Advancing a Human Onchocerciasis Vaccine From Antigen Discovery to Efficacy Studies Against Natural Infection of Cattle With Onchocerca ochengi
Human onchocerciasis is a devastating neglected tropical disease caused by infection of the filarial nematode Onchocerca volvulus. The infection can cause irreversible visual impairment or blindness and stigmatizing dermatitis. More than 32 million people were estimated to be infected with O. volvulus in Africa, and 385,000 suffered from blindness. Even though the implementation of mass drug administration (MDA) with ivermectin has reduced the global prevalence of onchocerciasis, O. volvulus infection remains challenging to control because MDA with ivermectin cannot be implemented in endemic areas co-endemic with loiasis d...
Source: Frontiers in cellular and infection microbiology - April 4, 2022 Category: Microbiology Source Type: research
Epileptogenesis in Common Parasitic Infections
AbstractPurpose of the reviewNeurocysticercosis (NCC) has been well recognized as a leading cause of epilepsy. More recently, studies of other parasitic diseases such as cerebral malaria (CM) and onchocerciasis are yielding novel insights into the pathogenesis of parasite-associated epilepsy. We compare the clinical and electrophysiological findings in epilepsy associated with these highly prevalent para sites and discuss the mechanisms involved in epileptogenesis.Recent FindingsElectrophysiological and imaging biomarkers continue to emerge, and individuals who are at-risk of developing parasite-associated epilepsies a...
Source: Current Neurology and Neuroscience Reports - April 1, 2022 Category: Neuroscience Source Type: research
Epileptogenesis in Common Parasitic Infections
Curr Neurol Neurosci Rep. 2022 Mar 25. doi: 10.1007/s11910-022-01187-6. Online ahead of print.ABSTRACTPURPOSE OF THE REVIEW: Neurocysticercosis (NCC) has been well recognized as a leading cause of epilepsy. More recently, studies of other parasitic diseases such as cerebral malaria (CM) and onchocerciasis are yielding novel insights into the pathogenesis of parasite-associated epilepsy. We compare the clinical and electrophysiological findings in epilepsy associated with these highly prevalent parasites and discuss the mechanisms involved in epileptogenesis.RECENT FINDINGS: Electrophysiological and imaging biomarkers conti...
Source: Epilepsy Curr - March 25, 2022 Category: Neurology Authors: Rajarshi Mazumder John K Lee Source Type: research
Epileptogenesis in Common Parasitic Infections
Curr Neurol Neurosci Rep. 2022 Mar 25. doi: 10.1007/s11910-022-01187-6. Online ahead of print.ABSTRACTPURPOSE OF THE REVIEW: Neurocysticercosis (NCC) has been well recognized as a leading cause of epilepsy. More recently, studies of other parasitic diseases such as cerebral malaria (CM) and onchocerciasis are yielding novel insights into the pathogenesis of parasite-associated epilepsy. We compare the clinical and electrophysiological findings in epilepsy associated with these highly prevalent parasites and discuss the mechanisms involved in epileptogenesis.RECENT FINDINGS: Electrophysiological and imaging biomarkers conti...
Source: Epilepsy Curr - March 25, 2022 Category: Neurology Authors: Rajarshi Mazumder John K Lee Source Type: research
Pharmacokinetics of oral moxidectin in individuals with < i > Onchocerca volvulus < /i > infection
Conclusion/SignificanceWe found no relationship between severity of infection (mild, moderate or severe) and exposure parameters (AUC0- ∞ and Cmax), T1/2 and Tmax for moxidectin. Tmax, volume of distribution (V/F) and oral clearance (CL/F) are similar to those in healthy volunteers from Europe. From a pharmacokinetic perspective, moxidectin is an attractive long-acting therapeutic option for the treatment of human onchocerciasis. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - March 25, 2022 Category: Tropical Medicine Authors: Beesan Tan Source Type: research
Epileptogenesis in Common Parasitic Infections
AbstractPurpose of the reviewNeurocysticercosis (NCC) has been well recognized as a leading cause of epilepsy. More recently, studies of other parasitic diseases such as cerebral malaria (CM) and onchocerciasis are yielding novel insights into the pathogenesis of parasite-associated epilepsy. We compare the clinical and electrophysiological findings in epilepsy associated with these highly prevalent para sites and discuss the mechanisms involved in epileptogenesis.Recent FindingsElectrophysiological and imaging biomarkers continue to emerge, and individuals who are at-risk of developing parasite-associated epilepsies a...
