CAA, so that they were stronger predictors compared to the Kobayashi score. The IDA indicators can be used to predict CAA development and suggest the need for early intervention. PMID: 30744317 [PubMed - as supplied by publisher] (Source: Korean Journal of Pediatrics)
Source: Korean Journal of Pediatrics - February 14, 2019 Category: Pediatrics Tags: Korean J Pediatr Source Type: research

Surfactants preparations for preterm infants with respiratory distress syndrome: past, present, and future.
Authors: Jeon GW Abstract After the first successful trial of surfactant replacement therapy for preterm infants with respiratory distress syndrome (RDS) by Fujiwara in 1980, several animal-derived natural surfactants and synthetic surfactants have been developed. Synthetic surfactants were made to overcome limitations of natural surfactants such as expensiveness, immune reactions, and infections due to animal proteins contained in natural surfactants. However, first-generation synthetic surfactants that are protein-free have failed to prove superiority over natural surfactants because they do not have surfactant p...
Source: Korean Journal of Pediatrics - February 14, 2019 Category: Pediatrics Tags: Korean J Pediatr Source Type: research

A Perspective on Partially Hydrolyzed Protein Infant Formula In Non-Exclusively Breastfed Infants.
The objectives of this paper were to review the evidence of pHF whey formula for non-breastfed infants, not only to prevent of atopic disease in high-risk infants but also as routine starter formula regardless of the allergic risk status. PMID: 30651423 [PubMed - as supplied by publisher] (Source: Korean Journal of Pediatrics)
Source: Korean Journal of Pediatrics - January 18, 2019 Category: Pediatrics Tags: Korean J Pediatr Source Type: research

What should we do to prevent and manage obesity in children and adolescents?
Authors: Yang HR PMID: 30651424 [PubMed - as supplied by publisher] (Source: Korean Journal of Pediatrics)
Source: Korean Journal of Pediatrics - January 18, 2019 Category: Pediatrics Tags: Korean J Pediatr Source Type: research

Genetic diagnosis of Alport syndrome.
Authors: Cheong HI PMID: 30651425 [PubMed - as supplied by publisher] (Source: Korean Journal of Pediatrics)
Source: Korean Journal of Pediatrics - January 18, 2019 Category: Pediatrics Tags: Korean J Pediatr Source Type: research

Clinical Practice Guideline for the Diagnosis and Treatment of Pediatric Obesity: Recommendations from the Committee on Pediatric Obesity of the Korean Society of Pediatric Gastroenterology Hepatology and Nutrition.
Authors: Yi DY, Kim SC, Lee JH, Lee EH, Kim JY, Kim YJ, Kang KS, Hong J, Shim JO, Lee Y, Kang B, Lee YJ, Kim MJ, Moon JS, Koh H, You J, Kwak YS, Lim H, Yang HR Abstract The Committee on Pediatric Obesity of the Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition newly developed the first Korean Guideline on the Diagnosis and Treatment of Obesity in Children and Adolescents to deliver an evidence-based systematic approach to childhood obesity in South Korea. The following areas were systematically reviewed, especially on the basis of all available references published in South Korea and worldwide,...
Source: Korean Journal of Pediatrics - December 29, 2018 Category: Pediatrics Tags: Korean J Pediatr Source Type: research

Efficacy and tolerability of adjunctive perampanel treatment in children under 12 years of age with refractory epilepsy.
Conclusion: Perampanel offers a treatment option for refractory epilepsy in children as in adults. Adjunctive treatment with perampanel requires special consideration in those with underlying medical conditions to prevent serious adverse events. PMID: 30590000 [PubMed - as supplied by publisher] (Source: Korean Journal of Pediatrics)
Source: Korean Journal of Pediatrics - December 29, 2018 Category: Pediatrics Tags: Korean J Pediatr Source Type: research

The association between preeclampsia and autism spectrum disorders among children: a meta-analysis.
Conclusions: Despite existing controversy, our findings indicated that preeclampsia is associated with increased risk of ASD among children. PMID: 30590001 [PubMed - as supplied by publisher] (Source: Korean Journal of Pediatrics)
Source: Korean Journal of Pediatrics - December 29, 2018 Category: Pediatrics Tags: Korean J Pediatr Source Type: research

Central line-associated bloodstream infections in neonates.
Authors: Cho HJ, Cho HK Abstract Newborn infants, including premature infants, are high-risk patients susceptible to various microorganisms. Catheter-related bloodstream infections are the most common type of nosocomial infections in this population. Regularly educating and training the medical staffs are most important as a preventive strategy for central line-associated bloodstream infections (CLABSIs). Bundle approaches and the use of checklists during the insertion and maintenance of central catheters are effective measures to reduce the incidence of CLABSIs. Chlorhexidine, commonly used as a skin disinfectant ...
Source: Korean Journal of Pediatrics - December 29, 2018 Category: Pediatrics Tags: Korean J Pediatr Source Type: research

