Observations of the effectiveness, dosage, and prognosis of intensity-modulated radiation therapy under ultrasonic guidance for cervical cancer patients
CONCLUSION: VMAT guided by ultrasound for patients with cervical cancer demonstrates promising short- and long-term treatment outcomes. It also leads to improvements in serum CEA, SCC-Ag, and CA724 levels, as well as reductions in the average radiation dosages to the radiotherapy target area, rectum, and bladder. This approach warrants attention from clinicians in clinical practice.PMID:38607778 | DOI:10.3233/THC-231977 (Source: Technology and Health Care)
Source: Technology and Health Care - April 12, 2024 Category: Medical Devices Authors: Chenxi Li Jian Li Yao Lu Jiahui Hou Zhaoyu Zhi Baocun Zhao Xiumei Zhang Source Type: research
Perceived control, self-management efficacy, and quality of life in patients treated with radiation therapy for breast cancer: a longitudinal study
ConclusionThe QoL, perceived control, and self-efficacy of patients with breast cancer show dynamic changes during radiotherapy. The higher the self-efficacy, the better the QoL, and the worse the QoL when the sense of disease control is poor. At the same time, more attention should be paid to the QoL of breast cancer radiotherapy patients with a long course of the disease, receiving chemotherapy, and different medical payment methods. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - April 12, 2024 Category: Cancer & Oncology Source Type: research
Diagnostic CT-Enabled Planning (DART): Results of a Randomized Trial in Palliative Radiation Therapy
Using diagnostic computed tomography (dCT) scans instead of CT simulation (CTsim) scans can increase departmental efficiency and reduce patient burden. The goal of the DART trial was to assess the efficacy and acceptability of dCT-based planning workflows with a focus on patient experiences, plan deliverability and adequacy of target coverage, and workflows. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - April 12, 2024 Category: Radiology Authors: Melissa O'Neil, Joanna M. Laba, Timothy K. Nguyen, Michael Lock, Christopher D. Goodman, Elizabeth Huynh, Jonatan Snir, Vikki Munro, Jenna Alce, Lidia Schrijver, Sylvia Lemay, Tara MacDonald, Andrew Warner, David A. Palma Tags: Clinical Investigation Source Type: research
Outcomes of extracranial stereotactic body radiation therapy for induced oligometastatic non-small cell lung cancer on novel systemic therapy
CONCLUSIONS: This study indicates that SBRT for OpersisD or OprogD in Stage IV NSCLC patients on osimertinib or ICIs is safe, very well tolerated, and may prolong the time before needing a shift in systemic therapy. Further prospective research is needed to validate and expand upon these findings.PMID:38601442 | PMC:PMC11002507 | DOI:10.21037/tlcr-23-802 (Source: Cell Research)
Source: Cell Research - April 11, 2024 Category: Cytology Authors: Eyal Tsur Philip Blumenfeld Yakir Rottenberg Hovav Nechushtan Johnathan Arnon Ori Wald Uzi Izhar Raphael Pfeffer Aron Krakow Marc Wygoda Aron Popovtzer Tal Falick Michaeli Source Type: research
Cancers, Vol. 16, Pages 1472: In Curative Stereotactic Body Radiation Therapy for Prostate Cancer, There Is a High Possibility That 45 Gy in Five Fractions Will Not Be Tolerated without a Hydrogel Spacer
This study was a phase 1 dose escalation trial conducted in Japan. Patients with histologically proven prostate cancer without lymph nodes or distant metastases were enrolled. The prescribed doses were 42.5, 45, or 47.5 Gy in five fractions. Dose-limiting toxicity (DLT) was defined as grade (G) 3+ gastrointestinal or genitourinary toxicity within 180 days after SBRT completion, and a 6 plus 6 design was used as the method of dose escalation. A total of 16 patients were enrolled, with 6 in the 42.5 Gy group and 10 in the 45 Gy group. No DLT was observed in the 42.5 Gy group. In the 45 Gy group, one patient experienced G3 re...
