Breaking the paradigm: Optimized Case Finding multiplies tuberculosis detection among key populations in Ukraine
Conclusions: The OCF strategy among key populations is highly effective in detecting TB cases and linking them to care. We advocate to scale-up this case finding strategy in Ukraine and beyond. (Source: The Journal of Infection in Developing Countries)
Source: The Journal of Infection in Developing Countries - October 6, 2021 Category: Infectious Diseases Source Type: research

Subacute transverse myelitis as a clinical presentation of neurobrucellosis
Brucella melitensis is the main cause of human brucellosis worldwide and is considered the most virulent and neurotropic species. In Mexico, this species is considered endemic, being reported since the first decade of the 20th century. Here we present a case of subacute transverse myelitis with the isolation and identification ofB. melitensisas the causative agent of Neurobrucellosis in a female patient from the coastal state of Guerrero, Mexico. (Source: The Journal of Infection in Developing Countries)
Source: The Journal of Infection in Developing Countries - September 29, 2021 Category: Infectious Diseases Source Type: research

Meningitis and bacteremia caused by Haemophilus influenzae Type e in an immunocompetent child
We report a case of an immunocompetent child who was clinically diagnosed with bacterial meningitis with bacteremia caused by Hie. The literature on infection especially meningitis caused by Hie is reviewed. (Source: The Journal of Infection in Developing Countries)
Source: The Journal of Infection in Developing Countries - September 29, 2021 Category: Infectious Diseases Source Type: research

The emergence of Dengue Fever in Sheikhupura, Pakistan: its seroprevalence and risk factors assessment during 2014-2017
Introduction: District Sheikhupura encountered its first dengue outbreak in 2014 but lacked serological evidence and reports of risk factors associated with it. To assess this, a hospital-based study was conducted from January 2014 to December 2017.Methodology: Blood from 333 participants was collected, the serum obtained was tested for IgG and IgM antibodies against DENV using a commercially available ELISA kit.Results: The results showed that out of all (n= 333) samples tested, 120 were turned up positive for DENV, making an overall prevalence of 36%. Of the 120 confirmed cases, 55% (n = 66) were recorded in 2014, 10% (n...
Source: The Journal of Infection in Developing Countries - September 29, 2021 Category: Infectious Diseases Source Type: research

Empiric antibiotic and in-vitro susceptibility of urosepsis pathogens: do they match? The outcome of a study from south India
Introduction: Urosepsis is life threatening, unless treated immediately. Empirical treatment with appropriate antibiotics lowers the risk of a poor outcome. However, with increasing resistance among common uropathogens, there is a need for continuous review of the existing protocol to determine whether there is a correlation between empirical antibiotic therapy and in-vitro susceptibility pattern of the pathogens causing urosepsis.Methodology: A prospective study was carried out on 66 confirmed cases of urosepsis from January 2017 to December 2018 after obtaining ethical clearance. Demographic details, risk factors, length...
Source: The Journal of Infection in Developing Countries - September 29, 2021 Category: Infectious Diseases Source Type: research

Prevalence of precancerous cervical lesions and high-risk human papillomavirus types in Yaounde, Cameroon
Conclusions: Our results suggest that HPV 16 and 18 are predominant in Yaounde, and are associated with more severe precancerous lesions. (Source: The Journal of Infection in Developing Countries)
Source: The Journal of Infection in Developing Countries - September 29, 2021 Category: Infectious Diseases Source Type: research

Immunogenicity and potential protection of DNA vaccine of Leishmania martiniquensis against Leishmania infection in mice
Introduction: In Thailand,Leishmania martiniquensisis the predominant species causing cutaneous and visceral leishmaniasis. Its incidence has been increasing among immunocompetent and immunocompromised hosts. We developed a prototype DNA vaccine using a partial consensus sequence of the cysteine protease B (cpb) gene derived fromL. martiniquensis from Thai patients.Methodology: The laboratory inbred strain of albino BALB/c mice were immunized intramuscularly three times at 2-week intervals (weeks 0, 2, and 4) withcpb plasmid DNA (pcDNA_cpb) with or without the adjuvant, monoolein (pcDNA_cpb-MO). Mice were challenged at wee...
Source: The Journal of Infection in Developing Countries - September 29, 2021 Category: Infectious Diseases Source Type: research

