Effect of repetitive peripheral magnetic stimulation of the common fibular nerve on the soleus muscle Hoffmann reflex
Conclusion] The change in the Hoffmann reflex amplitude may have been caused by the magnetic stimulation to I-a sensory fibers on the common fibular nerve, suggesting that magnetic stimulation induces reciprocal inhibition of motor neurons through synapses in the spinal cord.PMID:38694014 | PMC:PMC11060763 | DOI:10.1589/jpts.36.278 (Source: Physical Therapy)
Source: Physical Therapy - May 2, 2024 Category: Physiotherapy Authors: Kazunori Morozumi Katsuyuki Morishita Michio Tojima Takashi Inomata Source Type: research

Temporal dynamics of ocular torsion and vertical vergence during visual, vestibular, and visuovestibular rotations
This study investigated the onset times of ocular torsion (OT) and vertical vergence (VV) during visual, vestibular, and visuovestibular motion, as well as their relative decay rates following prolonged optokinetic stimulations. Temporal characteristics were retrieved from three separate investigations where the level of visual clutter and acceleration were controlled. Video eye-tracking was used to retrieve the eye-movement parameters from a total of 41 healthy participants across all trials. Ocular torsion consistently initiated earlier than vertical vergence, particularly evident under intensified visual information den...
Source: Experimental Brain Research - May 2, 2024 Category: Neuroscience Authors: Tobias Wibble Source Type: research

Bardet-Biedl syndrome with unique manifestations of congenital giant nevi and refractory anemia: a case report from Palestine
CONCLUSION: This case underscores BBS's rarity and complexity, featuring unique aspects like giant nevi and refractory IDA. Comprehensive management addresses renal, visual, cardiac, and neurologic aspects. Genetic counselling, prenatal testing, and preimplantation genetic diagnosis prevent transmission. Limitations include lacking local epidemiological data and prior studies in Palestine. This case contributes insights, stressing multidisciplinary management and prompting further research in underexplored populations.PMID:38694397 | PMC:PMC11060271 | DOI:10.1097/MS9.0000000000001954 (Source: Annals of Medicine)
Source: Annals of Medicine - May 2, 2024 Category: Internal Medicine Authors: Mohammad Milhem Daleen Shehadeh Yasmeen Abu Nawa Roa Arman Lara Masri Zeena Salman Mohammad Najajreh Source Type: research

Moyamoya disease in a 2-year-old patient from the middle east: a case report and literature review
CONCLUSION: This case highlights the importance of identifying MMD in regions where it is uncommon to be diagnosed. It emphasizes the need for diagnosis and appropriate intervention to reduce complications.PMID:38694386 | PMC:PMC11060278 | DOI:10.1097/MS9.0000000000001934 (Source: Annals of Medicine)
Source: Annals of Medicine - May 2, 2024 Category: Internal Medicine Authors: Haneen Mahmoud Nimer Habes Raneen B Alshareef Areen Amleh Ali A A Doudin Yousef Mahmoud Nimer Habes Mohammed Abdulrazzak Sharif Issa Basal Source Type: research

Temporal dynamics of ocular torsion and vertical vergence during visual, vestibular, and visuovestibular rotations
This study investigated the onset times of ocular torsion (OT) and vertical vergence (VV) during visual, vestibular, and visuovestibular motion, as well as their relative decay rates following prolonged optokinetic stimulations. Temporal characteristics were retrieved from three separate investigations where the level of visual clutter and acceleration were controlled. Video eye-tracking was used to retrieve the eye-movement parameters from a total of 41 healthy participants across all trials. Ocular torsion consistently initiated earlier than vertical vergence, particularly evident under intensified visual information den...
Source: Brain Research - May 2, 2024 Category: Neurology Authors: Tobias Wibble Source Type: research

