Changes in Onchocerciasis Ov16 IgG4 Rapid Diagnostic Test Results Over One-Month Follow-up: Lessons for Reading Timeframe and Decision-Making
Am J Trop Med Hyg. 2022 Aug 1:tpmd211201. doi: 10.4269/ajtmh.21-1201. Online ahead of print.ABSTRACTThe SD Bioline® IgG4 rapid diagnostic test (RDT) detects IgG4 antibodies induced by the Onchocerca volvulus-specific antigen Ov16. We evaluated the stability of the RDT results over 1 month, at different time points after completion of each assay, using eluted dried blood spots collected in central Cameroon. Agreement coefficients regarding positivity between 30 minutes and 24 hours, 1, 2, 3, and 4 weeks were, 96.4%, 93.4%, 93.3%, 93.2%, and 93.2%, respectively. Between 30 minutes and 24 hours, 3.6% of the 15,444 tests show...
Source: The American Journal of Tropical Medicine and Hygiene - August 1, 2022 Category: Tropical Medicine Authors: Hugues C Nana-Djeunga Capucine M Sicard Aude E Mogoung-Wafo C édric B Chesnais Hugo Del église Rufine Touka-Nounkeu Andr é Domche Allison Golden Amy D Klion Thomas B Nutman Michel Boussinesq Joseph Kamgno S ébastien D Pion Source Type: research
Changes in Onchocerciasis Ov16 IgG4 Rapid Diagnostic Test Results Over One-Month Follow-up: Lessons for Reading Timeframe and Decision-Making
Am J Trop Med Hyg. 2022 Aug 1:tpmd211201. doi: 10.4269/ajtmh.21-1201. Online ahead of print.ABSTRACTThe SD Bioline® IgG4 rapid diagnostic test (RDT) detects IgG4 antibodies induced by the Onchocerca volvulus-specific antigen Ov16. We evaluated the stability of the RDT results over 1 month, at different time points after completion of each assay, using eluted dried blood spots collected in central Cameroon. Agreement coefficients regarding positivity between 30 minutes and 24 hours, 1, 2, 3, and 4 weeks were, 96.4%, 93.4%, 93.3%, 93.2%, and 93.2%, respectively. Between 30 minutes and 24 hours, 3.6% of the 15,444 tests show...
Source: Am J Trop Med Hyg - August 1, 2022 Category: Infectious Diseases Authors: Hugues C Nana-Djeunga Capucine M Sicard Aude E Mogoung-Wafo C édric B Chesnais Hugo Del église Rufine Touka-Nounkeu Andr é Domche Allison Golden Amy D Klion Thomas B Nutman Michel Boussinesq Joseph Kamgno S ébastien D Pion Source Type: research
Changes in Onchocerciasis Ov16 IgG4 Rapid Diagnostic Test Results Over One-Month Follow-up: Lessons for Reading Timeframe and Decision-Making
Am J Trop Med Hyg. 2022 Aug 1:tpmd211201. doi: 10.4269/ajtmh.21-1201. Online ahead of print.ABSTRACTThe SD Bioline® IgG4 rapid diagnostic test (RDT) detects IgG4 antibodies induced by the Onchocerca volvulus-specific antigen Ov16. We evaluated the stability of the RDT results over 1 month, at different time points after completion of each assay, using eluted dried blood spots collected in central Cameroon. Agreement coefficients regarding positivity between 30 minutes and 24 hours, 1, 2, 3, and 4 weeks were, 96.4%, 93.4%, 93.3%, 93.2%, and 93.2%, respectively. Between 30 minutes and 24 hours, 3.6% of the 15,444 tests show...