Adherence to Community Acquired Pneumonia guideleines and patients outcomes in a peri-urban hospital in Natal, South Africa
Introduction: Community-acquired pneumonia (CAP) is an important cause of mortality and morbidity worldwide. This issue is further exacerbated by the Human Immunodeficiency Virus (HIV) epidemic.Methodology: The study was a retrospective, clinical record review of hospitalized patients (18 years and older) with a diagnosis of LRTI between the 1st of January 2012 and 31 December 2012, descriptive and comparable analysis was performed.Results: Number of patients was 274; 142 (51.8%) males. The commonest final diagnosis was Pulmonary Tuberclosis (PTB) in 131 (47.8%) and CAP in 127 (46.4%). The case fatality rate was 25.5% (70/...
Source: The Journal of Infection in Developing Countries - September 29, 2021 Category: Infectious Diseases Source Type: research

The bacterial colonization of healthcare workers ’ mobile phones in a large tertiary care teaching hospital in Saudi Arabia
Conclusions: In our study, the prevalence of bacterial colonization among healthcare workers ’ mobile phones was high. Our findings suggest that high-risk groups for mobile phone colonization—such as laboratory, neonatal intensive care unit, and medicine department staff—should be a priority for preventative measures, to improve infection control. (Source: The Journal of Infection in Developing Countries)
Source: The Journal of Infection in Developing Countries - September 29, 2021 Category: Infectious Diseases Source Type: research

Retrospective evaluation of intravenous fosfomycin in multi-drug resistant infections at a tertiary care hospital in Lebanon
Conclusions: Fosfomycin is a safe and effective option in the treatment of multi-drug resistant infections. Nevertheless, careful stewardship is important to maintain its efficacy and to reduce the risk of selection of antimicrobial resistance. (Source: The Journal of Infection in Developing Countries)
Source: The Journal of Infection in Developing Countries - September 29, 2021 Category: Infectious Diseases Source Type: research

Molecular Epidemiology of Mycobacterium tuberculosis strains isolated from pulmonary tuberculosis patients in south Ethiopia
Conclusions: The study revealed several clusters and drug resistant strains ofM. tuberculosisin the study area, suggesting recent transmission including of drug resistant tuberculosis. Wider monitoring of drug susceptibility testing and geospatial analysis of transmission trends is required to control tuberculosis in southern Ethiopia. (Source: The Journal of Infection in Developing Countries)
Source: The Journal of Infection in Developing Countries - September 29, 2021 Category: Infectious Diseases Source Type: research

Quantification of Gardnerella vaginalis, Atopobium vaginae and Lactobacillus spp. in bacterial vaginosis
Conclusions: According to the results of our study real-time PCR analysis was more sensitive in diagnosis of bacterial vaginosis than Amsel ’s method, as well as it represented fine tool in making a difference between microbial entities in healthy and bacterial vaginosis samples. (Source: The Journal of Infection in Developing Countries)
Source: The Journal of Infection in Developing Countries - September 29, 2021 Category: Infectious Diseases Source Type: research

Clinical analysis of COVID-19 positive cancer inpatients in National Cancer Center in Serbia
This study aimed to identify clinical characteristics of Coronavirus Disease 2019 (COVID-19) infected cancer inpatients, as well as what impact this infection had on radiation treatment of the patients.Methodology: In this retrospective study, we included cancer inpatients with laboratory confirmed COVID-19 infection during the radiotherapy or chemoradiation in April 2020 in National Cancer Research Center in Serbia. Data were obtained from the medical records between 1 April and 1 July 2020.Results: A total of 49 COVID-19 infected cancer inpatients were included. The most frequently reported cancers were head and neck can...
Source: The Journal of Infection in Developing Countries - September 29, 2021 Category: Infectious Diseases Source Type: research

The role of anxiety, stigma, religiosity, and economic condition in COVID-19 preventive efforts among lecturers
Conclusions: There was a relationship between anxiety, stigma, religiosity, and COVID-19 preventions, while there was no relationship between economic conditions and COVID-19 preventions. The most influencing variable was anxiety. Respondents must be able to manage anxiety levels related to COVID-19 with good coping strategies. (Source: The Journal of Infection in Developing Countries)
Source: The Journal of Infection in Developing Countries - September 29, 2021 Category: Infectious Diseases Source Type: research

