A Phase II Study Evaluating the Effect of Intensity-Modulated Post-Mastectomy Radiation Therapy on Implant Failure Rates in Breast Cancer Patients with Immediate, 2-Stage Implant Reconstruction, with an MRI imaging correlative substudy
Postmastectomy radiation therapy (PMRT) is a mainstay in the adjuvant treatment of node-positive breast cancer, but it poses risks for women with breast reconstruction. Multi-beam intensity-modulated radiation therapy (IMRT) improves dose conformality and homogeneity, potentially reducing complications in breast cancer patients with implant-based reconstruction. To investigate this hypothesis, we conducted a single-arm phase II clinical trial of breast cancer patients who underwent mastectomy/axillary dissection and prosthesis-based reconstruction. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - April 1, 2024 Category: Radiology Authors: Atif J. Khan, Catherine B. Marine, Jessica Flynn, Neelam Tyagi, Zhigang Zhang, Maria Thor, Daphna Gelblum, Babak Mehrara, Beryl McCormick, Simon N. Powell, Alice Y. Ho Tags: Clinical Investigation Source Type: research
Usefulness of the Constant load Cycle Endurance Test in patients with Lung Cancer during Radiation Therapy
The purpose of this study to determine the validity of constant load cycle endurance test (CET) on workload of 75% of maximal power in patients in lung cancer patients during radiation therapy. And we would like to know the usefulness and feasibility of CET in the results of pulmonary rehabilitation (PR). (Source: Archives of Physical Medicine and Rehabilitation)
Source: Archives of Physical Medicine and Rehabilitation - April 1, 2024 Category: Rehabilitation Authors: A Hyun Kim, Jung Hwa Do Tags: Research Poster 2522454 Source Type: research
Radiotherapy protocols for mouse cancer model
In this study, we present two comprehensive radiotherapy protocols for the treatment of orthotopic melanoma and glioblastoma tumors. These protocols utilize a small animal radiation research platform, which is an ideal radiation device for delivering localized and precise X-ray doses to the tumor mass. By employing these platforms, we aim to limit the side effects associated with irradiating healthy surrounding tissues. Our detailed protocols offer a valuable framework for conducting preclinical studies that closely mimic clinical radiotherapy techniques, bridging the gap between experimental results and patient outcomes.P...
Source: Cancer Control - March 31, 2024 Category: Cancer & Oncology Authors: Eneko Garate-Soraluze Javier Marco-Sanz Irantzu Serrano-Mendioroz Luc ía Marrodán Leticia Fernandez-Rubio Sara Labiano Mar ía E Rodríguez-Ruiz Source Type: research
Evaluation of the trend of set-up errors during the treatment period using set-up margin in prostate radiotherapy
This study aimed to develop an evaluation method of the temporal trends in a patient's specific prostate movement during treatment using image matching and margin values. This study included 65 patients who underwent prostate volumetric modulated arc therapy (mean treatment time, 87.2 s). Set-up errors were assessed using bone, inter-, and intra-fraction marker matching across 39 fractions. The set-up margin was determined by dividing the four periods into 39 fractions using Stroom's formula and correlation coefficient. The intra-fraction set-up error was biased in the anterior-superior (AS) direction during treatment. The...
Source: Cancer Control - March 31, 2024 Category: Cancer & Oncology Authors: Hinako Sasaki Takumi Morishita Naho Irie Rena Kojima Tetsukazu Kiriyama Akira Nakamoto Kunio Nishioka Shotaro Takahashi Yoshinori Tanabe Source Type: research
Post-radiation lichen planus: a case report and review of the literature
ConclusionOnce more biopsy-proven cases of post-radiation lichen planus are reported, hopefully the exact mechanism can be elucidated. This may identify risk factors and aid in treatment, with the goal of limiting radiation toxicity and palliation of symptoms that may affect the quality of daily life. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - March 31, 2024 Category: General Medicine Source Type: research
Cancers, Vol. 16, Pages 1384: Lonidamine Induced Selective Acidification and De-Energization of Prostate Cancer Xenografts: Enhanced Tumor Response to Radiation Therapy
t
Kavindra Nath
Prostate cancer is a multi-focal disease that can be treated using surgery, radiation, androgen deprivation, and chemotherapy, depending on its presentation. Standard dose-escalated radiation therapy (RT) in the range of 70–80 Gray (GY) is a standard treatment option for prostate cancer. It could be used at different phases of the disease (e.g., as the only primary treatment when the cancer is confined to the prostate gland, combined with other therapies, or as an adjuvant treatment after surgery). Unfortunately, RT for prostate cancer is associated with gastro-intestinal and genitourina...
