Enhancement of the Tumor Suppression Effect of High-dose Radiation by Low-dose Pre-radiation Through Inhibition of DNA Damage Repair and Increased Pyroptosis
Dose Response. 2024 Apr 11;22(2):15593258241245804. doi: 10.1177/15593258241245804. eCollection 2024 Apr-Jun.ABSTRACTRadiation therapy has been a critical and effective treatment for cancer. However, not all cells are destroyed by radiation due to the presence of tumor cell radioresistance. In the current study, we investigated the effect of low-dose radiation (LDR) on the tumor suppressive effect of high-dose radiation (HDR) and its mechanism from the perspective of tumor cell death mode and DNA damage repair, aiming to provide a foundation for improving the efficacy of clinical tumor radiotherapy. We found that LDR pre-i...
Source: Dose Response - April 15, 2024 Category: Drugs & Pharmacology Authors: Xinfeng Wei Junxuan Yi Citong Zhang Mingwei Wang Rui Wang Weiqiang Xu Mingqi Zhao Mengdie Zhao Teng Yang Wei Wei Shunzi Jin Hui Gao Source Type: research
Recent progress in radioactive seed implantation brachytherapy of non-small cell lung cancer: a narrative review
CONCLUSIONS: This review demonstrates that RSI-BT can be therapeutic in the treatment of both early and advanced NSCLC with manageable complications. There have also been reports on the combination of RSI-BT with other therapies, but more research is needed on the combination of RSI-BT with them.PMID:38617768 | PMC:PMC11009575 | DOI:10.21037/jtd-23-1600 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 15, 2024 Category: Respiratory Medicine Authors: Xinyu Wang Sen Tian Hui Shi Hao Qin Wei Zhang Yuchao Dong Chong Bai Source Type: research
Clinical-radiomics nomogram for the risk prediction of esophageal fistula in patients with esophageal squamous cell carcinoma treated with intensity-modulated radiation therapy or volumetric-modulated arc therapy
CONCLUSIONS: The clinical-radiomics nomogram can predict the risk of EF in ESCC patients and is helpful for the individualized treatment of EC.PMID:38617757 | PMC:PMC11009608 | DOI:10.21037/jtd-24-191 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 15, 2024 Category: Respiratory Medicine Authors: Zhaohui Li Jie Gong Liu Shi Jie Li Zhi Yang Guangjin Chai Bo Lv Geng Xiang Bin Wang Shamus R Carr Alfonso Fiorelli Mei Shi Yilin Zhao Lina Zhao Source Type: research
Primary intradural Extraosseous Ewing's sarcoma of the cauda equina: a Case Report and Literature Review
We report a case of a 66-year-old male who presented with a 2-month history of low back pain and bilateral S1 sciatica, with acute sphincter dysfunction. Imaging studies revealed an intradural extramedullary lesion in the cauda equina spanning from level L4 to S1. The patient underwent partial removal of the intradural lesion. Histopathological examination showed the presence of small round cells, which were consistent with Ewing Sarcoma. The patient was then treated with targeted radiation therapy and chemotherapy. The rarity of IEES in this specific location underscores the significance of evaluating and managing patient...
Source: Neuro-Chirurgie - April 15, 2024 Category: Neurosurgery Authors: Manel Krouma Kaissar Farah Anis Choucha Romain Appay Florence Duffaud Stephane Fuentes Henry Dufour Source Type: research
Enhancement of the Tumor Suppression Effect of High-dose Radiation by Low-dose Pre-radiation Through Inhibition of DNA Damage Repair and Increased Pyroptosis
Dose Response. 2024 Apr 11;22(2):15593258241245804. doi: 10.1177/15593258241245804. eCollection 2024 Apr-Jun.ABSTRACTRadiation therapy has been a critical and effective treatment for cancer. However, not all cells are destroyed by radiation due to the presence of tumor cell radioresistance. In the current study, we investigated the effect of low-dose radiation (LDR) on the tumor suppressive effect of high-dose radiation (HDR) and its mechanism from the perspective of tumor cell death mode and DNA damage repair, aiming to provide a foundation for improving the efficacy of clinical tumor radiotherapy. We found that LDR pre-i...