Severe pacemaker pocket infection during the COVID-19 pandemic, transvenous lead removal
Conclusions: A case showing delayed treatment of pacemaker pocket infection, due to delayed follow-up time during the COVID-19 pandemic. This patient underwent successful transvenous removal of the infected pacemaker lead, along with adequate antibiotic therapy, which has proven to be the most effective method of treating cardiac device-related endocarditis. (Source: The Journal of Infection in Developing Countries)
Source: The Journal of Infection in Developing Countries - September 29, 2021 Category: Infectious Diseases Source Type: research

Modification of immunosuppressive agents in a kidney transplant recipient with COVID-19 and acute kidney injury
Conclusions: In this case, successful modification of this immunosuppressive regimen was accomplished to reduce drug interaction complications, aiming to avoid calcineurin inhibitor nephrotoxicity while maintaining appropriate levels of immunosuppression to prevent organ rejection and to promote the patient ’s recovery from infection. (Source: The Journal of Infection in Developing Countries)
Source: The Journal of Infection in Developing Countries - September 29, 2021 Category: Infectious Diseases Source Type: research

Health related factors contributing to COVID-19 fatality rates in various communities across the world
Conclusions: Many factors contribute to COVID-19 severity and fatality rates. Comorbidity, age, and gender were the main reasons for the Case Fatality Rate. This review recommends to follow preventive measures for overcoming the challenges faced during this emerging pandemic disease. (Source: The Journal of Infection in Developing Countries)
Source: The Journal of Infection in Developing Countries - September 29, 2021 Category: Infectious Diseases Source Type: research

Severe COVID-19 infection in a kidney transplant recipient treated with lopinavir/ritonavir, hydroxychloroquine and dexamethasone
We described the case of a COVID-19 infected 70 year old female, previously had renal transplantation in 2017. The patient took immunosuppressive agents as routine drugs for transplant recipient status and received lopinavir/ritonavir, hydroxychloroquine, and dexamethasone daily at the hospitalization. Specific question arises about renal transplant recipients being infected by COVID-19 – whether the infection will get worse compared to those without immunosuppresive agent. In this case, author decided to stop the immunosuppressive agent followed administration of combination lopinavir/ritonavir, hydroxychloroquine, ...
Source: The Journal of Infection in Developing Countries - September 29, 2021 Category: Infectious Diseases Source Type: research

Evaluation of environmental cleaning quality: an observational study at a tertiary hospital in Wuhan, China
Conclusions: The cleaning staff showed poor environmental cleaning quality, especially the floor cleaning quality. The findings can help reveal deficiencies in cleaning practices, raise awareness of these deficiencies, and inform targeted strategies to improve cleaning quality and hospital safety. (Source: The Journal of Infection in Developing Countries)
Source: The Journal of Infection in Developing Countries - September 29, 2021 Category: Infectious Diseases Source Type: research

The Impact of COVID-19 on Iraqi Community: a descriptive study based on data reported from the Ministry of Health in Iraq
Conclusions: COVID-19 in Iraq comes to be limited via the procedures of Iraqi government. However, the infected people will be increased gradually and many international reports that predict the end of this pandemic in the world will be doubtful as there are many vaccines developed and under development which led to reduce to effect of this pandemic. (Source: The Journal of Infection in Developing Countries)
Source: The Journal of Infection in Developing Countries - September 29, 2021 Category: Infectious Diseases Source Type: research

Risk factors for poor outcome of patients with Coronavirus disease 2019 (COVID-19) in Albania
Conclusions: The risk of poor outcome can be predicted from the early stage of COVID 19 disease, using laboratory data and chest computed tomography. Among patients with COVID 19, lung parenchymal involvement and alterations> 75% on chest computed tomography on admission and laboratory findings, such as lymphocytopenia, and elevated lactate dehydrogenase and D dimer levels, turned out to be early risk factors for in-hospital mortality. (Source: The Journal of Infection in Developing Countries)
Source: The Journal of Infection in Developing Countries - September 29, 2021 Category: Infectious Diseases Source Type: research

