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Infectious Disease: Aspergillus
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Total 481 results found since Jan 2013.
Analysis of common allergens affecting patients with allergic rhinitis
This study aimed to identify the common allergens affecting patients with AR. A total of 52 patients with AR were identified for this study. AR was diagnosed based on the presenting symptoms and measurement of IgE levels and absolute eosinophil counts. Skin prick tests (SPT) were performed to identify the allergen sensitivity of the patients. Patient history, family history, and a detailed account of the symptoms were recorded. Finally, correlation between family history and allergy severity was statistically evaluated. All patients presented symptoms of rhinitis with sinusitis and 61.5% of these were mild or moderate alle...
Source: Bioinformation - September 18, 2023 Category: Bioinformatics Authors: Kumari Ranjana Maheshwari M Source Type: research
Hematopoietic 12/15-lipoxygenase activity negatively contributes to fungal-associated allergic asthma
Am J Physiol Lung Cell Mol Physiol. 2023 May 30. doi: 10.1152/ajplung.00090.2023. Online ahead of print.ABSTRACTAsthma is one of the most common non-communicable diseases in the world. Approximately 30% of severe cases are associated with fungal sensitization, often associated with allergy to the opportunistic mold Aspergillus fumigatus. Leukotrienes, immunopathogenic mediators derived from the metabolism of arachidonic acid (AA) by 5-lipoxygenase (5-LOX), are often elevated in severe asthma. As such, these mediators are FDA-approved therapeutic targets of the anti-asthmatic drugs Zileuton®/Zyflo® and Singulair®/Montelu...
Source: Am J Physiol Lung Ce... - May 30, 2023 Category: Respiratory Medicine Authors: Mgayya Makullah Diandra A Ellis MaryJane Jones Chad Steele Source Type: research
Exposure to household dust, allergens, and endotoxin and allergy-related outcomes alternation in the general U.S. population
Environ Res. 2023 Mar 17:115713. doi: 10.1016/j.envres.2023.115713. Online ahead of print.ABSTRACTIt has been widely reported that the general population was at an increased risk of allergy diseases, which probably be related with household allergens exposure. However, the difference of local and systemic allergic reactions exposure to allergens has not been reported in general population previously. The data of 1094 U.S. adults from the National Health and Nutrition Examination Survey (NHANES) 2005-2006 data bank were analyzed. Dust, allergens (Bia g 1, Bia g 2, Can f 1, Feld 1, Derp 1, Mus m 1, Rat n 1, Alternaria altern...
Source: Environmental Research - March 19, 2023 Category: Environmental Health Authors: Tenglong Yan Xin Song Xiaowen Ding Xiaodong Liu Tian Lan Tian Chen Minghui Wang Mengyang Wang Source Type: research
Analyzing airborne fungal concentration in Kolkata, India: temporal distribution, the effect of atmospheric parameters and health impact
AbstractAirborne fungal spores constitute a significant fraction of atmospheric bioparticles, and most of them are responsible for causing the respiratory allergy. The present study deals with the evaluation of fungal aerospora by microscopy-based and culture-based methods in one outdoor and six indoor microenvironments in Kolkata, India, from May 2014 to April 2017. The association of environmental parameters with spore concentrations was explored by Spearman ’s rank correlation analysis and multiple regression analysis. The impact of spore concentrations on the local population was assessed through a questionnaire surv...
Source: Air Quality, Atmosphere and Health - March 18, 2023 Category: Environmental Health Source Type: research
Molecular epidemiology and antifungal susceptibilities of Aspergillus species isolated from patients with invasive aspergillosis
CONCLUSION: Accurate identification of strains and antifungal susceptibility studies should be performed due to azole and amphotericin B resistance. Genotyping studies are important in infection control due to identifying sources of infection and transmission routes.PMID:36820712 | PMC:PMC9937602 | DOI:10.1590/1806-9282.20220441
Source: Cancer Control - February 23, 2023 Category: Cancer & Oncology Authors: Fatma Mutlu Sarig üzel Ayse Nedret Ko ç P ınar Sağiroğlu Mustafa Altay Atalay Arda Borlu Özlem Canöz Bedia Din ç Source Type: research
Mechanisms of airway disease development following inhalation exposure to indoor fungal contaminants Stachybotrys chartarum and Aspergillus versicolor
Fungi are found ubiquitously in the environment and chronic repeated exposures have been associated with pulmonary and cognitive effects in humans. Previous studies have shown that two prominent indoor fungal contaminants, Stachybotrys chartarum and Aspergillus versicolor, are associated with allergic airway disease, airway remodeling, and Th2-mediated immunological effects. To understand the mechanisms of disease development, genetically modified murine models are an invaluable tool.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Catherine Blackwood, Angela Lemons, Rachael Rush, Walter McKinney, Dori Germolec, Donald Beezhold, Brett Green, Tara Croston Source Type: research
< b > < i > Aspergillus fumigatus < /i > < /b > -Specific T Cells in Patients with Chronic Rhinosinusitis
Conclusion: Our findings indicate that patients with CRSwNP harbor a higher proportion ofA. fumigatus-reactive CD4+ T cells in the nasal mucosa than patients with CRSsNP.A. fumigatus-reactive CD4+ T cells of CRSwNP patients secreted TH2 cytokines and IL-17. Our findings suggest a role forA. fumigatus in the pathogenesis of CRSwNP and provide a rationale for targeted therapies.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - January 18, 2023 Category: Allergy & Immunology Source Type: research
Fatal Fungicide-Associated Triazole-Resistant A fumigatus Fatal Fungicide-Associated Triazole-Resistant A fumigatus
An older, immunocompromised patient presented with a case of triazole-resistant Aspergillus fumigatus infection that was linked to agricultural fungicide use.Emerging Infectious Diseases
Source: Medscape Allergy Headlines - December 19, 2022 Category: Allergy & Immunology Tags: Infectious Diseases Journal Article Source Type: news
Severe asthma with fungal sensitisation is associated with worse small airways dysfunction but similar symptom control
Severe asthma with fungal sensitisation (SAFS) is an allergic immune-mediated disorder existing on the spectrum between non-sensitised asthma and allergic bronchopulmonary aspergillosis (ABPA).1 Fungal sensitisation is associated with life-threatening acute asthma attacks requiring intensive care admissions and asthma-related deaths, and has a higher prevalence in patients severe asthma.2 Prospectively, it has been shown that IgE sensitisation to Aspergillus fumigatus is associated with worse lung function as forced expiratory volume in 1 second (FEV1), greater total IgE levels and a higher prevalence of A.
Source: Annals of Allergy, Asthma and Immunology - December 10, 2022 Category: Allergy & Immunology Authors: Rory Chan, Brian Lipworth Tags: Letters Source Type: research
Severe asthma with fungal sensitization is associated with worse small airway dysfunction but similar symptom control
Severe asthma with fungal sensitization (SAFS) is an allergic immune-mediated disorder existing on the spectrum between nonsensitized asthma and allergic bronchopulmonary aspergillosis (ABPA).1 Fungal sensitization is associated with life-threatening acute asthma attacks requiring intensive care admissions and asthma-related deaths, and it has a higher prevalence in patients with severe asthma.2 Prospectively, it has been found that immunoglobulin (Ig)E sensitization to Aspergillus fumigatus is associated with worse lung function as forced expiratory volume in 1 second (FEV1), greater total IgE levels, and a higher prevale...
Source: Annals of Allergy, Asthma and Immunology - December 10, 2022 Category: Allergy & Immunology Authors: Rory Chan, Brian Lipworth Tags: Letters Source Type: research