Source: The American Journal of Tropical Medicine and Hygiene - August 1, 2022 Category: Tropical Medicine Authors: Hugues C Nana-Djeunga Capucine M Sicard Aude E Mogoung-Wafo C édric B Chesnais Hugo Del église Rufine Touka-Nounkeu Andr é Domche Allison Golden Amy D Klion Thomas B Nutman Michel Boussinesq Joseph Kamgno S ébastien D Pion Source Type: research
Changes in Onchocerciasis Ov16 IgG4 Rapid Diagnostic Test Results Over One-Month Follow-up: Lessons for Reading Timeframe and Decision-Making
Am J Trop Med Hyg. 2022 Aug 1:tpmd211201. doi: 10.4269/ajtmh.21-1201. Online ahead of print.ABSTRACTThe SD Bioline® IgG4 rapid diagnostic test (RDT) detects IgG4 antibodies induced by the Onchocerca volvulus-specific antigen Ov16. We evaluated the stability of the RDT results over 1 month, at different time points after completion of each assay, using eluted dried blood spots collected in central Cameroon. Agreement coefficients regarding positivity between 30 minutes and 24 hours, 1, 2, 3, and 4 weeks were, 96.4%, 93.4%, 93.3%, 93.2%, and 93.2%, respectively. Between 30 minutes and 24 hours, 3.6% of the 15,444 tests show...
Source: Am J Trop Med Hyg - August 1, 2022 Category: Infectious Diseases Authors: Hugues C Nana-Djeunga Capucine M Sicard Aude E Mogoung-Wafo C édric B Chesnais Hugo Del église Rufine Touka-Nounkeu Andr é Domche Allison Golden Amy D Klion Thomas B Nutman Michel Boussinesq Joseph Kamgno S ébastien D Pion Source Type: research
Changes in Onchocerciasis Ov16 IgG4 Rapid Diagnostic Test Results Over One-Month Follow-up: Lessons for Reading Timeframe and Decision-Making
Am J Trop Med Hyg. 2022 Aug 1:tpmd211201. doi: 10.4269/ajtmh.21-1201. Online ahead of print.ABSTRACTThe SD Bioline® IgG4 rapid diagnostic test (RDT) detects IgG4 antibodies induced by the Onchocerca volvulus-specific antigen Ov16. We evaluated the stability of the RDT results over 1 month, at different time points after completion of each assay, using eluted dried blood spots collected in central Cameroon. Agreement coefficients regarding positivity between 30 minutes and 24 hours, 1, 2, 3, and 4 weeks were, 96.4%, 93.4%, 93.3%, 93.2%, and 93.2%, respectively. Between 30 minutes and 24 hours, 3.6% of the 15,444 tests show...
Source: The American Journal of Tropical Medicine and Hygiene - August 1, 2022 Category: Tropical Medicine Authors: Hugues C Nana-Djeunga Capucine M Sicard Aude E Mogoung-Wafo C édric B Chesnais Hugo Del église Rufine Touka-Nounkeu Andr é Domche Allison Golden Amy D Klion Thomas B Nutman Michel Boussinesq Joseph Kamgno S ébastien D Pion Source Type: research
Changes in Onchocerciasis Ov16 IgG4 Rapid Diagnostic Test Results Over One-Month Follow-up: Lessons for Reading Timeframe and Decision-Making
Am J Trop Med Hyg. 2022 Aug 1:tpmd211201. doi: 10.4269/ajtmh.21-1201. Online ahead of print.ABSTRACTThe SD Bioline® IgG4 rapid diagnostic test (RDT) detects IgG4 antibodies induced by the Onchocerca volvulus-specific antigen Ov16. We evaluated the stability of the RDT results over 1 month, at different time points after completion of each assay, using eluted dried blood spots collected in central Cameroon. Agreement coefficients regarding positivity between 30 minutes and 24 hours, 1, 2, 3, and 4 weeks were, 96.4%, 93.4%, 93.3%, 93.2%, and 93.2%, respectively. Between 30 minutes and 24 hours, 3.6% of the 15,444 tests show...
Source: Am J Trop Med Hyg - August 1, 2022 Category: Infectious Diseases Authors: Hugues C Nana-Djeunga Capucine M Sicard Aude E Mogoung-Wafo C édric B Chesnais Hugo Del église Rufine Touka-Nounkeu Andr é Domche Allison Golden Amy D Klion Thomas B Nutman Michel Boussinesq Joseph Kamgno S ébastien D Pion Source Type: research
Changes in Onchocerciasis Ov16 IgG4 Rapid Diagnostic Test Results Over One-Month Follow-up: Lessons for Reading Timeframe and Decision-Making
Am J Trop Med Hyg. 2022 Aug 1:tpmd211201. doi: 10.4269/ajtmh.21-1201. Online ahead of print.ABSTRACTThe SD Bioline® IgG4 rapid diagnostic test (RDT) detects IgG4 antibodies induced by the Onchocerca volvulus-specific antigen Ov16. We evaluated the stability of the RDT results over 1 month, at different time points after completion of each assay, using eluted dried blood spots collected in central Cameroon. Agreement coefficients regarding positivity between 30 minutes and 24 hours, 1, 2, 3, and 4 weeks were, 96.4%, 93.4%, 93.3%, 93.2%, and 93.2%, respectively. Between 30 minutes and 24 hours, 3.6% of the 15,444 tests show...