Source: Current Neurology and Neuroscience Reports - March 25, 2022 Category: Neuroscience Source Type: research
Lessons from Large-Scale Tolerability and Acceptability Studies of Triple Drug Mass Drug Administration Performed to Support Policy Change and Accelerate Elimination of Lymphatic Filariasis
Am J Trop Med Hyg. 2022 Mar 15:tpmd210840. doi: 10.4269/ajtmh.21-0840. Online ahead of print.ABSTRACTEarly clinical trials clearly demonstrated the superior efficacy of triple drug therapy with ivermectin plus DEC and albendazole (IDA) for clearing microfilaremia (Mf) in individuals with lymphatic filariasis (LF). Although these initial pharmacokinetic and efficacy studies were necessary first steps in the clinical development of IDA, they were not sufficient to justify policy changes necessary for widespread use of this new regimen by national filariasis elimination programs. Processes and procedures that led to the World...
Source: Am J Trop Med Hyg - March 16, 2022 Category: Infectious Diseases Authors: Gary J Weil Peter U Fischer Alison Krentel Source Type: research
Lessons from Large-Scale Tolerability and Acceptability Studies of Triple Drug Mass Drug Administration Performed to Support Policy Change and Accelerate Elimination of Lymphatic Filariasis
Am J Trop Med Hyg. 2022 Mar 15:tpmd210840. doi: 10.4269/ajtmh.21-0840. Online ahead of print.ABSTRACTEarly clinical trials clearly demonstrated the superior efficacy of triple drug therapy with ivermectin plus DEC and albendazole (IDA) for clearing microfilaremia (Mf) in individuals with lymphatic filariasis (LF). Although these initial pharmacokinetic and efficacy studies were necessary first steps in the clinical development of IDA, they were not sufficient to justify policy changes necessary for widespread use of this new regimen by national filariasis elimination programs. Processes and procedures that led to the World...
Source: The American Journal of Tropical Medicine and Hygiene - March 16, 2022 Category: Tropical Medicine Authors: Gary J Weil Peter U Fischer Alison Krentel Source Type: research
Lessons from Large-Scale Tolerability and Acceptability Studies of Triple Drug Mass Drug Administration Performed to Support Policy Change and Accelerate Elimination of Lymphatic Filariasis
Am J Trop Med Hyg. 2022 Mar 15:tpmd210840. doi: 10.4269/ajtmh.21-0840. Online ahead of print.ABSTRACTEarly clinical trials clearly demonstrated the superior efficacy of triple drug therapy with ivermectin plus DEC and albendazole (IDA) for clearing microfilaremia (Mf) in individuals with lymphatic filariasis (LF). Although these initial pharmacokinetic and efficacy studies were necessary first steps in the clinical development of IDA, they were not sufficient to justify policy changes necessary for widespread use of this new regimen by national filariasis elimination programs. Processes and procedures that led to the World...
Source: Am J Trop Med Hyg - March 16, 2022 Category: Infectious Diseases Authors: Gary J Weil Peter U Fischer Alison Krentel Source Type: research
Lessons from Large-Scale Tolerability and Acceptability Studies of Triple Drug Mass Drug Administration Performed to Support Policy Change and Accelerate Elimination of Lymphatic Filariasis
Am J Trop Med Hyg. 2022 Mar 15:tpmd210840. doi: 10.4269/ajtmh.21-0840. Online ahead of print.ABSTRACTEarly clinical trials clearly demonstrated the superior efficacy of triple drug therapy with ivermectin plus DEC and albendazole (IDA) for clearing microfilaremia (Mf) in individuals with lymphatic filariasis (LF). Although these initial pharmacokinetic and efficacy studies were necessary first steps in the clinical development of IDA, they were not sufficient to justify policy changes necessary for widespread use of this new regimen by national filariasis elimination programs. Processes and procedures that led to the World...
