Lactate and hydrogen ions play a predominant role in evoking the exercise pressor reflex during ischaemic contractions but not during freely perfused contractions
J Physiol. 2024 Apr 29. doi: 10.1113/JP286488. Online ahead of print.ABSTRACTWe investigated the role played by lactate and hydrogen in evoking the exercise pressor reflex (EPR) in decerebrated rats whose hindlimb muscles were either freely perfused or ischaemic. Production of lactate and hydrogen by the contracting hindlimb muscles was manipulated by knocking out the myophosphorylase gene (pygm). In knockout rats (pygm-/-; n = 13) or wild-type rats (pygm+/+; n = 13), the EPR was evoked by isometrically contracting the triceps surae muscles. Blood pressure, tension, blood flow, renal sympathetic nerve activity and blood la...
Source: The Journal of Physiology - April 30, 2024 Category: Physiology Authors: Guillaume P Ducrocq Laura Anselmi Victor Ruiz-Velasco Marc P Kaufman Source Type: research

Cardiovascular Reflexes - Vagus as the Key Player
This article intends to explain various reflexes involved in the homeostasis of the cardiovascular system and the role of vagus as the key component in all these reflexes. The article also explains the components of the reflex arc, the stimulus and response, and the role of reflex in a few diseases. This article describes 22 different cardiovascular reflexes in detail.PMID:38685784 | DOI:10.2174/011573403X284831240408053528 (Source: Current Cardiology Reviews)
Source: Current Cardiology Reviews - April 30, 2024 Category: Cardiology Authors: Shantala S Herlekar Ashwini R Doyizode Savitri P Siddangoudra Anupama V Source Type: research

Influence of Thyroglobulin (Tg) Autoantibodies on Tg levels Measured by Different Methodologies: (IMA, LC-MS/MS and RIA)
CONCLUSIONS: 1) Between-method Tg variability necessitates method continuity when monitoring the Tg trends of TgAb- DTC patients. 2) The presence and concentration of TgAb appeared to have a lowering effect on serum Tg measured by all methodologies (IMA, MS and RIA). 3) Since the reliability of Tg measured in the presence of TgAb is often uncertain, the TgAb trend (measured by the same method) may be a useful surrogate DTC tumor marker.PMID:38686504 | DOI:10.1210/clinem/dgae286 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 30, 2024 Category: Endocrinology Authors: Ivana Petrovic Jonathan LoPresti Shireen Fatemi Andrew Gianoukakis Kenneth Burman Cristiane J Gomez-Lima Caroline T Nguyen Carole Ann Spencer Source Type: research

Lactate and hydrogen ions play a predominant role in evoking the exercise pressor reflex during ischaemic contractions but not during freely perfused contractions
J Physiol. 2024 Apr 29. doi: 10.1113/JP286488. Online ahead of print.ABSTRACTWe investigated the role played by lactate and hydrogen in evoking the exercise pressor reflex (EPR) in decerebrated rats whose hindlimb muscles were either freely perfused or ischaemic. Production of lactate and hydrogen by the contracting hindlimb muscles was manipulated by knocking out the myophosphorylase gene (pygm). In knockout rats (pygm-/-; n = 13) or wild-type rats (pygm+/+; n = 13), the EPR was evoked by isometrically contracting the triceps surae muscles. Blood pressure, tension, blood flow, renal sympathetic nerve activity and blood la...
Source: The Journal of Physiology - April 30, 2024 Category: Physiology Authors: Guillaume P Ducrocq Laura Anselmi Victor Ruiz-Velasco Marc P Kaufman Source Type: research

Relationships Among Baseline Concussion Balance Test and Gaze Stability Test Scores in Division-I Collegiate Athletes
CONCLUSIONS: The direction of these relationships indicated that greater Concussion Balance Test errors were associated with greater Gaze Stabilization Test performance. These relationships may be attributed to the difficulty created by the foam conditions and the integration of more complex sensory tasks required to maintain balance during the more difficult conditions.PMID:38688463 | DOI:10.1123/jsr.2023-0254 (Source: Journal of Sport Rehabilitation)
Source: Journal of Sport Rehabilitation - April 30, 2024 Category: Sports Medicine Authors: Carolina P Quintana Anne D Olson Nicholas R Heebner Matthew C Hoch Source Type: research

