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Infectious Disease: Aspergillus

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Total 481 results found since Jan 2013.

Study of fungal allergen and Aspergillus fumigatus component sensitization in a Southern Chinese Cohort
Conclusion: In southern China, patients with respiratory tract allergic diseases are often sensitized to multiple fungal allergens possibly due to the cross-reaction between fungal allergens. Detection of Aspergillus fumigatus components may be helpful for diagnosing ABPA and asthma.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Luo, W., Sun, B., Wu, Z. Tags: Allergy and immunology Source Type: research

Diagnostic value of combined sIgG and sIgE of Aspergillus fumigatus in allergic broncho pulmonary aspergillosis and severe asthma with fungal sensitation
Conclusion: ABPA patients have higher levels of sIgG and sIgE of A.fumigatus than SAFS patients. Combination of sIgG and sIgE of A.fumigatus to diagnosis ABPA and SAFS patients is important.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Hu, H., Sun, B., Huang, H. Tags: Allergy and immunology Source Type: research

Microbiological features of the indicators of bronchial asthma (BA) and chronic obstructive pulmonary disease (COPD) during remission
Conclusion: A more pronounced quantitative content and a more diverse microbial landscape leads to a more severe course of the disease asthma combined with COPD, especially of the bronchitis type.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Smirnova-Saprytskaya, M., Osipova, G., Ospelnikova, T., Danilina, G., Zykov, K. Tags: Allergy and immunology Source Type: research

Bronchiectasis and aspergillus-associated diseases in severe asthma
Conclusions: SA patients with bronchiectasis should be screened for ABPA and CPA using both IgE-ASP and IgG-ASP. Early recognition and treatment of Aspergillus-associated bronchiectasis in SA might decrease exacerbations and evolution toward irreversible airway remodeling
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Solidoro, P., De Blasio, F., Dassetto, D., Ambrosanio, R., Rella, A., Riberi, L., Bucca, C. Tags: Allergy and immunology Source Type: research

Peripheral blood eosinophilia and sensitization to Aspergillus fumigatus in adult patients (pts) with non-cystic fibrosis bronchiectasis (B)
Conclusions: 1) More than 20% of adult B pts have an eosinophilic type of inflammation. 2) Blood eosinophilia is likely to be associated with sensitization to AF.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Gashynova, K., Dmytrychenko, V., Suska, K. Tags: Allergy and immunology Source Type: research

Prevalence of Allergic Bronchopulmonary Aspergillosis in Cystic Fibrosis Patients using Two Different Diagnostic Criteria.
Conclusions. The applied diagnostic criteria had no significant effect on the reported rate of ABPA prevalence. PMID: 31702121 [PubMed - as supplied by publisher]
Source: European Annals of Allergy and Clinical Immunology - November 11, 2019 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

M294 invasive aspergillosis presenting with subtle clinical symptoms in a cgd patient
We describe a case of a 32-month-old male with CGD who presented acutely with decreased energy and non-specific abdominal discomfort. Upon further work up he was found to have invasive Aspergillus fumigatus.
Source: Annals of Allergy, Asthma and Immunology - October 31, 2019 Category: Allergy & Immunology Authors: P. Tran Source Type: research

D201 dupilumab efficacy in patients with uncontrolled, moderate-to-severe asthma and serologic evidence of allergic bronchopulmonary aspergillosis
Dupilumab, a fully human monoclonal antibody, blocks the shared receptor component for IL-4/IL-13, key drivers of type 2 inflammation in multiple diseases. In the phase 3 LIBERTY ASTHMA QUEST study (NCT02414854), add-on dupilumab 200mg/300mg every 2 weeks vs placebo reduced severe exacerbations and improved pre-bronchodilator FEV1 in patients with uncontrolled, moderate-to-severe asthma. Treatment effects were greater in patients with elevated baseline type 2 biomarkers. Allergic bronchopulmonary aspergillosis (ABPA) is characterized by Aspergillus fumigatus (Af) hypersensitivity and robust type 2 inflammatory responses.
Source: Annals of Allergy, Asthma and Immunology - October 31, 2019 Category: Allergy & Immunology Authors: J. Corren, L. Sher, X. Zhu, M. Rice, Y. Deniz, P. Rowe, H. Staudinger, M. Ruddy, N. Patel, N. Graham, A. Teper, N. Amin Source Type: research

