Potential Single Nucleotide Polymorphisms markers for radiation dermatitis in head and neck cancer patients: a meta-analysis
ConclusionThe most prevalent SNPs may be predictors of acute RD. The analysis of SNP before starting radiation therapy may be a promising method to predict the risk of developing radiation dermatitis and allow radiosensitive patients to have a customized treatment. This current review provides new research directions. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - April 26, 2024 Category: Cancer & Oncology Source Type: research
Could nutrition status predict fatigue one week before in patients with nasopharynx cancer undergoing radiotherapy?
CONCLUSIONS: The PG-SGA may be a more accurate predictor of future-week fatigue than individual body composition indicators, particularly when HADS is controlled for as a time-dependent confounder.PMID:38659395 | DOI:10.1002/cam4.7191 (Source: Cancer Control)
Source: Cancer Control - April 25, 2024 Category: Cancer & Oncology Authors: Jihong Song Xinru Yang Jieling Wu Zilan Wu Litao Zhuo Jinsheng Hong Li Su Wenlong Lyu Jinru Ye Yan Fang Zhiying Zhan Hairong Zhang Xiaomei Li Source Type: research
A Monte Carlo simulation-based decision support system for radiation oncologists in the treatment of glioblastoma multiforme
Radiat Environ Biophys. 2024 Apr 25. doi: 10.1007/s00411-024-01065-4. Online ahead of print.ABSTRACTIn the present research, we have developed a model-based crisp logic function statistical classifier decision support system supplemented with treatment planning systems for radiation oncologists in the treatment of glioblastoma multiforme (GBM). This system is based on Monte Carlo radiation transport simulation and it recreates visualization of treatment environments on mathematical anthropomorphic brain (MAB) phantoms. Energy deposition within tumour tissue and normal tissues are graded by quality audit factors which ensur...
Source: Radiation and Environmental Biophysics - April 25, 2024 Category: Physics Authors: C Praveen Kumar Lalit M Aggarwal Saju Bhasi Neeraj Sharma Source Type: research
Could nutrition status predict fatigue one week before in patients with nasopharynx cancer undergoing radiotherapy?
ConclusionsThe PG-SGA may be a more accurate predictor of future-week fatigue than individual body composition indicators, particularly when HADS is controlled for as a time-dependent confounder. (Source: Cancer Medicine)
Source: Cancer Medicine - April 25, 2024 Category: Cancer & Oncology Authors: Jihong Song,
Xinru Yang,
Jieling Wu,
Zilan Wu,
Litao Zhuo,
Jinsheng Hong,
Li Su,
Wenlong Lyu,
Jinru Ye,
Yan Fang,
Zhiying Zhan,
Hairong Zhang,
Xiaomei Li Tags: RESEARCH ARTICLE Source Type: research
Cancers, Vol. 16, Pages 1665: Stereotactic Radiosurgery for Patients with Brain Metastases from Hepatopancreaticobiliary Cancers
Conclusions: Metastatic spread to the brain from HPB cancers occurs late in the course of the primary disease. In this study, all deceased patients ultimately died from primary disease progression. SRS is a non-invasive strategy that maximally preserves quality of life, and our results reported favorable outcomes compared to the existing literature. SRS should be considered as one of the primary management strategies for patients with brain metastatic spread from HPB cancer. (Source: Cancers)
Source: Cancers - April 25, 2024 Category: Cancer & Oncology Authors: Wei Srinivasan Patel Bednarz Flickinger Hadjipanayis Niranjan Lunsford Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1662: The Causes and Consequences of DNA Damage and Chromosomal Instability Induced by Human Papillomavirus
Mehta
Cosper
High-risk human papillomaviruses (HPVs) are the main cause of cervical, oropharyngeal, and anogenital cancers, which are all treated with definitive chemoradiation therapy when locally advanced. HPV proteins are known to exploit the host DNA damage response to enable viral replication and the epithelial differentiation protocol. This has far-reaching consequences for the host genome, as the DNA damage response is critical for the maintenance of genomic stability. HPV+ cells therefore have increased DNA damage, leading to widespread genomic instability, a hallmark of cancer, which can contribute to tumo...
Source: Cancers - April 25, 2024 Category: Cancer & Oncology Authors: Jones Bryan McCunn Lantz Blalock Ojeda Mehta Cosper Tags: Review Source Type: research
Neighborhood-Level Disadvantage and Delayed Adjuvant Therapy in Head and Neck Cancer
This multicenter cohort study examines if living in a socioeconomically disadvantaged neighborhood is associated with an increased likelihood of delays in initiating guideline-adherent adjuvant radiation therapy among patients with head and neck cancer. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - April 25, 2024 Category: ENT & OMF Source Type: research
Impact of data transfer between treatment planning systems on dosimetric parameters
The main goal in radiotherapy is to generate a quality treatment plan that best achieves the clinical prescription. This involves striking a balance between delivering a high dose to the tumor to maximize control and minimizing doses to organs at risk (OARs) to reduce treatment-related toxicity. Treatment planning involves several steps, from simulation to the computation and reporting of the clinical plan. Maintaining consistent quality throughout this process requires close collaboration and communication among clinicians, physicists, and radiation therapy technicians (RTT). (Source: Physica Medica: European Journal of Medical Physics)
Source: Physica Medica: European Journal of Medical Physics - April 25, 2024 Category: General Medicine Authors: Guenda Meffe, Claudio Votta, Gabriele Turco, Elena Chill è, Matteo Nardini, Angela Romano, Giuditta Chiloiro, Giulia Panza, Matteo Galetto, Amedeo Capotosti, Roberto Moretti, Maria Antonietta Gambacorta, Luca Boldrini, Luca Indovina, Lorenzo Placidi Tags: Technical Note Source Type: research
Clinical Outcomes of Salvage Microsurgical Resection after Radiation Therapy for Sporadic Vestibular Schwannomas
Conclusions Compared to patients with VS treated with surgery alone, previously radiated patients are less likely to achieve gross total resection in the salvage setting. Radiated patients scored better on facial nerve outcomes compared to nonradiated patients in the initial postoperative period but demonstrated similar long-term outcomes. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Journal of Neurological Surgery Part B: Skull Base)
Source: Journal of Neurological Surgery Part B: Skull Base - April 25, 2024 Category: Neurosurgery Authors: Moshtaghi, Omid Barba, Patrick Dixon, Peter Ren, Yin Schwartz, Marc Friedman, Rick Tags: Original Article Source Type: research
Immediate Lymphatic Reconstruction: Lessons Learned Over Eight Years
Immediate lymphatic reconstruction (ILR) is recognized as a surgical approach to reduce the risk of developing secondary lymphedema and evidence demonstrating the efficacy of ILR is favorable. Our Lymphatic Center has become a centralized location offering ILR for the risk-reduction of breast cancer related lymphedema (BCRL) in New England. Over the course of our experience, we have made several modifications and adapted our approach to enhance the operative success of this procedure. These include advancements in our use of ICG imaging to identify baseline lymphatic anatomical variation, the utilization of fluorescein iso...
