Conditional survival analysis and real-time prognosis prediction in stage III T3 –T4 colon cancer patients after surgical resection: a SEER database analysis
ConclusionsOur study developed nomograms and predictive models for postoperative stage III survival in T3 –T4 colon cancer with the aim of accurately estimating conditional survival. Survival bias in our analyses may lead to overestimation of survival outcomes, which may limit the applicability of our findings. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - April 19, 2024 Category: Gastroenterology Source Type: research
Hormone replacement therapy in women with iatrogenic premature ovarian insufficiency after radiotherapy for cervical cancer: A retrospective cohort and survey study
According to a GLOBOCAN summary of 185 countries in 2020, there were 604,127 cases of cervical cancer worldwide and 341,831 deaths. The majority of affected women are younger than 50 years of age at diagnosis [1]. As the average age of onset of natural menopause is 51 [2], most women diagnosed and treated for cervical cancer are premenopausal at the time of diagnosis. The treatment options for cervical cancer include surgery and/or (chemo)radiation therapy, depending on the s tage of the disease [3,4]. (Source: Maturitas)
Source: Maturitas - April 19, 2024 Category: Primary Care Authors: Charlotte van der Hoef, Lawrencia Dsane Bawuah, Nicoline Schuur, Yvonne V. Louwers, Jan Willem Mens, Nadia Hikary-Bhal, Helena C. van Doorn Tags: Original article Source Type: research
The impact of advancing the standard of care in radiotherapy on operational treatment resources
CONCLUSION: The clinical implementation of hypofractionated treatment regimens has successfully reduced the radiotherapy workload and operational treatment hours required to treat patients. This analysis describes the impact of changes to the standard of care on institutional resources.PMID:38634814 | DOI:10.1002/acm2.14363 (Source: Journal of Applied Clinical Medical Physics)
Source: Journal of Applied Clinical Medical Physics - April 18, 2024 Category: Physics Authors: Michael Roumeliotis Kundan Thind Hali Morrison Ben Burke Kevin Martell Lukas van Dyke Lisa Barbera Sarah Quirk Source Type: research
The impact of advancing the standard of care in radiotherapy on operational treatment resources
CONCLUSION: The clinical implementation of hypofractionated treatment regimens has successfully reduced the radiotherapy workload and operational treatment hours required to treat patients. This analysis describes the impact of changes to the standard of care on institutional resources.PMID:38634814 | DOI:10.1002/acm2.14363 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - April 18, 2024 Category: Cancer & Oncology Authors: Michael Roumeliotis Kundan Thind Hali Morrison Ben Burke Kevin Martell Lukas van Dyke Lisa Barbera Sarah Quirk Source Type: research
The impact of advancing the standard of care in radiotherapy on operational treatment resources
CONCLUSION: The clinical implementation of hypofractionated treatment regimens has successfully reduced the radiotherapy workload and operational treatment hours required to treat patients. This analysis describes the impact of changes to the standard of care on institutional resources.PMID:38634814 | DOI:10.1002/acm2.14363 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 18, 2024 Category: Cancer & Oncology Authors: Michael Roumeliotis Kundan Thind Hali Morrison Ben Burke Kevin Martell Lukas van Dyke Lisa Barbera Sarah Quirk Source Type: research
The impact of advancing the standard of care in radiotherapy on operational treatment resources
CONCLUSION: The clinical implementation of hypofractionated treatment regimens has successfully reduced the radiotherapy workload and operational treatment hours required to treat patients. This analysis describes the impact of changes to the standard of care on institutional resources.PMID:38634814 | DOI:10.1002/acm2.14363 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 18, 2024 Category: Cancer & Oncology Authors: Michael Roumeliotis Kundan Thind Hali Morrison Ben Burke Kevin Martell Lukas van Dyke Lisa Barbera Sarah Quirk Source Type: research
The impact of advancing the standard of care in radiotherapy on operational treatment resources
CONCLUSION: The clinical implementation of hypofractionated treatment regimens has successfully reduced the radiotherapy workload and operational treatment hours required to treat patients. This analysis describes the impact of changes to the standard of care on institutional resources.PMID:38634814 | DOI:10.1002/acm2.14363 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - April 18, 2024 Category: Cancer & Oncology Authors: Michael Roumeliotis Kundan Thind Hali Morrison Ben Burke Kevin Martell Lukas van Dyke Lisa Barbera Sarah Quirk Source Type: research
An assessment of the association between patient characteristics and timely lung cancer treatment
ConclusionsWithin a Medicare Advantage population, patient demographics were found to be significantly associated with the decision to pursue surgery, but factors other than stage were not significantly associated with time to non-systemic treatment. (Source: Cancer Causes and Control)
Source: Cancer Causes and Control - April 18, 2024 Category: Cancer & Oncology Source Type: research
Aggressive variant prostate cancer with multiple subcutaneous metastases: a case report
AbstractA 71-year-old man with bone metastasis of hormone-sensitive prostate cancer was treated with androgen deprivation therapy and apalutamide. Radium-223 and radiation therapy were administered after it become castration resistant. Although prostate-specific antigen levels remained low, multiple subcutaneous metastases of neuroendocrine prostate cancer were observed. A review of the pre-treatment prostate needle biopsy revealed a small component with features suggestive of neuroendocrine differentiation. Phosphatase and tensine homolog loss and tumor protein p53 overexpression were observed, confirming the diagnosis of...