Guidelines of the French Society of Otorhinolaryngology and Head and Neck Surgery (SFORL) for vestibular rehabilitation in children with vestibular dysfunction. A systematic review
CONCLUSION: It is recommended that a vestibular assessment be carried out before VR, including a study of vestibulo-ocular reflex, otolithic function, and postural control. In cases of vestibular dysfunction, physiotherapy treatment is recommended from an early age to train different aspects of postural control, including anticipatory and reactive postural adjustments. VR adapted to the pediatric population is recommended for children whose vestibular dysfunction leads to functional disorders or symptoms of vertigo for those who have suffered head trauma. It is recommended that children with bilateral vestibular impairment...
Source: Archives de Pediatrie - May 2, 2024 Category: Pediatrics Authors: Pierre Reynard Jos é Ortega-Solís Sophie Tronche Vincent Darrouzet Hung Thai-Van Source Type: research

Clinical validation of automated depth camera-based measurement of the Fugl-Meyer assessment for upper extremity
CONCLUSION: The integration of depth camera technology and machine learning models for automated Fugl-Meyer Assessment demonstrated acceptable validity and feasibility, suggesting its potential as a valuable tool in rehabilitation assessment.PMID:38693881 | DOI:10.1177/02692155241251434 (Source: Clinical Rehabilitation)
Source: Clinical Rehabilitation - May 2, 2024 Category: Rehabilitation Authors: Zhaoyang Wang Tao Zhang Jingyuan Fan Fanbin Gu Qiuhua Yu Honggang Wang Jiantao Yang Qingtang Zhu Source Type: research

Observing the Clinical Course of Duchenne Muscular Dystrophy in Medicaid Real-World Healthcare Data
CONCLUSIONS: This study is the first to use diagnosis and procedure codes from real-world Medicaid claims to document the clinical course in DMD. Findings were consistent with previously published estimates from commercially insured populations and clinical registries; and contribute to the expanding body of real-world evidence around clinical progression of patients with DMD.PMID:38698169 | DOI:10.1007/s12325-024-02865-2 (Source: Adv Data)
Source: Adv Data - May 2, 2024 Category: Epidemiology Authors: Christina Qian Alexa C Klimchak Shelagh M Szabo Evan Popoff Susan T Iannaccone Katherine L Gooch Source Type: research

Cardiac Sympathetic Denervation and Anxiety in Parkinson Disease
Anxiety in Parkinson disease (PD) negatively impacts quality of life. While research predominantly focuses on central nervous system changes, some evidence suggests a connection between peripheral autonomic dysfunctions and PD-related anxiety. The role of the peripheral autonomic nervous system in this context may be overlooked. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 2, 2024 Category: Neurology Authors: G. Carli, P. Kanel, F. Michalakis, S. Roytman, J.L.B. Bohnen, T.P. Wigstrom, P. Scott, R.L. Albin, K.K. Wong, D. Raffel, N.I. Bohnen Source Type: research

Observing the Clinical Course of Duchenne Muscular Dystrophy in Medicaid Real-World Healthcare Data
ConclusionsThis study is the first to use diagnosis and procedure codes from real-world Medicaid claims to document the clinical course in DMD. Findings were consistent with previously published estimates from commercially insured populations and clinical registries; and contribute to the expanding body of real-world evidence around clinical progression of patients with DMD. (Source: Advances in Therapy)
Source: Advances in Therapy - May 2, 2024 Category: Drugs & Pharmacology Source Type: research

Laryngopharyngeal reflux disease: Updated examination of mechanisms, pathophysiology, treatment, and association with gastroesophageal reflux disease
World J Gastroenterol. 2024 Apr 28;30(16):2209-2219. doi: 10.3748/wjg.v30.i16.2209.ABSTRACTLaryngopharyngeal reflux disease (LPRD) is an inflammatory condition in the laryngopharynx and upper aerodigestive tract mucosa caused by reflux of stomach contents beyond the esophagus. LPRD commonly presents with sym-ptoms such as hoarseness, cough, sore throat, a feeling of throat obstruction, excessive throat mucus. This complex condition is thought to involve both reflux and reflex mechanisms, but a clear understanding of its molecular mechanisms is still lacking. Currently, there is no standardized diagnosis or treatment protoc...
Source: World Journal of Gastroenterology - May 1, 2024 Category: Gastroenterology Authors: Na Cui Ting Dai Yang Liu Ya-Yu Wang Jia-Yu Lin Qing-Fan Zheng Dong-Dong Zhu Xue-Wei Zhu Source Type: research