Source: The American Journal of Tropical Medicine and Hygiene - March 16, 2022 Category: Tropical Medicine Authors: Gary J Weil Peter U Fischer Alison Krentel Source Type: research
Lessons from Large-Scale Tolerability and Acceptability Studies of Triple Drug Mass Drug Administration Performed to Support Policy Change and Accelerate Elimination of Lymphatic Filariasis
Am J Trop Med Hyg. 2022 Mar 15:tpmd210840. doi: 10.4269/ajtmh.21-0840. Online ahead of print.ABSTRACTEarly clinical trials clearly demonstrated the superior efficacy of triple drug therapy with ivermectin plus DEC and albendazole (IDA) for clearing microfilaremia (Mf) in individuals with lymphatic filariasis (LF). Although these initial pharmacokinetic and efficacy studies were necessary first steps in the clinical development of IDA, they were not sufficient to justify policy changes necessary for widespread use of this new regimen by national filariasis elimination programs. Processes and procedures that led to the World...
Source: Am J Trop Med Hyg - March 16, 2022 Category: Infectious Diseases Authors: Gary J Weil Peter U Fischer Alison Krentel Source Type: research
Lessons from Large-Scale Tolerability and Acceptability Studies of Triple Drug Mass Drug Administration Performed to Support Policy Change and Accelerate Elimination of Lymphatic Filariasis
Am J Trop Med Hyg. 2022 Mar 15:tpmd210840. doi: 10.4269/ajtmh.21-0840. Online ahead of print.ABSTRACTEarly clinical trials clearly demonstrated the superior efficacy of triple drug therapy with ivermectin plus DEC and albendazole (IDA) for clearing microfilaremia (Mf) in individuals with lymphatic filariasis (LF). Although these initial pharmacokinetic and efficacy studies were necessary first steps in the clinical development of IDA, they were not sufficient to justify policy changes necessary for widespread use of this new regimen by national filariasis elimination programs. Processes and procedures that led to the World...
Source: The American Journal of Tropical Medicine and Hygiene - March 16, 2022 Category: Tropical Medicine Authors: Gary J Weil Peter U Fischer Alison Krentel Source Type: research
Lessons from Large-Scale Tolerability and Acceptability Studies of Triple Drug Mass Drug Administration Performed to Support Policy Change and Accelerate Elimination of Lymphatic Filariasis
Am J Trop Med Hyg. 2022 Mar 15:tpmd210840. doi: 10.4269/ajtmh.21-0840. Online ahead of print.ABSTRACTEarly clinical trials clearly demonstrated the superior efficacy of triple drug therapy with ivermectin plus DEC and albendazole (IDA) for clearing microfilaremia (Mf) in individuals with lymphatic filariasis (LF). Although these initial pharmacokinetic and efficacy studies were necessary first steps in the clinical development of IDA, they were not sufficient to justify policy changes necessary for widespread use of this new regimen by national filariasis elimination programs. Processes and procedures that led to the World...
Source: Am J Trop Med Hyg - March 16, 2022 Category: Infectious Diseases Authors: Gary J Weil Peter U Fischer Alison Krentel Source Type: research
Drug development for the treatment of onchocerciasis: Population pharmacokinetic and adverse events modeling of emodepside
Conclusions/SignificancePharmacokinetic modeling and simulation was used to derive an optimized, body weight-based dosing regimen, which allows for achievement of extended emodepside exposures above target concentrations while maintaining acceptable tolerability margins. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - March 10, 2022 Category: Tropical Medicine Authors: Frauke Assmus Source Type: research
Habitat preference of blackflies in Omo Gibe river basin (southwest Ethiopia): Implications for onchocerciasis elimination and control
In conclusion, the findings of this study showed that the habitat preference ofS.damnosum larvae is determined by environmental factors and that the presence and abundance of the larvae are affected by macroinvertebrate predators. It is essential to establish buffer zones as a part of watershed management to retain pollutants and prevent them from entering directly into water courses to improve water quality and the assemblages of macroinvertebrate predators and enhance biocontrol of blackflies. (Source: PLoS One)
Source: PLoS One - March 4, 2022 Category: Biomedical Science Authors: Beekam Kebede Olkeba Source Type: research