Source: Cancers - March 31, 2024 Category: Cancer & Oncology Authors: Stepan Orlovskiy Pradeep Kumar Gupta Jeffrey Roman Fernando Arias-Mendoza David S. Nelson Cameron J. Koch Vivek Narayan Mary E. Putt Kavindra Nath Tags: Article Source Type: research
Reirradiation salvage radiotherapy for recurrent prostate cancer after primary low-dose brachytherapy
ConclusionsOur data suggest that the treatment of locally recurrent prostate cancer with S-EBRT could provide adequate disease control safely and be used as an additional treatment in the natural history of prostate cancer patients. However, the results are still early and the sample is small; larger studies with longer follow-up would be mandatory. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - March 30, 2024 Category: Cancer & Oncology Source Type: research
A five-year review of chemoradiotherapy practice in anal cancer: Radiotherapy audit results from a cancer centre in Wales, UK
CONCLUSION: Audit results matched with the standards in six domains. Overall treatment time of 37.9 days, colostomy rates of 1.2%, and the 30-day mortality rate of 1.2% were commendable. Overall time interval between consent and CRT delivery can be achieved by time-constrained measures.PMID:38553430 | DOI:10.1177/03008916241241424 (Source: Tumori)
Source: Tumori - March 30, 2024 Category: Cancer & Oncology Authors: Mutahar A Tunio Nicki Davies Elliot Caparros Janis Davies Stuart Foyle Source Type: research
Commissioning and clinical implementation of an independent dose calculation system for scanned proton beams
CONCLUSION: IDC has been successfully commissioned and integrated into the MedAustron clinical workflow for protons in 2021. IDC has been stepwise and safely substituting experimental PSQA since February 2021. The initial reduction of proton experimental PSQA was about 25% and reached up to 90% after 1 year.PMID:38553788 | DOI:10.1002/acm2.14328 (Source: Journal of Applied Clinical Medical Physics)
Source: Journal of Applied Clinical Medical Physics - March 30, 2024 Category: Physics Authors: Ralf Dreindl Marta Bolsa-Ferruz Rosa Fayos-Sola Fatima Padilla Cabal Lukas Scheuchenpflug Alessio Elia Antonio Amico Antonio Carlino Markus Stock Lo ïc Grevillot Source Type: research
Dosimetric comparison between carotid-sparing IMRT and 3DCRT in early glottic cancer patients treated with definitive radiation therapy
CONCLUSION: Carotid-sparing IMRT resulted in better PTV coverage and lower carotid artery dose as compared to 3DCRT in early glottic cancer patients.PMID:38554342 | DOI:10.4103/jcrt.jcrt_1912_22 (Source: Cell Research)
Source: Cell Research - March 30, 2024 Category: Cytology Authors: Harkirat Kaur Niketa Thakur Ramita Sharma Meena Sudan Neeraj Jain Supreet Kaur Priyanka Lehal Source Type: research
Evaluation of the neuroprotective effect of quercetin against damage caused by gamma radiation
CONCLUSION: Consequently, quercetin may be a potential pharmacological agent in modulating radiation-induced damage in rats. However, extra experimental and preclinical studies are needed to confirm our findings before they can be used clinically.PMID:38554331 | DOI:10.4103/jcrt.jcrt_348_21 (Source: Cell Research)
Source: Cell Research - March 30, 2024 Category: Cytology Authors: Munevver Baran Kemal E Ba şaran Ozlem Oz Gergin Ozge Ceng ız O ğuz G Yıldız Arzu Yay Source Type: research
Extramedullary plasmacytoma of the larynx - Case report
The objective of this clinical case report is to highlight the diagnosis and management of a unique case such as this. A 77-year-old gentleman presented with complaints of hoarseness for 1 year. Computed tomography image revealed a soft tissue mass lesion involving the right true vocal cord. Direct laryngoscopic biopsy was performed and subjected to histopathological examination, which showed collection of plasma cells. Immunohistochemistry confirmed the presence of Kappa and Lambda cells. Multiple myeloma (MM) was ruled out. The patient received radical intent radiation therapy using 3DCRT technique with a dose of 50Gy in...
Source: Cancer Control - March 30, 2024 Category: Cancer & Oncology Authors: Ajinkya Gupte Ajay Sasidharan Debnarayan Dutta R Anoop Source Type: research
Evaluation of the neuroprotective effect of quercetin against damage caused by gamma radiation
CONCLUSION: Consequently, quercetin may be a potential pharmacological agent in modulating radiation-induced damage in rats. However, extra experimental and preclinical studies are needed to confirm our findings before they can be used clinically.PMID:38554331 | DOI:10.4103/jcrt.jcrt_348_21 (Source: Cancer Control)
Source: Cancer Control - March 30, 2024 Category: Cancer & Oncology Authors: Munevver Baran Kemal E Ba şaran Ozlem Oz Gergin Ozge Ceng ız O ğuz G Yıldız Arzu Yay Source Type: research
Risk factors for local recurrence of keloids and hypertrophic scars after postoperative electron beam radiotherapy
CONCLUSION: This result could be used for follow-up and as a determinant for the optimal dose/fractionation of postoperative radiotherapy.PMID:38554315 | DOI:10.4103/jcrt.jcrt_1861_22 (Source: Cancer Control)
Source: Cancer Control - March 30, 2024 Category: Cancer & Oncology Authors: Atsuto Katano Masanari Minamitani Hideomi Yamashita Source Type: research
Efficacy of matrix rhythm therapy (MaRhyThe) over conventional therapy on radiation induced trismus-A pilot randomised control trial
J Cancer Res Ther. 2024 Jan 1;20(1):118-125. doi: 10.4103/jcrt.jcrt_1198_22. Epub 2023 Apr 8.ABSTRACTBACKGROUND AND OBJECTIVES: Prevalence of radiation induced trismus in head and neck cancer (HNC) is 38% to 42% globally. Radiation induced trismus depends on the dosage of the radiation therapy and the surgical procedure. Myofascial release (MFR) and Matrix rhythm therapy (MaRhyThe©) are techniques used to treat the myofascial pain and muscular restriction. The present study aimed to compare the effect of MFR and MaRhyThe© on pain, mouth opening, TMJ disability index (TDI), Gothenburg Trismuus Questionnaire (GTQ), Functio...
Source: Cancer Control - March 30, 2024 Category: Cancer & Oncology Authors: Rushil Deepak Tanna Renu B Pattanshetty Imtiaz Ahmed Source Type: research
