Pharmacokinetics of oral moxidectin in individuals with < i > Onchocerca volvulus < /i > infection

Conclusion/SignificanceWe found no relationship between severity of infection (mild, moderate or severe) and exposure parameters (AUC0- ∞ and Cmax), T1/2 and Tmax for moxidectin. Tmax, volume of distribution (V/F) and oral clearance (CL/F) are similar to those in healthy volunteers from Europe. From a pharmacokinetic perspective, moxidectin is an attractive long-acting therapeutic option for the treatment of human onchocerciasis.

Source: PLoS Neglected Tropical Diseases - March 25, 2022 Category: Tropical Medicine Authors: Beesan Tan Source Type: research