Source: Cancers - April 11, 2024 Category: Cancer & Oncology Authors: Subaru Sawayanagi Hideomi Yamashita Mami Ogita Taketo Kawai Yusuke Sato Haruki Kume Tags: Article Source Type: research
IOeRT conventional and FLASH treatment planning system implementation exploiting fast GPU Monte Carlo: The case of breast cancer
Partial breast irradiation for the treatment of early-stage breast cancer patients can be performed by means of Intra Operative electron Radiation Therapy (IOeRT). One of the main limitations of this technique is the absence of a treatment planning system (TPS) that could greatly help in ensuring a proper coverage of the target volume during irradiation. An IOeRT TPS has been developed using a fast Monte Carlo (MC) and an ultrasound imaging system to provide the best irradiation strategy (electron beam energy, applicator position and bevel angle) and to facilitate the optimisation of dose prescription and delivery to the t...
Source: Physica Medica: European Journal of Medical Physics - April 11, 2024 Category: General Medicine Authors: G. Franciosini, D. Carlotti, F. Cattani, A. De Gregorio, V. De Liso, F. De Rosa, M. Di Francesco, F. Di Martino, G. Felici, J. Harold Pensavalle, M.C. Leonardi, M. Marafini, A. Muscato, F. Paiar, V. Patera, P. Poortmans, A. Sciubba, A. Schiavi, M. Toppi, Tags: Original paper Source Type: research
Prospective trial of Functional Lung Avoidance Radiation Therapy for Lung Cancer: Quality of Life Report
A novel form of lung function imaging has been developed that uses 4DCT data to generate lung ventilation images (4DCT-ventilation). Functional avoidance uses 4DCT-ventilation to reduce doses to functional lung with the aim of reducing pulmonary side-effects. A 4DCT-ventilation functional avoidance, phase II, multi-center clinical trial was completed. The purpose of this work is to quantify patient reported outcomes (PRO) changes for patients treated with functional avoidance and to determine which metrics are predictive of PRO changes. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - April 11, 2024 Category: Radiology Authors: Joseph Lombardo, Edward Castillo, Richard Castillo, Ryan Miller, Bernard Jones, Moyed Miften, Brian Kavanagh, Adam Dicker, Cullen Boyle, Benjamin Leiby, Joshua Banks, Nicole L. Simone, Benjamin Movsas, Inga Grills, Thomas Guerrero, Chad G. Rusthoven, Yevg Tags: Physics Contribution Source Type: research
Long-term survival outcomes and quality of life of image-guided proton therapy for operable stage I non-small cell lung cancer: A phase 2 study
Definitive radiation therapy (RT), especially stereotactic body RT (SBRT), is an important treatment option for stage I non-small cell lung cancer (NSCLC). Surgical resection is the first-line management for operable patients, with SBRT recommended for medically inoperable patients or those who refuse surgery [1]. A recent pooled randomized and propensity-matched prospective study reported that SBRT was comparable to surgery in operable patients [2]. As patient preferences diversify, offering effective non-surgical options in the treatment decision process holds considerable clinical value. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - April 11, 2024 Category: Radiology Authors: Koichiro Nakajima, Masanosuke Oguri, Hiromitsu Iwata, Yukiko Hattori, Shingo Hashimoto, Kento Nomura, Kensuke Hayashi, Toshiyuki Toshito, Kenji Akita, Fumiya Baba, Hiroyuki Ogino, Akio Hiwatashi Tags: Original Article Source Type: research
Robust Optimization for Prostate Radiation Therapy: Assessment of Delivered Dose by Incorporating Intrafraction Prostate Position Deviations
CONCLUSIONS: Robust optimization resulted in lower V40 and V60 values for the bladder compared with PTV-based planning. However, no difference in CTV dose accuracy was found between the 2 approaches.PMID:38596454 | PMC:PMC11002539 | DOI:10.1016/j.adro.2024.101455 (Source: Adv Data)
Source: Adv Data - April 10, 2024 Category: Epidemiology Authors: Sankar Arumugam Mark Sidhom Source Type: research
Favorable Response of 225Ac-PSMA in the Treatment of Castration-Resistant Prostate Cancer With High Bone Metastasis Burden
Clin Nucl Med. 2024 Apr 5. doi: 10.1097/RLU.0000000000005222. Online ahead of print.ABSTRACT225Ac-PSMA treatment demonstrated low hematologic toxicity for prostate cancer with diffuse red marrow infiltration. A 70-year-old man with diffuse bone metastases of castration-resistant prostate cancer received 225Ac-PSMA radiation therapy. After 1 treatment cycle, the patient's skeletal lesions demonstrated a significant response and a significant decrease in PSA. 225Ac-PSMA may be a promising therapeutic option for metastatic castration-resistant prostate cancer patients with high bone metastatic burden.PMID:38598741 | DOI:10.10...
