Reflex Sympathetic Dystrophy Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Metformin inhibits nerve growth factor (NGF)-induced sympathetic neuron differentiation through p35/CDK5 inhibition
In this study, we investigated the impact of metformin on NGF-induced sympathetic neuronal differentiation using rat pheochromocytoma PC12 cells as a model. We examined the regulation of TrkA-p35/CDK5 signaling in NGF-induced PC12 differentiation. Our results demonstrate that metformin reduces NGF-induced PC12 differentiation by inactivating the TrkA receptor, subsequently inhibiting ERK and EGR1. Inhibition of this cascade ultimately leads to the down-regulation of p35/CDK5 in PC12 cells. Furthermore, metformin inhibits the activation of the pre-synaptic protein Synapsin-I, a substrate of CDK5, in PC12 differentiation. Ad...
Source: Am J Physiol Cell Ph... - April 29, 2024 Category: Cytology Authors: Muhammet Oner Mei-Chih Chen Pang-Ting Cheng Ho Lin Source Type: research

Metformin inhibits nerve growth factor (NGF)-induced sympathetic neuron differentiation through p35/CDK5 inhibition
In this study, we investigated the impact of metformin on NGF-induced sympathetic neuronal differentiation using rat pheochromocytoma PC12 cells as a model. We examined the regulation of TrkA-p35/CDK5 signaling in NGF-induced PC12 differentiation. Our results demonstrate that metformin reduces NGF-induced PC12 differentiation by inactivating the TrkA receptor, subsequently inhibiting ERK and EGR1. Inhibition of this cascade ultimately leads to the down-regulation of p35/CDK5 in PC12 cells. Furthermore, metformin inhibits the activation of the pre-synaptic protein Synapsin-I, a substrate of CDK5, in PC12 differentiation. Ad...
Source: American Journal of Physiology. Cell Physiology - April 29, 2024 Category: Cytology Authors: Muhammet Oner Mei-Chih Chen Pang-Ting Cheng Ho Lin Source Type: research

Nitrous oxide-induced myeloneuropathy in a Thai adolescent: a case report
Paediatr Int Child Health. 2024 Apr 29:1-4. doi: 10.1080/20469047.2024.2344403. Online ahead of print.ABSTRACTNitrous oxide, an inhalational anaesthetic, is popular with adolescents worldwide as an accessible recreational drug which induces a euphoric effect. However, chronic abuse leads to serious complications such as myeloneuropathy and bone marrow suppression by inactivation of vitamin B12. A 17-year-old girl presented with nitrous oxide-induced myeloneuropathy. She reported chronic nitrous oxide inhalation for 10 months and was admitted to the emergency department on account of repeated falls for 2 weeks. She also had...
Source: Paediatrics and international child health - April 29, 2024 Category: Pediatrics Authors: S Puetpaiboon M Meepolprapai P Saengpanit P Laohathai W Prasertsup S Khiewbanyang R Charupash O Sanmaneechai Worapant Kriengsoontornkij Source Type: research

Epidemiology and molecular characterization of adult genetic myopathies in a southeastern region of Spain
CONCLUSION: The prevalence of GMs can vary considerably depending on the geographical region and the studied population. The analysis of diagnostic yield suggests that genetic studies should be considered useful in the diagnosis of genetic myopathies.PMID:38682761 | DOI:10.33588/rn.7809.2024071 (Source: Revista de Neurologia)
Source: Revista de Neurologia - April 29, 2024 Category: Neurology Authors: P Ros-Arlanz ón L Pelegr ín-Durá C Aledo-Sala L Moreno-Navarro Y Vaamonde-Esteban A Mu ñoz-Ambit R S ánchez-Pérez C D íaz-Marín Source Type: research

The Limb Girdle Muscular Dystrophy Health Index (LGMD-HI)
Limb girdle muscular dystrophy (LGMD) is a genetically diverse group of rare, autosomal muscular dystrophies caused by mutations in genes encoding proteins that are needed for muscle maintenance, repair and normal function [1,2]. Using next-generation sequencing (NGS), more than 30 subtypes of LGMD at different autosomal loci have been identified in LGMD [2]. Since 2018 these have been categorized with the nomenclature “LGMD D” for autosomal dominant and “LGMD R” for autosomal recessive mutations [3]. (Source: Neuromuscular Disorders)
Source: Neuromuscular Disorders - April 29, 2024 Category: Neurology Authors: Joy A. Stouffer, Kameron Bates, Leroy R. Thacker, Chad Heatwole, Nicholas E. Johnson Source Type: research

