The preparatory phase for ground larviciding implementation for chocerciasis control in the Meme River Basin in South West Cameroon: the COUNTDOWN Consortium alternative strategy implementation trial
Onchocerciasis control using ivermectin alone has been achieved in some endemic savannah zones of Africa. In the forest regions, the co-endemicity with Loa loa has led to severe adverse events (SAEs) resulting in... (Source: Parasites and Vectors)
Source: Parasites and Vectors - June 21, 2022 Category: Microbiology Authors: Relindis Ekanya, Elisabeth Dibando Obie, Louise Hamill, Sophie Thorogood, Raphael Awah Abong, Abdel Jelil Njouendou, Andrew Amuam, Bertrand Lontum Ndzeshang, Desmond Akumtoh Nkimbeng, Jerome Fru Cho, Mathias Eyong Esum, Peter Enyong, Joseph D. Turner, Mar Tags: Research Source Type: research
Correction to: High infection rates for onchocerciasis and soil-transmitted helminthiasis in children under five not receiving preventive chemotherapy: a bottleneck to elimination
(Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - June 6, 2022 Category: Infectious Diseases Source Type: research
Crystal structure of an extracellular superoxide dismutase from Onchocerca volvulus and implications for parasite-specific drug development
Superoxide dismutases (SODs) are metalloproteins that are responsible for the dismutation of superoxide anion radicals. SODs are consequently protective against oxidative damage to cellular components. Among other protective mechanisms, the filarial parasite Onchocerca volvulus has a well developed defense system to scavenge toxic free radicals using SODs during migration and sojourning of the microfilariae and adult worms in the human body. O. volvulus is responsible for the neglected disease onchocerciasis or `river blindness'. In the present study, an extracellular Cu/Zn-SOD from O. volvulus (OvEC-SOD) was cloned, purif...
Source: Acta Crystallographica Section F - May 27, 2022 Category: Biochemistry Authors: Moustafa, A. Perbandt, M. Liebau, E. Betzel, C. Falke, S. Tags: X-ray crystallography Cu/Zn superoxide dismutases metal ion coordination Onchocerca volvulus parasites docking drug targets research communications Source Type: research
Characterization of a novel microfilarial antigen for diagnosis of < i > Wuchereria bancrofti < /i > infections
ConclusionsWb-Bhp-1 is a novel antigen that is useful for serologic diagnosis of bancroftian filariasis. Additional studies are needed to assess the value of this antigen for monitoring the success of filariasis elimination programs. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - May 23, 2022 Category: Tropical Medicine Authors: Sarah E. Greene Source Type: research
Ivermectin as a possible treatment for COVID-19: a review of the 2022 protocols
Braz J Biol. 2022 May 20;84:e258325. doi: 10.1590/1519-6984.258325. eCollection 2022.ABSTRACTIvermectin is a safe and effective drug in humans and has been approved for use in numerous parasitic infections for over 50 years. In addition, many studies have already shown its antiviral activity. Ivermectin is generally well tolerated, with no indication of central nervous system-associated toxicity at doses up to 10 times the highest FDA-approved dose of 200 µg/kg. The in vitro results of ivermectin for reducing SARS-CoV-2 viral load are promising and show that Ivermectin kills SARS-CoV-2 within 48 hours. A hypothesized mech...
Source: Braz J Biol - May 18, 2022 Category: Biology Authors: L L M Marques S C Beneti C Pinzon F A R Cardoso Source Type: research
Ivermectin as a possible treatment for COVID-19: a review of the 2022 protocols
Braz J Biol. 2022 May 20;84:e258325. doi: 10.1590/1519-6984.258325. eCollection 2022.ABSTRACTIvermectin is a safe and effective drug in humans and has been approved for use in numerous parasitic infections for over 50 years. In addition, many studies have already shown its antiviral activity. Ivermectin is generally well tolerated, with no indication of central nervous system-associated toxicity at doses up to 10 times the highest FDA-approved dose of 200 µg/kg. The in vitro results of ivermectin for reducing SARS-CoV-2 viral load are promising and show that Ivermectin kills SARS-CoV-2 within 48 hours. A hypothesized mech...
Source: Braz J Biol - May 18, 2022 Category: Biology Authors: L L M Marques S C Beneti C Pinzon F A R Cardoso Source Type: research
Forging Ahead the Repositioning of Multitargeted Drug Ivermectin
This article also provides a glimpse of regulatory considerations of drug repurposing and current formulation strategies. Due to its broad-spectrum activity, multitargeted nature and promising efforts are put towards the repurposing of this drug throughout the field of medicine. This single drug originated from a microbe, changed the face of global health by proving its unmatched success and progressive efforts continue in maintaining its bequestnin the management of global health by decreasing the burden of various diseases worldwide.PMID:35578879 | DOI:10.2174/1567201819666220516163242 (Source: Current Drug Delivery)
Source: Current Drug Delivery - May 17, 2022 Category: Drugs & Pharmacology Authors: Srividya Atmakuri Shweta Nene Dharmendra Khatri Shashi Bala Singh V R Sinha Saurabh Srivastava Source Type: research
Forging Ahead the Repositioning of Multitargeted Drug Ivermectin
This article also provides a glimpse of regulatory considerations of drug repurposing and current formulation strategies. Due to its broad-spectrum activity, multitargeted nature and promising efforts are put towards the repurposing of this drug throughout the field of medicine. This single drug originated from a microbe, changed the face of global health by proving its unmatched success and progressive efforts continue in maintaining its bequestnin the management of global health by decreasing the burden of various diseases worldwide.PMID:35578879 | DOI:10.2174/1567201819666220516163242 (Source: Current Drug Delivery)
Source: Current Drug Delivery - May 17, 2022 Category: Drugs & Pharmacology Authors: Srividya Atmakuri Shweta Nene Dharmendra Khatri Shashi Bala Singh V R Sinha Saurabh Srivastava Source Type: research
Wilful Blindness: Sleeping Sickness and Onchocerciasis in Colonial Northern Ghana, 1909-1957
Soc Hist Med. 2022 Feb 8;35(2):635-660. doi: 10.1093/shm/hkab119. eCollection 2022 May.ABSTRACTAs a contribution to the existing literature on deliberate or unintended neglect, concealment and ignorance regarding significant and enduring public health problems-produced by economic marginality, lack of political power and institutional failures affecting specific places and groups-this article discusses the history of epidemic sleeping sickness and endemic onchocerciasis in colonial northern Ghana from 1909 to 1957. Despite accumulating evidence of their serious impacts on the health of northern communities, and calls to ac...
Source: Medical History - May 13, 2022 Category: History of Medicine Authors: David Bannister Source Type: research
