Characterization of the IDENTIFY < sup > TM < /sup > surface scanning system for radiation therapy setup on a closed-bore linac
CONCLUSION: The IDENTIFYTM system can adequately be used for motion monitoring on a closed-bore linac with submillimeter accuracy. The results of the performed measurements meet the clinical requirements described in the guidelines of the AAPM and the ESTRO.PMID:38497554 | DOI:10.1002/acm2.14326 (Source: Journal of Applied Clinical Medical Physics)
Source: Journal of Applied Clinical Medical Physics - March 18, 2024 Category: Physics Authors: Janita Dekker Sander van Het Schip Marion Essers Mariska de Smet Martijn Kusters Willy de Kruijf Source Type: research

Cancers, Vol. 16, Pages 1192: Comprehensive 3DCRT Hypofractionated Radiotherapy Schedule for Localized Prostate Adenocarcinoma in the Era of IMRT: Dosimetric and Endoscopic Analysis
Conclusions: A thorough delineation of the rectal wall and its subsegments, together with the dosimetric analysis of these structures, may reduce late rectal toxicity. Dosimetric parameters such as V52.17Gy and V56.52Gy were identified to have a significant impact on rectal mucosal injury; additional dose endpoint validation and its relation to late GI toxicity is needed. (Source: Cancers)
Source: Cancers - March 18, 2024 Category: Cancer & Oncology Authors: Andromachi Kougioumtzopoulou Nick Syrigos Anna Zygogianni Ioannis Georgakopoulos Kalliopi Platoni George Patatoukas Kimon Tzannis Aristotelis Bamias Nikolaos Kelekis Vasileios Kouloulias Tags: Article Source Type: research

A Single Institution Review of the Use of Radiation in the Adjuvant and Definitive Management of Keloids
And purpose: Many individuals suffer from keloids that are refractory to standard treatment modalities, including surgical excision alone. Radiation therapy can be used to reduce the risk of recurrent keloids post-operatively, as well as be used as primary treatment for keloids not amenable to surgical resection. The purpose of this study was to review our institutional experience of radiation therapy for keloid management. (Source: Clinical Oncology)
Source: Clinical Oncology - March 18, 2024 Category: Radiology Authors: Jason Fernandes, Donna Liao, Archya Dasgupta, May N. Tsao, Elizabeth A. Barnes Tags: Original Article Source Type: research

Systematic review of hypofractionated radiation therapy for the treatment of oesophageal squamous cell carcinoma and oesophageal adenocarcinoma
There has been limited progress made in improving the suboptimal outcomes delivered by conventionally fractionated radiotherapy (RT) for oesophageal adenocarcinoma (OAC) and squamous cell carcinoma (OSCC). A greater biological effect may be achieved using hypofractionated RT (HFRT), though the toxicity, tolerability and efficacy of this approach in OAC and OSCC is uncertain. (Source: Clinical Oncology)
Source: Clinical Oncology - March 18, 2024 Category: Radiology Authors: Chandan Sanghera, Dylan McClurg, Christopher M. Jones Tags: Original Article Source Type: research

Molecular changes in breast cancer induced by radiation therapy
Breast cancer treatments are based on prognostic clinicopathological features that form the basis for therapeutic guidelines. While the utilization of these guidelines has decreased breast cancer-associated mortality rates over the past three decades, they are not adequate for individualized therapy. Radiation therapy (RT) is the backbone of breast cancer treatment. Although a highly successful therapeutic modality clinically, from a biological perspective, preclinical studies have shown RT to have the potential to alter tumor cell phenotype, immunogenicity and the surrounding microenvironment, potentially changing the beh...
Source: International Journal of Radiation Oncology * Biology * Physics - March 18, 2024 Category: Radiology Authors: Kim Sheva, Sangita Roy Chowdhury, Nataly Kravchenko-Balasha, Amichay Meirovitz Tags: Critical Review Source Type: research

