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Direct proteomic detection and prioritization of 19 onchocerciasis biomarker candidates in humans
This study has identified a promising novel set of proteins that will be carried forward to develop assays that can be used for diagnosis of O. volvulus infections and for monitoring treatment efficacy.PMID:36435333 | DOI:10.1016/j.mcpro.2022.100454 (Source: Molecular and Cellular Proteomics : MCP)
Source: Molecular and Cellular Proteomics : MCP - November 26, 2022 Category: Molecular Biology Authors: Bruce A Rosa Kurt Curtis Petra Erdmann Gilmore John Martin Qiang Zhang Robert Sprung Gary J Weil R Reid Townsend Peter U Fischer Makedonka Mitreva Source Type: research

Direct proteomic detection and prioritization of 19 onchocerciasis biomarker candidates in humans
Mol Cell Proteomics. 2022 Nov 23:100454. doi: 10.1016/j.mcpro.2022.100454. Online ahead of print.NO ABSTRACTPMID:36435333 | DOI:10.1016/j.mcpro.2022.100454 (Source: Molecular and Cellular Proteomics : MCP)
Source: Molecular and Cellular Proteomics : MCP - November 26, 2022 Category: Molecular Biology Authors: Bruce A Rosa Kurt Curtis Petra Erdmann Gilmore John Martin Qiang Zhang Robert Sprung Gary J Weil R Reid Townsend Peter U Fischer Makedonka Mitreva Source Type: research

Implication of apoptosis and oxidative stress in mitigation of ivermectin long-term hazards by zinc nanoparticles in male rabbits
In conclusion, ZnNPs exhibited promising ability for improving the growth and fertility status of rabbits and reducing the deleterious effects of IVM possibly through the suppression of apoptotic and oxidative pathways.PMID:36372859 | DOI:10.1007/s11356-022-24095-1 (Source: Environmental Science and Pollution Research International)
Source: Environmental Science and Pollution Research International - November 14, 2022 Category: Environmental Health Authors: Set A El-Shobokshy Magda I Abo-Samaha Ferial M Sahwan Samia M Abd El-Rheem Mohamed Emam Asmaa F Khafaga Source Type: research

Identification of the onchocerciasis vector in the Kakoi-Koda focus of the Democratic Republic of Congo
Conclusions/SignificanceSimulium dentulosum currently appears to be the main vector of human onchocerciasis within the Kakoi-Koda focus, andS.vorax may be a secondary vector. It remains possible thatS.neavei was the main (or only) vector in the past having now become rare as a result of the removal of tree-cover and land-use changes.Simulium vorax has previously been shown to support the development ofO.volvulus in the laboratory, but this is the first time thatS.dentulosum has been implicated as a probable vector of onchocerciasis, and this raises the possibility that other blackfly species which are not generally conside...
Source: PLoS Neglected Tropical Diseases - November 4, 2022 Category: Tropical Medicine Authors: Rory J. Post Source Type: research

Integrated xenosurveillance of Loa loa , Wuchereria bancrofti , Mansonella perstans and Plasmodium falciparum using mosquito carcasses and faeces: A pilot study in Cameroon
ConclusionsMosquito xenosurveillance may provide a useful tool for the surveillance of loiasis alongside other parasitic diseases. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - November 2, 2022 Category: Tropical Medicine Authors: Joseph Pryce Source Type: research

Eosinophils in filarial infections: Inducers of protection or pathology?
Filariae are parasitic roundworms, which can cause debilitating diseases such as lymphatic filariasis and onchocerciasis. Lymphatic filariasis, also known as elephantiasis, and onchocerciasis, commonly referred to as river blindness, can lead to stigmatizing pathologies and present a socio-economic burden for affected people and their endemic countries. Filariae typically induce a type 2 immune response, which is characterized by cytokines, i.e., IL-4, IL-5 and IL-13 as well as type 2 immune cells including alternatively activated macrophages, innate lymphoid cells and Th2 cells. However, the hallmark characteristic of fil...
Source: Frontiers in Immunology - October 31, 2022 Category: Allergy & Immunology Source Type: research

Ivermectin treatment response in two rural villages with a high prevalence of onchocerciasis and epilepsy, Mahenge Tanzania
Conclusion: Our study reports a decrease in microfilarial density following ivermectin treatment in most individuals. Optimizing ivermectin coverage will address the ongoing onchocerciasis transmission in Mahenge.Keywords: Onchocerciasis, ivermectin; treatment response, epilepsy; Tanzania. (Source: African Health Sciences)
Source: African Health Sciences - October 28, 2022 Category: African Health Authors: Dan Bhwana, Bruno P Mmbando, Alfred Dusabimana, Athanas Mhina, Daniel P Challe, Joseph N Siewe Fodjo, Williams H Makunde, Robert Colebunders Source Type: research

Prevalence of epilepsy in Ndom Health District (Littoral Region, Cameroon) after long-term ivermectin-based preventive chemotherapy for the control of onchocerciasis
This study aimed at assessing the prevalence of epilepsy in an onchocerciasis endemic area under annual CDTI for 16 years. A cross-sectional survey was conducted in two communities (Kelleng and Nkonkwalla) located in the Ndom Health District (Littoral Region, Cameroon) to assess the prevalence of epilepsy using a standardized questionnaire for non-specialists in tropical areas. Data on the nuisance of onchocerciasis vector and distance of surveyed households to the river were also collected. Epilepsy status was collected from 367 participants (sex ratio (M/F): 1.13). The crude prevalence of epilepsy was estimated at 8.4 % ...
Source: Epilepsy and Behaviour - October 17, 2022 Category: Neurology Authors: Arnauld Efon-Ekangouo Hugues C Nana-Djeunga Philippe Nwane Elvis Lisongue-Tonga Andr é Domche Laurentine Sumo Mike Yaw Osei-Atweneboana Anne Geiger Joseph Kamgno Source Type: research