Genome structure and population genomics of the canine heartworm Dirofilaria immitis
This study aimed to improve the genomic resources of D. immitis to enable a more precise understanding of how genetic variation is distributed within and between parasite populations worldwide, which will inform the likelihood and rate by which parasites, and in turn, resistant alleles, might spread. We have guided the scaffolding of a recently published genome assembly for D. immitis (ICBAS_JMDir_1.0) using the chromosomal-scale reference genomes of Brugia malayi and Onchocerca volvulus, resulting in an 89.5 Mb assembly composed of four autosomal- and one sex-linked chromosomal-scale scaffolds representing 99.7% of the ge...
Source: International Journal for Parasitology - August 31, 2023 Category: Parasitology Authors: Javier Gandasegui Rosemonde I Power Emily Curry Daisy Ching-Wai Lau Connor M O'Neill Adrian Wolstenholme Roger Prichard Jan Šlapeta Stephen R Doyle Source Type: research
Genome structure and population genomics of the canine heartworm Dirofilaria immitis
This study aimed to improve the genomic resources of D. immitis to enable a more precise understanding of how genetic variation is distributed within and between parasite populations worldwide, which will inform the likelihood and rate by which parasites, and in turn, resistant alleles, might spread. We have guided the scaffolding of a recently published genome assembly for D. immitis (ICBAS_JMDir_1.0) using the chromosomal-scale reference genomes of Brugia malayi and Onchocerca volvulus, resulting in an 89.5 Mb assembly composed of four autosomal- and one sex-linked chromosomal-scale scaffolds representing 99.7% of the ge...
Source: International Journal for Parasitology - August 31, 2023 Category: Parasitology Authors: Javier Gandasegui Rosemonde I Power Emily Curry Daisy Ching-Wai Lau Connor M O'Neill Adrian Wolstenholme Roger Prichard Jan Šlapeta Stephen R Doyle Source Type: research
Genome structure and population genomics of the canine heartworm Dirofilaria immitis
This study aimed to improve the genomic resources of D. immitis to enable a more precise understanding of how genetic variation is distributed within and between parasite populations worldwide, which will inform the likelihood and rate by which parasites, and in turn, resistant alleles, might spread. We have guided the scaffolding of a recently published genome assembly for D. immitis (ICBAS_JMDir_1.0) using the chromosomal-scale reference genomes of Brugia malayi and Onchocerca volvulus, resulting in an 89.5 Mb assembly composed of four autosomal- and one sex-linked chromosomal-scale scaffolds representing 99.7% of the ge...
Source: International Journal for Parasitology - August 31, 2023 Category: Parasitology Authors: Javier Gandasegui Rosemonde I Power Emily Curry Daisy Ching-Wai Lau Connor M O'Neill Adrian Wolstenholme Roger Prichard Jan Šlapeta Stephen R Doyle Source Type: research
Genome structure and population genomics of the canine heartworm Dirofilaria immitis
This study aimed to improve the genomic resources of D. immitis to enable a more precise understanding of how genetic variation is distributed within and between parasite populations worldwide, which will inform the likelihood and rate by which parasites, and in turn, resistant alleles, might spread. We have guided the scaffolding of a recently published genome assembly for D. immitis (ICBAS_JMDir_1.0) using the chromosomal-scale reference genomes of Brugia malayi and Onchocerca volvulus, resulting in an 89.5 Mb assembly composed of four autosomal- and one sex-linked chromosomal-scale scaffolds representing 99.7% of the ge...
Source: International Journal for Parasitology - August 31, 2023 Category: Parasitology Authors: Javier Gandasegui Rosemonde I Power Emily Curry Daisy Ching-Wai Lau Connor M O'Neill Adrian Wolstenholme Roger Prichard Jan Šlapeta Stephen R Doyle Source Type: research
Management of onchocerciasis among adolescents in nkwanta north district of Ghana: Qualitative study of adolescents ’ perception, community and health system support
ConclusionInadequate education and communication about onchocerciasis resulted in diverse and erroneous meanings of onchocerciasis among community members. Our research recognises that community and health system supports is very important in the effective management of Onchocerciasis, contributing to the attainment of Sustainable Development Goal (SDG) 3.3, which is targeted at ending the epidemic of NTDs like onchocerciasis by 2030. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - August 29, 2023 Category: Tropical Medicine Authors: Sitsofe Gbogbo Source Type: research
Pharmacokinetics of Moxidectin combined with Albendazole or Albendazole plus Diethylcarbamazine for Bancroftian Filariasis
by Yashpal S. Chhonker, Catherine Bjerum, Veenu Bala, Allassane F. Ouattara, Benjamin G. Koudou, Toki P. Gabo, Abdullah Alshehri, Abdoulaye Me ïté, Peter U. Fischer, Gary J. Weil, Christopher L. King, Philip J. Budge, Daryl J. Murry
Moxidectin (MOX) is a milbemycin endectocide recently approved by the U.S. FDA for the treatment of onchocerciasis in persons at least 12 years of age. MOX has been shown to have a good safety profile in recent clinical trials. The efficacy of MOX for the treatment of lymphatic filariasis (LF) and its potential use in mass drug administration protocols for the elimination of LF is currently ...