Source: The American Journal of Tropical Medicine and Hygiene - August 1, 2022 Category: Tropical Medicine Authors: Hugues C Nana-Djeunga Capucine M Sicard Aude E Mogoung-Wafo C édric B Chesnais Hugo Del église Rufine Touka-Nounkeu Andr é Domche Allison Golden Amy D Klion Thomas B Nutman Michel Boussinesq Joseph Kamgno S ébastien D Pion Source Type: research
Changes in Onchocerciasis Ov16 IgG4 Rapid Diagnostic Test Results Over One-Month Follow-up: Lessons for Reading Timeframe and Decision-Making
Am J Trop Med Hyg. 2022 Aug 1:tpmd211201. doi: 10.4269/ajtmh.21-1201. Online ahead of print.ABSTRACTThe SD Bioline® IgG4 rapid diagnostic test (RDT) detects IgG4 antibodies induced by the Onchocerca volvulus-specific antigen Ov16. We evaluated the stability of the RDT results over 1 month, at different time points after completion of each assay, using eluted dried blood spots collected in central Cameroon. Agreement coefficients regarding positivity between 30 minutes and 24 hours, 1, 2, 3, and 4 weeks were, 96.4%, 93.4%, 93.3%, 93.2%, and 93.2%, respectively. Between 30 minutes and 24 hours, 3.6% of the 15,444 tests show...
Source: Am J Trop Med Hyg - August 1, 2022 Category: Infectious Diseases Authors: Hugues C Nana-Djeunga Capucine M Sicard Aude E Mogoung-Wafo C édric B Chesnais Hugo Del église Rufine Touka-Nounkeu Andr é Domche Allison Golden Amy D Klion Thomas B Nutman Michel Boussinesq Joseph Kamgno S ébastien D Pion Source Type: research
Changes in Onchocerciasis Ov16 IgG4 Rapid Diagnostic Test Results Over One-Month Follow-up: Lessons for Reading Timeframe and Decision-Making
Am J Trop Med Hyg. 2022 Aug 1:tpmd211201. doi: 10.4269/ajtmh.21-1201. Online ahead of print.ABSTRACTThe SD Bioline® IgG4 rapid diagnostic test (RDT) detects IgG4 antibodies induced by the Onchocerca volvulus-specific antigen Ov16. We evaluated the stability of the RDT results over 1 month, at different time points after completion of each assay, using eluted dried blood spots collected in central Cameroon. Agreement coefficients regarding positivity between 30 minutes and 24 hours, 1, 2, 3, and 4 weeks were, 96.4%, 93.4%, 93.3%, 93.2%, and 93.2%, respectively. Between 30 minutes and 24 hours, 3.6% of the 15,444 tests show...
Source: The American Journal of Tropical Medicine and Hygiene - August 1, 2022 Category: Tropical Medicine Authors: Hugues C Nana-Djeunga Capucine M Sicard Aude E Mogoung-Wafo C édric B Chesnais Hugo Del église Rufine Touka-Nounkeu Andr é Domche Allison Golden Amy D Klion Thomas B Nutman Michel Boussinesq Joseph Kamgno S ébastien D Pion Source Type: research
Changes in Onchocerciasis Ov16 IgG4 Rapid Diagnostic Test Results Over One-Month Follow-up: Lessons for Reading Timeframe and Decision-Making
Am J Trop Med Hyg. 2022 Aug 1:tpmd211201. doi: 10.4269/ajtmh.21-1201. Online ahead of print.ABSTRACTThe SD Bioline® IgG4 rapid diagnostic test (RDT) detects IgG4 antibodies induced by the Onchocerca volvulus-specific antigen Ov16. We evaluated the stability of the RDT results over 1 month, at different time points after completion of each assay, using eluted dried blood spots collected in central Cameroon. Agreement coefficients regarding positivity between 30 minutes and 24 hours, 1, 2, 3, and 4 weeks were, 96.4%, 93.4%, 93.3%, 93.2%, and 93.2%, respectively. Between 30 minutes and 24 hours, 3.6% of the 15,444 tests show...
