Prevalence of epilepsy in Ndom Health District (Littoral Region, Cameroon) after long-term ivermectin-based preventive chemotherapy for the control of onchocerciasis
This study aimed at assessing the prevalence of epilepsy in an onchocerciasis endemic area under annual CDTI for 16 years. A cross-sectional survey was conducted in two communities (Kelleng and Nkonkwalla) located in the Ndom Health District (Littoral Region, Cameroon) to assess the prevalence of epilepsy using a standardized questionnaire for non-specialists in tropical areas. Data on the nuisance of onchocerciasis vector and distance of surveyed households to the river were also collected. Epilepsy status was collected from 367 participants (sex ratio (M/F): 1.13). The crude prevalence of epilepsy was estimated at 8.4 % ...
Source: Epilepsy and Behaviour - October 17, 2022 Category: Neurology Authors: Arnauld Efon-Ekangouo Hugues C Nana-Djeunga Philippe Nwane Elvis Lisongue-Tonga Andr é Domche Laurentine Sumo Mike Yaw Osei-Atweneboana Anne Geiger Joseph Kamgno Source Type: research
NKp46+ natural killer cells develop an activated/memory-like phenotype and contribute to innate immunity against experimental filarial infection
Lymphatic filariasis and onchocerciasis are major neglected tropical diseases affecting over 90 million people worldwide with painful and profoundly disfiguring pathologies (such as lymphoedema or blindness). Type 2 inflammation is a hallmark of filarial nematode tissue infection and is implicated both in eosinophil dependent immunity and lymphatic or ocular immunopathologies. Type-2 innate lymphoid cells (ILC2) are known to play an important role in the initiation of type 2 inflammation in helminth infection. We therefore tracked comparative IL-12Rβ2+ ILC1, ST2+ ILC2 and NKp46+ natural killer (NK) innate lymphoid cell po...
Source: Frontiers in Immunology - September 27, 2022 Category: Allergy & Immunology Source Type: research
Knowledge, Attitude, and Preventive Practice Related to Onchocerciasis and Associated Factors among Resource-Limited Selamogo Woreda Residents, South West Ethiopia, 2021
CONCLUSION: The KAP related to Onchocerciasis is very poor compared to the indicators and evidence in the country. An intervention that considers local resources like taking the experience of groups with good knowledge, attitude, and preventive practice led by educated plus positive attitude people regarding the preventability and treatability of Onchocerciasis might be mandatory to improve the status.PMID:36072827 | PMC:PMC9444457 | DOI:10.1155/2022/2481841 (Source: Journal of Tropical Medicine)
Source: Journal of Tropical Medicine - September 8, 2022 Category: Tropical Medicine Authors: Girma Gilano None Mulugeta Shegaze Amanuel Dubale Source Type: research
The prevalence of onchocerciasis in Africa and Yemen, 2000 –2018: a geospatial analysis
Onchocerciasis is a disease caused by infection with Onchocerca volvulus, which is transmitted to humans via the bite of several species of black fly, and is responsible for permanent blindness or vision loss, as... (Source: BMC Medicine)
Source: BMC Medicine - September 7, 2022 Category: Internal Medicine Authors: Chris A. Schmidt, Elizabeth A. Cromwell, Elex Hill, Katie M. Donkers, Megan F. Schipp, Kimberly B. Johnson, David M. Pigott and Simon I. Hay Tags: Research article Source Type: research
The Th1/Tfh-like biased responses elicited by the rASP-1 innate adjuvant are dependent on TRIF and Type I IFN receptor pathways
This study is aimed to provide a deeper insight into the molecular networks that underline the adjuvanticity of rASP-1. Here we show that rASP-1 stimulates mouse CD11c+ bone marrow-derived dendritic (BMDCs) to secrete elevated levels of IL-12p40, TNF-α, IP-10 and IFN-β in a TRIF-dependent but MyD88-independent manner. rASP-1-activated BMDCs promoted the differentiation of naïve CD4+ T cells into Th1 cells (IFN-γ+) that was TRIF- and type I interferon receptor (IFNAR)-dependent, and into Tfh-like cells (IL21+) and Tfh1 (IFN-γ+ IL21+) that were TRIF-, MyD88- and IFNAR-dependent. rASP-1-activated BMDCs promoted the diffe...
