A Critical View of Specific Antibody Deficiencies

A Critical View of Specific Antibody Deficiencies Ricardo U. Sorensen1,2,3* 1Professor Emeritus of Pediatrics, Department of Pediatrics, Louisiana State University Health Science Center, New Orleans, LA, United States 2Louisiana Primary Immunodeficiency Network, New Orleans, LA, United States 3Honorary Professor, Faculty of Medicine, University of La Frontera, Temuco, Chile In thisopinion manuscript the author postulates that the present definition of Specific Antibody Deficiency (SAD) needs to be revised and expanded. It is presently defined as a syndrome of low IgG antibody responses to purified Streptococcus pneumoniae capsular polysaccharides vaccines with normal concentrations of IgG, IgA, IgM, and IgG subclasses. Responses to protein antigens and to pneumococcal polysaccharides conjugated to proteins are normal (1, 2). Severe, moderate and memory SAD forms have been arbitrarily defined by expert committees. These definitions miss the imperfections of a diagnosis based on mainly poorly standardized laboratory tests and curtail the search for many other clinically relevant specific deficiencies of antibodies to bacterial, viral and fungal pathogens. The Laboratory Tests on Which the Diagnoses of SAD are Based are Variable and Imperfect The assessment of IgG antibodies against S. pneumonia serotype-specific capsular vaccine antigens are widely used to diagnose a patient's ability to develop IgG antibody responses. Available vaccines include a 23-...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research

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Publication date: Available online 16 September 2019Source: Journal of Science and Medicine in SportAuthor(s): Fabian Garcia-Byrne, Jonathan D. Buckley, Chris Bishop, Stephen Schwerdt, John Porter, David Bailey, Thomas P. WycherleyAbstractObjectiveTo quantify the external and internal workloads of women’s Twenty–Twenty (T20) cricket and compare match demands between International, National and Youth level cricket players.DesignA retrospective analysis of data collected form T20 matches played by Australian teams (International level, n = 3; National level, n = 12; Youth level, n&thin...
Source: Journal of Science and Medicine in Sport - Category: Sports Medicine Source Type: research
Authors: Pitsios C, Vasiliadis A, Karakatsanis KP, Matzaras R, Minasidis T, Nteveros A, Samanis G, Nikolopoulos G PMID: 31523943 [PubMed - in process]
Source: European Annals of Allergy and Clinical Immunology - Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research
This article examines how CAM practitioners discuss vaccinations with parents in Switzerland, with a focus on childhood vaccinations and human papillomavirus (HPV) vaccinations. We describe how the CAM providers we interviewed (N = 17) and observed during vaccination consultations (N = 18 observations with 5 providers) employed individualized approaches to vaccination. Triangulation of qualitative evidence from interviews and observations allowed us to analyze their discourses and descriptions of experiences (i.e. what they said) and their practices in situ (i.e. what they did). Evidence gathered shows that practit...
Source: Social Science and Medicine - Category: Psychiatry & Psychology Source Type: research
The organization granted Breakthrough Therapy Designation to V920 in July 2016 and it now has a target action date of March 14, 2020
Source: PharmaManufacturing.com - Category: Pharmaceuticals Source Type: news
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Source: Journal of Emergency Nursing - Category: Nursing Source Type: research
An outbreak of a vaping-related illness in the United States has sickened hundreds, and an epidemic of youth vaping there has been called a "public health crisis." In the UK, e-cigarettes have been embraced mostly as an effective way for adults to quit combustible cigarettes.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
A California man has become the seventh person to die from a vaping-related illness in the United States as the nation's leading health agency activates emergency operations to better investigate the outbreak of lung injuries associated with e-cigarettes.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
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Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Hematology-Oncology News Alert Source Type: news
Publication date: Available online 16 September 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Sofia Oliveira, Renato Oliveira
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
This study sought to compare patient demographics, operative course, and peri-operative outcomes between unilateral and bilateral cleft patients. Primary cleft lip repairs were isolated from the National Surgical Quality Improvement Program Pediatric Database (NSQIP-P). Unilateral and bilateral cases of primary cleft lip were identified by ICD codes. Demographics, comorbidities, and post-operative outcomes were compared between cohorts. Patients were propensity matched to control for differences before repeating the analysis. About 4550 cleft lip repairs were evaluated over the 5-year period. Of the cases where the cleft t...
Source: Journal of Plastic Surgery and Hand Surgery - Category: Surgery Tags: J Plast Surg Hand Surg Source Type: research
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