Cardiovascular Reflexes - Vagus as the Key Player
This article intends to explain various reflexes involved in the homeostasis of the cardiovascular system and the role of vagus as the key component in all these reflexes. The article also explains the components of the reflex arc, the stimulus and response, and the role of reflex in a few diseases. This article describes 22 different cardiovascular reflexes in detail.PMID:38685784 | DOI:10.2174/011573403X284831240408053528 (Source: Current Cardiology Reviews)
Source: Current Cardiology Reviews - April 30, 2024 Category: Cardiology Authors: Shantala S Herlekar Ashwini R Doyizode Savitri P Siddangoudra Anupama V Source Type: research

Influence of Thyroglobulin (Tg) Autoantibodies on Tg levels Measured by Different Methodologies: (IMA, LC-MS/MS and RIA)
CONCLUSIONS: 1) Between-method Tg variability necessitates method continuity when monitoring the Tg trends of TgAb- DTC patients. 2) The presence and concentration of TgAb appeared to have a lowering effect on serum Tg measured by all methodologies (IMA, MS and RIA). 3) Since the reliability of Tg measured in the presence of TgAb is often uncertain, the TgAb trend (measured by the same method) may be a useful surrogate DTC tumor marker.PMID:38686504 | DOI:10.1210/clinem/dgae286 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 30, 2024 Category: Endocrinology Authors: Ivana Petrovic Jonathan LoPresti Shireen Fatemi Andrew Gianoukakis Kenneth Burman Cristiane J Gomez-Lima Caroline T Nguyen Carole Ann Spencer Source Type: research

Relationships Among Baseline Concussion Balance Test and Gaze Stability Test Scores in Division-I Collegiate Athletes
CONCLUSIONS: The direction of these relationships indicated that greater Concussion Balance Test errors were associated with greater Gaze Stabilization Test performance. These relationships may be attributed to the difficulty created by the foam conditions and the integration of more complex sensory tasks required to maintain balance during the more difficult conditions.PMID:38688463 | DOI:10.1123/jsr.2023-0254 (Source: Journal of Sport Rehabilitation)
Source: Journal of Sport Rehabilitation - April 30, 2024 Category: Sports Medicine Authors: Carolina P Quintana Anne D Olson Nicholas R Heebner Matthew C Hoch Source Type: research

Cardiovascular Reflexes - Vagus as the Key Player
This article intends to explain various reflexes involved in the homeostasis of the cardiovascular system and the role of vagus as the key component in all these reflexes. The article also explains the components of the reflex arc, the stimulus and response, and the role of reflex in a few diseases. This article describes 22 different cardiovascular reflexes in detail.PMID:38685784 | DOI:10.2174/011573403X284831240408053528 (Source: Current Cardiology Reviews)
Source: Current Cardiology Reviews - April 30, 2024 Category: Cardiology Authors: Shantala S Herlekar Ashwini R Doyizode Savitri P Siddangoudra Anupama V Source Type: research

Relationships Among Baseline Concussion Balance Test and Gaze Stability Test Scores in Division-I Collegiate Athletes
CONCLUSIONS: The direction of these relationships indicated that greater Concussion Balance Test errors were associated with greater Gaze Stabilization Test performance. These relationships may be attributed to the difficulty created by the foam conditions and the integration of more complex sensory tasks required to maintain balance during the more difficult conditions.PMID:38688463 | DOI:10.1123/jsr.2023-0254 (Source: Journal of Sport Rehabilitation)
Source: Journal of Sport Rehabilitation - April 30, 2024 Category: Sports Medicine Authors: Carolina P Quintana Anne D Olson Nicholas R Heebner Matthew C Hoch Source Type: research

