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Comparison of Structural Changes in Nodding Syndrome and Other Epilepsies Associated With Onchocerca volvulus
Discussion This is the first study to show that cerebral and cerebellar atrophy correlated with the severity of NS disability, providing an imaging marker for these endemic epileptic disorders that until now have remained poorly characterized. Both NS and OAE have cerebral and cerebellar atrophy, and the levels of Ov-associated antibodies do not seem to be related to the structural changes on MRI. (Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - December 21, 2022 Category: Neurology Authors: Mazumder, R., Lubowa, S. K., Salamon, N., Jackson, N. J., Kawooya, M., Akun, P. R., Anguzu, R., Ogwang, R. J., Kubofcik, J., Nutman, T., Marsh, K., Newton, C., Vincent, A., Idro, R. Tags: Research Article Source Type: research

Evaluating the impact of alternative intervention strategies in accelerating onchocerciasis elimination in an area of persistent transmission in the West Region of Cameroon
by Kareen Atekem, Ruth Dixon, Aude Wilhelm, Benjamin Biholong, Joseph Oye, Hugues Nana Djeunga, Philippe Nwane, Franklin Ayisi, Daniel Boakye, Joseph Kamgno, Elena Schmidt, Rogers Nditanchou, Laura Senyonjo BackgroundAlternative strategies are recommended to accelerate onchocerciasis elimination in problematic areas including areas where annual ivermectin (IVM) distributions are unable to interrupt transmission. The aim of this study was to accelerate progress towards elimination in the Massangam health district, West Region of Cameroon where impact evaluations demonstrated ongoing transmission of onchocerciasis infection ...
Source: PLoS Neglected Tropical Diseases - December 21, 2022 Category: Tropical Medicine Authors: Kareen Atekem Source Type: research

Onchocerciasis-associated epilepsy: an update and future perspectives
Trends Parasitol. 2022 Dec 15:S1471-4922(22)00283-5. doi: 10.1016/j.pt.2022.11.010. Online ahead of print.NO ABSTRACTPMID:36528471 | DOI:10.1016/j.pt.2022.11.010 (Source: Trends in Parasitology)
Source: Trends in Parasitology - December 17, 2022 Category: Parasitology Authors: Amber Hadermann Luis-Jorge Amaral Gilles Van Cutsem Joseph N Siewe Fodjo Robert Colebunders Source Type: research

Onchocerciasis-associated epilepsy: an update and future perspectives
Trends Parasitol. 2022 Dec 15:S1471-4922(22)00283-5. doi: 10.1016/j.pt.2022.11.010. Online ahead of print.ABSTRACTOnchocerciasis-associated epilepsy (OAE) is an important neglected public health problem in areas with high ongoing onchocerciasis transmission. The risk that children in such areas develop epilepsy is related to their Onchocerca volvulus microfilarial (mf) load. Before the implementation of mass treatment with ivermectin, microfilariae were detected in cerebrospinal fluid (CSF). More recently, neither O. volvulus microfilariae nor DNA were detected in CSF or brain tissue; however, these samples were obtained y...
Source: Trends in Parasitology - December 17, 2022 Category: Parasitology Authors: Amber Hadermann Luis-Jorge Amaral Gilles Van Cutsem Joseph N Siewe Fodjo Robert Colebunders Source Type: research

Two Nigerian States (Plateau and Nasarawa) Have Eliminated Transmission of Human Onchocerciasis-A Report of Post-ivermectin Mass Drug Administration Surveillance
Am J Trop Med Hyg. 2022 Nov 30:tpmd220491. doi: 10.4269/ajtmh.22-0491. Online ahead of print.ABSTRACTTransmission of Onchocerca volvulus (causing "river blindness") was interrupted in two states of Nigeria (Plateau and Nasarawa) in 2017 in accordance with 2016 WHO guidelines. Ivermectin mass drug administration was halted in January 2018, and posttreatment surveillance activities were conducted over a 3-year period. Vector Simulium damnosum s.l. flies were collected during the 2019 (39 sites) and 2020 (42 sites) transmission seasons. Head pools were tested by polymerase chain reaction for the presence of third-stage O. vol...
Source: The American Journal of Tropical Medicine and Hygiene - November 30, 2022 Category: Tropical Medicine Authors: Emmanuel S Miri Abel Eigege Barminas Kahansim Kenrick Nwodu Yohana Sambo Bulus Mancha Solomon Adelamo John Umaru Jonathan Kadimbo Jacob Danboyi Hayward Mafuyai Emeka Makata Nse Akpan Joel Akilah Michael Igbe Jenna Coalson Lindsay Rakers Emily Griswold Tho Source Type: research

Two Nigerian States (Plateau and Nasarawa) Have Eliminated Transmission of Human Onchocerciasis-A Report of Post-ivermectin Mass Drug Administration Surveillance
Am J Trop Med Hyg. 2022 Nov 30:tpmd220491. doi: 10.4269/ajtmh.22-0491. Online ahead of print.ABSTRACTTransmission of Onchocerca volvulus (causing "river blindness") was interrupted in two states of Nigeria (Plateau and Nasarawa) in 2017 in accordance with 2016 WHO guidelines. Ivermectin mass drug administration was halted in January 2018, and posttreatment surveillance activities were conducted over a 3-year period. Vector Simulium damnosum s.l. flies were collected during the 2019 (39 sites) and 2020 (42 sites) transmission seasons. Head pools were tested by polymerase chain reaction for the presence of third-stage O. vol...
Source: Am J Trop Med Hyg - November 30, 2022 Category: Infectious Diseases Authors: Emmanuel S Miri Abel Eigege Barminas Kahansim Kenrick Nwodu Yohana Sambo Bulus Mancha Solomon Adelamo John Umaru Jonathan Kadimbo Jacob Danboyi Hayward Mafuyai Emeka Makata Nse Akpan Joel Akilah Michael Igbe Jenna Coalson Lindsay Rakers Emily Griswold Tho Source Type: research