Source: Frontiers in Immunology - September 2, 2022 Category: Allergy & Immunology Source Type: research
Ivermectin mass drug administration for onchocerciasis elimination: can it reduce the prevalence of scabies in Ethiopia?
Conclusions: The implementation of ivermectin MDA for onchocerciasis control was not associated with reduced scabies prevalence. Consequently, standard scabies MDA should be deployed for scabies control. (Source: The Journal of Infection in Developing Countries)
Source: The Journal of Infection in Developing Countries - August 30, 2022 Category: Infectious Diseases Source Type: research
Onchocerciasis: Target product profiles of in vitro diagnostics to support onchocerciasis elimination mapping and mass drug administration stopping decisions
by Marco A. Biamonte, Paul T. Cantey, Yaya I. Coulibaly, Katherine M. Gass, Louise C. Hamill, Christopher Hanna, Patrick J. Lammie, Joseph Kamgno, Thomas B. Nutman, David W. Oguttu, Dieudonn é P. Sankara, Wilma A. Stolk, Thomas R. Unnasch
In June 2021, the World Health Organization (WHO), recognizing the need for new diagnostics to support the control and elimination of onchocerciasis, published the target product profiles (TPPs) of new tests that would support the two most immediate needs: (a) mapping onchocerciasis in areas of low prevalence and (b) deciding when to stop mass drug administration programs. In both insta...
Source: PLoS Neglected Tropical Diseases - August 3, 2022 Category: Tropical Medicine Authors: Marco A. Biamonte Source Type: research
Changes in Onchocerciasis Ov16 IgG4 Rapid Diagnostic Test Results Over One-Month Follow-up: Lessons for Reading Timeframe and Decision-Making
Am J Trop Med Hyg. 2022 Aug 1:tpmd211201. doi: 10.4269/ajtmh.21-1201. Online ahead of print.ABSTRACTThe SD Bioline® IgG4 rapid diagnostic test (RDT) detects IgG4 antibodies induced by the Onchocerca volvulus-specific antigen Ov16. We evaluated the stability of the RDT results over 1 month, at different time points after completion of each assay, using eluted dried blood spots collected in central Cameroon. Agreement coefficients regarding positivity between 30 minutes and 24 hours, 1, 2, 3, and 4 weeks were, 96.4%, 93.4%, 93.3%, 93.2%, and 93.2%, respectively. Between 30 minutes and 24 hours, 3.6% of the 15,444 tests show...
Source: The American Journal of Tropical Medicine and Hygiene - August 1, 2022 Category: Tropical Medicine Authors: Hugues C Nana-Djeunga Capucine M Sicard Aude E Mogoung-Wafo C édric B Chesnais Hugo Del église Rufine Touka-Nounkeu Andr é Domche Allison Golden Amy D Klion Thomas B Nutman Michel Boussinesq Joseph Kamgno S ébastien D Pion Source Type: research
Changes in Onchocerciasis Ov16 IgG4 Rapid Diagnostic Test Results Over One-Month Follow-up: Lessons for Reading Timeframe and Decision-Making
Am J Trop Med Hyg. 2022 Aug 1:tpmd211201. doi: 10.4269/ajtmh.21-1201. Online ahead of print.ABSTRACTThe SD Bioline® IgG4 rapid diagnostic test (RDT) detects IgG4 antibodies induced by the Onchocerca volvulus-specific antigen Ov16. We evaluated the stability of the RDT results over 1 month, at different time points after completion of each assay, using eluted dried blood spots collected in central Cameroon. Agreement coefficients regarding positivity between 30 minutes and 24 hours, 1, 2, 3, and 4 weeks were, 96.4%, 93.4%, 93.3%, 93.2%, and 93.2%, respectively. Between 30 minutes and 24 hours, 3.6% of the 15,444 tests show...
Source: Am J Trop Med Hyg - August 1, 2022 Category: Infectious Diseases Authors: Hugues C Nana-Djeunga Capucine M Sicard Aude E Mogoung-Wafo C édric B Chesnais Hugo Del église Rufine Touka-Nounkeu Andr é Domche Allison Golden Amy D Klion Thomas B Nutman Michel Boussinesq Joseph Kamgno S ébastien D Pion Source Type: research