Diagnostic Cutoffs and Clinical Utility of Recombinant Aspergillus fumigatus Antigens in the Diagnosis of Allergic Bronchopulmonary Aspergillosis
ConclusionsIgE against rAsp f1 and f2 (using receiver-operating characteristic–derived cutoffs) were found to be the most useful in differentiating ABPA from ASA. Because this study was conducted at a single center, our results require further validation.
Source: The Journal of Allergy and Clinical Immunology: In Practice - October 2, 2019 Category: Allergy & Immunology Source Type: research

Diagnostic cut-offs and clinical utility of recombinant Aspergillus fumigatus antigens in the diagnosis of allergic bronchopulmonary aspergillosis
ConclusionIgE against rAsp f1 and f2 (using ROC derived cut-offs) were found to be the most useful in differentiating ABPA from ASA. Due to conduct at single-center, our results require further validation.
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 11, 2019 Category: Allergy & Immunology Source Type: research

Spectrum of Pulmonary Aspergillosis in Hyper-IgE Syndrome with Autosomal-Dominant STAT3 Deficiency
ConclusionsChronic and allergic forms of aspergillosis occurred in 17.5% of STAT3-deficient patients, mostly in lung cavities. Almost half had recurrences, despite prolonged antifungal treatment and/or surgery.
Source: The Journal of Allergy and Clinical Immunology: In Practice - July 3, 2019 Category: Allergy & Immunology Source Type: research

Evaluation of a Novel Aspergillus Antigen Enzyme-Linked Immunosorbent Assay Mycology
Invasive aspergillosis (IA) is a life-threatening infection that mainly occurs in immunocompromised patients. Here, we compared the novel Aspergillus-specific galactomannoprotein (GP) enzyme-linked immunosorbent assay (ELISA) (Euroimmun Medizinische Labordiagnostika AG) to the established Platelia Aspergillus galactomannan (GM) ELISA (Bio-Rad Laboratories) for the detection of IA. A total of 267 serum samples from 45 cases of proven and 4 episodes of probable IA (according to European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Inf...
Source: Journal of Clinical Microbiology - June 24, 2019 Category: Microbiology Authors: Dichtl, K., Seybold, U., Ormanns, S., Horns, H., Wagener, J. Tags: Mycology Source Type: research

Metabolic Control of Dendritic Cell Functions: Digesting Information
In conclusion, a delicate balance of the complex system of nutrient sensing and mTOR (mTORC1) signaling is crucial to ensure appropriate development of DCs (23). Strikingly, loss of both mTOR complexes results in opposite effects on in vivo DC development compared with loss of mTORC1 alone, probably indicating differential inhibition of mTOR downstream targets and collaboration of mTOR complexes. Indeed, DC loss upon TSC1 deficiency is accompanied by increased DC apoptosis and enhanced metabolic activity due to TSC1-dependent inhibition of Myc, an effector downstream of mTOR (Figure 1), and reversed upon Myc loss (35). Of ...
Source: Frontiers in Immunology - April 24, 2019 Category: Allergy & Immunology Source Type: research

Editorial: Shaping of Human Immune System and Metabolic Processes by Viruses and Microorganisms
Conclusions In conclusion, articles in this Research Topic made a very significant contribution to our understanding of the role played by environmental factors, dysbiotic conditions, and infections in triggering diseases. Since this is a rapidly expanding area of research, many other factors contributing to the onset of these diseases are not covered here. We are confident, however, that further studies will expand the list as well as bring a better understanding of mechanisms involved in the onset of autoimmune and autoinflammatory diseases. Author Contributions All authors listed have made a substantial, direct and i...
Source: Frontiers in Microbiology - April 16, 2019 Category: Microbiology Source Type: research

Incidence and Outcome of Invasive Fungal Diseases in Children With Hematological Malignancies and/or Allogeneic Hematopoietic Stem Cell Transplantation: Results of a Prospective Multicenter Study
Conclusion: This prospective multicenter study provides information on the current incidence and outcome of IFD in the real life setting. Practice variation between the centers may help to ultimately improve antifungal management in children at highest risk for IFDs. Introduction Available data on the incidence and outcome of invasive fungal diseases (IFD) in children treated for a hematological malignancy or undergoing allogeneic hematopoietic stem cell transplantation (HSCT) are mostly based on single site, retrospective studies or on studies performed prior to the availability of newer compounds such as broad-sp...
Source: Frontiers in Microbiology - April 15, 2019 Category: Microbiology Source Type: research