Source: Am J Trop Med Hyg - August 1, 2022 Category: Infectious Diseases Authors: Hugues C Nana-Djeunga Capucine M Sicard Aude E Mogoung-Wafo C édric B Chesnais Hugo Del église Rufine Touka-Nounkeu Andr é Domche Allison Golden Amy D Klion Thomas B Nutman Michel Boussinesq Joseph Kamgno S ébastien D Pion Source Type: research
Geospatial modeling of pre-intervention nodule prevalence of < i > Onchocerca volvulus < /i > in Ethiopia as an aid to onchocerciasis elimination
Conclusions/SignificanceNodule prevalence distribution was correlated with habitat suitability for vector breeding and associated biting behavior. The modeled pre-intervention prevalence can be used as a guide for determining priorities for elimination mapping in regions of Ethiopia that are currently unmapped, most of which have comparatively low infection prevalence. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - July 18, 2022 Category: Tropical Medicine Authors: Himal Shrestha Source Type: research
Historical overview and geographical distribution of neglected tropical diseases amenable to preventive chemotherapy in the Republic of the Congo: A systematic review
ConclusionsExcept for trachoma, whose epidemiological situation should be better evaluated, PC-NTDs are endemic in the RoC, and actions to control them have been taken by health authorities. To eliminate PC-NTDs, which are still present in some locations, new mapping surveys are needed, and increased investment in scientific research should be encouraged in the country. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - July 11, 2022 Category: Tropical Medicine Authors: Joseph A. Ngatse Source Type: research
The effect of ivermectin on the viral load and culture viability in early treatment of nonhospitalized patients with mild COVID-19 – a double-blind, randomized placebo-controlled trial
Ivermectin is a Food and Drug Administration-approved broad-spectrum antiparasitic agent, initially approved for humans in 1987 to treat onchocerciasis and awarded the Nobel Prize of Medicine to the discoverers in 2015. Its primary use is treating infections caused by roundworm parasites. However, over the years, the spectrum was extended to include a variety of parasitic skin infections, such as scabies (Laing et al., 2017). (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - July 7, 2022 Category: Infectious Diseases Authors: Asaf Biber, Geva Harmelin, Dana Lev, Li Ram, Amit Shaham, Ital Nemet, Limor Kliker, Oran Erster, Michal Mandelboim, Eli Schwartz Source Type: research
Prevalence of malaria and helminth infections in rural communities in northern Sierra Leone, a baseline study to inform Ebola vaccine study protocols
ConclusionMalaria and hookworm are the most prevalent parasite infections and those most likely to influence long-term immune response to Ebola vaccines among the trial participants. (Source: PLoS One)
Source: PLoS One - July 6, 2022 Category: Biomedical Science Authors: Frank Baiden Source Type: research
Knowledge, Attitude, and Practice of Community towards an Onchocerciasis Elimination Program from South West Ethiopia
J Trop Med. 2022 Jun 24;2022:1417804. doi: 10.1155/2022/1417804. eCollection 2022.ABSTRACTOnchocerciasis is a neglected tropical disease that is prevalent throughout Africa, including developing countries such as Ethiopia. It affects around 37 million people, the majority of whom are from Africa. As a result, the study was designed to look into the community's knowledge, attitude, and practice about the onchocerciasis elimination campaign. Four communities from Gesha town, Southwest Ethiopia, were chosen. The population was selected using a basic random selection procedure, and 312 people were identified for the study base...
Source: Journal of Tropical Medicine - July 5, 2022 Category: Tropical Medicine Authors: Haile Worku Misganaw Mola Bizuwork Derebew Alemu Sebwedin Surur Jemal Aklilu Ayiza Samuel Getachew Nitin Mahendra Chauhan Sunil Tulshiram Hajare Suresh Chandra Singh Mohammed Kuddus Vijay J Upadhye Source Type: research
