Wilful Blindness: Sleeping Sickness and Onchocerciasis in Colonial Northern Ghana, 1909-1957
Soc Hist Med. 2022 Feb 8;35(2):635-660. doi: 10.1093/shm/hkab119. eCollection 2022 May.ABSTRACTAs a contribution to the existing literature on deliberate or unintended neglect, concealment and ignorance regarding significant and enduring public health problems-produced by economic marginality, lack of political power and institutional failures affecting specific places and groups-this article discusses the history of epidemic sleeping sickness and endemic onchocerciasis in colonial northern Ghana from 1909 to 1957. Despite accumulating evidence of their serious impacts on the health of northern communities, and calls to ac...
Source: Medical History - May 13, 2022 Category: History of Medicine Authors: David Bannister Source Type: research
< i > Onchocerca volvulus < /i > -specific antibody and cellular responses in onchocerciasis patients treated annually with ivermectin for 30 years and exposed to parasite transmission in central Togo
Conclusions/SignificanceRepeated annual ivermectin treatment of onchocerciasis patients durably inhibited their patentO.volvulus infections despite ongoing low-level parasite transmission in the study area. Repeated MDA with ivermectin affects the expression of immunity in patients.O.volvulus parasite-specific antibody levels diminished to levels seen in infection-free endemic controls. With low antibody levels, antibody-dependent cellular cytotoxic responses against tissue-dwellingO.volvulus larvae will weaken.O.volvulus antigen inducible cytokine and chemokine production increased in treated mf-negative patients, while t...
Source: PLoS Neglected Tropical Diseases - May 3, 2022 Category: Tropical Medicine Authors: Saskia I. Johanns Source Type: research
Relationship between skin snip and Ov16 ELISA: Two diagnostic tools for onchocerciasis in a focus in Cameroon after two decades of ivermectin-based preventive chemotherapy
This study aimed at determining the relationship between microfilaridermia and anti-Ov16 IgG4, and their variation according to age, gender and ivermectin intake history. MethodologyA cross-sectional survey was conducted in an area where ivermectin-based MDA has been implemented since more than 20 years. A questionnaire was used to record ivermectin intake history for the last 5 years. All volunteers aged ≥2 years were tested for microfilaridermia. IgG4 antibodies against Ov16 antigen were determined using the Standard Diagnostic Ov16 IgG4 ELISA kits and the recombinant anti-Ov16 AbD19432 antibodies. Prevalences, microfi...
Source: PLoS Neglected Tropical Diseases - May 2, 2022 Category: Tropical Medicine Authors: Linda Djune-Yemeli Source Type: research
High infection rates for onchocerciasis and soil-transmitted helminthiasis in children under five not receiving preventive chemotherapy: a bottleneck to elimination
ConclusionsThis study reveals that children < 5 years of age are highly infected with STH and onchocerciasis, and could contribute to the spread of these diseases, perpetuating a vicious circle of transmission and hampering elimination efforts. These findings reveal the urgent need to provide (or scale) treatments (likely pediatric formulat ions) to these preschool-aged children, especially in areas of high transmission, to accelerate efforts to reach WHO 2030 target.Graphical Abstract (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - April 28, 2022 Category: Infectious Diseases Source Type: research
Anti-Th17 and anti-Th2 responses effects of hydro-ethanolic extracts of < i > Aframomum melegueta < /i > , < i > Khaya senegalensis and Xylopia aethiopica < /i > in hyperreactive onchocerciasis individuals ’ peripheral blood mononuclear cells
This study showed that in addition to their anthelminthic ef fects, hydro-ethanolic extracts of Aframomum melegueta,Xylopia aethiopica andKhaya senegalensis could downregulate both Th17 and Th2 responses and prevent the severe skin disorder observed. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - April 25, 2022 Category: Tropical Medicine Authors: Gnatoulma Katawa Source Type: research
Black flies and Onchocerciasis: Knowledge, attitude and practices among inhabitants of Alabameta, Osun State, Southwestern, Nigeria
This study reports knowledge of residents of Alabameta community, Osun State, Nigeria on the bioecology and socio-economic burden of black flies and onchocerciasis. MethodsUsing structured questionnaires and Focus Group Discussion (FGD), a total of 150 community respondents participated in the study. ResultsThe knowledge of the residents on the existence of black flies in the community was significant (p (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - April 21, 2022 Category: Tropical Medicine Authors: Lateef O. Busari Source Type: research
Community-based trial assessing the impact of annual versus semiannual mass drug administration with ivermectin plus albendazole and praziquantel on helminth infections in northwestern Liberia
Acta Trop. 2022 Apr 8:106437. doi: 10.1016/j.actatropica.2022.106437. Online ahead of print.ABSTRACTWe assessed the impact of three annual vs five semiannual rounds of mass drug administration (MDA) with ivermectin plus albendazole followed by praziquantel for the control or elimination of lymphatic filariasis (LF), onchocerciasis, soil-transmitted helminth (STH) infections and schistosomiasis in Lofa County, Liberia. The study started in 2012 and was interrupted in 2014 during the Ebola virus outbreak. Repeated cross-sectional surveys were conducted in individuals 5 years and older to measure infection markers. Wuchereria...