A systemic review of literatures on human Salmonella enterica serovars in Nigeria (1999-2018)
Conclusions: This study revealed 39 Invasive and 31 non-invasiveSalmonella serotypes. Ampicillin, cotrimoxazole, amoxicillin-clavulanate and tetracycline are the most frequently reported antibiotics resisted bySalmonella isolates. This antimicrobial resistance exhibited poses a threat to public health. Data generated from this review would serve as a baseline information for future surveillance studies. (Source: The Journal of Infection in Developing Countries)
Source: The Journal of Infection in Developing Countries - September 29, 2021 Category: Infectious Diseases Source Type: research

Campylobacter concisus
has been described as the etiological agent of periodontal disease, inflammatory bowel diseases, and enterocolitis. It is also detected in healthy individuals. There are differences between strains in healthy individuals and affected ones by production of two exototoxins. In this mini review authors discuss major facts about cultivation, isolation, virulence and immune response toC. concisus. (Source: The Journal of Infection in Developing Countries)
Source: The Journal of Infection in Developing Countries - September 29, 2021 Category: Infectious Diseases Source Type: research

Subacute transverse myelitis as a clinical presentation of neurobrucellosis
Brucella melitensis is the main cause of human brucellosis worldwide and is considered the most virulent and neurotropic species. In Mexico, this species is considered endemic, being reported since the first decade of the 20th century. Here we present a case of subacute transverse myelitis with the isolation and identification ofB. melitensisas the causative agent of Neurobrucellosis in a female patient from the coastal state of Guerrero, Mexico. (Source: The Journal of Infection in Developing Countries)
Source: The Journal of Infection in Developing Countries - September 29, 2021 Category: Infectious Diseases Source Type: research

Meningitis and bacteremia caused by Haemophilus influenzae Type e in an immunocompetent child
We report a case of an immunocompetent child who was clinically diagnosed with bacterial meningitis with bacteremia caused by Hie. The literature on infection especially meningitis caused by Hie is reviewed. (Source: The Journal of Infection in Developing Countries)
Source: The Journal of Infection in Developing Countries - September 29, 2021 Category: Infectious Diseases Source Type: research

The emergence of Dengue Fever in Sheikhupura, Pakistan: its seroprevalence and risk factors assessment during 2014-2017
Introduction: District Sheikhupura encountered its first dengue outbreak in 2014 but lacked serological evidence and reports of risk factors associated with it. To assess this, a hospital-based study was conducted from January 2014 to December 2017.Methodology: Blood from 333 participants was collected, the serum obtained was tested for IgG and IgM antibodies against DENV using a commercially available ELISA kit.Results: The results showed that out of all (n= 333) samples tested, 120 were turned up positive for DENV, making an overall prevalence of 36%. Of the 120 confirmed cases, 55% (n = 66) were recorded in 2014, 10% (n...
Source: The Journal of Infection in Developing Countries - September 29, 2021 Category: Infectious Diseases Source Type: research

Empiric antibiotic and in-vitro susceptibility of urosepsis pathogens: do they match? The outcome of a study from south India
Introduction: Urosepsis is life threatening, unless treated immediately. Empirical treatment with appropriate antibiotics lowers the risk of a poor outcome. However, with increasing resistance among common uropathogens, there is a need for continuous review of the existing protocol to determine whether there is a correlation between empirical antibiotic therapy and in-vitro susceptibility pattern of the pathogens causing urosepsis.Methodology: A prospective study was carried out on 66 confirmed cases of urosepsis from January 2017 to December 2018 after obtaining ethical clearance. Demographic details, risk factors, length...
Source: The Journal of Infection in Developing Countries - September 29, 2021 Category: Infectious Diseases Source Type: research

Prevalence of precancerous cervical lesions and high-risk human papillomavirus types in Yaounde, Cameroon
Conclusions: Our results suggest that HPV 16 and 18 are predominant in Yaounde, and are associated with more severe precancerous lesions. (Source: The Journal of Infection in Developing Countries)
Source: The Journal of Infection in Developing Countries - September 29, 2021 Category: Infectious Diseases Source Type: research