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - April 25, 2024 Category: Cosmetic Surgery Authors: Rosie Friedman, Mohamed A. Ismail Aly, James E. Fanning, Jaime A. Pardo, Anna Rose Johnson, Bernard T. Lee, Ted James, Dhruv Singhal Source Type: research
Automatic segmentation of tumour and organs at risk in 3D MRI for cervical cancer radiation therapy with anatomical variations
Phys Eng Sci Med. 2024 Apr 24. doi: 10.1007/s13246-024-01415-y. Online ahead of print.ABSTRACTCervical cancer is a common cancer in women globally, with treatment usually involving radiation therapy (RT). Accurate segmentation for the tumour site and organ-at-risks (OARs) could assist in the reduction of treatment side effects and improve treatment planning efficiency. Cervical cancer Magnetic Resonance Imaging (MRI) segmentation is challenging due to a limited amount of training data available and large inter- and intra- patient shape variation for OARs. The proposed Masked-Net consists of a masked encoder within the 3D U...
Source: Health Physics - April 24, 2024 Category: Physics Authors: Sze-Nung Leung Shekhar S Chandra Karen Lim Tony Young Lois Holloway Jason A Dowling Source Type: research
Therapeutic benefit of larotrectinib over the historical standard of care in patients with locally advanced or metastatic infantile fibrosarcoma (EPI VITRAKVI study)
CONCLUSIONS: Treatment with larotrectinib reduced the need of subsequent therapies compared to SOC with chemotherapy in children with locally advanced or metastatic IFS, regardless of the line of treatment.PMID:38657345 | DOI:10.1016/j.esmoop.2024.103006 (Source: Cancer Control)
Source: Cancer Control - April 24, 2024 Category: Cancer & Oncology Authors: D Orbach M Carton S K Khadir M Feuilly M Kurtinecz C Vokuhl E Koscielniak G Pierron L Lemelle M Sparber-Sauer Source Type: research
Automatic segmentation of tumour and organs at risk in 3D MRI for cervical cancer radiation therapy with anatomical variations
Phys Eng Sci Med. 2024 Apr 24. doi: 10.1007/s13246-024-01415-y. Online ahead of print.ABSTRACTCervical cancer is a common cancer in women globally, with treatment usually involving radiation therapy (RT). Accurate segmentation for the tumour site and organ-at-risks (OARs) could assist in the reduction of treatment side effects and improve treatment planning efficiency. Cervical cancer Magnetic Resonance Imaging (MRI) segmentation is challenging due to a limited amount of training data available and large inter- and intra- patient shape variation for OARs. The proposed Masked-Net consists of a masked encoder within the 3D U...
Source: Health Physics - April 24, 2024 Category: Physics Authors: Sze-Nung Leung Shekhar S Chandra Karen Lim Tony Young Lois Holloway Jason A Dowling Source Type: research
Pulmonary artery pseudoaneurysm after thoracic radiation therapy: A case report and review of the literature
We describe a 72-year-old patient, with a past medical history of a lung carcinoma for which she was treated with chemoradiotherapy 6 years prior, who presented with hemoptysis. She was hemodynamically stable and there were no other complaints. CT angiography of the thorax showed a PAP originating from a branch of the right pulmonary artery in the previously irradiated area. The patient was successfully treated by an embolizati on with plugs. Treatment of lung carcinoma with chemoradiotherapy can result in the development of a PAP. Clinicians should be aware of this complication, even years after the therapy. In literat...
Source: Respirology Case Reports - April 24, 2024 Category: Respiratory Medicine Authors: Gerdinique (G. C.) Maessen,
Thijs ( T. W.) Hoffman,
Lidwien ( L.) Graat ‐Verboom,
Marc ( M.) van Leersum,
Hans‐Jurgen ( J. J.) Mager Tags: CASE REPORT Source Type: research
Single versus multiple reoperations for recurrent intracranial meningiomas
ConclusionThe extent of resection and the multicentric-diffuse pattern of regrowth at first recurrence are the main risk factors for multiple recurrences and reoperations. Repeated reoperations might be considered even in patients with extensive recurrent tumors before the anaplastic transformation occurs. In such cases, even partial tumor resections followed by radiation therapy may allow long survival in good clinical conditions. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 24, 2024 Category: Cancer & Oncology Source Type: research