Source: Acta Tropica - April 11, 2022 Category: Infectious Diseases Authors: Obiora A Eneanya Lincoln Gankpala Charles W Goss Aaron T Momolu Enoch S Nyan Emmanuiel B Gray Kerstin Fischer Kurt Curtis Fatorma K Bolay Gary J Weil Peter U Fischer Source Type: research
Community-based trial assessing the impact of annual versus semiannual mass drug administration with ivermectin plus albendazole and praziquantel on helminth infections in northwestern Liberia
Acta Trop. 2022 Apr 8:106437. doi: 10.1016/j.actatropica.2022.106437. Online ahead of print.ABSTRACTWe assessed the impact of three annual vs five semiannual rounds of mass drug administration (MDA) with ivermectin plus albendazole followed by praziquantel for the control or elimination of lymphatic filariasis (LF), onchocerciasis, soil-transmitted helminth (STH) infections and schistosomiasis in Lofa County, Liberia. The study started in 2012 and was interrupted in 2014 during the Ebola virus outbreak. Repeated cross-sectional surveys were conducted in individuals 5 years and older to measure infection markers. Wuchereria...
Source: Acta Tropica - April 11, 2022 Category: Infectious Diseases Authors: Obiora A Eneanya Lincoln Gankpala Charles W Goss Aaron T Momolu Enoch S Nyan Emmanuiel B Gray Kerstin Fischer Kurt Curtis Fatorma K Bolay Gary J Weil Peter U Fischer Source Type: research
Vector control and entomological capacity for onchocerciasis elimination
Trends Parasitol. 2022 Apr 1:S1471-4922(22)00060-5. doi: 10.1016/j.pt.2022.03.003. Online ahead of print.ABSTRACTMass drug administration (MDA) of ivermectin is currently the main strategy to achieve elimination of transmission (EoT) of onchocerciasis. Modelling suggests that EoT may not be reached in all endemic foci using annual MDA alone. Onchocerciasis and loiasis are coendemic in forest areas of Central Africa where ivermectin treatment can lead to severe adverse events in individuals with heavy loiasis load, rendering MDA inappropriate. Vector control has been proposed as a complementary intervention strategy. Here, ...
Source: Trends in Parasitology - April 5, 2022 Category: Parasitology Authors: I ñaki Tirados Edward Thomsen Eve Worrall Lassane Koala Tito T Melachio Mar ía-Gloria Basáñez Source Type: research
Vector control and entomological capacity for onchocerciasis elimination
Trends Parasitol. 2022 Apr 1:S1471-4922(22)00060-5. doi: 10.1016/j.pt.2022.03.003. Online ahead of print.ABSTRACTMass drug administration (MDA) of ivermectin is currently the main strategy to achieve elimination of transmission (EoT) of onchocerciasis. Modelling suggests that EoT may not be reached in all endemic foci using annual MDA alone. Onchocerciasis and loiasis are coendemic in forest areas of Central Africa where ivermectin treatment can lead to severe adverse events in individuals with heavy loiasis load, rendering MDA inappropriate. Vector control has been proposed as a complementary intervention strategy. Here, ...
Source: Trends in Parasitology - April 5, 2022 Category: Parasitology Authors: I ñaki Tirados Edward Thomsen Eve Worrall Lassane Koala Tito T Melachio Mar ía-Gloria Basáñez Source Type: research
Vector control and entomological capacity for onchocerciasis elimination
Trends Parasitol. 2022 Apr 1:S1471-4922(22)00060-5. doi: 10.1016/j.pt.2022.03.003. Online ahead of print.ABSTRACTMass drug administration (MDA) of ivermectin is currently the main strategy to achieve elimination of transmission (EoT) of onchocerciasis. Modelling suggests that EoT may not be reached in all endemic foci using annual MDA alone. Onchocerciasis and loiasis are coendemic in forest areas of Central Africa where ivermectin treatment can lead to severe adverse events in individuals with heavy loiasis load, rendering MDA inappropriate. Vector control has been proposed as a complementary intervention strategy. Here, ...