Immunogenicity and potential protection of DNA vaccine of Leishmania martiniquensis against Leishmania infection in mice
Introduction: In Thailand,Leishmania martiniquensisis the predominant species causing cutaneous and visceral leishmaniasis. Its incidence has been increasing among immunocompetent and immunocompromised hosts. We developed a prototype DNA vaccine using a partial consensus sequence of the cysteine protease B (cpb) gene derived fromL. martiniquensis from Thai patients.Methodology: The laboratory inbred strain of albino BALB/c mice were immunized intramuscularly three times at 2-week intervals (weeks 0, 2, and 4) withcpb plasmid DNA (pcDNA_cpb) with or without the adjuvant, monoolein (pcDNA_cpb-MO). Mice were challenged at wee...
Source: The Journal of Infection in Developing Countries - September 29, 2021 Category: Infectious Diseases Source Type: research

Adherence to Community Acquired Pneumonia guideleines and patients outcomes in a peri-urban hospital in Natal, South Africa
Introduction: Community-acquired pneumonia (CAP) is an important cause of mortality and morbidity worldwide. This issue is further exacerbated by the Human Immunodeficiency Virus (HIV) epidemic.Methodology: The study was a retrospective, clinical record review of hospitalized patients (18 years and older) with a diagnosis of LRTI between the 1st of January 2012 and 31 December 2012, descriptive and comparable analysis was performed.Results: Number of patients was 274; 142 (51.8%) males. The commonest final diagnosis was Pulmonary Tuberclosis (PTB) in 131 (47.8%) and CAP in 127 (46.4%). The case fatality rate was 25.5% (70/...
Source: The Journal of Infection in Developing Countries - September 29, 2021 Category: Infectious Diseases Source Type: research

The bacterial colonization of healthcare workers ’ mobile phones in a large tertiary care teaching hospital in Saudi Arabia
Conclusions: In our study, the prevalence of bacterial colonization among healthcare workers ’ mobile phones was high. Our findings suggest that high-risk groups for mobile phone colonization—such as laboratory, neonatal intensive care unit, and medicine department staff—should be a priority for preventative measures, to improve infection control. (Source: The Journal of Infection in Developing Countries)
Source: The Journal of Infection in Developing Countries - September 29, 2021 Category: Infectious Diseases Source Type: research

Retrospective evaluation of intravenous fosfomycin in multi-drug resistant infections at a tertiary care hospital in Lebanon
Conclusions: Fosfomycin is a safe and effective option in the treatment of multi-drug resistant infections. Nevertheless, careful stewardship is important to maintain its efficacy and to reduce the risk of selection of antimicrobial resistance. (Source: The Journal of Infection in Developing Countries)
Source: The Journal of Infection in Developing Countries - September 29, 2021 Category: Infectious Diseases Source Type: research

Molecular Epidemiology of Mycobacterium tuberculosis strains isolated from pulmonary tuberculosis patients in south Ethiopia
Conclusions: The study revealed several clusters and drug resistant strains ofM. tuberculosisin the study area, suggesting recent transmission including of drug resistant tuberculosis. Wider monitoring of drug susceptibility testing and geospatial analysis of transmission trends is required to control tuberculosis in southern Ethiopia. (Source: The Journal of Infection in Developing Countries)
Source: The Journal of Infection in Developing Countries - September 29, 2021 Category: Infectious Diseases Source Type: research

Quantification of Gardnerella vaginalis, Atopobium vaginae and Lactobacillus spp. in bacterial vaginosis
Conclusions: According to the results of our study real-time PCR analysis was more sensitive in diagnosis of bacterial vaginosis than Amsel ’s method, as well as it represented fine tool in making a difference between microbial entities in healthy and bacterial vaginosis samples. (Source: The Journal of Infection in Developing Countries)
Source: The Journal of Infection in Developing Countries - September 29, 2021 Category: Infectious Diseases Source Type: research

Clinical analysis of COVID-19 positive cancer inpatients in National Cancer Center in Serbia
This study aimed to identify clinical characteristics of Coronavirus Disease 2019 (COVID-19) infected cancer inpatients, as well as what impact this infection had on radiation treatment of the patients.Methodology: In this retrospective study, we included cancer inpatients with laboratory confirmed COVID-19 infection during the radiotherapy or chemoradiation in April 2020 in National Cancer Research Center in Serbia. Data were obtained from the medical records between 1 April and 1 July 2020.Results: A total of 49 COVID-19 infected cancer inpatients were included. The most frequently reported cancers were head and neck can...
Source: The Journal of Infection in Developing Countries - September 29, 2021 Category: Infectious Diseases Source Type: research