Delayed Commissuroplasty Increases Interincisal Distance in Buccogingival Cancer Patients Treated with Free Flap Reconstruction of the Oral Commissure
Conclusion Delayed commissuroplasty increased interincisal distance and normalize drooling in patients who required full-thickness excision of the buccal mucosa and oral commissure and free tissue reconstruction. The presented data can help to educate patients on expected postoperative outcomes and likely advocates for a second-stage procedure after completion of adjunct radiotherapy to achieve optimal commissural placement and oral competence. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Sou...
Source: Journal of Reconstructive Microsurgery - March 18, 2024 Category: Surgery Authors: Hung, Shao Yu Hanba, Curtis Chang, Tommy Nai-Jen Chen, Yan-Lin Lu, Johnny Chuieng-Yi Tags: Original Article Source Type: research

Breast cancer derived exosomes: Theragnostic perspectives and implications
Clin Chim Acta. 2024 Mar 15:117875. doi: 10.1016/j.cca.2024.117875. Online ahead of print.ABSTRACTBreast cancer (BC) is the most prevalent malignancy affecting women worldwide. Although conventional treatments such as chemotherapy, surgery, hormone therapy, radiation therapy, and biological therapy are commonly used, they often entail significant side effects. Therefore, there is a critical need to investigate more cost-effective and efficient treatment modalities in BC. Extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies, play a crucial role in modulating recipient cell behaviour and driv...
Source: International Journal of Clinical Chemistry - March 17, 2024 Category: Chemistry Authors: Ram Mohan Ram Kumar Logesh Rajan Suresh Joghee Source Type: research

A Randomized Trial Comparing Quality of Life After LDR or HDR Prostate Brachytherapy Boost with Pelvic External Beam Radiation Therapy
CONCLUSIONS: Patient experience for combined EBRT and prostate BT is improved with HDR BT. Urinary QoL improves over time to be equivalent between the 2 modalities after 18 months, but LDR patients report lasting bowel symptoms.PMID:38493901 | DOI:10.1016/j.ijrobp.2024.02.064 (Source: Health Physics)
Source: Health Physics - March 17, 2024 Category: Physics Authors: Juanita Crook Nikitha Moideen Greg Arbour Felipe Castro C ánovas Cynthia Araujo Deidre Batchelar Ross Halperin Michelle Hilts David Kim David Petrik Jim Rose J C Cheng Francois Bachand Source Type: research

Breast cancer derived exosomes: Theragnostic perspectives and implications
Clin Chim Acta. 2024 Mar 15:117875. doi: 10.1016/j.cca.2024.117875. Online ahead of print.ABSTRACTBreast cancer (BC) is the most prevalent malignancy affecting women worldwide. Although conventional treatments such as chemotherapy, surgery, hormone therapy, radiation therapy, and biological therapy are commonly used, they often entail significant side effects. Therefore, there is a critical need to investigate more cost-effective and efficient treatment modalities in BC. Extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies, play a crucial role in modulating recipient cell behaviour and driv...
Source: Clinical Breast Cancer - March 17, 2024 Category: Cancer & Oncology Authors: Ram Mohan Ram Kumar Logesh Rajan Suresh Joghee Source Type: research

Breast cancer derived exosomes: Theragnostic perspectives and implications
Clin Chim Acta. 2024 Mar 15:117875. doi: 10.1016/j.cca.2024.117875. Online ahead of print.ABSTRACTBreast cancer (BC) is the most prevalent malignancy affecting women worldwide. Although conventional treatments such as chemotherapy, surgery, hormone therapy, radiation therapy, and biological therapy are commonly used, they often entail significant side effects. Therefore, there is a critical need to investigate more cost-effective and efficient treatment modalities in BC. Extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies, play a crucial role in modulating recipient cell behaviour and driv...
Source: Clinical Genitourinary Cancer - March 17, 2024 Category: Cancer & Oncology Authors: Ram Mohan Ram Kumar Logesh Rajan Suresh Joghee Source Type: research

