Development of a dynamic motion platform with two independent drive systems for radiotherapy
CONCLUSIONS: A new dynamic platform for radiation therapy with two drive systems capable of three-axis motion was developed, and the positional accuracy of the drive axes was confirmed to be less than 0.2 mm.PMID:36951306 | DOI:10.1002/acm2.13971 (Source: Journal of Applied Clinical Medical Physics)
Source: Journal of Applied Clinical Medical Physics - March 23, 2023 Category: Physics Authors: Masahide Saito Hideyuki Kawakami Toshihiro Suzuki Hidekazu Suzuki Koji Ueda Hikaru Nemoto Naoki Sano Hiroshi Onishi Source Type: research
Clinically Translatable Transcrocetin Delivery Platform for Correction of Tumor Hypoxia and Enhancement of Radiation Therapy Effects (Small 12/2023)
Enhancement of Radiation Therapy EffectsLiposome-based nanoparticles encapsulating transcrocetin (NP TSC) act as therapeutic radiosensitizer. In article number2205961, Alexandre Detappe and co-workers perform a study on mouse to confirm their ability to reoxygenate triple negative breast cancer tumors for up to 48h. This reoxygenation effect leads to normalisation of the vasculature which enhances the radiation therapy effects. (Source: Small)
Source: Small - March 23, 2023 Category: Nanotechnology Authors: Marie ‐Charlotte Diringer,
Pierre Coliat,
Clélia Mathieu,
Nina Laurent,
Carole Mura,
Mainak Banerjee,
Chen Zhu,
Anna Grabowska,
Alison Ritchie,
Philip Clarke,
Alexandre Bernard,
Claire Vit,
Hélène Burckel,
Georges Noel,
Peter Harvey,
X Tags: Frontispiece Source Type: research
Neoadjuvant radiotherapy plus single-incision thoracoscopic surgery in the treatment of type B3 thymomas
ConclusionNeoadjuvant radiotherapy followed by minimally invasive surgery was a safe and efficacious procedure for the treatment of type B3 thymomas, with less postoperative pain and faster recovery. This strategy, of tumor shrinkage prior to surgery, may make possible the easier removal of type B3 thymomas by single-incision thoracoscopy. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 23, 2023 Category: Cancer & Oncology Source Type: research
Cancers, Vol. 15, Pages 1922: Predicting Breast Cancer Events in Ductal Carcinoma In Situ (DCIS) Using Generative Adversarial Network Augmented Deep Learning Model
Polar
Sunil S. Badve
Standard clinicopathological parameters (age, growth pattern, tumor size, margin status, and grade) have been shown to have limited value in predicting recurrence in ductal carcinoma in situ (DCIS) patients. Early and accurate recurrence prediction would facilitate a more aggressive treatment policy for high-risk patients (mastectomy or adjuvant radiation therapy), and simultaneously reduce over-treatment of low-risk patients. Generative adversarial networks (GAN) are a class of DL models in which two adversarial neural networks, generator and discriminator, compete with each other to generate hi...
Source: Cancers - March 23, 2023 Category: Cancer & Oncology Authors: Soumya Ghose Sanghee Cho Fiona Ginty Elizabeth McDonough Cynthia Davis Zhanpan Zhang Jhimli Mitra Adrian L. Harris Aye Aye Thike Puay Hoon Tan Yesim G ökmen-Polar Sunil S. Badve Tags: Article Source Type: research
Erratum: Overcoming immune resistance with radiation therapy in prostate cancer
(Source: Frontiers in Immunology)
Source: Frontiers in Immunology - March 23, 2023 Category: Allergy & Immunology Source Type: research
Intensity-modulated radiation therapy for intermediate-risk prostate cancer: does ADT still have an impact in the dose-escalated external beam radiation therapy era?
CONCLUSION: ADT may not always be effective in all Japanese IR-PCA patients treated with DE-EBRT, but it can improve biochemical control in patients with GS 4 + 3.PMID:36946312 | DOI:10.1093/jjco/hyad019 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - March 22, 2023 Category: Cancer & Oncology Authors: Takashi Soyano Takuyo Kozuka Kenichi Kashihara Yu Murakami Junji Yonese Kazuma Sasamura Nana Shimoyachi Tairo Kashihara Yasuo Yoshioka Masahiko Oguchi Source Type: research
Metastatic breast cancer from a hepatocellular carcinoma: a case report
Korean J Clin Oncol. 2022 Dec;18(2):93-96. doi: 10.14216/kjco.22013. Epub 2022 Dec 30.ABSTRACTBreast metastases from extramammary malignancies are rare. Here, we report a case of breast metastasis from hepatocellular carcinoma (HCC) after breast mass excision in a 63-year-old woman. A new breast nodule was noticed after transarterial chemoembolization, transarterial radioembolization, and stereotactic body radiation therapy for HCC. Breast ultrasound and core needle biopsy were performed to differentiate between the breast tumors. The biopsy result was invasive breast carcinoma, and wide excision of the breast was performe...
Source: Clinical Genitourinary Cancer - March 22, 2023 Category: Cancer & Oncology Authors: Hyewon Bang Nam-Hee Kim Seung Hye Choi Si Hyun Bae Eun Sun Jung Ki Ouk Min Yong Hwa Eom Source Type: research
Intensity-modulated radiation therapy for intermediate-risk prostate cancer: does ADT still have an impact in the dose-escalated external beam radiation therapy era?