The role of anxiety, stigma, religiosity, and economic condition in COVID-19 preventive efforts among lecturers
Conclusions: There was a relationship between anxiety, stigma, religiosity, and COVID-19 preventions, while there was no relationship between economic conditions and COVID-19 preventions. The most influencing variable was anxiety. Respondents must be able to manage anxiety levels related to COVID-19 with good coping strategies. (Source: The Journal of Infection in Developing Countries)
Source: The Journal of Infection in Developing Countries - September 29, 2021 Category: Infectious Diseases Source Type: research

Severe pacemaker pocket infection during the COVID-19 pandemic, transvenous lead removal
Conclusions: A case showing delayed treatment of pacemaker pocket infection, due to delayed follow-up time during the COVID-19 pandemic. This patient underwent successful transvenous removal of the infected pacemaker lead, along with adequate antibiotic therapy, which has proven to be the most effective method of treating cardiac device-related endocarditis. (Source: The Journal of Infection in Developing Countries)
Source: The Journal of Infection in Developing Countries - September 29, 2021 Category: Infectious Diseases Source Type: research

Modification of immunosuppressive agents in a kidney transplant recipient with COVID-19 and acute kidney injury
Conclusions: In this case, successful modification of this immunosuppressive regimen was accomplished to reduce drug interaction complications, aiming to avoid calcineurin inhibitor nephrotoxicity while maintaining appropriate levels of immunosuppression to prevent organ rejection and to promote the patient ’s recovery from infection. (Source: The Journal of Infection in Developing Countries)
Source: The Journal of Infection in Developing Countries - September 29, 2021 Category: Infectious Diseases Source Type: research

Health related factors contributing to COVID-19 fatality rates in various communities across the world
Conclusions: Many factors contribute to COVID-19 severity and fatality rates. Comorbidity, age, and gender were the main reasons for the Case Fatality Rate. This review recommends to follow preventive measures for overcoming the challenges faced during this emerging pandemic disease. (Source: The Journal of Infection in Developing Countries)
Source: The Journal of Infection in Developing Countries - September 29, 2021 Category: Infectious Diseases Source Type: research

Severe COVID-19 infection in a kidney transplant recipient treated with lopinavir/ritonavir, hydroxychloroquine and dexamethasone
We described the case of a COVID-19 infected 70 year old female, previously had renal transplantation in 2017. The patient took immunosuppressive agents as routine drugs for transplant recipient status and received lopinavir/ritonavir, hydroxychloroquine, and dexamethasone daily at the hospitalization. Specific question arises about renal transplant recipients being infected by COVID-19 – whether the infection will get worse compared to those without immunosuppresive agent. In this case, author decided to stop the immunosuppressive agent followed administration of combination lopinavir/ritonavir, hydroxychloroquine, ...
Source: The Journal of Infection in Developing Countries - September 29, 2021 Category: Infectious Diseases Source Type: research

Evaluation of environmental cleaning quality: an observational study at a tertiary hospital in Wuhan, China
Conclusions: The cleaning staff showed poor environmental cleaning quality, especially the floor cleaning quality. The findings can help reveal deficiencies in cleaning practices, raise awareness of these deficiencies, and inform targeted strategies to improve cleaning quality and hospital safety. (Source: The Journal of Infection in Developing Countries)
Source: The Journal of Infection in Developing Countries - September 29, 2021 Category: Infectious Diseases Source Type: research

The Impact of COVID-19 on Iraqi Community: a descriptive study based on data reported from the Ministry of Health in Iraq
Conclusions: COVID-19 in Iraq comes to be limited via the procedures of Iraqi government. However, the infected people will be increased gradually and many international reports that predict the end of this pandemic in the world will be doubtful as there are many vaccines developed and under development which led to reduce to effect of this pandemic. (Source: The Journal of Infection in Developing Countries)
Source: The Journal of Infection in Developing Countries - September 29, 2021 Category: Infectious Diseases Source Type: research

Risk factors for poor outcome of patients with Coronavirus disease 2019 (COVID-19) in Albania
Conclusions: The risk of poor outcome can be predicted from the early stage of COVID 19 disease, using laboratory data and chest computed tomography. Among patients with COVID 19, lung parenchymal involvement and alterations> 75% on chest computed tomography on admission and laboratory findings, such as lymphocytopenia, and elevated lactate dehydrogenase and D dimer levels, turned out to be early risk factors for in-hospital mortality. (Source: The Journal of Infection in Developing Countries)
Source: The Journal of Infection in Developing Countries - September 29, 2021 Category: Infectious Diseases Source Type: research

