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Infectious Disease: Aspergillus

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Total 481 results found since Jan 2013.

Application of the ISHAM criteria for diagnosis of ABPA in a clinical cohort at a university teaching hospital
Conclusion: Our study demonstrates the difficulty in applying the ISHAM criteria to historic cohorts and our results are similar to the study by Page et al(2). The ISHAM criteria are a huge step in standardising the diagnosis of ABPA for future clinical and research studies. Obligatory Criterian=111Total IgE>1000 IU/ml79(71%)+ve Af IgE108(97%)Both obligatory criteria fulfilled79(71%)Full diagnostic criteria fulfilled73(66%)‘Other’ CriteriaRaised Af IgG/+ve precipitins94(85%)Eosinophil>500/uL97(87%)Radiological features of ABPA101(91%)‘Other’ criteria combinations1 ‘other’ criterion...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Banka, R., Kamath, A. Tags: Allergy and immunology Source Type: research

Immuno-allertypes in non-cystic fibrosis bronchiectasis
Conclusion: Two distinct and clinically relevant immuno-allertypes of non-CF bronchiectasis were identified representing a potential ‘treatable trait’ for a disease where limited treatment options currently existFunding: This research is supported by the Singapore Ministry of Health’s National Medical Research Council under its Transition Award (NMRC/TA/0048/2016) (S.H.C) and the Changi General Hospital Research Grant (CHF2016.03-P) (T.B.L).
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Tiew, P. y., Mac Aogain, M., Lim, A. Y. H., Low, T. B., Tan, G. L., Hassan, T., Ong, T. H., Pang, S. L., Lee, Z. Y., Gwee, X. W., Martinus, C., Sio, Y. Y., Matta, A., Ong, T. C., Tiong, L. Y. S., Wong, K. N., Narayanan, S., Au, V. B., Marlier, D., Keir, H Tags: Allergy and immunology Source Type: research

Prevalence of sensitization to avian or fungal proteins in different work environments.
Conclusions: A high degree of sensitization to avian and fungal antigens was observed in the study population, probably due to the high exposure rate of these employees.Funded by Fis PI15 / 01954, FEDER and FUCAP.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Cruz Carmona, M. J., Montalvo, T., Ojanuren, I., Romero-Mesones, C., Untoria, M.-D., Sanchez-Diez, S., Senar, J.-C., Franco-Gutierrez, S., Peracho-Tobena, V., Morell, F., Munoz, X. Tags: Allergy and immunology Source Type: research

Clinical peculiarities of seasonal respiratory allergy in children
Conclusion: Presence of mold hypersensitivity in children determines more severe nasal and bronchial symptoms, lower asthma control and prolonged exacerbation (p<0,05).
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Kuznietsova, O., Nedelska, S. Tags: Allergy and immunology Source Type: research

A Health Literacy Readability Analysis of Online Allergy and Immunology-Based Patient Education Resources
Conference abstracts
Source: The Aspergillus Website - updates - November 16, 2018 Category: Respiratory Medicine Authors: GAtherton Source Type: news

Resolution of allergic bronchopulmonary aspergillosis after diagnosis of common variable immunodeficiency
Allergic Bronchopulmonary Aspergillosis (ABPA) is characterized by asthma, elevated IgE and a hyperactive immune response to Aspergillus colonization. Low serum IgE is a sensitive and specific marker for Common Variable Immunodeficiency (CVID), but an atopic endotype has been reported.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: M. Watts, J. Kwah, L. Grammer Tags: M241 Source Type: research

The role of galactomannan Aspergillus antigen in diagnosing acute invasive fungal sinusitis
International Forum of Allergy&Rhinology, EarlyView.
Source: International Forum of Allergy and Rhinology - October 25, 2018 Category: Allergy & Immunology Authors: C. Claire Melancon, Jennifer Lindsey, Gregory B. Russell, John D. Clinger Source Type: research

Aspergillus fumigatus conidia stimulate lung epithelial cells (TC-1 JHU-1) to produce IL-12, IFNγ, IL-13 and IL-17 cytokines: Modulatory effect of propolis extract
This study was designed to evaluate the effect of A. fumigatus conidia on IL-12, IFNγ, IL-13 and IL-17 release from mouse LECs and to investigate the effect of propolis on cytokines modulation. Cells were divided to two groups, one was exposed to 3 × 104 conidia of Aspergillus fumigatus and another group was treated by propolis (25 μg/mL) as well as exposed to A. fumigatus conidia. Cytokines IL-13, IL-12, IFNγ and IL-17 were measured at times 0, 6 and 12 hours after exposure using ELISA assay. The results indicated that A. fumigatus could increase the release of the cytokines with IL-13 and IL-17...
Source: Journal of Medical Mycology - October 23, 2018 Category: Biology Source Type: research