Source: PLoS Neglected Tropical Diseases - August 24, 2023 Category: Tropical Medicine Authors: Yashpal S. Chhonker Source Type: research
Scientific literature on neglected tropical diseases: a bibliometric analysis
Pathog Glob Health. 2023 Aug 22:1-8. doi: 10.1080/20477724.2023.2250619. Online ahead of print.ABSTRACTNeglected tropical diseases (NTDs) are a group of diseases mainly affecting people in low- and middle-income Countries. The aim of this study was to perform a bibliometric analysis of the scientific literature on NTDs. Using the MeSH database, we quantified the number of publications on MEDLINE targeting each NTD, which were published from 1 January 1999 to 31 January 2019. In order to weight the number of publications targeting a given NTD according to the total number of publications/year, we calculated a Yearly Publica...
Source: Pathogens and Global Health - August 22, 2023 Category: International Medicine & Public Health Authors: Gianpiero Tebano Elisa Vanino Paolo Muratori Francesco Cristini Source Type: research
Prevalence of epilepsy in the onchocerciasis endemic middle belt of Ghana after 27 years of mass drug administration with ivermectin
ConclusionsThe 1.4% prevalence of epilepsy in the Bono region is similar to the median epilepsy prevalence in sub-Saharan Africa. However, the persistent microfilarial prevalence and low ivermectin study coverage call for the Ghana Onchocerciasis Elimination Programme to step up its efforts to ensure that the gains achieved are consolidated and improved to achieve the elimination of onchocerciasis by 2030.Graphical Abstract (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - August 17, 2023 Category: Infectious Diseases Source Type: research
The onchocerciasis hypothesis of nodding syndrome
by Robert Colebunders, Amber Hadermann, Joseph Nelson Siewe Fodjo
Nodding syndrome (NS) is a phenotypic presentation of onchocerciasis-associated epilepsy (OAE). OAE is an important public health problem in areas with high ongoingOnchocerca volvulus transmission. OAE, including NS, is preventable by strengthening onchocerciasis elimination programs. The presence of tau in OAE postmortem brains could be the consequence of neuroinflammation directly or indirectly induced byO.volvulus. Omics research is needed to investigate whetherO.volvulus worms contain a neurotropic virus. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - August 17, 2023 Category: Tropical Medicine Authors: Robert Colebunders Source Type: research
Soil-transmitted helminths: A critical review of the impact of co-infections and implications for control and elimination
by Sarah Lebu, Winnie Kibone, Chimdi C. Muoghalu, Stephen Ochaya, Aaron Salzberg, Felix Bongomin, Musa Manga
Researchers have raised the possibility that soil-transmitted helminth (STH) infections might modify the host ’s immune response against other systemic infections. STH infections can alter the immune response towards type 2 immunity that could then affect the likelihood and severity of other illnesses. However, the importance of co-infections is not completely understood, and the impact and direction of t heir effects vary considerably by infection. This review synthesizes evidence regarding the relevance of STH ...
Source: PLoS Neglected Tropical Diseases - August 10, 2023 Category: Tropical Medicine Authors: Sarah Lebu Source Type: research
Effects of the suspension of mass drug administration during the COVID-19 pandemic on onchocerciasis prevalence in the Bandjoun and Massangam health districts, West Region of Cameroon
The objective of this study was to evaluate the effects of the suspension of implementation activities towards combating onchocerciasis in the Bandjoun and Massangam health districts in the West Region of Cameroon as a consequence of the COVID-19 pandemic. Data on socio-demographic and clinical characteristics were obtained using a structured questionnaire. All participants in both health districts were examined for the presence of clinical manifestations of onchocerciasis. In addition, two skin snips were obtained from the knee of each participant and examined for the presence of microfilaria. All data were categorized, c...
Source: Acta Tropica - August 7, 2023 Category: Infectious Diseases Authors: Cabirou Mounchili Shintouo Robert Adamu Shey Bernis Neneyoh Yengo Ntang Emmaculate Yaah Rene Ning Teh Roland Akwelle Ngwese Lawrence Ayong Luc Vanhamme Jacob Souopgui Stephen Mbigha Ghogomu Rose Njemini Source Type: research