The adiposity rebound in the 21st century children: meaning for what?
Authors: Kang MJ Abstract With the increase in the prevalence of overweight and obesity worldwide, early adiposity rebound, which is known to have a strong association with obesity, has recently been a focus of research. Early adiposity rebound is conventionally known to have a close relationship with non-communicable diseases. However, novel insights into early adiposity rebound have implied an acceleration of growth and puberty, which is directly reflected in the trends in the timing of adiposity rebound, in the 21st century compared with in the past. Furthermore, the observation that lean mass changes rather tha...
Source: Korean Journal of Pediatrics - December 28, 2018 Category: Pediatrics Tags: Korean J Pediatr Source Type: research

Secular change in waist circumference and waist-height ratio and optimal cutoff of waist-height ratio for abdominal obesity among Korean children and adolescents.
Conclusions: The presented data of WC and WHR showed no secular change over 10 years. The optimal WHR cutoff for abdominal obesity, 0.48 would be helpful to diagnose and to manage obesity in Korean 13-18 years old adolescents, preventing obesity related cardiometabolic complications. PMID: 30514064 [PubMed - as supplied by publisher] (Source: Korean Journal of Pediatrics)
Source: Korean Journal of Pediatrics - December 6, 2018 Category: Pediatrics Tags: Korean J Pediatr Source Type: research

Comparison of effectiveness of growth hormone therapy according to disease-causing genes in children with Noonan syndrome.
Conclusions: The 3-year GH therapy in the 23 prepubertal patients with NS was effective in improving height SDS, GV, and serum IGF-1 levels. FGU group showed a better response to rhGH therapy compared with the detected groups with PTPN11, RAF1, and SOS1 groups. PMID: 30514065 [PubMed - as supplied by publisher] (Source: Korean Journal of Pediatrics)
Source: Korean Journal of Pediatrics - December 6, 2018 Category: Pediatrics Tags: Korean J Pediatr Source Type: research

A contact investigation after exposure to a child with disseminated tuberculosis mimicking inflammatory bowel disease.
CONCLUSION: This is the first reported case of TB transmission among young children from a pediatric patient with disseminated TB in Korea. TB should be emphasized as a possible cause of chronic diarrhea and failure to thrive in children. A national TB control policy has been actively applied to identify Korean children with LTBI. PMID: 30481995 [PubMed] (Source: Korean Journal of Pediatrics)
Source: Korean Journal of Pediatrics - December 1, 2018 Category: Pediatrics Tags: Korean J Pediatr Source Type: research

De novo mutations in COL4A5 identified by whole exome sequencing in two girls with Alport syndrome in Korea.
Authors: Han KH, Park JE, Ki CS Abstract Alport syndrome (ATS) is an inherited glomerular disease caused by mutations in one of the type IV collagen novel chains (α3, α4, and α5). ATS is characterized by persistent microscopic hematuria starting from infancy, eventually leading to either progressive nephritis or end-stage renal disease. There are three known genetic forms of ATS, i.e., X-linked ATS, autosomal recessive ATS, and autosomal dominant ATS. About 80% of patients with ATS have X-linked ATS, caused by mutations in the type IV collagen α5 chain gene, COL4A5. Mutation detection rates ...
Source: Korean Journal of Pediatrics - November 29, 2018 Category: Pediatrics Tags: Korean J Pediatr Source Type: research

Serum alanine aminotransferase levels are closely associated with metabolic disturbances in apparently healthy young adolescents independent of obesity.
Authors: Kim KE, Baek KS, Han S, Kim JH, Sheen YH Abstract Purpose: Liver metabolism plays a pivotal role in the development of metabolic disorders. We aimed to investigate the clinical and laboratory risk factors associated with alanine aminotransferase (ALT) levels in young adolescents from an urban population in Korea. Methods: A population of 120 apparently healthy adolescents aged 12-13 years was included in the cross-sectional design study; 58 were overweight or obese and 62 were of normal weight. We estimated anthropometric and laboratory measurements, including waist-to-height ratio, blood pressure, ins...
Source: Korean Journal of Pediatrics - November 29, 2018 Category: Pediatrics Tags: Korean J Pediatr Source Type: research

Change of Coronary Artery Indices according to Coronary Dominance Pattern in Early Childhood.
This study aimed to examine coronary dominance pattern according to objective Coronary artery (CA) indices. Methods: CA diameter, aortic valve annulus, and abdominal aorta were measured with cross-sectional echocardiography in 69 children without any cardiovascular disease at Chungnam National University Hospital. To evaluate the coronary dominance pattern, echocardiography was primarily used and additionally, coronary computed tomographic angiography or Coronary angiography (CAG). Coronary dominance was determined according to the coronary artery that gives rise to the posterior descending artery. Results: The mea...
Source: Korean Journal of Pediatrics - November 24, 2018 Category: Pediatrics Tags: Korean J Pediatr Source Type: research