Different neuropsychological and brain volumetric profiles in a pair of identical twins with myotonic dystrophy type 1 indicate a non-genetic modulation of clinical phenotype
Myotonic Dystrophy type 1 (DM1) is an autosomal dominant [1] genetic disorder caused by a CTG triplet repeat expansion within the DM1 protein kinase gene (DMPK) located on chromosome 19q13.3 [2]. DM1 is a heterogeneous multisystemic syndrome characterised by congenital, childhood-juvenile or adult clinical onset [1]. Psychopathological/psychiatric [3-4] and cognitive symptoms including social cognition disorders [5-6] have been previously described. Social cognition is a complex of cognitive and affective functions that entail the recognition of believes and intentions of others (theory of mind), emotional processing, and ...
Source: Neuromuscular Disorders - April 30, 2024 Category: Neurology Authors: Laura Serra, Antonio Petrucci, Michela Bruschini, Annalisa Botta, Corrado Campisi, Carlo Caltagirone, Marco Bozzali Tags: Case report Source Type: research

Social difficulties and care burden of adult Duchenne muscular dystrophy in Japan: a questionnaire survey based on the Japanese Registry of Muscular Dystrophy (Remudy)
Little is known about the social difficulties and health care needs of adult Duchenne muscular dystrophy (DMD) patients in Japan, as well as the financial and physical stress experienced by their caregivers. T... (Source: Orphanet Journal of Rare Diseases)
Source: Orphanet Journal of Rare Diseases - April 30, 2024 Category: Internal Medicine Authors: Madoka Mori-Yoshimura, Keiko Ishigaki, Yuko Shimizu-Motohashi, Naoko Ishihara, Atushi Unuma, Sumiko Yoshida and Harumasa Nakamura Tags: Research Source Type: research

336. Autonomic Nervous System Coordination Alters PTSD Risk Following Childhood Maltreatment
Individuals with post-traumatic stress disorder (PTSD) often exhibit dysregulation of the autonomic nervous system (ANS), characterized by heightened sympathetic nervous system (SNS) activity or reduced parasympathetic nervous system activity (PNS), which may contribute to the hyperarousal and hypervigilance symptoms commonly observed in PTSD. Additionally, altered ANS functioning has been associated with the severity and persistence of PTSD symptoms. However, most studies have included only one measure of the ANS (i.e., SNS or PNS) without attention to the role of ANS coordination. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Meredith Gruhn, Rachel Siciliano, Allegra Anderson, Allison Vreeland, Lauren Henry, Kelly Watson, Jon Ebert, Tarah Kuhn, Bruce Compas Source Type: research

209. Angiotensin Converting Enzyme Polymorphism Affects Ventricular and Gray Matter Volume in Patients With Recurrent Depression – Interaction With Childhood Trauma
High aldosterone concentrations are associated with worse treatment outcome in MDD. Aldosterone release is regulated by the sympathetic nervous system and the hypothalamus-pituitary-adrenocortical (HPA) axis. A high aldosterone/cortisol ratio is associated with enlarged ventricular and choroid plex volumes and treatment refractoriness. For the angiotensin-converting-enzyme ACE, a key regulator of the RAAS, polymorphisms exist, which are associated with treatment outcome. Also, childhood trauma is associated with increased ventricular volume and aldosterone saliva concentration. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Harald Murck, Sophia Zesakes, Katharina Brosch, Andreas Jansen, Tilo Kircher, Frederike Stein Source Type: research

208. Heart Rate Variability in Patients With Treatment-Resistant Depression During Ketamine Infusion
Depression is associated with reduced heart rate variability (HRV) and compromised vagal control. Acute ketamine administration triggers significant cardiovascular shifts, increasing heart rate (HR) and blood pressure through sympathetic activation. This autonomic response provides potential understanding of ketamine's antidepressant mechanisms. This investigation examines ketamine's influence on HR and HRV in major depressive disorder (MDD), assessing their potential as treatment response predictors. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Taliah Soleymani, Dede Greenstein, Carlos Zarate, Jennifer Evans Source Type: research