Molecular Testing in Lung Cancer: Recommendations and Update
Surg Pathol Clin. 2024 Jun;17(2):307-320. doi: 10.1016/j.path.2023.11.012. Epub 2023 Dec 16.ABSTRACTAdoption of molecular testing in lung cancer is increasing. Molecular testing for staging and prediction of response for targeted therapy remain the main indications, and although utilization of blood-based testing for tumor is growing, the use of the diagnostic cytology and tissue specimens is equally important. The pathologist needs to optimize reflex testing, incorporate stage-based algorithms, and understand types of tests for timely and complete assessment in the majority of cases. When tissue is limited, testing should...
Source: Clinical Lung Cancer - May 1, 2024 Category: Cancer & Oncology Authors: Alain C Borczuk Source Type: research

Hypoxic and Autonomic Mechanisms from Sleep-Disordered Breathing Leading to Cardiopulmonary Dysfunction
Sleep Med Clin. 2024 Jun;19(2):229-237. doi: 10.1016/j.jsmc.2024.02.003. Epub 2024 Mar 7.ABSTRACTObstructive sleep apnea (OSA) is a common sleep-related breathing disorder. Its prevalence has increased due to increasing obesity and improved screening and diagnostic strategies. OSA overlaps with cardiopulmonary diseases to promote intermittent hypoxia and autonomic dysfunction. Intermittent hypoxia increases the risk for oxidative stress and inflammation, which promotes endothelial dysfunction and predisposes to atherosclerosis and other cardiovascular complications. OSA is associated with an increased sympathetic nervous s...
Source: Atherosclerosis - May 1, 2024 Category: Cardiology Authors: Avantika Nathani Amy Attaway Reena Mehra Source Type: research

Laryngopharyngeal reflux disease: Updated examination of mechanisms, pathophysiology, treatment, and association with gastroesophageal reflux disease
World J Gastroenterol. 2024 Apr 28;30(16):2209-2219. doi: 10.3748/wjg.v30.i16.2209.ABSTRACTLaryngopharyngeal reflux disease (LPRD) is an inflammatory condition in the laryngopharynx and upper aerodigestive tract mucosa caused by reflux of stomach contents beyond the esophagus. LPRD commonly presents with sym-ptoms such as hoarseness, cough, sore throat, a feeling of throat obstruction, excessive throat mucus. This complex condition is thought to involve both reflux and reflex mechanisms, but a clear understanding of its molecular mechanisms is still lacking. Currently, there is no standardized diagnosis or treatment protoc...
Source: World Journal of Gastroenterology : WJG - May 1, 2024 Category: Gastroenterology Authors: Na Cui Ting Dai Yang Liu Ya-Yu Wang Jia-Yu Lin Qing-Fan Zheng Dong-Dong Zhu Xue-Wei Zhu Source Type: research

Quality of life and support needs in children, adolescents, and young adults with facioscapulohumeral dystrophy, a mixed-method study
DISCUSSION: Quality of life in childhood FSHD is diminished caused by their physical limitations, altered appearance, fear of social rejection, and uncertainty of the disease progression in the future. A fear of social rejection most likely contributes to striving for normality regardless of physical discomfort. Support should be focused on acceptance and coping with hurtful comments. It should preferably be individualized, easily accessible and not offered as therapy but rather as tutoring for children.PMID:38692157 | DOI:10.1016/j.ejpn.2024.04.006 (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - May 1, 2024 Category: Neurology Authors: Jildou N Dijkstra Nathani ël B Rasing Helena T M Boon Sandra Altena-Rensen Edith H C Cup Anke Lanser Ietske J Siemann Baziel G van Engelen Corrie E Erasmus Nicol C Voermans Source Type: research