Risk factors for the Occurrence and Persistence of Coronary Aneurysm in Kawasaki Disease.
Conclusion: This data showed early and late follow up of coronary aneurysm in our unit. Further studies are needed to determine the mechanisms involved in the disappearance of coronary aneurysm and related factors. PMID: 30463400 [PubMed - as supplied by publisher] (Source: Korean Journal of Pediatrics)
Source: Korean Journal of Pediatrics - November 24, 2018 Category: Pediatrics Tags: Korean J Pediatr Source Type: research

Scabies mimicking graft versus host disease in a hematopoietic cell transplant recipient.
We report the first Korean case of scabies in a hematopoietic cell transplant recipient, initially suspected for skin graft versus host disease (GVHD). A T-cell acute lymphocytic leukemia patient underwent a sibling matched allogeneic HCT and developed pruritus after cell engraftment. Treatment for GVHD did not improve the symptoms. He was diagnosed with scabies after 30 days of symptom onset. PMID: 30428645 [PubMed - as supplied by publisher] (Source: Korean Journal of Pediatrics)
Source: Korean Journal of Pediatrics - November 16, 2018 Category: Pediatrics Tags: Korean J Pediatr Source Type: research

Renal replacement therapy in neonates with an inborn error of metabolism.
Authors: Cho H Abstract Hyperammonemia can caused by several different genetic inborn errors of metabolism including urea cycle defects, organic acidemias, fatty acid oxidation defects, and certain disorders of amino acid metabolism. High levels of ammonia are extremely neurotoxic, leading to astrocyte swelling, brain edema, coma, severe disability, and even death. Thus, emergency treatment for hyperammonemia must begin before a precise diagnosis is established. In neonates with hyperammonemia caused by an inborn error of metabolism, a few studies have suggested that peritoneal dialysis, intermittent hemodialysis, ...
Source: Korean Journal of Pediatrics - November 9, 2018 Category: Pediatrics Tags: Korean J Pediatr Source Type: research

High antistreptolysin O titer is associated with coronary artery lesions in patients with Kawasaki disease.
Conclusion: It is not certain whether acute streptococcal infection may cause KD, but this study revealed that KD with high ASO titers showed higher rates of severe clinical course. It may be helpful to analyze concurrent streptococcal infection in patients with a severe clinical course. PMID: 30404429 [PubMed - as supplied by publisher] (Source: Korean Journal of Pediatrics)
Source: Korean Journal of Pediatrics - November 9, 2018 Category: Pediatrics Tags: Korean J Pediatr Source Type: research

Particulate matter and childhood allergic diseases.
Authors: Yang SI Abstract Particulate matter (PM) is a ubiquitous air pollutant that is a growing public health concern. Previous studies have suggested that PM is associated with asthma development and exacerbation of asthma symptoms. Although several studies have suggested increased risks of atopic dermatitis, allergic rhinitis, and allergic sensitization in relation to PM exposure, the evidence remains inconsistent. The plausible mechanisms underlying these effects are related to oxidative stress, enhancement of sensitization to allergens, inflammatory and immunological responses, and epigenetics. This review di...
Source: Korean Journal of Pediatrics - November 9, 2018 Category: Pediatrics Tags: Korean J Pediatr Source Type: research

Drug eruption by antihistamine mistaken for chronic urticaria in a child.
Authors: Lee GM, Chu SY, Kang SY, Kim HB, Park JS, Kim JK Abstract Although rare, antihistamines can casue adverse effects, including drug-induced eruptions or anaphylaxis. A 4-year-old child visited the pediatric department of a hospital for skin eruptions after administration of antihistamines, (e.g., ucerax® (hydroxyzine) or leptizine® (levocetirizine), for cholinergic rashes; he did not have pruritus. Skin prick, intradermal, and drug provocation tests were performed to determine the relationship between the antihistamines and eruptions. Levocetirizine induced wheals in the skin prick test and a rash in...
Source: Korean Journal of Pediatrics - November 2, 2018 Category: Pediatrics Tags: Korean J Pediatr Source Type: research

Reninoma: a rare cause of curable hypertension.
We report a case of reninoma in a female adolescent with a typical clinical presentation, in whom surgical removal of the tumor completely cured hypertension. We have discussed the clinical features, imaging studies, and immunohistochemical examination of the tumor that established the diagnosis, as well as the management of this condition. PMID: 30376707 [PubMed - as supplied by publisher] (Source: Korean Journal of Pediatrics)
Source: Korean Journal of Pediatrics - November 2, 2018 Category: Pediatrics Tags: Korean J Pediatr Source Type: research