Breast cancer derived exosomes: Theragnostic perspectives and implications
Clin Chim Acta. 2024 Mar 15:117875. doi: 10.1016/j.cca.2024.117875. Online ahead of print.ABSTRACTBreast cancer (BC) is the most prevalent malignancy affecting women worldwide. Although conventional treatments such as chemotherapy, surgery, hormone therapy, radiation therapy, and biological therapy are commonly used, they often entail significant side effects. Therefore, there is a critical need to investigate more cost-effective and efficient treatment modalities in BC. Extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies, play a crucial role in modulating recipient cell behaviour and driv...
Source: International Journal of Clinical Chemistry - March 17, 2024 Category: Chemistry Authors: Ram Mohan Ram Kumar Logesh Rajan Suresh Joghee Source Type: research

Pelvic bone marrow dose-volume predictors of late lymphopenia following pelvic lymph node radiation therapy for prostate cancer
The interest concerning radiation-induced hematological toxicity (HT) increased in the last years [1 –7]. The occurrence of severe decrease of blood counts is a well assessed side-effect experienced by many patients undergoing radiochemotherapy [1,6,8–10] and several investigations showed clear association between the incidence and severity of HT and the extent of bone marrow (BM) and of body i rradiated, as well as the delivered dose and fractionation [1,11–14]. On the other hand, the interest in quantifying these effects induced by radiation only (i.e.: without chemotherapy) is equally high, aiming to estimate the ...
Source: Radiotherapy and Oncology - March 17, 2024 Category: Radiology Authors: Maddalena Pavarini, Lisa Alborghetti, Stefania Aimonetto, Angelo Maggio, Valeria Landoni, Paolo Ferrari, Antonella Bianculli, Edoardo Petrucci, Alessandro Cicchetti, Bruno Farina, Maria Giulia Ubeira Gabellini, Paolo Salmoiraghi, Eugenia Moretti, Barbara Tags: Original Article Source Type: research

Radiation Therapy Quality Assurance Analysis of Alliance A021501: Preoperative mFOLFIRINOX or mFOLFIRINOX plus hypofractionated radiation therapy for borderline resectable adenocarcinoma of the pancreas
CONCLUSION: Despite rigorous QA, we encountered variability in simulation, contouring, plan coverage, and dose on trial. While clinical outcomes did not appear to be impacted, findings from this analysis serve to inform subsequent PDAC SBRT trial designs and QA requirements.PMID:38492812 | DOI:10.1016/j.ijrobp.2024.03.013 (Source: Health Physics)
Source: Health Physics - March 16, 2024 Category: Physics Authors: Leila T Tchelebi Diana Segovia Koren Smith Qian Shi T J Fitzgerald Michael D Chuong Tyler J Zemla Eileen M O'Reilly Jeffrey Meyerhardt Eugene J Koay Jessica Leif Ardaman Shergill Matthew Hg Katz Joseph M Herman Source Type: research

Assessment of Postmastectomy Radiation Therapy Receipt by Age and Association With Outcomes in Women With Breast Cancer
CONCLUSION: Patients <50 years were more likely to undergo PMRT and to receive RNI to the internal mammary nodes but were also more likely to have other risk factors for recurrence that would warrant a PMRT recommendation. PMRT improved OS and RFS for all patients.PMID:38492996 | DOI:10.1016/j.clbc.2024.02.021 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - March 16, 2024 Category: Cancer & Oncology Authors: Carolina E Fasola Elaina Graham Wei Sha Courtney R Schepel Sally J Trufan Anna Hecksher Richard L White Lejla Hadzikadic-Gusic Source Type: research

Assessment of Postmastectomy Radiation Therapy Receipt by Age and Association With Outcomes in Women With Breast Cancer
CONCLUSION: Patients <50 years were more likely to undergo PMRT and to receive RNI to the internal mammary nodes but were also more likely to have other risk factors for recurrence that would warrant a PMRT recommendation. PMRT improved OS and RFS for all patients.PMID:38492996 | DOI:10.1016/j.clbc.2024.02.021 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - March 16, 2024 Category: Cancer & Oncology Authors: Carolina E Fasola Elaina Graham Wei Sha Courtney R Schepel Sally J Trufan Anna Hecksher Richard L White Lejla Hadzikadic-Gusic Source Type: research