Severe asthma with fungal sensitisation is associated with worse small airways dysfunction but similar symptom control

Severe asthma with fungal sensitisation (SAFS) is an allergic immune-mediated disorder existing on the spectrum between non-sensitised asthma and allergic bronchopulmonary aspergillosis (ABPA).1 Fungal sensitisation is associated with life-threatening acute asthma attacks requiring intensive care admissions and asthma-related deaths, and has a higher prevalence in patients severe asthma.2 Prospectively, it has been shown that IgE sensitisation to Aspergillus fumigatus is associated with worse lung function as forced expiratory volume in 1 second (FEV1), greater total IgE levels and a higher prevalence of A.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research