Source: Dose Response - April 15, 2024 Category: Drugs & Pharmacology Authors: Xinfeng Wei Junxuan Yi Citong Zhang Mingwei Wang Rui Wang Weiqiang Xu Mingqi Zhao Mengdie Zhao Teng Yang Wei Wei Shunzi Jin Hui Gao Source Type: research
Primary intradural Extraosseous Ewing's sarcoma of the cauda equina: a Case Report and Literature Review
We report a case of a 66-year-old male who presented with a 2-month history of low back pain and bilateral S1 sciatica, with acute sphincter dysfunction. Imaging studies revealed an intradural extramedullary lesion in the cauda equina spanning from level L4 to S1. The patient underwent partial removal of the intradural lesion. Histopathological examination showed the presence of small round cells, which were consistent with Ewing Sarcoma. The patient was then treated with targeted radiation therapy and chemotherapy. The rarity of IEES in this specific location underscores the significance of evaluating and managing patient...
Source: Neurochirurgie - April 15, 2024 Category: Neurosurgery Authors: Manel Krouma Kaissar Farah Anis Choucha Romain Appay Florence Duffaud Stephane Fuentes Henry Dufour Source Type: research
Enhancement of the Tumor Suppression Effect of High-dose Radiation by Low-dose Pre-radiation Through Inhibition of DNA Damage Repair and Increased Pyroptosis
Dose Response. 2024 Apr 11;22(2):15593258241245804. doi: 10.1177/15593258241245804. eCollection 2024 Apr-Jun.ABSTRACTRadiation therapy has been a critical and effective treatment for cancer. However, not all cells are destroyed by radiation due to the presence of tumor cell radioresistance. In the current study, we investigated the effect of low-dose radiation (LDR) on the tumor suppressive effect of high-dose radiation (HDR) and its mechanism from the perspective of tumor cell death mode and DNA damage repair, aiming to provide a foundation for improving the efficacy of clinical tumor radiotherapy. We found that LDR pre-i...
Source: Dose Response - April 15, 2024 Category: Drugs & Pharmacology Authors: Xinfeng Wei Junxuan Yi Citong Zhang Mingwei Wang Rui Wang Weiqiang Xu Mingqi Zhao Mengdie Zhao Teng Yang Wei Wei Shunzi Jin Hui Gao Source Type: research
Recent progress in radioactive seed implantation brachytherapy of non-small cell lung cancer: a narrative review
CONCLUSIONS: This review demonstrates that RSI-BT can be therapeutic in the treatment of both early and advanced NSCLC with manageable complications. There have also been reports on the combination of RSI-BT with other therapies, but more research is needed on the combination of RSI-BT with them.PMID:38617768 | PMC:PMC11009575 | DOI:10.21037/jtd-23-1600 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 15, 2024 Category: Respiratory Medicine Authors: Xinyu Wang Sen Tian Hui Shi Hao Qin Wei Zhang Yuchao Dong Chong Bai Source Type: research
Clinical-radiomics nomogram for the risk prediction of esophageal fistula in patients with esophageal squamous cell carcinoma treated with intensity-modulated radiation therapy or volumetric-modulated arc therapy
CONCLUSIONS: The clinical-radiomics nomogram can predict the risk of EF in ESCC patients and is helpful for the individualized treatment of EC.PMID:38617757 | PMC:PMC11009608 | DOI:10.21037/jtd-24-191 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 15, 2024 Category: Respiratory Medicine Authors: Zhaohui Li Jie Gong Liu Shi Jie Li Zhi Yang Guangjin Chai Bo Lv Geng Xiang Bin Wang Shamus R Carr Alfonso Fiorelli Mei Shi Yilin Zhao Lina Zhao Source Type: research
Primary intradural Extraosseous Ewing's sarcoma of the cauda equina: a Case Report and Literature Review
We report a case of a 66-year-old male who presented with a 2-month history of low back pain and bilateral S1 sciatica, with acute sphincter dysfunction. Imaging studies revealed an intradural extramedullary lesion in the cauda equina spanning from level L4 to S1. The patient underwent partial removal of the intradural lesion. Histopathological examination showed the presence of small round cells, which were consistent with Ewing Sarcoma. The patient was then treated with targeted radiation therapy and chemotherapy. The rarity of IEES in this specific location underscores the significance of evaluating and managing patient...