A Multidisciplinary Approach Improves Sexual Healthcare for Youth with Duchenne Muscular Dystrophy
We sought to determine the prevalence of sexual health counseling in patients with Duchenne muscular dystrophy (DMD) in a single-institution setting. Keywords related to sexual health and development concerns were documented at least once for 75% of patients across the duration of their care. Integration of sexual health discussions was facilitated by comprehensive multidisciplinary support, particularly with the inclusion of specialists in endocrinology and adolescent medicine. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - April 29, 2024 Category: Pediatrics Authors: Ellis Barrera, John M. Baronas, Sherice Sutherland, Alyssa Rohan, Robin E. Margolin, Elizabeth R. Boskey, Nora E. Renthal Tags: Brief Reports Source Type: research

Bruno 1/CELF regulates splicing and cytoskeleton dynamics to ensure correct sarcomere assembly < i > Drosophila < /i > flight muscles
by Elena Nikonova, Jenna DeCata, Marc Canela, Christiane Barz, Alexandra Esser, Jessica Bouterwek, Akanksha Roy, Heidemarie Gensler, Martin He ß, Tobias Straub, Ignasi Forne, Maria L. Spletter Muscles undergo developmental transitions in gene expression and alternative splicing that are necessary to refine sarcomere structure and contractility. CUG-BP and ETR-3-like (CELF) family RNA-binding proteins are important regulators of RNA processing during myogenesis that are misregulated in diseases such as Myotonic Dystrophy Type I (DM1). Here, we report a conserved function for Bruno 1 (Bru1, Arrest), a CELF1/2 family homolo...
Source: PLoS Biology: Archived Table of Contents - April 29, 2024 Category: Biology Authors: Elena Nikonova Source Type: research

Mentalis nerve branches supplying the lower lip revisited: a study of human fetuses and donated elderly cadavers
ConclusionThe lower lip skin was innervated by a perforating branch passing through the orbicularis oris muscle, that was different from the lip mucosa. A sudden change in the nerve ending configuration at the mucocutaneous junction seemed to develop postnatally. (Source: Surgical and Radiologic Anatomy)
Source: Surgical and Radiologic Anatomy - April 29, 2024 Category: Anatomy Source Type: research

Enhancing sciatic nerve regeneration with osteopontin-loaded acellular nerve allografts in rats: Effects on macrophage polarization
In conclusion, the study suggested that ANA loaded with 2 nM OPN effectively repaired transected sciatic nerves in rats, potentially through enhancing axonal sprouting and exerting anti-inflammatory effects.PMID:38678741 | DOI:10.1016/j.tice.2024.102379 (Source: Tissue and Cell)
Source: Tissue and Cell - April 28, 2024 Category: Cytology Authors: Shukur Wasman Smail Shang Ziyad Abdulqadir Lana Sardar Saleh Alalem Taban Kamal Rasheed Zhikal Omar Khudhur Abdullah Faqiyazdin Ahmed Mzury Harem Khdir Awla Mohammad B Ghayour Arash Abdolmaleki Source Type: research

Adipose tissue rearrangement in cancer cachexia: The involvement of β3-adrenergic receptor associated pathways
Biochim Biophys Acta Rev Cancer. 2024 Apr 26:189103. doi: 10.1016/j.bbcan.2024.189103. Online ahead of print.ABSTRACTCancer-associated cachexia (CAC) is a complex multiple organ syndrome that significantly contributes to reduced quality of life and increased mortality among many cancer patients. Its multifactorial nature makes its early diagnosis and effective therapeutic interventions challenging. Adipose tissue is particularly impacted by cachexia, typically through increased lipolysis, browning and thermogenesis, mainly at the onset of the disease. These processes lead to depletion of fat mass and contribute to the dysf...
Source: Biochimica et Biophysica Acta - April 28, 2024 Category: Biochemistry Authors: In ês N R Mota Setareh Satari In ês Soares Marques Joana M O Santos Rui Medeiros Source Type: research

Regional cerebral blood flow in a patient with asystole episodes associated with anti-NMDA receptor encephalitis
Neurocase. 2024 Apr 27:1-4. doi: 10.1080/13554794.2024.2348221. Online ahead of print.ABSTRACTAnti-N-methyl-D-aspartate (NMDA) receptor encephalitis is a rare and severe autoimmune encephalitis that displays neuropsychiatric symptoms and autonomic instability, e.g., hypoventilation and cardiac arrhythmia. Severe arrhythmia including asystole associated with this encephalitis is rare. Several causes have been suggested. Nevertheless, no report of the literature has described examination by functional brain imaging of a patient with asystole during anti-NMDA receptor encephalitis. This case is that of a 34-year-old woman dia...
Source: Neurocase - April 27, 2024 Category: Neurology Authors: Gaku Aboshi Takaki Akahane Keisuke Noto Ryota Kobayashi Masakazu Akiho Akihito Suzuki Source Type: research