CONCLUSION: ADT may not always be effective in all Japanese IR-PCA patients treated with DE-EBRT, but it can improve biochemical control in patients with GS 4 + 3.PMID:36946312 | DOI:10.1093/jjco/hyad019 (Source: Cancer Control)
Source: Cancer Control - March 22, 2023 Category: Cancer & Oncology Authors: Takashi Soyano Takuyo Kozuka Kenichi Kashihara Yu Murakami Junji Yonese Kazuma Sasamura Nana Shimoyachi Tairo Kashihara Yasuo Yoshioka Masahiko Oguchi Source Type: research
Unraveling the patterns and pathways of local recurrence of nasopharyngeal carcinoma: evidence for individualized clinical target volume delineation
CONCLUSIONS: Local recurrence of NPC varied according to T classification, followed a stepwise pattern, spread via neural foramina, and recurred at ipsilateral cavernous sinus. This provides meaningful clinical evidence for delineation of CTV, especially individualized delineation.PMID:36944958 | DOI:10.1186/s13014-023-02199-3 (Source: Cancer Control)
Source: Cancer Control - March 22, 2023 Category: Cancer & Oncology Authors: Xiaomin Ou Wenbin Yan Yangle Huang Xiayun He Hongmei Ying Xueguan Lu Hui Zhu Bin Wu Jiazhou Wang Chaosu Hu Source Type: research
Radiation Therapy in the Treatment of Localized and Advanced Renal Cancer
Urol Clin North Am. 2023 May;50(2):325-334. doi: 10.1016/j.ucl.2023.01.008. Epub 2023 Feb 20.ABSTRACTRenal cell carcinoma (RCC) has historically been considered resistant to radiotherapy. However, advances in the field of radiation oncology have led to safe delivery of higher radiation doses through the use of stereotactic body radiotherapy (SBRT) that have shown significant activity against RCC. SBRT has now been shown to be a highly effective modality for management of localized RCC for nonsurgical candidates. Increasing evidence also points to a role for SBRT in the management of oligometastatic RCC as a means for not o...
Source: The Urologic Clinics of North America - March 22, 2023 Category: Urology & Nephrology Authors: Kendrick Yim Jonathan E Leeman Source Type: research
Sensitivity of a bone-equivalent polymer gel dosimeter for measuring the dose to bone during radiation therapy
In this study, we developed a bone-equivalent polymer gel dosimeter (BPGD) that can measure the dose absorbed by the bone and investigated its sensitivity. The BPGDs were prepared by adding 3.0 mol of calcium hydrogen phosphate dihydrate as a component of bone to an improved dose-sensitive polyacrylamide gelatin and tetrakis hydroxymethyl phosphonium chloride (iPAGAT). One day after preparation, the BPGDs were irradiated with a field size of 15 × 15 cm2 using a 10 MV X-ray beam to evaluate the dose sensitivity, dose-rate dependence, and dose-integration dependence. One day after dose exposure, the BPGDs were scanned using...
Source: Health Physics - March 22, 2023 Category: Physics Authors: Narumi Kumahara Akihiro Takemura Shouta Ishihara Kimiya Noto Hironori Kojima Naoki Isomura Haruna Yokoyama Itsuki Goto Source Type: research
Applications of deep learning to reduce the need for iodinated contrast media for CT imaging: a systematic review
ConclusionDL-generated contrast-enhanced or non-contrast CT may assist in diagnosis and radiation therapy planning; however, further work to optimize protocols to reduce or eliminate ICM for specific pathology is still needed along with a dedicated assessment of the clinical utility of these synthetic images. (Source: International Journal of Computer Assisted Radiology and Surgery)
Source: International Journal of Computer Assisted Radiology and Surgery - March 22, 2023 Category: Intensive Care Source Type: research
Sensitivity of a bone-equivalent polymer gel dosimeter for measuring the dose to bone during radiation therapy
In this study, we developed a bone-equivalent polymer gel dosimeter (BPGD) that can measure the dose absorbed by the bone and investigated its sensitivity. The BPGDs were prepared by adding 3.0 mol of calcium hydrogen phosphate dihydrate as a component of bone to an improved dose-sensitive polyacrylamide gelatin and tetrakis hydroxymethyl phosphonium chloride (iPAGAT). One day after preparation, the BPGDs were irradiated with a field size of 15 × 15 cm2 using a 10 MV X-ray beam to evaluate the dose sensitivity, dose-rate dependence, and dose-integration dependence. One day after dose exposure, the BPGDs were scanned...
Source: Radiological Physics and Technology - March 22, 2023 Category: Physics Source Type: research
Safety and efficacy of single insertion accelerated MR-image guided brachytherapy following chemo-radiation in locally advanced cervix cancer: modifying our EMBRACE during the COVID pandemic
CONCLUSIONS: This study demonstrated the utility of mIGABT and VMAT CRT in a small cohort with LACC. Loco-regional control was achieved in all cases with minimal emergent toxicity. Single insertion mIGABT was logistically efficient, cost-saving, and patient-centric during the COVID-19 pandemic.PMID:36941643 | DOI:10.1186/s13014-023-02240-5 (Source: Cancer Control)
Source: Cancer Control - March 21, 2023 Category: Cancer & Oncology Authors: Mark J Stevens Florence Ko Judith Martland Ryan Brown Linda Bell John Atyeo Jackie Yim Source Type: research
Modulation of the nanoscale motion rate of Candida albicans by X-rays
In this study, we explored the effects of ionizing radiation and an antifungal drug and their combined effect on C. albicans.MethodsThe study essentially relied on a novel technique, referred to as optical nanomotion detection (ONMD) that monitors the viability and metabolic activity of the yeast cells in a label and attachment-free manner.Results and discussionOur findings demonstrate that after exposure to X-ray radiation alone or in combination with fluconazole, low-frequency nanoscale oscillations of whole cells are suppressed and the nanomotion rate depends on the phase of the cell cycle, absorbed dose, fluconazole co...
Source: Frontiers in Microbiology - March 21, 2023 Category: Microbiology Source Type: research