Source: Neuro-Chirurgie - April 15, 2024 Category: Neurosurgery Authors: Manel Krouma Kaissar Farah Anis Choucha Romain Appay Florence Duffaud Stephane Fuentes Henry Dufour Source Type: research
Primary intradural Extraosseous Ewing's sarcoma of the cauda equina: a Case Report and Literature Review
We report a case of a 66-year-old male who presented with a 2-month history of low back pain and bilateral S1 sciatica, with acute sphincter dysfunction. Imaging studies revealed an intradural extramedullary lesion in the cauda equina spanning from level L4 to S1. The patient underwent partial removal of the intradural lesion. Histopathological examination showed the presence of small round cells, which were consistent with Ewing Sarcoma. The patient was then treated with targeted radiation therapy and chemotherapy. The rarity of IEES in this specific location underscores the significance of evaluating and managing patient...
Source: Neurochirurgie - April 15, 2024 Category: Neurosurgery Authors: Manel Krouma Kaissar Farah Anis Choucha Romain Appay Florence Duffaud Stephane Fuentes Henry Dufour Source Type: research
Recent progress in radioactive seed implantation brachytherapy of non-small cell lung cancer: a narrative review
CONCLUSIONS: This review demonstrates that RSI-BT can be therapeutic in the treatment of both early and advanced NSCLC with manageable complications. There have also been reports on the combination of RSI-BT with other therapies, but more research is needed on the combination of RSI-BT with them.PMID:38617768 | PMC:PMC11009575 | DOI:10.21037/jtd-23-1600 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 15, 2024 Category: Respiratory Medicine Authors: Xinyu Wang Sen Tian Hui Shi Hao Qin Wei Zhang Yuchao Dong Chong Bai Source Type: research
Clinical-radiomics nomogram for the risk prediction of esophageal fistula in patients with esophageal squamous cell carcinoma treated with intensity-modulated radiation therapy or volumetric-modulated arc therapy
CONCLUSIONS: The clinical-radiomics nomogram can predict the risk of EF in ESCC patients and is helpful for the individualized treatment of EC.PMID:38617757 | PMC:PMC11009608 | DOI:10.21037/jtd-24-191 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 15, 2024 Category: Respiratory Medicine Authors: Zhaohui Li Jie Gong Liu Shi Jie Li Zhi Yang Guangjin Chai Bo Lv Geng Xiang Bin Wang Shamus R Carr Alfonso Fiorelli Mei Shi Yilin Zhao Lina Zhao Source Type: research
Primary intradural Extraosseous Ewing's sarcoma of the cauda equina: a Case Report and Literature Review
We report a case of a 66-year-old male who presented with a 2-month history of low back pain and bilateral S1 sciatica, with acute sphincter dysfunction. Imaging studies revealed an intradural extramedullary lesion in the cauda equina spanning from level L4 to S1. The patient underwent partial removal of the intradural lesion. Histopathological examination showed the presence of small round cells, which were consistent with Ewing Sarcoma. The patient was then treated with targeted radiation therapy and chemotherapy. The rarity of IEES in this specific location underscores the significance of evaluating and managing patient...
Source: Neuro-Chirurgie - April 15, 2024 Category: Neurosurgery Authors: Manel Krouma Kaissar Farah Anis Choucha Romain Appay Florence Duffaud Stephane Fuentes Henry Dufour Source Type: research
Impact of outside referral and dental extractions on package time with post ‐operative radiation therapy for head and neck cancer
ConclusionsWe identified that outside referrals, but not dental extractions, prolong treatment package times. We also saw no effect of package time on RFS or OS. These results suggest that patients requesting outside facility referrals for RT may benefit from a streamlined program that expedites the referral process. (Source: Journal of Medical Imaging and Radiation Oncology)
Source: Journal of Medical Imaging and Radiation Oncology - April 15, 2024 Category: Radiology Authors: Joseph Nguyen,
Christopher McLaughlin Tags: Radiation Oncology —Original Article Source Type: research