Source: Clinical Prostate Cancer - April 10, 2024 Category: Cancer & Oncology Authors: Yudi Wang Qingchu Hua Yu Zhang Wei Wang Yue Chen Source Type: research
Gamma knife radiosurgery for clival metastasis: case series and systematic review
CONCLUSION: Clival metastasis is rare and associated with poor prognosis. GKRS is a safe, effective treatment for clival metastasis.PMID:38598088 | DOI:10.1007/s11060-024-04648-9 (Source: Cancer Control)
Source: Cancer Control - April 10, 2024 Category: Cancer & Oncology Authors: Sakibul Huq Regan M Shanahan Samuel Adida Othman Bin-Alamer Hussam Abou-Al-Shaar Ajay Niranjan Constantinos G Hadjipanayis L Dade Lunsford Source Type: research
Intra-fractional lung tumor motion monitoring using arbitrary gantry angles during radiotherapy treatment
This study attempts to answer the question of whether automatic 2D/3D registration is possible using kV images as well as kV-MV image pairs for gantry angles other than the AP direction. We also investigated the effect of additional portal MV images paired with kV images to improve 2D/3D registration in extracting cranio-caudal (CC) and AP displacement at arbitrary gantry angles and different fractions. The kV and MV image sequences as well as 3D volume data from five patients suffering from non-small cell lung cancer undergoing SBRT were used. Diaphragm motion served as the reference signal. The CC and AP displacements re...
Source: Zeitschrift fur Medizinische Physik - April 10, 2024 Category: Radiology Authors: Sepideh Hatamikia Soraya Elmirad Hugo Furtado Gernot Kronreif Elisabeth Steiner Wolfgang Birkfellner Source Type: research
Robust Optimization for Prostate Radiation Therapy: Assessment of Delivered Dose by Incorporating Intrafraction Prostate Position Deviations
CONCLUSIONS: Robust optimization resulted in lower V40 and V60 values for the bladder compared with PTV-based planning. However, no difference in CTV dose accuracy was found between the 2 approaches.PMID:38596454 | PMC:PMC11002539 | DOI:10.1016/j.adro.2024.101455 (Source: Adv Data)
Source: Adv Data - April 10, 2024 Category: Epidemiology Authors: Sankar Arumugam Mark Sidhom Source Type: research
Technical note: Visual, rapid, scintillation point dosimetry for in vivo MV photon beam radiotherapy treatments
CONCLUSIONS: Plastic scintillator discs have characteristics that are well-suited for in vivo optical dosimetry for x-ray radiotherapy treatments. Unlike typical point dosimeters, there is no inherent readout time delay, and an optical recording of the measurement is saved after treatment for future reference. While several factors influence the integral output for the same dose, they have been quantified here and may be corrected in post-processing.PMID:38598093 | DOI:10.1002/mp.17071 (Source: Health Physics)
Source: Health Physics - April 10, 2024 Category: Physics Authors: Savannah M Decker Petr Bruza Rongxiao Zhang Benjamin B Williams Lesley A Jarvis Brian W Pogue David J Gladstone Source Type: research
Favorable Response of 225Ac-PSMA in the Treatment of Castration-Resistant Prostate Cancer With High Bone Metastasis Burden
Clin Nucl Med. 2024 Apr 5. doi: 10.1097/RLU.0000000000005222. Online ahead of print.ABSTRACT225Ac-PSMA treatment demonstrated low hematologic toxicity for prostate cancer with diffuse red marrow infiltration. A 70-year-old man with diffuse bone metastases of castration-resistant prostate cancer received 225Ac-PSMA radiation therapy. After 1 treatment cycle, the patient's skeletal lesions demonstrated a significant response and a significant decrease in PSA. 225Ac-PSMA may be a promising therapeutic option for metastatic castration-resistant prostate cancer patients with high bone metastatic burden.PMID:38598741 | DOI:10.10...
Source: Clinical Prostate Cancer - April 10, 2024 Category: Cancer & Oncology Authors: Yudi Wang Qingchu Hua Yu Zhang Wei Wang Yue Chen Source Type: research