Source: International Cancer Conference Journal - April 18, 2024 Category: Cancer & Oncology Source Type: research
Intracranial malignant peripheral nerve sheath tumor: A case report and comprehensive literature review
CONCLUSION: MPNSTs comprise a group of highly aggressive neoplasms that rarely arise intracranially. Gross total surgical resection should be pursued when feasible.PMID:38628513 | PMC:PMC11021080 | DOI:10.25259/SNI_931_2023 (Source: Surgical Neurology International)
Source: Surgical Neurology International - April 17, 2024 Category: Neurosurgery Authors: Brandon Michael Wilkinson Michael A Duncan Richard Davila Brian Nicholas Harish Babu Source Type: research
Phase II, Single-Arm Trial of Induction and Concurrent Vismodegib With Curative-Intent Radiation Therapy for Locally Advanced, Unresectable Basal Cell Carcinoma
CONCLUSION: In patients with unresectable LA BCC, the combination of vismodegib and RT yielded high rates of LRC and PFS and durable improvements in PRQOL.PMID:38630954 | DOI:10.1200/JCO.23.01708 (Source: Cancer Control)
Source: Cancer Control - April 17, 2024 Category: Cancer & Oncology Authors: Christopher A Barker Suzanne Dufault Sarah T Arron Alan L Ho Alain P Algazi Lara A Dunn Audrey A Humphries Carter Hultman Ming Lian P Daniel Knott Sue S Yom Source Type: research
Combination therapy involving HSP90 inhibitors for combating cancer: an overview of clinical and preclinical progress
Arch Pharm Res. 2024 Apr 17. doi: 10.1007/s12272-024-01494-1. Online ahead of print.ABSTRACTThe molecular chaperone heat shock protein 90 (HSP90) regulates multiple crucial signalling pathways in cancer by driving the maturation of key signalling components, thereby playing a crucial role in tumorigenesis and drug resistance in cancer. Inhibition of HSP90 results in metastable conformational collapse of its client proteins and their proteasomal degradation. Considerable efforts have been devoted to the development of small-molecule inhibitors targeting HSP90, and more than 20 inhibitors have been evaluated in clinical tria...
Source: Archives of Pharmacal Research - April 17, 2024 Category: Drugs & Pharmacology Authors: Yajun Liu Chenyao Li Hongwei Liu Shutao Tan Source Type: research
Incorporating functional lung imaging (FLI) into radiation therapy planning in patients with lung cancer: A systematic review and meta-analysis
CONCLUSIONS: FLI shows promise as a method to spare FL during thoracic RT, but interventional trials related to FL avoidance planning are sparse. Such trials are critical to understanding the impact of FL avoidance planning on toxicity reduction and patient outcomes.PMID:38631538 | DOI:10.1016/j.ijrobp.2024.04.001 (Source: Health Physics)
Source: Health Physics - April 17, 2024 Category: Physics Authors: Julie Midroni Rohan Salunkhe Zhihui Liu Ronald Chow Gabriel Boldt David Palma Douglas Hoover Yevgeniy Vinogradskiy Srinivas Raman Source Type: research
Intracranial malignant peripheral nerve sheath tumor: A case report and comprehensive literature review
CONCLUSION: MPNSTs comprise a group of highly aggressive neoplasms that rarely arise intracranially. Gross total surgical resection should be pursued when feasible.PMID:38628513 | PMC:PMC11021080 | DOI:10.25259/SNI_931_2023 (Source: Surgical Neurology International)
Source: Surgical Neurology International - April 17, 2024 Category: Neurosurgery Authors: Brandon Michael Wilkinson Michael A Duncan Richard Davila Brian Nicholas Harish Babu Source Type: research
Combination therapy involving HSP90 inhibitors for combating cancer: an overview of clinical and preclinical progress
Arch Pharm Res. 2024 Apr 17. doi: 10.1007/s12272-024-01494-1. Online ahead of print.ABSTRACTThe molecular chaperone heat shock protein 90 (HSP90) regulates multiple crucial signalling pathways in cancer by driving the maturation of key signalling components, thereby playing a crucial role in tumorigenesis and drug resistance in cancer. Inhibition of HSP90 results in metastable conformational collapse of its client proteins and their proteasomal degradation. Considerable efforts have been devoted to the development of small-molecule inhibitors targeting HSP90, and more than 20 inhibitors have been evaluated in clinical tria...
Source: Archives of Pharmacal Research - April 17, 2024 Category: Drugs & Pharmacology Authors: Yajun Liu Chenyao Li Hongwei Liu Shutao Tan Source Type: research