Molecular characterization of Aspergilli isolated from outdoor air
Publication date: Available online 3 October 2018Source: Journal de Mycologie MédicaleAuthor(s): S. Aghaei-Gharehbolagh, M. Shams-Ghahfarokhi, S. Amanloo, M. Razzaghi-AbyanehAbstractUbiquitous airborne conidia of the genus Aspergillus are responsible for a diverse group of human disorders from allergy to life treating invasive aspergillosis and mycotoxicoses. The aim of this study was to determine the population structure of Aspergillus isolated from outdoor air in Tehran by comparing the nucleotide sequences of ITS region and the PCR-RFLP molecular method. Internal transcribed spacer domains of 47 Aspergillus spp. were a...
Source: Journal of Medical Mycology - October 5, 2018 Category: Biology Source Type: research

Aerial fungal spectrum of Kolkata, India, along with their allergenic impact on the public health: a quantitative and qualitative evaluation
AbstractAirborne fungal spores are well documented to trigger respiratory allergy. The present study provides baseline information on the quantitative and qualitative aspects of aerospores for the first time in a typical urban area of Kolkata metropolis, India. An aeromonitoring was performed by Burkard volumetric 7-day sampler for two consecutive years (August 2012 –July 2014). Total concentration, seasonal variations and intradiurnal periodicities of fungal spores were estimated. Spearman’s rank correlation analysis was performed using various weather parameters. The prevalence of fungal spore allergy was investigate...
Source: Aerobiologia - September 17, 2018 Category: Environmental Health Source Type: research

Correlation Between β-Glucan and Neutrophil/Eosinophil Ratio of Paranasal Sinus Mucosa and Blood in the Diagnosis of Chronic Fungal Rhinosinusitis.
Conclusions: β-glucan can be used to establish the diagnosis of chronic fungal rhinosinusitis. However, differential diagnosis of allergy or infection cannot be excluded by examination of blood NER. Still, it is hoped that the process of diagnosis can be obtained quickly and precisely without the need for invasive procedure although it requires more research, especially related to the diagnostic test. PMID: 30210718 [PubMed]
Source: Oman Medical Journal - September 15, 2018 Category: Middle East Health Tags: Oman Med J Source Type: research

Allergic bronchopulmonary aspergillosis complicating Swyer-James-Macleod's syndrome: case report and review of literature.
Authors: Sehgal IS, Dhooria S, Behera D, Agarwal R Abstract Allergic bronchopulmonary aspergillosis (ABPA) is a pulmonary disorder that results from immune responses mounted against antigens of Aspergillus fumigatus, resulting in non-specific respiratory symptoms and structural lung damage. Classically defined in individuals suffering from bronchial asthma and cystic fibrosis, ABPA has recently been described in other lung diseases including COPD, pulmonary tuberculosis, idiopathic bronchiectasis and others. Herein, we report the first case of ABPA complicating Swyer-James-Macleod's syndrome that was successfully t...
Source: European Annals of Allergy and Clinical Immunology - September 15, 2018 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Is there an overlap in immune response between allergic bronchopulmonary and chronic pulmonary aspergillosis?
ConclusionsAbout 5% of subjects with CPA fulfilled all the immunological criteria used for diagnosing ABPA while 22% met the obligatory criteria for ABPA. Whether these patients would require a different management protocol requires further investigation.
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 9, 2018 Category: Allergy & Immunology Source Type: research

The Role of the Environment in Eosinophilic Esophagitis
AbstractEosinophilic esophagitis (EoE) is a chronic, immune-mediated inflammatory disease with incompletely understood pathogenesis. Though disease manifestations were initially ascribed to a delayed reaction to food allergens, emerging evidence suggests that modifiable host factors and environmental allergen exposure may also play critical roles in the pathogenesis and ongoing manifestations of EoE. As with other atopic diseases, lack of early-life exposure to microbial pathogens leads to an immune tolerance defect and reprograms the commensal gut microflora toward a type 2 T helper (Th2) phenotype; the esophageal microbi...
Source: Clinical Reviews in Allergy and Immunology - July 21, 2018 Category: Allergy & Immunology Source Type: research