Mechanisms of airway disease development following inhalation exposure to indoor fungal contaminants Stachybotrys chartarum and Aspergillus versicolor

Fungi are found ubiquitously in the environment and chronic repeated exposures have been associated with pulmonary and cognitive effects in humans. Previous studies have shown that two prominent indoor fungal contaminants, Stachybotrys chartarum and Aspergillus versicolor, are associated with allergic airway disease, airway remodeling, and Th2-mediated immunological effects. To understand the mechanisms of disease development, genetically modified murine models are an invaluable tool.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research