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Infectious Disease: Aspergillus

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Total 481 results found since Jan 2013.

Microbiological profile in chronic granulomatous disease patients in a single Brazilian primary immunodeficiency center
CONCLUSION: Staphylococcus sp., Staphylococcus aureus, and Aspergillus sp. were the most frequent agents found in this cohort. M. tuberculosis should be considered in endemic area. Detection of infectious agents drives to the adequate treatment and benefits the evolution of patients with CGD.PMID:33641311 | DOI:10.15586/aei.v49i2.82
Source: Allergologia et Immunopathologia - February 28, 2021 Category: Allergy & Immunology Authors: Aim ée Filippini Bifulco Oliveira Antonio Carlos Pastorino Mayra de Barros Dorna Ana Paula Beltran Moschione Castro Jos é Roberto Mendes Pegler Beni Morgenstern Magda Maria Sales Carneiro-Sampaio Source Type: research

Identifying novel allergens from a common indoor mould Aspergillus ochraceus
This study aims to examine the allergenic potency of mycelial proteins of a common indoor fungus Aspergillus ochraceus to a selected atopic patient cohort as well as to identify the novel IgE-binding proteins through an immunoproteomic approach. 1-D and 2-D IgE specific western blot detected the IgE reactive proteins which were identified through MALDI-TOF/TOF and manual de novo peptide sequencing. The results revealed the detection of 10 cross-reactive IgE-binding proteins. Cluster analysis of 1-D immunoblot with individual patient sera identified NADP(+)-dependent glycerol dehydrogenase (GldB) homologous protein as a maj...
Source: Journal of Proteomics - February 24, 2021 Category: Biochemistry Authors: Sangeeta Roy Bodhisattwa Saha Swati Gupta Bhattacharya Source Type: research

Do Airborne Mold Counts Predict Asthma Exacerbations?
Airborne fungal spore counts including Alternaria, Cladiosporium, Ascospores, Aspergillus, Epicoccum, Agrocybe and Basidiospores have been correlated with asthma exacerbation requiring ER visits and hospitalizations in children and adults with asthma, particularly those sensitized to mold. Airborne fungi have also been suggested as a possible etiology for “thunderstorm asthma” driven more commonly by grass pollen. We hypothesized there would be a correlation between airborne mold and asthma exacerbations reflected in ER visits, nonurgent outpatient visits and hospitalization.
Source: Journal of Allergy and Clinical Immunology - February 1, 2021 Category: Allergy & Immunology Authors: Kelsey Kaman, Christopher Randolph Source Type: research

Genetic susceptibility to fungal infection in children
Purpose of review Fungal infections have steadily increased in incidence, emerging as a significant cause of morbidity and mortality in patients with iatrogenic immunosuppression. Simultaneously, we have witnessed a growing population of newly described inherited immune disorders that have enhanced our understanding of the human immune response against fungi. In the present review, we provide an overview and diagnostic roadmap to inherited disorders which confer susceptibility to superficial and invasive fungal infections. Recent findings Inborn errors of fungal immunity encompass a heterogeneous group of disord...
Source: Current Opinion in Pediatrics - November 11, 2020 Category: Pediatrics Tags: ALLERGY, IMMUNOLOGY AND RELATED DISORDERS: Edited by Jordan S. Orange Source Type: research

M202 benralizumab for management of abpa in a cf patient
ABPA (Allergic Bronchopulmonary Aspergillosis) is an immunologic pulmonary disease characterized by hypersensitivity to Aspergillus fumigatus, resulting in airway inflammation, eosinophilia, and lung infiltration. A prior case report described successful treatment of ABPA with benralizumab, but to our knowledge, this is the first in a cystic fibrosis (CF) patient.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2020 Category: Allergy & Immunology Authors: N. Canon, B. Modena Source Type: research

M261 brucella infection causing recurrent fevers in a patient with chronic granulomatous disease
Chronic granulomatous disease (CGD) patients are highly susceptible to Aspergillus, Burkholderia, Serratia, Nocardia, and Staphylococcus due to impaired phagocyte oxidase function. Here we report a CGD patient with suspected Brucellosis which has not been previously reported.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2020 Category: Allergy & Immunology Authors: F. Tachibana, J. Tam, N. Izadi Source Type: research

Clinico-radiological and serological features in Allergic bronchopulmonary aspergillosis
Conclusions: There is a high prevalence of ABPA in asthmatic patients presenting at our hospital. The disease entity is still underrecognized in India, the vast majority of patients have bronchiectasis at presentation, and almost half are initially misdiagnosed as having pulmonary tuberculosis. There is a need to redefine the diagnostic criteria of ABPA and to develop a gold standard diagnostic test. This study places emphasis on using IgE levels specific for Aspergillus fumigatus as a screening test for ABPA.
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Prasanth, P. Tags: Allergy and immunology Source Type: research

Allergy testing in asthmatics and severe asthmatics: habits among respiratory physicians in Belgium
Conclusions: There is a large heterogeneity among Belgian respiratory physicians regarding decision making in allergy testing in patients with asthma.
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Flahou, B., Van Schoor, J., Vancayzeele, S., Gurdain, S. Tags: Allergy and immunology Source Type: research

Fungal and bacterial microbiome dysbiosis and imbalance of trans-kingdom network in asthma
ConclusionWe showed mycobiome and bacteriome dysbiosis in asthma featured by alterations in biodiversity, community composition, inter-kingdom and intra-kingdom network. We also observed several functional genes associated with asthma.
Source: Clinical and Translational Allergy - October 22, 2020 Category: Allergy & Immunology Source Type: research

Value of Component Resolved Diagnostics to < b > < i > Aspergillus fumigatus < /i > < /b > in Patients with Upper Airway Complaints
Conclusions: Component resolved diagnostic testing toward the major allergen Asp f 1 was less sensitive than skin prick test and serology toAspergillus fumigatus protein extract. However, sensitivity of component resolved diagnostics might be underestimated. Diagnostics of the species-specific allergens Asp f 1, 2, and 4 might allow to differentiate between genuine and cross-reactive sensitization. In the clinical routine, skin prick test and serology to crude extract remain the methods of choice.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - September 17, 2020 Category: Allergy & Immunology Source Type: research