Source: Trends in Parasitology - April 5, 2022 Category: Parasitology Authors: I ñaki Tirados Edward Thomsen Eve Worrall Lassane Koala Tito T Melachio Mar ía-Gloria Basáñez Source Type: research
Vector control and entomological capacity for onchocerciasis elimination
Trends Parasitol. 2022 Apr 1:S1471-4922(22)00060-5. doi: 10.1016/j.pt.2022.03.003. Online ahead of print.ABSTRACTMass drug administration (MDA) of ivermectin is currently the main strategy to achieve elimination of transmission (EoT) of onchocerciasis. Modelling suggests that EoT may not be reached in all endemic foci using annual MDA alone. Onchocerciasis and loiasis are coendemic in forest areas of Central Africa where ivermectin treatment can lead to severe adverse events in individuals with heavy loiasis load, rendering MDA inappropriate. Vector control has been proposed as a complementary intervention strategy. Here, ...
Source: Trends in Parasitology - April 5, 2022 Category: Parasitology Authors: I ñaki Tirados Edward Thomsen Eve Worrall Lassane Koala Tito T Melachio Mar ía-Gloria Basáñez Source Type: research
Vector control and entomological capacity for onchocerciasis elimination
Trends Parasitol. 2022 Apr 1:S1471-4922(22)00060-5. doi: 10.1016/j.pt.2022.03.003. Online ahead of print.ABSTRACTMass drug administration (MDA) of ivermectin is currently the main strategy to achieve elimination of transmission (EoT) of onchocerciasis. Modelling suggests that EoT may not be reached in all endemic foci using annual MDA alone. Onchocerciasis and loiasis are coendemic in forest areas of Central Africa where ivermectin treatment can lead to severe adverse events in individuals with heavy loiasis load, rendering MDA inappropriate. Vector control has been proposed as a complementary intervention strategy. Here, ...
Source: Trends in Parasitology - April 5, 2022 Category: Parasitology Authors: I ñaki Tirados Edward Thomsen Eve Worrall Lassane Koala Tito T Melachio Mar ía-Gloria Basáñez Source Type: research
Vector control and entomological capacity for onchocerciasis elimination
Trends Parasitol. 2022 Apr 1:S1471-4922(22)00060-5. doi: 10.1016/j.pt.2022.03.003. Online ahead of print.ABSTRACTMass drug administration (MDA) of ivermectin is currently the main strategy to achieve elimination of transmission (EoT) of onchocerciasis. Modelling suggests that EoT may not be reached in all endemic foci using annual MDA alone. Onchocerciasis and loiasis are coendemic in forest areas of Central Africa where ivermectin treatment can lead to severe adverse events in individuals with heavy loiasis load, rendering MDA inappropriate. Vector control has been proposed as a complementary intervention strategy. Here, ...
Source: Trends in Parasitology - April 5, 2022 Category: Parasitology Authors: I ñaki Tirados Edward Thomsen Eve Worrall Lassane Koala Tito T Melachio Mar ía-Gloria Basáñez Source Type: research
Vector control and entomological capacity for onchocerciasis elimination
Trends Parasitol. 2022 Apr 1:S1471-4922(22)00060-5. doi: 10.1016/j.pt.2022.03.003. Online ahead of print.ABSTRACTMass drug administration (MDA) of ivermectin is currently the main strategy to achieve elimination of transmission (EoT) of onchocerciasis. Modelling suggests that EoT may not be reached in all endemic foci using annual MDA alone. Onchocerciasis and loiasis are coendemic in forest areas of Central Africa where ivermectin treatment can lead to severe adverse events in individuals with heavy loiasis load, rendering MDA inappropriate. Vector control has been proposed as a complementary intervention strategy. Here, ...
Source: Trends in Parasitology - April 5, 2022 Category: Parasitology Authors: I ñaki Tirados Edward Thomsen Eve Worrall Lassane Koala Tito T Melachio Mar ía-Gloria Basáñez Source Type: research