A systemic review of literatures on human Salmonella enterica serovars in Nigeria (1999-2018)
Conclusions: This study revealed 39 Invasive and 31 non-invasiveSalmonella serotypes. Ampicillin, cotrimoxazole, amoxicillin-clavulanate and tetracycline are the most frequently reported antibiotics resisted bySalmonella isolates. This antimicrobial resistance exhibited poses a threat to public health. Data generated from this review would serve as a baseline information for future surveillance studies. (Source: The Journal of Infection in Developing Countries)
Source: The Journal of Infection in Developing Countries - September 29, 2021 Category: Infectious Diseases Source Type: research

Campylobacter concisus
has been described as the etiological agent of periodontal disease, inflammatory bowel diseases, and enterocolitis. It is also detected in healthy individuals. There are differences between strains in healthy individuals and affected ones by production of two exototoxins. In this mini review authors discuss major facts about cultivation, isolation, virulence and immune response toC. concisus. (Source: The Journal of Infection in Developing Countries)
Source: The Journal of Infection in Developing Countries - September 29, 2021 Category: Infectious Diseases Source Type: research

9-12 months short treatment for patients with MDR-TB increases treatment success in Kyrgyzstan
Introduction: MDR/RR-TB is a growing problem in Kyrgyzstan. In 2005, the country introduced standard or individualized treatment for 20-24 months. Because of poor treatment outcomes, in 2017 a short treatment with strict eligibility criteria was introduced. The aim of this study was to compare characteristics and treatment outcomes of MDR/RR-TB patients receiving short (9-12 months) treatment in 2017 with those receiving standard or individualized (20-24 months) treatment in 2016/2017.Methodology: A comparative cohort study using routine programmatic data. Characteristics, sputum culture conversion and treatment outcomes w...
Source: The Journal of Infection in Developing Countries - September 28, 2021 Category: Infectious Diseases Source Type: research

Scale-up and impact of digital and molecular diagnostic technologies on TB diagnosis and timely linkage to care in Tajikistan
Introduction: Tajikistan is scaling up molecular diagnostic and digital technologies to strengthen its fight against drug-resistant TB (DR-TB). The study aimed to document national scale-up GeneXpert/GxAlert and Open MRS from 2012-2019 and compare time taken from TB diagnosis to treatment and quality of data recording before and after the introduction of GxAlert.Methodology: This was a longitudinal study that included a comparison of historical cohorts. Continuous variables were compared using Wilcoxon Rank-Sum test and categorical variables using the chi square test.Results: GeneXpert was introduced in 2011 and scaled up ...
Source: The Journal of Infection in Developing Countries - September 28, 2021 Category: Infectious Diseases Source Type: research

People Who Inject Drugs and have tuberculosis: Opioid Substitution Therapy improves treatment outcomes in Ukraine
Introduction:Opioid substitution therapy (OST) is one of the pillars of harm reduction strategies for People Who Inject Drugs (PWID). It should be an integral part of tuberculosis (TB) care to increase the uptake, compliance and effectiveness of treatment and also curtail risk behaviors. We aimed to compare TB treatment outcomes in relation to OST among PWID in six regions of Ukraine.Methodology:A retrospective cohort study using routine programmatic data from centers offering integrated TB and OST (December 2016 – May 2020). OST involved use of methadone or buprenorphine. TB treatment outcomes were standardized.Resu...
Source: The Journal of Infection in Developing Countries - September 28, 2021 Category: Infectious Diseases Source Type: research

A five-year audit of gaps in HIV testing and associations with TB treatment outcomes in Armenia, 2015-2019
Conclusions: An analysis of nationwide data revealed incompleteness of the national TB electronic database for HIV data. Patients with HIV status “not tested” and “not recorded” had higher risk of unsuccessful TB treatment outcomes. Upgrade of the electronic database with information on key indicators of TB-HIV services will facilitate improved monitoring and reporting. (Source: The Journal of Infection in Developing Countries)
Source: The Journal of Infection in Developing Countries - September 28, 2021 Category: Infectious Diseases Source Type: research